Review
Oncology
Lachlan McDowell, Danny Rischin, Karla Gough, Christina Henson
Summary: Head and neck squamous cell carcinoma (HNSCC) is a common cancer with various risk factors. The treatment of HNSCC can cause significant side effects, and age is considered in treatment recommendations. However, there is limited evidence of vulnerability in older patients with HNSCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Nik Ruzyanei Nik Jaafar, Nur Amirah Hamdan, Norhaliza Abd Hamid, Rama Krsna Rajandram, Raynuha Mahadevan, Hazli Zakaria, Mohd Razif Mohamad Yunus, Mohammad Farris Iman Leong Bin Abdullah
Summary: This study investigated the level of posttraumatic growth (PTG) among head and neck cancer patients within the first year of diagnosis, as well as the association between unmet supportive care needs and fear of cancer progression with PTG. The results showed that higher levels of unmet needs and fear of cancer progression predicted lower PTG in these patients.
Article
Oncology
Gerben van Hinte, Ruud A. Leijendekkers, Matthias A. W. Merkx, Robert P. Takes, Maria W. G. Nijhuis-van der Sanden, Caroline M. Speksnijder
Summary: The study found that survivors of head and neck cancer have unmet needs and limitations in physical health to some extent. There is a certain degree of correlation between unmet needs and limitations in physical performance. Therefore, using SCNS and physical performance measurements during routine follow-up can help in early detection and identification of these issues.
EUROPEAN JOURNAL OF CANCER CARE
(2021)
Article
Multidisciplinary Sciences
Kensuke Yoshida, Yasumitsu Kodama, Yusuke Tanaka, Kyongsun Pak, Marie Soga, Akira Toyama, Kouji Katsura, Ritsuo Takagi
Summary: The study found that the pharmacist-involved education program in a multidisciplinary team had a positive impact on the severity of oral mucositis and length of hospital stay in head-and-neck cancer patients undergoing chemoradiotherapy.
Review
Medicine, Research & Experimental
Taksim Ahmed, Fuh-Ching Franky Liu, Brian Lu, HoYin Lip, Elliya Park, Ibrahim Alradwan, Jackie Fule Liu, Chunsheng He, Abdulmottaleb Zetrini, Tian Zhang, Amin Ghavaminejad, Andrew M. Rauth, Jeffrey T. Henderson, Xiao Yu Wu
Summary: This review discusses the potential and current applications of nanomedicine and nanotechnology-enabled advanced drug delivery systems (DDS) in addressing complex diseases, as well as the role of computational analysis in designing DDS. It also highlights the versatility of nanomedicine and DDS in diagnostics, anticancer therapy, and diabetes management.
MOLECULAR PHARMACEUTICS
(2022)
Article
Oncology
Changyi Shang, Linfei Feng, Ying Gu, Houlin Hong, Lilin Hong, Jun Hou
Summary: The study found that the use of MDTM in treating HNC patients resulted in higher survival rates, but did not significantly improve survival rates in patients with stage IV HNC. Future research should focus on the efficacy of MDTM in cancer patients at different stages.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Mayur D. Mody, James W. Rocco, Sue S. Yom, Robert Haddad, Nabil F. Saba
Summary: Head and neck cancer is the seventh most common type of cancer worldwide, with the predominant risk factors being tobacco use, alcohol abuse, and oncogenic viruses. Treatment typically involves a multidisciplinary approach with surgery, radiotherapy, and systemic therapy, and is challenging due to site-specific and histology-specific variations.
Article
Oncology
Dean Vuksanovic, Jasotha Sanmugarajah, Dominic Lunn, Raja Sawhney, Kelly Eu, Rhea Liang
Summary: The transition from breast cancer patient to survivor is challenging, with significant physical, psychological, and social challenges. Multidisciplinary evidence-based care in the post-treatment period is crucial. Despite high satisfaction with survivorship care, unmet needs were common, particularly among younger participants, and the use of multidisciplinary care was inconsistent and underutilized.
