Article
Pharmacology & Pharmacy
Gabriela Becker, Maria Fernanda Pessano Fialho, Indiara Brusco, Sara Marchesan Oliveira
Summary: Cisplatin is a commonly used chemotherapy drug for solid tumors, but its effectiveness is limited by neurotoxic side effects such as peripheral neuropathy. This study investigates the role of kinin B-1 and B-2 receptors in cisplatin-induced peripheral neuropathy in mice. The results suggest that targeting these receptors may be a potential strategy for treating the painful symptoms caused by cisplatin treatment.
Article
Gastroenterology & Hepatology
Gillian Watermeyer, Yaw Awuku, Ernst Fredericks, David Epstein, Mashiko Setshedi, Smita Devani, Wisdom Mudombi, Chris Kassianides, Leolin Katsidzira, Ghassa
Summary: Inflammatory bowel disease (IBD) is possibly underestimated in sub-Saharan Africa due to the high burden of communicable diseases and difficulties in detection. Gastrointestinal infections that resemble IBD can complicate diagnosis and treatment decisions. Constraints in endoscopic capacity and a lack of qualified diagnostic pathologists add to the challenges. Despite high costs and unavailability of medication, cost-effective approaches can be employed to manage IBD in this region.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Cell Biology
Carola E. Matus, Pamela Ehrenfeld, Carlos D. Figueroa
Summary: The human skin is a complex organ composed of the epidermis and dermis layers. The epidermis serves as a protective barrier against harmful agents, while the dermis provides support and various structures. The kallikrein family and kinins play crucial roles in maintaining skin homeostasis and regulating inflammation and cell differentiation.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Alejandra Abeledo-Machado, Milagros Pena-Zanoni, Dana Bornancini, Maria Andrea Camilletti, Erika Yanil Faraoni, Agustina Marcial, Susana Rulli, Francois Alhenc-Gelas, Graciela Susana Diaz-Torga
Summary: Sex differences in prolactin secretion control were studied, and it was found that male pituitaries have higher levels of B2R compared to female pituitaries. Estrogen downregulates B2R gene expression, while dopamine only affects females. Activation of B1R or B2R induces prolactin secretion in male pituitaries but inhibits it in females. Increased B2R content was observed in pituitaries of mutated animals developing prolactinomas.
Review
Immunology
Zivile Bekassy, Ingrid Lopatko Fagerstrom, Michael Bader, Diana Karpman
Summary: This review explores the complex interactions between the renin-angiotensin system, complement system, and kallikrein-kinin system, as well as their dysregulation in different conditions and therapeutic implications. Various mediators modulate the balance between vascular tone, inflammation, coagulation, and thrombosis during severe inflammatory and infectious diseases. These systems play important roles in cell biological functions, such as regulating vascular tone, inflammation, and thrombosis.
NATURE REVIEWS IMMUNOLOGY
(2022)
Article
Immunology
Enrique Alfaro, Elena Diaz-Garcia, Sara Garcia-Tovar, Ester Zamarron, Alberto Mangas, Raul Galera, Kapil Nanwani-Nanwani, Rebeca Perez-de-Diego, Eduardo Lopez-Collazo, Francisco Garcia-Rio, Carolina Cubillos-Zapata
Summary: COVID-19 has caused devastating effects worldwide. This study focuses on the bradykinin cascade and its impact on disease severity in COVID-19 patients. The researchers found dysregulation of the kallikrein-kinin system in COVID-19 patients, associated with inflammation, hypercoagulation, and lymphopenia. BK1-8/BK plasma concentration combined with D-dimer levels may serve as independent predictors for ICU admission in COVID-19 patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Ana Carolina Oliveira, Amanda Roberta Revoredo Vicentino, Daniele Andrade, Isabela Resende Pereira, Leonardo Saboia-Vahia, Otacilio da Cruz Moreira, Carla Eponina Carvalho-Pinto, Julia Barbalho da Mota, Leonardo Maciel, Glaucia Vilar-Pereira, Joao B. Pesquero, Joseli Lannes-Vieira, Pierre Sirois, Antonio Carlos Campos de Carvalho, Julio Scharfstein
Summary: We investigated the role of B1R receptor in the development of Chagas disease caused by Trypanosoma cruzi. Our findings suggest that blocking the B1R receptor can reduce heart parasitism and cardiac injury in acute and chronic Chagas disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Anne G. Savitt, Samantha Manimala, Tiara White, Marina Fandaros, Wei Yin, Huiquan Duan, Xin Xu, Brian Geisbrecht, David A. Rubenstein, Allen P. Kaplan, Ellinor Peerschke, Berhane Ghebrehiwet
Summary: Infection with SARS-CoV-2 activates innate inflammatory pathways, leading to severe respiratory syndrome and multi-organ failure. The viral structural proteins bind C1q, FXII, HK, and gC1qR, activating the complement system and KKS. This suggests targeting these proteins may be an effective therapeutic strategy for treating COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Marie Villumsen, Astrid Blicher Schelde, Espen Jimenez-Solem, Tine Jess, Kristine Hojgaard Allin
Summary: Patients with inflammatory bowel disease (IBD) and type 2 diabetes treated with GLP-1 based therapies had a lower risk of adverse clinical events compared to those treated with other antidiabetics. This suggests that GLP-1 based therapies may improve the disease course of IBD.
