CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest

Thrombospondin 1 and Vasoactive Agents Indirectly Alter Tumor Blood Flow

(2015) Jeff S. Isenberg et al.   NEOPLASIA

Thrombospondin-1 and Angiotensin II Inhibit Soluble Guanylyl Cyclase through an Increase in Intracellular Calcium Concentration

(2011) Saumya Ramanathan et al.   BIOCHEMISTRY

Fusion between Intestinal Epithelial Cells and Macrophages in a Cancer Context Results in Nuclear Reprogramming

(2011) Anne E. Powell et al.   CANCER RESEARCH

A new disulfide-linked dimer of a single-chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor-1α pathway

(2011) Morihiko Sagawa et al.   CANCER SCIENCE

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Heparan Sulfate Modification of the Transmembrane Receptor CD47 Is Necessary for Inhibition of T Cell Receptor Signaling by Thrombospondin-1

(2011) Sukhbir Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Thrombospondin-1 Is a Plasmatic Marker of Peripheral Arterial Disease That Modulates Endothelial Progenitor Cell Angiogenic Properties

(2010) David M. Smadja et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thrombospondin-1 is an inhibitor of pharmacological activation of soluble guanylate cyclase

(2010) Thomas W Miller et al.   BRITISH JOURNAL OF PHARMACOLOGY

Therapeutic Antibody Targeting of CD47 Eliminates Human Acute Lymphoblastic Leukemia

(2010) Mark P. Chao et al.   CANCER RESEARCH

Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation

(2010) Eileen M. Bauer et al.   CARDIOVASCULAR RESEARCH

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

(2010) Mark P. Chao et al.   CELL

T regulatory cells in cancer: recent advances and therapeutic potential

(2010) Eyad Elkord et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Activation of CD47 receptors causes proliferation of human astrocytoma but not normal astrocytes via an Akt-dependent pathway

(2010) Emilie Sick et al.   GLIA

Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47

(2010) Sukhbir Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombospondin-1 inhibition of vascular smooth muscle cell responses occurs via modulation of both cAMP and cGMP

(2010) Mingyi Yao et al.   PHARMACOLOGICAL RESEARCH

Amyloid-β Inhibits No-cGMP Signaling in a CD36- and CD47-Dependent Manner

(2010) Thomas W. Miller et al.   PLoS One

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

(2010) M. P. Chao et al.   Science Translational Medicine

Blockade of Thrombospondin-1-CD47 Interactions Prevents Necrosis of Full Thickness Skin Grafts

(2009) Jeff S. Isenberg et al.   ANNALS OF SURGERY

Therapeutic antibodies: successes, limitations and hopes for the future

(2009) Patrick Chames et al.   BRITISH JOURNAL OF PHARMACOLOGY

CD47 Regulates Bone Mass and Tumor Metastasis to Bone

(2009) O. Uluckan et al.   CANCER RESEARCH

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

(2009) Ravindra Majeti et al.   CELL

Activation of CD47 receptors causes histamine secretion from mast cells

(2009) E. Sick et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton

(2009) S. Barbier et al.   HAEMATOLOGICA

Structure of Signal-regulatory Protein α

(2009) Deborah Hatherley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurovascular effects of CD47 signaling: Promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro

(2009) Changhong Xing et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Thrombospondin-1–CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO–cGMP pathway activation

(2009) Jeff S. Isenberg et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Thrombospondin-1/CD47 Blockade following Ischemia-Reperfusion Injury Is Tissue Protective

(2009) Justin B. Maxhimer et al.   PLASTIC AND RECONSTRUCTIVE SURGERY

CD47 Regulates Collagen I-Induced Cyclooxygenase-2 Expression and Intestinal Epithelial Cell Migration

(2009) Oliver Jay Broom et al.   PLoS One

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells

(2009) K. S. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radioprotection in Normal Tissue and Delayed Tumor Growth by Blockade of CD47 Signaling

(2009) J. B. Maxhimer et al.   Science Translational Medicine

Thrombospondin-1 and CD47 Limit Cell and Tissue Survival of Radiation Injury

(2008) Jeff S. Isenberg et al.   AMERICAN JOURNAL OF PATHOLOGY

Gene Silencing of CD47 and Antibody Ligation of Thrombospondin-1 Enhance Ischemic Tissue Survival in a Porcine Model

(2008) Jeff S. Isenberg et al.   ANNALS OF SURGERY

Human thrombospondin’s (TSP-1) C-terminal domain opens to interact with the CD-47 receptor: A molecular modeling study

(2008) Nicolas Floquet et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Endothelial CD47 interaction with SIRP  is required for human T-cell transendothelial migration under shear flow conditions in vitro

(2008) M. Stefanidakis et al.   BLOOD

Inhibition of “self” engulfment through deactivation of myosin-II at the phagocytic synapse between human cells

(2008) Richard K. Tsai et al.   JOURNAL OF CELL BIOLOGY

Paired Receptor Specificity Explained by Structures of Signal Regulatory Proteins Alone and Complexed with CD47

(2008) Deborah Hatherley et al.   MOLECULAR CELL

Treatment of liver ischemia–reperfusion injury by limiting thrombospondin-1/CD47 signaling

(2008) Jeff S. Isenberg et al.   SURGERY

Association of CD47 with Natural Killer Cell-Mediated Cytotoxicity of Head-and-Neck Squamous Cell Carcinoma Lines

(2008) Min Jung Kim et al.   TUMOR BIOLOGY

Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling

(2007) J. S. Isenberg et al.   BLOOD