Article
Oncology
Maria Karampela, Talya Porat, Vasiliki Mylonopoulou, Minna Isomursu
Summary: This study examined the needs of patients, caregivers, and healthcare professionals during HNC rehabilitation, with service delivery and emotional needs being identified as the most prevalent. Stakeholders' needs were found to be interrelated, highlighting the importance of including all actors in the design of future healthcare interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kristina Bertl, Philippe Savvidis, Edmund Benjamin Kukla, Steffen Schneider, Konstantin Zauza, Corinna Bruckmann, Andreas Stavropoulos
Summary: Including dental professionals in the multidisciplinary treatment team of HNSCC patients has a positive impact on patient oral health status, especially in terms of periodontal disease, 6 months and longer after finishing cancer therapy.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Oncology
Cristiana Bergamini, Stefano Cavalieri, Carlo Resteghini, Salvatore Alfieri, Imperia Nuzzolese, Elena Colombo, Arianna Ottini, Giuseppina Calareso, Andrea Vingiani, Nicola Alessandro Iacovelli, Marzia Franceschini, Marco Guzzo, Alberto Deganello, Lisa Licitra
Summary: 15 cases of pregnancy-associated cancer (PAC) were investigated, with 5 cases of salivary cancer, 4 cases of nasopharyngeal cancer, 3 cases of thyroid cancer, 2 cases of oral cavity cancer, and 1 case of HPV-related carcinoma. The study also included a literature review on PAC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Teng Li, Yin-Ping Zhang, Jun-Juan Kong, Min Kong, Ge Meng, Wen-Xin Shi
Summary: The study evaluated the effectiveness of timing it right (TIR) applications in patients undergoing radiotherapy for head and neck cancer. The TIR intervention program significantly improved the unmet needs and psychological pain of these patients. The TIR group showed significant improvements in various aspects, including information needs, health and psychological problems, healthcare staff, physical symptoms, health facilities and services, religious/spiritual support, and psychological pain.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Oncology
Jebrane Bouaoud, Paolo Bossi, Moshe Elkabets, Sandra Schmitz, Leon C. van Kempen, Pierre Martinez, Sankar Jagadeeshan, Ingrid Breuskin, Gerwin J. Puppels, Caroline Hoffmann, Keith D. Hunter, Christian Simon, Jean-Pascal Machiels, Vincent Gregoire, Chloe Bertolus, Ruud H. Brakenhoff, Senada Koljenovic, Pierre Saintigny
Summary: Oral cavity is a common site for cancer, with the main causes being tobacco and alcohol consumption. Oral leukoplakia is the most common oral potentially malignant disorder, which can transform into oral cancer. However, there is currently no effective intervention to prevent this transformation. In this article, experts discuss the challenges in oral cancer prevention, including the need for a new classification system, better identification of high-risk patients, and the development of treatment strategies.
Article
Oncology
Laura D. Locati, Elena Colombo, Marek Dedecjus, Christelle de la Fouchardiere, Ward Sents, Massimo Bongiovanni, Romana Netea-Maier
Summary: Anaplastic thyroid carcinoma (ATC) is a rare and deadly cancer, and there are challenges in prescribing novel treatments in Europe as they haven't been licensed for ATC yet. Patients manage to receive these drugs through alternative ways. An investigation showed disparities in access to new treatments, and it emphasized the urgent need for access to cutting-edge therapies and the feasibility of clinical trials.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Kira S. van Hof, Arta Hoesseini, Maarten C. Dorr, Irma M. M. Verdonck-de Leeuw, Femke Jansen, C. Rene Leemans, Robert P. Takes, Chris H. J. Terhaard, Robert J. Baatenburg de Jong, Aniel Sewnaik, Marinella P. J. Offerman
Summary: This study examines the unmet supportive care needs of informal caregivers of head and neck cancer patients. The findings suggest that there is a high prevalence of unmet needs among caregivers, particularly in the healthcare & illness domain. The study highlights the importance of providing optimal support to caregivers and involving them in the counseling and support process.
