Article
Anatomy & Morphology
Z. Junde, L. Tingting, Z. Lu, C. Shan, Y. Dan, Z. Yizhen
Summary: This study found that lithium chloride exerts neuroprotective effects and improves neural restoration after cerebral ischemia by activating the Wnt signaling pathway, suggesting its potential clinical application in the prevention and treatment of ischemic stroke.
FOLIA MORPHOLOGICA
(2023)
Article
Pharmacology & Pharmacy
Shirley H. T. Truong, Benjamin Bonnici, Samoda Rupasinghe, Barbara K. Kemp-Harper, Chrishan S. Samuel, Brad R. S. Broughton
Summary: Brain inflammation and apoptosis contribute to neuronal damage and loss following ischaemic stroke, leading to cognitive and functional disability. H2-relaxin, a hormone with anti-inflammatory and anti-apoptotic effects, shows potential as a therapeutic for stroke. This study investigated the effects of post-stroke administration of H2-relaxin and found that it improved motor function and decreased apoptosis in a dose-dependent manner.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Shannon M. Stuckey, Lin Kooi Ong, Lyndsey E. Collins-Praino, Renee J. Turner
Summary: Ischaemic stroke is a leading cause of death and disability worldwide, affecting over 17 million people each year. Neuroinflammation and immune mediators play a crucial role in acute and long-term neuronal tissue damage and healing following stroke, with specific spikes in neuroinflammation observed in sites of secondary neurodegeneration. However, the exact mechanisms driving stroke-induced neuroinflammation remain poorly understood, leading to a lack of effectiveness in current anti-inflammatory treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Reai Shan, Hongyan Zhou, Xinfang Liu, Guangjun Su, Guangsen Liu, Xiaoli Zhang, Cong Sun, Zining Yu, Lifang Zhan, Zhihua Huang
Summary: This study evaluated the protective effects of different fluids on the blood-brain barrier in cerebral ischaemia/reperfusion injury, and the results showed that HSH and other fluids could alleviate neurological deficits, brain infarction, brain oedema, and increased BBB permeability.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Urology & Nephrology
Carlos Munoz-Lopez, Kieran Lewis, Worapat Attawettayanon, Yosuke Yasuda, Joao Pedro Emrich Accioly, Nityam Rathi, Zaeem Lone, Melissa Boumitri, Rebecca A. Campbell, Andrew Wood, Jihad H. Kaouk, Georges-Pascal Haber, Mohamad Eltemamy, Venkatesh Krishnamurthi, Robert Abouassaly, Samuel C. Haywood, Christopher J. Weight, Steven C. Campbell
Summary: A rigorous assessment of factors affecting functional recovery after partial nephrectomy (PN) was conducted, revealing the potential impact of secondary factors such as ischaemia. The study identified the main determinant of functional recovery as parenchymal volume preservation, as well as other factors including comorbidities, increased tumour complexity, and ischaemia-related factors that are also independently associated with impaired recovery.
Article
Cardiac & Cardiovascular Systems
Alexandra J. Lansky, Rajendra Makkar, Tamim Nazif, Steven Messe, John Forrest, Rahul Sharma, Joachim Schofer, Axel Linke, David Brown, Abhijeet Dhoble, Phillip Horwitz, Ming Zang, Frederico DeMarco, Vivek Rajagopal, Michael G. Dwyer, Robert Zivadinov, Pieter Stella, Joshua Rovin, Helen Parise, Susheel Kodali, Andreas Baumbach, Jeffrey Moses
Summary: The REFLECT I trial investigated the safety and effectiveness of the TriGuard(TM) HDH(TG) cerebral embolic deflection device in patients undergoing transcatheter aortic valve replacement. The study enrolled 258 patients, with the primary safety outcome being met but the primary efficacy endpoint not being met. TG was found to be safe compared to historical TAVR data, but did not meet the predefined effectiveness endpoint compared with unprotected TAVR controls.
EUROPEAN HEART JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Qian Zhang, Jinwei Dai, Zhibing Song, Yuchen Guo, Shanshan Deng, Yongsheng Yu, Tiejun Li, Yuefan Zhang
Summary: The study showed that MQ improved neurobehavior, reduced cerebral infarction areas, altered blood flow, and morphological changes in the cortex and hippocampus in a rat model of brain ischemia-reperfusion injury. Additionally, it decreased neuronal apoptosis and malondialdehyde levels, while increasing superoxide dismutase levels. In vitro studies demonstrated that MQ enhanced cell survival rates and decreased reactive oxygen species levels. Furthermore, protein and mRNA expressions involved in apoptosis were significantly decreased, suggesting a neuroprotective effect of MQ in cerebral ischemia by blocking the p-JNK/Bax pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Manish Kumar, Komalpreet Kaur, Thakur Gurjeet Singh
Summary: This study demonstrates that carbonic anhydrase inhibitors (CAIs) and cAMP activation can enhance the therapeutic outcome against ischemia-reperfusion injury, improving brain function and reducing the impact of biochemical parameters on brain damage.