Article
Multidisciplinary Sciences
M. D. Martin-Arranz, L. Garcia-Ramirez, M. Hernandez-Perez, D. Montero Vega, E. Martin-Arranz, M. Sanchez-Azofra, J. Poza Cordon, J. L. Rueda Garcia, J. Noci Belda, T. Verges Martinez-Meco, P. Blanco San Miguel, C. Suarez Ferrer
Summary: Patients with inflammatory bowel disease (IBD) treated with biologic and/or immunosuppressant drugs have a higher risk of opportunistic infections. Seroprevalence studies can confirm the diagnosis of SARS-CoV-2 infections and associated risk factors. This descriptive study found that 18.64% of IBD patients tested positive for SARS-CoV-2 antibodies after one year of the pandemic, higher than the general population (15.7%). There was no significant difference in the probability of developing antibodies between patients with or without immunosuppressive treatment.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Ioanna Aggeletopoulou, Efthymios P. P. Tsounis, Christos Triantos
Summary: Interleukin-33 (IL-33) is a pleiotropic cytokine with both extracellular and nuclear functions, and its receptor ST2 plays a critical role in regulating inflammatory disorders. The IL-33/ST2 axis is involved in maintaining intestinal homeostasis and mucosal defenses. This review focuses on the pro- and anti-inflammatory effects of the IL-33/ST2 axis in ulcerative colitis and Crohn's disease, as well as the molecular mechanisms underlying its association with IBD pathogenesis. Understanding the IL-33/ST2-mediated mechanisms in IBD has potential for clinical applications as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Melanie Bailey, Dermot Linden, Hong Guo-Parke, Olivia Earley, Tunde Peto, Danny F. F. McAuley, Clifford Taggart, Joseph Kidney
Summary: SARS-CoV-2 binds to ACE2 receptors in the lungs, leading to endothelial pathology and activation of the contact-kinin pathway, resulting in clotting and inflammatory lung disease. Blood tests of hospitalized patients show prolonged APTT, decreased platelet counts, and lymphopenia, indicating consumption and emergence of lymphocytic pneumonitis. Bradykinin is involved in the development of edema and release of IL-6, contributing to thrombosis and lymphocytic pneumonitis. Measurements of platelets, lymphocytes, and APTT can help stratify the risk of developing ARDS.
FRONTIERS IN MEDICINE
(2023)
Article
Parasitology
Jianling Bao, Wenjing Qi, Chang Sun, Mengxiao Tian, Hongjie Jiao, Gang Guo, Baoping Guo, Yuan Ren, Huajun Zheng, Yuezhu Wang, Mei Yan, Zhaoxia Zhang, Donald P. McManus, Jun Li, Wenbao Zhang
Summary: This study demonstrates that Echinococcus granulosus infection and antigen B (AgB) can alleviate symptoms and tissue damage in inflammatory bowel disease (IBD) induced by dextran sodium sulfate (DSS). This treatment may improve IBD conditions by inducing an increase in M2-predominant cells and a decrease in type 1 macrophages in the intestinal lamina propria. Additionally, AgB can alter the composition of the gut microbiota and reverse nitric oxide expression.
