4.7 Article

Antibodies against the cardiac sodium/bicarbonate co-transporter (NBCe1) as pharmacological tools

Journal

BRITISH JOURNAL OF PHARMACOLOGY
Volume 164, Issue 8, Pages 1976-1989

Publisher

WILEY
DOI: 10.1111/j.1476-5381.2011.01496.x

Keywords

Na; HCO3-co-transporter; cardiac myocytes; functional antibodies

Funding

  1. Agencia Nacional de Promocion Cientifica y Tecnologica de Argentina [PICT 1040, PICT 01011]
  2. Sociedad Argentina de Hipertension (SAHA)
  3. Sanofi-Aventis (Germany)
  4. Heart and Stroke Foundation of Alberta

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BACKGROUND AND PURPOSE Na+/HCO3- co-transport (NBC) regulates intracellular pH (pHi) in the heart. We have studied the electrogenic NBC isoform NBCe1 by examining the effect of functional antibodies to this protein.

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