NEUROMOLECULAR MEDICINE
(2022)
Article
Behavioral Sciences
Alexandre Morin, Marilou Poitras, Helene Plamondon
Summary: The study investigated the neurobehavioral effects of global cerebral ischemia (GCI) in the developing brain and the impact of adolescent exposure to vanillic acid (VA) on post-ischemic outcomes. Results showed significant hippocampal injury and changes in cognitive and emotional behaviors following adolescent GCI, but VA supplementation did not provide protection. Additionally, the study found alterations in glucocorticoid receptor expression in different brain regions post-GCI.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Anna Katarzyna Greda, Dorota Nowicka
Summary: Perineuronal nets (PNNs) are believed to restrict plasticity in adult animals, but after ischemic stroke, their massive breakdown leads to rejuvenated neuronal plasticity. The study suggests that early intervention to inhibit hyaluronidase activity improves post-stroke recovery without affecting the number of PNNs, indicating a significant reorganization of polysaccharide content after stroke.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Saige Yin, Ailan Pang, Chengxing Liu, Yilin Li, Naixin Liu, Shanshan Li, Chao Li, Huilin Sun, Zhe Fu, Yinglei Wang, Yue Zhang, Meifeng Yang, Jun Sun, Ying Wang, Xinwang Yang
Summary: The study investigated the protective mechanism of the novel antistroke drug OM-LV20 on astrocytes, finding that OM-LV20 may exert protection on astrocytes through the 'PAC1R/JNK/TPH1' axis, highlighting TPH1 as a novel target for antistroke drugs.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Tao Guo, Yi-hao Deng, Ling-ling Dong, Lu Ren, Hong-yun He
Summary: Autophagy was found to confer neuroprotection in the subacute phase of transient ischemic stroke, but had minimal effects on neurological outcomes after permanent ischemic stroke.
CURRENT MEDICAL SCIENCE
(2021)
Article
Neurosciences
Hui Yang, Zhenqian Liu, Xiaomei Liu, Xiaowei Cao, Mo Chen, Shiying Lou, Liangqun Rong, Yun Xu, Qingxiu Zhang
Summary: This study demonstrates that Tat-SynGAP (670-685aa) reduces neuronal apoptosis and cerebral infarction volume by inhibiting MST1/JNK signaling pathway, while maintaining vascular stability and blood-brain barrier integrity.
BRAIN RESEARCH BULLETIN
(2022)
Article
Immunology
Xiu-fen Zheng, Xiang-jian Zhang, Li-peng Dong, Jing-ru Zhao, Cong Zhang, Rong Chen
Summary: Sal B protects brain tissues from cerebral ischemia-reperfusion injury by activating its anti-inflammatory properties.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Biology
Clara Alice Musi, Anna Maria Castaldo, Anna Elisa Valsecchi, Sara Cimini, Noemi Morello, Riccardo Pizzo, Alessandra Renieri, Ilaria Meloni, Maurizio Bonati, Maurizio Giustetto, Tiziana Borsello
Summary: The study revealed altered JNK signaling in models of RTT and suggested that treatment with a specific JNK inhibitor can prevent clinical symptoms, showing consistent results at the cellular, molecular, and functional levels. This provides the first evidence that JNK plays a crucial role in RTT and its inhibition could be a new potential therapeutic tool for tackling this disorder.
Article
Physiology
Catherine Le Quement, Isabelle Guenon, Jean-Yves Gillon, Vincent Lagente, Elisabeth Boichot
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2008)
Article
Microbiology
Andreanne Lupien, Anthony Vocat, Caroline Shi-Yan Foo, Emilyne Blattes, Jean-Yves Gillon, Vadim Makarov, Stewart T. Cole
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Pharmacology & Pharmacy
C. Le Quement, I. Guenon, J-Y Gillon, S. Valenca, V. Cayron-Elizondo, V. Lagente, E. Boichot
BRITISH JOURNAL OF PHARMACOLOGY
(2008)
Article
Pharmacology & Pharmacy
Jean-Yves Gillon, Jeremy Dennison, Frans van den Berg, Sophie Delhomme, Karen Dequatre Cheeseman, Claudia Pena Rossi, Nathalie Strub Wourgaft, Sabine Specht, Belen Pedrique, Frederic Monnot, Susanne Skrabs, Maria-Luisa Rodriguez, Heino Stass
Summary: Emodepside, originally developed for veterinary use, was tested in healthy subjects in two phase I studies to assess safety and pharmacokinetics of liquid service formulation (LSF) and immediate release (IR) tablet. Results showed rapid absorption of LSF with dose-proportional increase in plasma concentrations, while tablets had significantly lower absorption rate and extent.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Alison Luckey, Emilie Alirol, Sophie Delhomme, John O'Donnell, Esther Bettiol, John Mueller, Seamus O'Brien, Jean-Yves Gillon
Summary: The study found that food intake influenced the pharmacokinetics of zoliflodacin, resulting in delayed absorption rate but no impact on elimination. Peak concentration and overall systemic exposure to zoliflodacin significantly increased with food intake. The administration of zoliflodacin as granules for oral suspension with a high-fat meal was well-tolerated and led to increased drug exposure.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
J. -Y. Gillon, B. Lechartier, V. A. Makarov, S. T. Cole
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2015)
Article
Biochemistry & Molecular Biology
S Carboni, B Antonsson, P Gaillard, JP Gotteland, JY Gillon, PA Vitte
JOURNAL OF NEUROCHEMISTRY
(2005)