SUPPORTIVE CARE IN CANCER
(2023)
Review
Otorhinolaryngology
Joanna Dimelow, Derek Lowe, Simon N. Rogers
Summary: The study found that during the COVID-19 pandemic, most HNC patients prefer face-to-face follow-up consultations, while their fears of cancer recurrence and COVID-19 were relatively low. The key conclusion is that any redesign of outpatient follow-up mode and frequency in light of COVID-19 should involve discussions with patient groups and individuals.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
P. James, F. Bekiroglu, D. Broderick, O. Khattak, D. Lowe, A. Schache, R. J. Shaw, S. N. Rogers
Summary: The COVID-19 pandemic prompted a shift in postoperative care for microvascular free tissue transfer patients from the high dependency unit (HDU) to the ward. This retrospective study compared outcomes before and during the pandemic, and found that ward-based care was safe and helped alleviate bed pressures in the HDU. Case selection should be done carefully.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2022)
Article
Otorhinolaryngology
Simon N. Rogers, Ashni Adatia, Stephanie Hackett, Angela Boscarino, Anika Patel, Derek Lowe, Christopher J. Butterworth
Summary: This study reports on the changes in reconstruction and oral rehabilitation of maxillary defects since 1994. A total of 186 patients were included, with the majority of tumors located in the alveolus and hard palate. Significant changes were observed over time in reconstruction type, use of implants, dental restoration, and length of hospital stay.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
J. Twigg, A. Kanatas, G. M. Humphris, D. Lowe, S. N. Rogers
Summary: The aim of this study was to evaluate the usability of a single-page condition-specific prompt list, the Patient Concerns Inventory (PCIHN), in assessing health-related quality of life (HRQOL). The results showed that certain items and the total number of items in the PCI-HN could predict poor HRQOL.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Oncology
Anastasios Kanatas, Derek Lowe, Simon N. Rogers
Summary: During clinical follow-up, using HRQOL questionnaires and prompt lists can help identify the needs of head and neck cancer patients and provide additional support. Baseline HRQOL is a significant predictor of HRQOL 12 months later, and patients with lower baseline HRQOL may benefit more from using prompt lists.
Article
Economics
Victory 'Segun Ezeofor, Llinos Haf Spencer, Simon N. Rogers, Anastasios Kanatas, Derek Lowe, Cherith J. Semple, Jeffrey R. Hanna, Seow Tien Yeo, Rhiannon Tudor Edwards
Summary: The study conducted an economic evaluation of the PCI in head and neck cancer patients, finding that the PCI intervention was cost-effective and cost-saving, with a higher quality-adjusted life-year (QALY) gain compared to the non-PCI group. Consultants using the PCI reported a better awareness of patients' post-treatment needs, showing that the PCI is a low-cost intervention that provides benefits to patients and is supported in routine practice.
PHARMACOECONOMICS-OPEN
(2022)
Article
Dentistry, Oral Surgery & Medicine
S. N. Rogers, D. Lowe, A. W. Midgley
Summary: This study examined the interest and reasons for participation in an exercise program among head and neck cancer patients. The findings suggest that personalized interventions tailored to the specific needs of the patients, supported by patient peers, can help motivate participation in exercise.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Review
Otorhinolaryngology
Anastasios Kanatas, Derek Lowe, Simon N. Rogers
Summary: This article reviews the development, validation, and clinical implications of the Patient Concerns Inventory for head and neck cancer (PCI-HN). It provides an overview of the PCI-HN's background, evaluation, and utility, which is essential for multidisciplinary teams and researchers.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Physiology
Adrian W. Midgley, Andrew R. Levy, Felipe A. Cunha, Angela Key, Joanne M. Patterson, Simon N. Rogers
Summary: The purpose of this study was to assess the safety and feasibility of using the cardiopulmonary exercise test (CPET) for evaluating head and neck cancer (HaNC) survivors. The study also aimed to compare their cardiorespiratory fitness to age and sex-matched norms and establish their current physical activity levels. The results showed that most HaNC survivors had lower levels of cardiorespiratory fitness, which should be taken into account when determining an appropriate ramp rate.
CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING
(2023)
Article
Oncology
Cecilie Hollaender-Mieritz, Anne Marie Juhl Elsborg, Claus Andrup Kristensen, Simon N. Rogers, Helle Pappot, Karin Piil
Summary: This study aims to establish a patient concerns inventory (PCI-HNC-PT) for patients with advanced head and neck cancer receiving palliative treatment. Through patient interviews and a focus group interview with oncology nurses, the items and concerns for the PCI-HNC-PT were determined.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Otorhinolaryngology
Hisham Mehanna, Ben Carter, Andrew K. Hartley, Ahmad K. Abou-Foul, Jill Brooks, June Jones, Lydia Fresco, Laura M. Moss, Terence M. N. Jones, Simon N. P. Rogers, Randall P. Morton, ETERMIN Study Management Grp
Summary: The study aims to determine patients' preferences and willingness to complete commonly used head-and-neck cancer quality of life questionnaires in routine follow-up clinics. Results showed that 82% of respondents found the questionnaires useful for communicating their health concerns, with patients preferring structured disease-specific instruments and disliking unstructured patient-generated lists. However, only 55% of patients expressed support for completing questionnaires routinely at the clinic.
CLINICAL OTOLARYNGOLOGY
(2023)
Article
Multidisciplinary Sciences
Adrian W. Midgley, Andrew R. Levy, Simon N. Rogers, Rachel C. Brooker, Valerie Bryant, Mary Gemma Cherry, Steven Lane, Michael M. Nugent, Ruth Price, Andrew G. Schache, Bridget Young, Joanne M. Patterson
Summary: The aim of this study is to investigate the feasibility and acceptability of introducing a remotely delivered, fully personalised, collaborative, and flexible exercise programme into the usual care pathway for head and neck cancer patients. The study will recruit 70 patients and assess the retention, uptake, and adherence to the exercise programme, as well as the impact on fatigue, quality of life, physical activity levels, and physical fitness. The results of this feasibility study will inform the design of a future randomised controlled trial.
Review
Oncology
Hannah C. Doughty, Ruaraidh A. Hill, Andrew Riley, Adrian W. Midgley, Joanne M. Patterson, Lynne M. Boddy, Simon N. Rogers, Michelle Maden, Nefyn H. Williams
Summary: This review explored barriers to and facilitators of physical activity promotion and participation in cancer patients. Educating patients and healthcare professionals on the benefits and safety of physical activity may facilitate promotion, uptake, and adherence. Head and neck cancer patients experienced barriers not cited across other cancers, and research exploring physical activity promotion in this patient group is required to improve physical activity engagement.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Corrie Dicks, Simon N. Rogers, Anastasios Kanatas, Derek Lowe, Calum Mchale, Gerry Humphris
Summary: This study investigated the number of concerns raised by patients using the Patient Concerns Inventory (PCI) and those who did not raise concerns. The study also examined who initiated the concerns and the factors that may predict this initiation.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Surgery
A. Kanatas, D. Coffey, J. Spellman, J. Twigg, D. Lowe, S. N. Rogers
Summary: This study reports on the follow-up pattern of head and neck cancer patients in two large UK centers during the COVID-19 pandemic. The findings suggest that remote consultations were favored by clinicians, but variations in practice were observed, leading to a "hybrid follow-up approach". The study recommends developing a personalized follow-up model based on risk stratification, and further evaluating the mode of such consultations.
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2023)