Flavan-3-ol esters: new agents for exploring modulatory sites on GABAA receptors

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Numerous Classes of General Anesthetics Inhibit Etomidate Binding to γ-Aminobutyric Acid Type A (GABAA) Receptors

(2010) Guo-Dong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding, activation and modulation of Cys-loop receptors

(2010) Paul S. Miller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

γ-Amino Butyric Acid Type A Receptor Mutations at β2N265 Alter Etomidate Efficacy While Preserving Basal and Agonist-dependent Activity

(2009) Rooma Desai et al.   ANESTHESIOLOGY

Synthesis and biological evaluation of flavan-3-ol derivatives as positive modulators of GABAA receptors

(2009) Kenneth N. Mewett et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mutations of the GABA-A Receptor  1 Subunit M1 Domain Reveal Unexpected Complexity for Modulation by Neuroactive Steroids

(2008) G. Akk et al.   MOLECULAR PHARMACOLOGY

Tryptophan Mutations at Azi-Etomidate Photo-Incorporation Sites on  1 or  2 Subunits Enhance GABAA Receptor Gating and Reduce Etomidate Modulation

(2008) D. Stewart et al.   MOLECULAR PHARMACOLOGY

Flavan-3-ol derivatives are positive modulators of GABAA receptors with higher efficacy for the α2 subtype and anxiolytic action in mice

(2008) Sebastian P. Fernandez et al.   NEUROPHARMACOLOGY

Targeted deletion of the GABRA2 gene encoding α2-subunits of GABAA receptors facilitates performance of a conditioned emotional response, and abolishes anxiolytic effects of benzodiazepines and barbiturates

(2008) C.I. Dixon et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR