Article
Engineering, Environmental
Yinkun Sun, Dongwei Lu, Hui Zhang, Guanjin Liu, Yichao Hu, Haijiao Xie, Jun Ma
Summary: Oxygen vacancies in metal oxide electrocatalytic membranes have a dual role in generating and transforming ROS, acting as promoters at low concentrations but as inhibitors at high concentrations.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jiaen Wu, Shanshan Xu, Charles C. Han, Guangcui Yuan
Summary: Neutron techniques were used to investigate the drug loading and releasing properties of PLGA. The hydration of PLGA, reversible with humidity and temperature changes, was found to originate from molecular compatibility with water. The evolution of drug domains inside electrospun PLGA fibers was tracked using SANS, with domain size and relaxation speed related to temperature and PLGA's glassy property. The release kinetics from fibers with different drug loading were discussed based on SANS and USANS findings.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Jiang-Pei Yuan, Zong-Jie Guan, Heng-Yu Lin, Bing Yan, Kang-Kai Liu, Hong-Cai Zhou, Yu Fang
Summary: Mimicking the active site and substrate binding cavity of enzymes, PCCs can achieve specificity in catalytic reactions. PCC-6-M (M = Zn/Ni/Co) exhibit distinct catalytic activities, which are significant for studying the regulation of ROS generation by supramolecular catalysts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Medicinal
Stijn H. S. Koshari, Xutao Shi, Linda Jiang, Debby Chang, Karthikan Rajagopal, Abraham M. Lenhoff, Norman J. Wagner
Summary: An extensive data set was used to advance the development of a model-informed design of controlled drug release. An improved drug-release model incorporating mechanistic modeling of hydrolytic polymer degradation was used and validated against in vitro experiments. The study demonstrates the potential for achieving a priori design of controlled drug release by combining parameter estimates from the literature with model fits to the data set. The results highlight the importance of careful selection of the polymer grade and the need for better understanding of phenomena like pore formation in designing drug release systems.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Physical
Haiyin Zhan, Qixing Zhou, Mingmei Li, Ruiren Zhou, Yueshuang Mao, Pengfei Wang
Summary: By designing B-x-C3N4 material, the efficiency of photocatalytic activity is greatly improved due to the enhanced O-2 adsorption energy and electron transfer efficiency. This leads to a significant enhancement in photocatalytic degradation.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Engineering, Biomedical
Ren Zhu, Qi He, Zhiling Li, Yuhao Ren, Yixian Liao, Zejun Zhang, Quan Dai, Chengying Wan, Sihui Long, Lingyi Kong, Wenpei Fan, Wenying Yu
Summary: Many chemotherapeutic drugs and photosensitizers face challenges such as poor solubility, unspecific delivery, and uncontrollable release, which limit their biomedical applications. In this study, a novel type of ROS-cleavable hydrophilic diselenide nanoparticles was designed to overcome these limitations, allowing for precise and controlled release of the hydrophobic drug and photosensitizer. The NIR-controlled release of the drugs led to on-demand synergistic chemo-/photodynamic therapeutic effects, maximizing tumor growth suppression and minimizing side effects.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Tao Luo, Duo Wang, Lidong Liu, Yan Zhang, Chuangye Han, Ying Xie, Yan Liu, Jingchen Liang, Guanhua Qiu, Hongxue Li, Danke Su, Junjie Liu, Kun Zhang
Summary: A photocleaved O-2-released nanoplatform is developed to convert ROS into RNS for long-lasting antitumor effects, by continuously releasing oxygen and alleviating hypoxia to elevate ROS levels.
Review
Cell Biology
Sandeep Chenna, Werner J. H. Koopman, Jochen H. M. Prehn, Niamh M. C. Connolly
Summary: This article discusses the mechanistic models and minimal models of mitochondrial reactive oxygen species (ROS) homeostasis. Mechanistic models provide valuable insights but are complex, while minimal models use a smaller set of equations to describe empirical relationships and generate hypotheses. Finally, the article illustrates the application of minimal models in studying the pathophysiology of ROS.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuxuan Ge, Zhenhua Hu, Jili Chen, Yujie Qin, Fei Wu, Tuo Jin
Summary: GLP-1 receptor agonists are a class of diabetes medicines that offer self-regulating glycemic efficacy, with exenatide requiring the least dose and able to achieve long-lasting effects through controlled-release microspheres.
Article
Clinical Neurology
Moinay Kim, Joonho Byun, Yeongu Chung, Si Un Lee, Ji Eun Park, Wonhyoung Park, Jung Cheol Park, Jae Sung Ahn, Seungjoo Lee
Summary: Administering ROS scavengers to patients with acute ICH significantly reduced PHE volume, shortened time to reach target Richmond Agitation Sedation Scale, and reduced length of stay in the intensive care unit.
Article
Chemistry, Multidisciplinary
Zhen Xu, Li Zhang, Min Pan, Qunying Jiang, Yunjie Huang, Fuan Wang, Xiaoqing Liu
Summary: Nanozymes have great potential in nanomedicine, but their clinical translation is limited by biotoxicity. A new type of bionanozyme with ultrahigh and light-controlled catalytic activity has been developed through self-assembly and in situ polymerization, showing potential for tumor-specific therapy with minimal biotoxicity.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Agricultural Engineering
Andrey A. Lipin, Aleksandr G. Lipin, Ryszard Wojtowicz
Summary: A new diffusion model is proposed to simulate nutrient release from coated fertiliser particles at all stages. The model is universal and can predict the release rate and pattern for all types of coatings given a diffusion mechanism. The model considers nutrient diffusion in the solution within the coating layer, depending on the moisture content and counter diffusive flux of moisture. Experimentally verified with urea release data, the model adequately describes nutrient release from polymer-coated urea.
BIOSYSTEMS ENGINEERING
(2023)
Article
Engineering, Environmental
Jiaqi Tao, Wenhao Wu, Daohui Lin, Kun Yang
Summary: Understanding the microbial degradation of biochar-adsorbed organic pollutants is crucial for improving the adsorption performance of biochars and reducing secondary pollution in soil remediation. This study investigated the degradation of non-desorbable organic compounds on a specific wood chip-derived biochar by a specific bacterium. The results showed significant microbial degradation of the non-desorbable compounds, which could be attributed to the presence of extracellular •OH in the bacterial fluid. This study provides new insight into the microbial degradation of biochar-adsorbed organic pollutants in soil remediation.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Pharmacology & Pharmacy
S. Wachowiak, F. Danede, J. F. Willart, F. Siepmann, J. Siepmann, M. Hamoudi
Summary: The aim of this study was to investigate the effect of PLGA polymer chemistry on drug release from implants prepared by melting and molding. The drug used was dexamethasone. Variation in PLGA molecular weight, lactic acid:glycolic acid ratio, and end groups type were studied. The results showed that the drug release profiles were similar in all cases, with no burst release observed. The lag time for drug release decreased with decreasing polymer molecular weight, increasing glycolic acid content, and the presence of -COOH end groups.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Amogh Kumar Baranwal, G. Keerthiga, L. Mohan, Sayan Deb Dutta, Pallavi Gupta, Ki-Taek Lim, Tuhin Subhra Santra
Summary: Titanium-dioxide nanotubes loaded with ciprofloxacin were fabricated using anodic oxidation. Coating the drug-loaded nanotubes with different thicknesses of PLGA allowed for controlled drug release, leading to better osseointegration and treatment of bone infections.
MATERIALS TODAY COMMUNICATIONS
(2022)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)