Article
Biochemistry & Molecular Biology
Kathleen A. Trychta, Brandon K. Harvey
Summary: Drug abuse can lead to hyperthermia, triggering endoplasmic reticulum (ER) stress and the unfolded protein response (UPR). This study demonstrates that the combination of MDMA and caffeine exacerbates disruption of ER proteostasis, contributing to cellular toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zijuan Bi, Shisheng Zhang, Yangyang Meng, Ya Feng, Yinshu Wang, Enkang Wang, Xiangxue Pan, Ruixin Zhu, Haiting Fan, Shuhua Pang, Lixin Zhu, Jianye Yuan
Summary: The knockout of the SERT gene may lead to changes in the serotonin system, causing VH and accelerated gastrointestinal motility in female rats, which can be used as an animal model of IBS.
Article
Medicine, Research & Experimental
Elias B. Nascimento Jr., R. L. Romero, Marcela M. G. B. Dutra, Bernd L. Fiebich, Igor D. G. Duarte, Marcio M. Coelho
Summary: The activation of 5-HT1D and 5-HT7 receptors plays a role in mechanical allodynia induced by 5-HT in mice, while peripheral 5-HT3 receptors have an inhibitory role in the nociceptive response induced by 5-HT or carrageenan.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Susan Schenk, Quenten Highgate
Summary: MDMA preferentially stimulates serotonin release and has relatively small effects on dopamine, with drugs having higher dopamine to serotonin ratios more likely to be abused. Repeated exposure to MDMA can lead to neuroadaptive responses in serotonin and dopamine that may explain self-administration in animals and substance use disorder in humans. Serotonin inhibits the acquisition of MDMA self-administration, while dopamine plays a critical role in maintaining self-administration in laboratory animals, with limited research on the effects of MDMA exposure on serotonin receptors and circuits modulating dopamine activity.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Silvia Maggi, Carlotta Bon, Stefano Gustincich, Valter Tucci, Raul R. Gainetdinov, Stefano Espinoza
Summary: Trace amine-associated receptor 5 (TAAR5) modulates cognitive processes, potentially affecting the number of errors and the rate of task improvement.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Ulrich Gergs, Tobias Brueckner, Britt Hofmann, Joachim Neumann
Summary: The study revealed that lowering temperature can increase arrhythmias in mice overexpressing the human 5-HT4 receptor in their cardiac myocytes, suggesting a potential link between 5-HT4 receptors and hypothermia-induced arrhythmias in human patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Edward Ofori, Edem K. Onyameh, Uma M. Gonela, Chandrashekhar Voshavar, Barbara Bricker, Tracy L. Swanson, Amy J. Eshleman, Jennifer L. Schmachtenberg, Shelley H. Bloom, Aaron J. Janowsky, Seth Y. Ablordeppey
Summary: We have conducted a study to explore the potential of dual 5-HT1AR and 5-HT7R ligands, resulting in the identification of a new compound with high affinity for these receptors. This compound, designated as 21, shows promising functional characteristics as a potential antidepressant agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Jarkko Johansson, Madelene Ericsson, Jan Axelsson, Sara af Bjerken, Ana Virel, Nina Karalija
Summary: Mapping the effects of drugs on the entire brain is crucial for understanding the neural mechanisms behind drug-related behaviors. Using PET, this study investigated the regional and temporal characteristics of amphetamine-induced dopamine release in the brain, revealing distinct responses in different brain regions.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Sebastien Belliveau, Woojin Kang, Samantha Bovaird, Adjia Hamadjida, Dominique Bedard, Numa Dancause, Thomas Stroh, Philippe Huot
Summary: The study quantified the distribution of 5-HT3 receptors in the substantia nigra (SN) and the dorsal raphe nucleus (DRN) in adult rats, finding that 5-HT3A receptor-positive cells are present in the SNr, but not in the DRN. The results support the presence of 5-HT3 receptors in the SN, but not in the DRN.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)
Article
Neurosciences
Yukio Ago, Rei Yokoyama, Satoshi Asano, Hitoshi Hashimoto
Summary: The antidepressant effects of ketamine may be related to both the dopaminergic system and the serotonergic system, while the effects of (R)-ketamine may be independent of the monoaminergic system. Ketamine metabolites differ in their ability to regulate monoamine neurotransmitters, and some metabolites may share common serotonergic signaling mechanisms with ketamine.
Article
Neurosciences
Miguel A. Nunez-Ochoa, Gustavo A. Chipres-Tinajero, Laura Medina-Ceja
Summary: The study observed a general depletion in 5-HT and 5-HIIA levels in hippocampal tissue of epileptic animals, along with a decrease in immunoreactivity for three 5-HT receptors, especially in the DG region. These findings may support the establishment of an excitatory/inhibitory imbalance in the trisynaptic circuit underlying the generation of fast ripples in epilepsy.
