Article
Environmental Sciences
Jessica R. Shoaff, Jill Hahn, Antonia M. Calafat, Susan A. Korrick
Summary: This study investigated the impact of exposure to endocrine disrupting chemicals (EDCs) in adolescence. It found that antiandrogenic phthalates are associated with a decrease in math computation scores, particularly among adolescents with greater psychosocial stress.
ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Ricardo Correia da Silva, Mariana Pires Teixeira, Luciana Souza de Paiva, Leandro Miranda-Alves
Summary: TBT is an environmental contaminant with potent biocidal action that can be found on all continents, including Antarctica. Despite being effectively banned in 2003, it still remains in the environment due to its long half-life and misuse. TBT not only has endocrine-disrupting effects but also has immunotoxic effects, which have been observed in both in vitro and in vivo studies. This review summarizes the literature on the impacts of TBT on the immune system and discusses the gaps in knowledge that still need to be explored.
Article
Environmental Sciences
Yingji Wu, Yubo Liu, Hesam Kamyab, Manivasagan Rajasimman, Natarajan Rajamohan, Gia Huy Ngo, Changlei Xia
Summary: Due to their harmful effects on human health and the environment, there is significant concern regarding the widespread occurrence of endocrine-disrupting hazardous chemicals (EDHCs). To address this concern, various physicochemical and biological remediation techniques have been developed. This review paper provides a comprehensive overview of the state-of-the-art remediation techniques for eliminating EDHCs, including adsorption, membrane filtration, photocatalysis, biodegradation, phytoremediation, and microbial fuel cells. The review discusses the effectiveness, advantages, limitations, and factors affecting the performance of each technique, as well as recent developments and future perspectives in EDHCs remediation.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Reinaldo Sousa Dos Santos, Regla Maria Medina-Gali, Ignacio Babiloni-Chust, Laura Marroqui, Angel Nadal
Summary: Identification tests for Metabolism Disrupting Chemicals (MDCs) with diabetogenic activity are necessary. This study used various cell lines to assess the effects of endocrine disruptors on cell viability and glucose-stimulated insulin secretion (GSIS). Results suggest that one chemical could be a new diabetogenic agent, and the EndoC-beta H1 cell line is a suitable human beta-cell model for testing diabetogenic MDCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Di Feng, Xueyan Li, Xiaojie Fan, Yifan Guo, Jingwei Zhang, Hang Yuan, Wenjuan Wang, Tingting Zhao, Tian Han
Summary: The cytotoxicity and endocrine-disruption activity of 42 food contact silicone products (FCSPs) obtained from the Chinese market were studied. The results showed that 96% of the kitchenwares and 84% of the products showed cytotoxicity and estrogenic/anti-estrogenic/androgenic/anti-androgenic activities respectively. However, 11 bottle nipples showed no cytotoxicity or hormonal activity. Overall, it is important to detect the toxicity of final products since FCSPs can contain complex chemical substances that result in biological toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Food Science & Technology
Quang Luu Quoc, Thi Bich Tra Cao, Seo-Hee Kim, Yeji Choi, Min Sook Ryu, Youngwoo Choi, Hae-Sim Park, Yoo Seob Shin
Summary: Corticosteroid resistance, progressive lung function decline, and frequent asthma exacerbations are characteristics of neutrophilic asthma (NA). This study provides insights into the precise mechanism and inflammatory effects of endocrine-disrupting chemicals, specifically mono-n-butyl phthalate (MnBP), on an NA model. The findings show that exposure to MnBP increases airway hyperresponsiveness, neutrophilic inflammation, and M1M9 cells in NA mice. In vitro experiments demonstrate that MnBP induces neutrophil activation, M9 polarization, and airway epithelial cell damage. Treatment with hydroxychloroquine alleviates the effects of MnBP. These results suggest that MnBP exposure increases the risk of neutrophilic inflammation in severe asthma and targeted therapies for the autophagy pathway can mitigate MnBP-induced harm.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Samantha Schildroth, Lauren A. Wise, Amelia K. Wesselink, Traci N. Bethea, Victoria Fruh, Kyla W. Taylor, Antonia M. Calafat, Donna D. Baird, Birgit Claus Henn
Summary: This study found that personal care product use, diet, and contraceptive measures may be the main sources of exposure to multiple non-persistent endocrine disrupting chemicals among reproductive-aged Black women.
