Carvedilol targets human K2P3.1 (TASK1) K+leak channels

Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability

(2010) Birgit C. Donner et al.   BASIC RESEARCH IN CARDIOLOGY

New antiarrhythmic drugs for treatment of atrial fibrillation

(2010) Dobromir Dobrev et al.   LANCET

Novel pharmacological approaches for antiarrhythmic therapy

(2010) Ursula Ravens   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Molecular Background of Leak K+ Currents: Two-Pore Domain Potassium Channels

(2010) Péter Enyedi et al.   PHYSIOLOGICAL REVIEWS

The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone

(2009) Jakob Gierten et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein

(2008) J Gierten et al.   BRITISH JOURNAL OF PHARMACOLOGY

Electrophysiological Effects of Carvedilol Administration in Patients with Dilated Cardiomyopathy

(2008) Emmanuel M. Kanoupakis et al.   CARDIOVASCULAR DRUGS AND THERAPY

Atrial Remodeling and Atrial Fibrillation

(2008) Stanley Nattel et al.   Circulation-Arrhythmia and Electrophysiology

Alternative Translation Initiation in Rat Brain Yields K2P2.1 Potassium Channels Permeable to Sodium

(2008) Dierk Thomas et al.   NEURON

Comparison of the efficacy of metoprolol and carvedilol for preventing atrial fibrillation after coronary bypass surgery

(2007) Sadik Acikel et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Comparison of HERG channel blocking effects of various β-blockers - implication for clinical strategy

(2005) Kazunobu Kawakami et al.   BRITISH JOURNAL OF PHARMACOLOGY