Article
Biochemistry & Molecular Biology
Georg A. Petroianu
Summary: This article discusses the neural circuitry and neurotransmitters involved in temperature control in homeothermic animals, as well as the mechanisms for regulating hyperthermia and hypothermia. The article also presents an ideal antidote profile against serotonin syndrome hyperthermia and highlights the need for identifying better matches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Rashid Giniatullin
Summary: 5-hydroxytryptamine (5-HT) is considered a key mediator in migraine, but the role of 5-HT3 receptors in pain transmission remains controversial. The applicability of currently available 5-HT3 antagonists in migraine treatment is not clearly supported by clinical data.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Clinical Neurology
Karolina E. Kolaczynska, Paula Ducret, Daniel Trachsel, Marius C. Hoener, Matthias E. Liechti, Dino Luethi
Summary: This article examines the pharmacological properties of MDA analogs and related amphetamine-based compounds, including monoamine uptake inhibition and release, as well as transporter and receptor binding and activation properties. The study finds that some MDA analogs have similar pharmacological profiles to MDMA, while others have more pronounced dopaminergic activity. Further research on the pharmacokinetics and pharmacodynamics of these drugs is needed to better evaluate their risks and therapeutic potential.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Immunology
Minjie Wan, Zhanchuan Ma, Jiawen Han, Min Rao, Feng Hu, Pujun Gao, Xiaocong Wang
Summary: The 5-HT/5-HT7R signaling pathway helps to constrain inflammation through functional Bregs in ulcerative colitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Karen M. Ryan, Eadaoin W. Griffin, Katie J. Ryan, Riffat Tanveer, Natacha Vanattou-Saifoudine, Eoin N. McNamee, Emer Fallon, Sheena Heffernan, Andrew Harkin, Thomas J. Connor
BRAIN BEHAVIOR AND IMMUNITY
(2016)
Article
Psychology, Biological
Shane Gormley, Jennifer Rouine, Allison McIntosh, Christian Kerskens, Andrew Harkin
PHYSIOLOGY & BEHAVIOR
(2016)
Article
Biochemistry & Molecular Biology
Kelly Doolin, Chloe Farrell, Leonardo Tozzi, Andrew Harkin, Thomas Frodl, Veronica O'Keane
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Review
Neurosciences
Katherine O'Farrell, Andrew Harkin
Article
Immunology
Justin D. Yssel, Eoin O'Neill, Yvonne M. Nolan, Thomas J. Connor, Andrew Harkin
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Psychiatry
Chloe Farrell, Kelly Doolin, Niamh O'Leary, Chaitra Jairaj, Darren Roddy, Leonardo Tozzi, Derek Morris, Andrew Harkin, Thomas Frodl, Zsofia Nemoda, Moshe Szyf, Linda Booij, Veronica O'Keane
PSYCHIATRY RESEARCH
(2018)
Editorial Material
Immunology
Andrew Harkin, Declan M. McLoughlin
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Neurosciences
Eoin O'Neill, Rosa Chiara Goisis, Ruth Haverty, Andrew Harkin
JOURNAL OF NEUROSCIENCE RESEARCH
(2019)
Article
Behavioral Sciences
J. David, S. Gormley, A. L. McIntosh, V. Kebede, G. Thuery, A. Varidaki, E. T. Coffey, A. Harkin
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Pharmacology & Pharmacy
Eoin O'Neill, Justin D. Yssel, Caoimhe McNamara, Andrew Harkin
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Neurosciences
Kate O'Reilly, Katherine O'Farrell, Oivind Midttun, Yuliia Rakovets, Jennifer David -Bercholz, Andrew Harkin
Summary: This study demonstrates that brain glia produce neuroactive metabolites via tryptophan-kynurenine catabolism and play a role in reactive glial associated neurodegeneration. Results suggest that inhibiting the kynurenine pathway (KP) metabolites can protect against neuronal atrophy associated with reactive glia.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Clinical Neurology
Karen M. Ryan, Martha Finnegan, Andrew Harkin, Declan M. McLoughlin
Summary: The study found no significant association between telomerase activity and depression, the therapeutic response to ECT, or exposure to adversity.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Rebecca Maher, Almudena Moreno-Borrallo, Dhruvi Jindal, Binh T. Mai, Eduardo Ruiz-Hernandez, Andrew Harkin
Summary: Nanomedicine focuses on developing nanocarriers to improve drug delivery to the brain for the treatment of neuropsychiatric disorders and neurological diseases. Polymer and lipid-based drug carriers have advantages in delivering drugs to the central nervous system (CNS) due to their safety, drug loading capacity, and controlled release properties. These carriers have shown potential in penetrating the blood-brain barrier (BBB) and have been extensively studied in glioblastoma, epilepsy, and neurodegenerative disease models. Intranasal administration has emerged as an attractive route to bypass the BBB using tailored nanocarriers. This review explores the characteristics of polymeric and lipid-based nanocarriers and their potential for CNS drug repurposing, as well as the progress in intranasal drug delivery for neurological diseases.
Article
Behavioral Sciences
Eoin Sherwin, Valentina Gigliucci, Andrew Harkin
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Pharmacology & Pharmacy
Eimear O'Neill, Billy Kwok, Jennifer S. Day, Thomas J. Connor, Andrew Harkin
PHARMACOLOGY RESEARCH & PERSPECTIVES
(2016)