Value of non-clinical cardiac repolarization assays in supporting the discovery and development of safer medicines

Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives

(2009) Rashmi R Shah   BRITISH JOURNAL OF PHARMACOLOGY

Integrated risk assessment and predictive value to humans of non-clinical repolarization assays

(2009) Robert M Wallis   BRITISH JOURNAL OF PHARMACOLOGY

Dog left ventricular midmyocardial myocytes for assessment of drug-induced delayed repolarization: short-term variability and proarrhythmic potential

(2009) Najah Abi-Gerges et al.   BRITISH JOURNAL OF PHARMACOLOGY

A HESI consortium approach to assess the human predictive value of non-clinical repolarization assays

(2009) Elena S. Trepakova et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

In vitromodels of proarrhythmia

(2008) C L Lawrence et al.   BRITISH JOURNAL OF PHARMACOLOGY

Principles of Safety Pharmacology

(2008) M K Pugsley et al.   BRITISH JOURNAL OF PHARMACOLOGY

Safety and secondary pharmacology: Successes, threats, challenges and opportunities

(2008) Jean-Pierre Valentin et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS