Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Xenosensors CAR and PXR at Work: Impact on Statin Metabolism

(2011) Maria Marino et al.   CURRENT DRUG METABOLISM

Effects of SLCO1B1 and ABCB1 genotypes on the pharmacokinetics of atorvastatin and 2-hydroxyatorvastatin in healthy Korean subjects

(2011) Y.J. Lee et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Multi-species Analyses of Direct Activators of the Constitutive Androstane Receptor

(2011) Curtis J. Omiecinski et al.   TOXICOLOGICAL SCIENCES

The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes

(2011) Katharine Howe et al.   XENOBIOTICA

Rational quantitative structure–activity relationship (RQSAR) screen for PXR and CAR isoform-specific nuclear receptor ligands

(2010) Ann M. Dring et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Profiling Induction of Cytochrome P450 Enzyme Activity by Statins Using a New Liquid Chromatography-Tandem Mass Spectrometry Cocktail Assay in Human Hepatocytes

(2010) D. M. Feidt et al.   DRUG METABOLISM AND DISPOSITION

Activation of xenobiotic receptors: driving into the nucleus

(2010) Haishan Li et al.   Expert Opinion on Drug Metabolism & Toxicology

UDP-Glucuronosyltransferase (UGT) Polymorphisms Affect Atorvastatin Lactonization In Vitro and In Vivo

(2009) S Riedmaier et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells

(2009) Daisuke Yamasaki et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects

(2009) Alessandra di Masi et al.   MOLECULAR ASPECTS OF MEDICINE

Statin regulation of CYP3A4 and CYP3A5 expression

(2009) Maria Alice Vieira Willrich et al.   PHARMACOGENOMICS

ABCB1 Haplotypes Differentially Affect the Pharmacokinetics of the Acid and Lactone Forms of Simvastatin and Atorvastatin

(2008) JE Keskitalo et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Drug Interaction Potential of 2-((3,4-Dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the Novel Nonstatin-Type Cholesterol-Lowering Agent

(2008) K. Monostory et al.   DRUG METABOLISM AND DISPOSITION