Article
Environmental Sciences
Yuhao Wu, Junke Wang, Yuexin Wei, Jiadong Chen, Lian Kang, Chunlan Long, Shengde Wu, Lianju Shen, Guanghui Wei
Summary: Research suggests that prenatal exposure to endocrine-disrupting chemicals may increase the risk of hypospadias in males, though the relationship with cryptorchidism remains inconclusive.
Article
Engineering, Environmental
Samantha Schildroth, Lauren A. Wise, Amelia K. Wesselink, Payton De La Cruz, Traci N. Bethea, Jennifer Weuve, Victoria Fruh, Julianne C. Botelho, Andreas Sjodin, Antonia M. Calafat, Donna D. Baird, Birgit Claus Henn
Summary: The study found that older age, lower body mass index, and higher smoking levels were associated with greater exposure to EDC mixtures in Black women. Other behaviors and traits, such as dietary factors and time since last birth, were also found to be correlated with EDC mixtures.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Endocrinology & Metabolism
Maia Corpuz-Hilsabeck, Martine Culty
Summary: Sertoli cells play crucial roles in male reproduction, and dysregulation of their functions can have lifelong adverse effects on testis development and spermatogenesis. Understanding the impact of endocrine disrupting chemicals and drugs on Sertoli cells is important for comprehending the adverse outcomes on the reproductive system that these compounds may induce.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Inhye Lee, Kyunghee Ji
Summary: The study found that common household chemical products contain a variety of chemicals that disrupt the endocrine system. Cleaning products, detergents, fabric softeners, air fresheners, and deodorants are hotspots for these chemicals, with fragrances and preservatives being the most prevalent endocrine disruptors.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Engineering, Environmental
Yanyan Liu, Shushan Yuan, Mingshuo Chi, Yue Wang, Gilles Van Eygen, Rui Zhao, Xi Zhang, Guichuan Li, Alexander Volodine, Songqing Hu, Junfeng Zheng, Bart Van der Bruggen
Summary: In this study, a novel thin film nanocomposite (TFN) membrane was developed by incorporating covalent organic frameworks (COFs) into conventional polyamide (PA) nanofiltration (NF) membranes. The TFN-COF membrane showed high rejection of endocrine disrupting compounds (EDCs) and improved water permeance as well as salt rejection.
Article
Environmental Sciences
Sujin Lee, Bareum Kwon, Junhyeok Jeong, Younglim Kho, Kyunghee Ji
Summary: In this study, the adverse effects of benzisothiazolinone (BIT) on the thyroid neuroendocrine system of zebrafish embryos/larvae were investigated. BIT exposure resulted in coagulation and hatching delay, decreased hatchability and larval survival, and altered gene expression related to thyroid hormones and thyrotropin-releasing hormone secretion. The underlying mechanisms involve central regulation, receptor binding, and deiodination.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Aris Ismanto, Tony Hadibarata, Risky Ayu Kristanti, Lilik Maslukah, Novia Safinatunnajah, Wulan Kusumastuti
Summary: Endocrine disrupting chemicals (EDCs) have adverse impacts on human and environmental well-being, being associated with diseases such as cancer, cardiovascular risk, behavioral disorders, autoimmune defects, and reproductive diseases. Conventional treatment methods are insufficient to fully remove EDCs from water, necessitating the use of advanced psychochemical and biological treatments. The lack of laws regarding acute concentration limits of EDCs in various water sources contributes to the intensified concerns about these mixed contaminants. Further data is needed to address the risks associated with the presence of EDCs in the environment.
ENVIRONMENTAL POLLUTION
(2022)
Review
Multidisciplinary Sciences
Leila Peivasteh-roudsari, Raziyeh Barzegar-bafrouei, Kurush Aghbolagh Sharifi, Shamimeh Azimisalim, Marziyeh Karami, Solmaz Abedinzadeh, Shabnam Asadinezhad, Behrouz Tajdar-oranj, Vahideh Mahdavi, Adel Mirza Alizadeh, Parisa Sadighara, Margherita Ferrante, Gea Oliveri Conti, Aynura Aliyeva, Amin Mousavi Khaneghah
Summary: Endocrine-disrupting chemicals (EDCs) pose a growing public health concern globally. While consumption of food is considered a major exposure route, inhalation and dermal contact are alternative pathways for human exposure. These compounds in various food products are widely concerning to the general population, including canned food, bottled water, dairy products, fish, meat, egg, and vegetables. Therefore, understanding the origin, exposure, toxicological impact, and legal aspects of EDCs is crucial for their environmental and food control.