PARASITES & VECTORS
(2022)
Review
Medical Laboratory Technology
Dorsa Sohaei, Morley Hollenberg, Sok-Ja Janket, Eleftherios P. Diamandis, Gennady Poda, Ioannis Prassas
Summary: COVID-19 initially presents as a respiratory infection but can progress to a systemic disease involving multiple organs and microthromboses. The SARS-CoV-2 virus enters host cells by binding to the ACE2 receptor. ACE2 is expressed in various tissues, including the lung, heart, intestine, kidney, testis, gallbladder, vasculature, and immune cells. Interference with ACE2 signaling can lead to systemic pathologies such as endothelial dysfunction, microthromboses, and systemic inflammation. Understanding these targets may be valuable for the treatment of COVID-19 and other virus-induced coagulopathies in the future.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Article
Endocrinology & Metabolism
Elizabeth K. M. Johnstone, Mohammed Akli Ayoub, Rebecca J. Hertzman, Heng B. See, Rekhati S. Abhayawardana, Ruth M. Seeber, Kevin D. G. Pfleger
Summary: This study investigated the heteromerization of AT(2) and B-2 receptors in HEK293FT cells. The results demonstrated the functional interaction between these receptors and the differences in signaling, providing important evidence for studying GPCR pharmacology and signaling diversity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xavier Charest-Morin, Robert Lodge, Francois Marceau
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2018)
Editorial Material
Immunology
Francois Marceau
INTERNATIONAL IMMUNOPHARMACOLOGY
(2018)
Reprint
Immunology
Francois Marceau
INTERNATIONAL IMMUNOPHARMACOLOGY
(2018)
Review
Biochemistry & Molecular Biology
Francois Marceau, Marie-Therese Bawolak, Jean-Philippe Fortin, Guillaume Morissette, Caroline Roy, Helene Bachelard, Lajos Gera, Xavier Charest-Morin
Review
Immunology
Francois Marceau, Helene Bachelard, Johanne Bouthillier, Jean-Philippe Fortin, Guillaume Morissette, Marie-Therese Bawolak, Xavier Charest-Morin, Lajos Gera
INTERNATIONAL IMMUNOPHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Anne Lesage, Christoph Gibson, Francois Marceau, Horst-Dieter Ambrosi, Joern Saupe, Werner Katzer, Brigitte Loenders, Xavier Charest-Morin, Jochen Knolle
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Medicine, General & Internal
Francois Marceau, Georges E. Rivard, Julie M. Gauthier, Karen E. Binkley, Arnaud Bonnefoy, Isabelle Boccon-Gibod, Laurence Bouillet, Matthieu Picard, Ghislain Levesque, Hannah Laure Elfassy, Helene Bachelard, Jacques Hebert, Konrad Bork
FRONTIERS IN MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Guillaume Pare, Julien Vitry, Francois Marceau, Myriam Vaillancourt, Philip Winter, Helene Bachelard, Paul H. Naccache, Jack A. Tuszynski, Maria J. Fernandes
BIOCHEMICAL PHARMACOLOGY
(2020)
Review
Chemistry, Medicinal
Francois Marceau, Helene Bachelard, Xavier Charest-Morin, Jacques Hebert, Georges E. Rivard
Editorial Material
Immunology
James E. Talmadge, Francois Marceau
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Chemistry, Medicinal
Francois Marceau, Helene Bachelard
Summary: Bradykinin (BK) plays various roles in the body, and the clinical applications of B2R antagonists are still under investigation. The classical smooth muscle contractility assay is crucial for studying drug potency. The use of the isolated human umbilical vein in experiments allows for verification of different types of drugs' effects on B2R.
Article
Immunology
Anne Lesage, Francois Marceau, Christoph Gibson, Brigitte Loenders, Werner Katzer, Horst-Dieter Ambrosi, Jorn Saupe, Alexander Faussner, Evangelia Pardali, Jochen Knolle
Summary: PHA-022121 is a novel small molecule antagonist of the human bradykinin B-2 receptor that shows high affinity, high antagonist potency, and high selectivity, making it a potential treatment and prevention option for hereditary angioedema attacks.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biology
Francois Marceau, Helene Bachelard, Georges-Etienne Rivard, Jacques Hebert
BMC RESEARCH NOTES
(2019)
Meeting Abstract
Medicine, General & Internal
Maria Fernandes, Guillaume Pare, Julien Vitry, Myriam Vaillancourt, Francois Marceau, Paul Naccache, Jack Tuszynski
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Helene Bachelard, Xavier Charest-Morin, Francois Marceau