Journal
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
Volume 49, Issue 7, Pages 503-506Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.bjoms.2010.07.016
Keywords
Cancer stem cells; Squamous cell carcinoma of the head and neck; Tumour markers; Chemoresistance; Oral squamous cell carcinoma
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The existence of a small subpopulation of tumourigenic cancer stem cells in the bulk of human head and neck squamous cancers (SCC) has been recognised in recent reports. This subpopulation has self-renewal properties and is responsible for the production of differentiated daughter cells that form the bulk of the tumour. Stem cells in head and neck SCC can be identified functionally using their self-renewal properties, or by their characteristic surface markers. As their resistance to contemporary cancer treatments may eventually lead to the failure of treatment there is an urgent need to better understand their biology with the ultimate goal of developing new diagnostic markers and curative cancer treatments. (C) 2010 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
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