The α7 nicotinic ACh receptor agonist compound B and positive allosteric modulator PNU-120596 both alleviate inflammatory hyperalgesia and cytokine release in the rat

The antihyperalgesic effect of cytidine-5′-diphosphate-choline in neuropathic and inflammatory pain models

(2011) Deniz Bagdas et al.   BEHAVIOURAL PHARMACOLOGY

Role of α7 nicotinic acetylcholine receptors in regulating tumor necrosis factor-α (TNF-α) as revealed by subtype selective agonists

(2011) Jinhe Li et al.   JOURNAL OF NEUROIMMUNOLOGY

A question of balance – Positive versus negative allosteric modulation of GABAA receptor subtypes as a driver of analgesic efficacy in rat models of inflammatory and neuropathic pain

(2011) Gordon Munro et al.   NEUROPHARMACOLOGY

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

Intrathecal injection of an alpha seven nicotinic acetylcholine receptor agonist attenuates gp120-induced mechanical allodynia and spinal pro-inflammatory cytokine profiles in rats

(2010) Lisa C. Loram et al.   BRAIN BEHAVIOR AND IMMUNITY

Guidelines for reporting experiments involving animals: the ARRIVE guidelines

(2010) JC McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Diclofenac: an update on its mechanism of action and safety profile

(2010) Tong J. Gan   CURRENT MEDICAL RESEARCH AND OPINION

Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain

(2010) BaoXi Gao et al.   PAIN

Protective effect of alpha7 nAChR: Behavioural and morphological features on neuropathy

(2010) Alessandra Pacini et al.   PAIN

Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin

(2009) Yan-li Liu et al.   ACTA PHARMACOLOGICA SINICA

The Effect of Peripherally Administered CDP-Choline in an Acute Inflammatory Pain Model: The Role of α7 Nicotinic Acetylcholine Receptor

(2009) Mine Sibel Gurun et al.   ANESTHESIA AND ANALGESIA

Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice

(2009) Marjolein A. van Maanen et al.   ARTHRITIS AND RHEUMATISM

Pharmacological assessment of the rat formalin test utilizing the clinically used analgesic drugs gabapentin, lamotrigine, morphine, duloxetine, tramadol and ibuprofen: Influence of low and high formalin concentrations

(2009) Gordon Munro   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of the Cholinergic Anti-Inflammatory System by Nicotine Attenuates Neuroinflammation via Suppression of Th1 and Th17 Responses

(2009) E. Nizri et al.   JOURNAL OF IMMUNOLOGY

Physiological Concentrations of Choline Activate Native  7-Containing Nicotinic Acetylcholine Receptors in the Presence of PNU-120596 [1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea]

(2009) A. G. Gusev et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

An Allosteric Modulator of  7 Nicotinic Receptors, N-(5-Chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596), Causes Conformational Changes in the Extracellular Ligand Binding Domain Similar to Those Caused by Acetylcholine

(2009) S. C. Barron et al.   MOLECULAR PHARMACOLOGY

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

(2009) Antoine Taly et al.   NATURE REVIEWS DRUG DISCOVERY

A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain

(2009) Michael C. Rowbotham et al.   PAIN

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Nociceptors Are Interleukin-1  Sensors

(2008) A. M. Binshtok et al.   JOURNAL OF NEUROSCIENCE

Activation of the α7-Nicotinic Acetylcholine Receptor Reverses Complete Freund Adjuvant–Induced Mechanical Hyperalgesia in the Rat Via a Central Site of Action

(2008) Stephen J. Medhurst et al.   JOURNAL OF PAIN

Comparison of the Novel Subtype-Selective GABAA Receptor-Positive Allosteric Modulator NS11394 [3'-[5-(1-Hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with Diazepam, Zolpidem, Bretazenil, and Gaboxadol in Rat Models of Inflammatory and Neuropathic Pain

(2008) G. Munro et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The selective nicotinic acetylcholine receptor α7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain

(2008) Dominik Feuerbach et al.   NEUROPHARMACOLOGY