Function of hyperekplexia-causing α1R271Q/L glycine receptors is restored by shifting the affected residue out of the allosteric signalling pathway

Pathophysiological Mechanisms of Dominant and Recessive GLRA1 Mutations in Hyperekplexia

(2013) S.-K. Chung et al.   JOURNAL OF NEUROSCIENCE

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Allostery and population shift in drug discovery

(2010) Gozde Kar et al.   CURRENT OPINION IN PHARMACOLOGY

A glycine residue essential for high ivermectin sensitivity in Cys-loop ion channel receptors

(2010) Timothy Lynagh et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

PATH40 Spectrum of clinical disease in hyperekplexia: the genotypes and phenotypes of 48 cases

(2010) R. H. Thomas et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Chimera construction using multiple-template-based sequential PCRs

(2010) Qiang Shan et al.   JOURNAL OF NEUROSCIENCE METHODS

Nicotinic Acetylcholine Receptor Transmembrane Mutations Convert Ivermectin from a Positive to a Negative Allosteric Modulator

(2010) T. Collins et al.   MOLECULAR PHARMACOLOGY

Folding and binding cascades: Dynamic landscapes and population shifts

(2010) Sandeep Kumar et al.   PROTEIN SCIENCE

The structural basis of function in Cys-loop receptors

(2010) Andrew J. Thompson et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Binding, activation and modulation of Cys-loop receptors

(2010) Paul S. Miller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain

(2009) Jeremy M.R. Lambert et al.   CANCER CELL

Binding to Gating Transduction in Nicotinic Receptors: Cys-Loop Energetically Couples to Pre-M1 and M2-M3 Regions

(2009) W. Y. Lee et al.   JOURNAL OF NEUROSCIENCE

Clonazepam is an effective treatment for hyperekplexia due to a SLC6A5 (GlyT2) mutation

(2009) Mirte J. Bakker et al.   MOVEMENT DISORDERS

The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways

(2009) Antonio del Sol et al.   STRUCTURE

ILLUMINATING THE STRUCTURE AND FUNCTION OF CYS-LOOP RECEPTORS

(2008) Stephan A Pless et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

(2008) Nicholas P. Franks   NATURE REVIEWS NEUROSCIENCE

The genetics of hyperekplexia: more than startle!

(2008) Robert J. Harvey et al.   TRENDS IN GENETICS