Review
Medicine, General & Internal
Katharina Boch, Ewan A. Langan, Khalaf Kridin, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber
Summary: Lichen planus is a T cell-mediated disease affecting the skin and mucous membranes, characterized by inflammatory infiltrate and basal layer degeneration. While usually self-limiting, it can cause significant morbidity. Current treatment includes corticosteroids, but new options like Janus kinase inhibitors and biologics may lead to a change in treatment landscape.
FRONTIERS IN MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Honglin Liao, Yuxue Luo, Li Long, Jiakuan Peng, Xuemei Qiu, Peiyang Yuan, Hao Xu, Lu Jiang
Summary: The study found that anxiety levels were higher in OLP patients compared to healthy individuals, with female patients showing higher levels of anxiety. Gender had an impact on anxiety levels among OLP patients. The research suggests that OLP patients can be classified into weakly anxiety-related or highly anxiety-related types.
Review
Dentistry, Oral Surgery & Medicine
Asma El-Howati, Martin H. Thornhill, Helen E. Colley, Craig Murdoch
Summary: Oral lichen planus (OLP) is a T cell-mediated inflammatory disease of the oral mucosa. The mechanisms of pathogenesis are still not fully understood, but evidence suggests a chronic, dysregulated immune response leading to increased expression of cytokines, chemokines, and adhesion molecules. CD8+ cytotoxic and CD4+ Th1 polarised T cells are the main lymphocytes involved, but recent evidence indicates the involvement of other T cell subsets.
Review
Dermatology
Agathe Louisy, Eiryann Humbert, Mahtab Samimi
Summary: Oral lichen planus (OLP) is a chronic inflammatory disease characterized by T-cell mediated, epithelium-directed inflammation. The disease presents with various clinical manifestations and symptoms, ranging from discomfort to severe pain. The first-line treatment for symptomatic flares is topical superpotent corticosteroids, while a wide range of second/third-line treatments are available. Follow-up of patients is important to identify the transformation into squamous cell carcinoma, which occurs in approximately 1% of patients.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Article
Oncology
Xinjia Cai, Jianyun Zhang, Heyu Zhang, Tiejun Li
Summary: This study investigated the association between oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC) in a retrospective cohort of 3568 patients. The findings suggest that not all cases of OSCC are transformed from OLP, indicating that the previous understanding of OLP transformation may have been overestimated. Strict diagnostic criteria for OLP and close surveillance are important in correctly identifying the origin of OSCC and avoiding overestimation of the risk of OLP transformation.
Article
Oncology
Katharina Theresa Obermeier, Sabina Noreen Wuersching, Paris Liokatis, Wenko Smolka, Philipp Poxleitner, Christin Kleye, Michael Ehrenfeld, Maximilian Kollmuss, Sven Otto
Summary: Oral lichen ruber planus (OLP) is a chronic inflammatory disease of the oral mucosa that can progress to oral squamous cell carcinoma (OSCC) in a small percentage of cases. Surgical treatment, including tumor resection and neck dissection, is recommended. This study examined 103 OLP patients and compared their lymph node metastasis and survival rates with a group of OSCC patients without OLP. The analysis showed that patients with OLP had a significantly lower risk of lymph node metastasis compared to those without OLP.
Article
Dentistry, Oral Surgery & Medicine
Rakefet Czerninski, Zinat Awadieh, Svetlana Feldman, Naama Keshet, Abraham Zlotogorski, Yuval Ramot
Summary: This study describes familial OLP in 20 families, predominantly Jewish. The high prevalence of hypothyroidism and oral squamous cell carcinoma in familial OLP patients suggests a potential predisposition to malignant transformation in this high-risk group.
Article
Immunology
Qionghua Li, Fei Wang, Yujie Shi, Liang Zhong, Shumin Duan, Wenjing Kuang, Na Liu, En Luo, Yu Zhou, Lu Jiang, Hongxia Dan, Xiaobo Luo, Dunfang Zhang, Qianming Chen, Xin Zeng, Taiwen Li
Summary: This study characterized the mucosal immune microenvironment of oral lichen planus (OLP) using single-cell RNA sequencing and immune repertoire sequencing. Activated tissue-resident memory CD8+ T cells were found in OLP tissues, along with clonal expansion of T cell receptor repertoires and BCR clonal expansion. Fibroblasts were identified as potential promoters of immune cell recruitment into connective tissue in OLP.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Yunshan Li, Yaodong He, Junwei Xiang, Linfei Feng, Yuanyin Wang, Ran Chen
Summary: Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), play important regulatory roles in eukaryotes by post-transcriptionally inhibiting gene expression. The role and mechanisms of miRNAs in oral lichen planus (OLP) are still unclear, but they show potential as biomarkers for OLP diagnosis and therapeutic targets.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Cristovao Antunes de lanna, Beatriz Nascimento Monteiro da Silva, Andreia Cristina de Melo, Martin H. Bonamino, Lisia Daltro Borges Alves, Luis Felipe Ribeiro Pinto, Abel Silveira Cardoso, Heliton Spindola Antunes, Mariana Boroni, Daniel Cohen Goldemberg
Summary: By comparing the gene expression profiles of Oral Lichen Planus and Oral Squamous Cell Carcinoma, similarities were found in processes such as keratinization, cell proliferation, and immune response. Key tumor suppressors and oncogenes were dysregulated in both diseases.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
M. Contaldo, R. Grassi, F. Fiori, G. M. Nardi, R. Borgia, A. Romano, R. Serpico, M. Petruzzi
Summary: Oral Lichen planus is an immune-mediated disease with unknown causes that affects the oral mucous. Human papillomavirus infection may be correlated with Oral Lichen Planus.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Biochemistry & Molecular Biology
Fabrizio Guarneri, Lucrezia Bertino, Giovanni Pioggia, Marco Casciaro, Sebastiano Gangemi
Summary: Oxidative stress plays a critical role in chronic inflammatory diseases, with antioxidant treatments showing potential therapeutic benefits for conditions like psoriasis, vitiligo, and lichen planus. However, existing studies on antioxidant therapies in dermatology are limited, heterogeneous, and often require combination with standard drug treatments to achieve measurable results. Further research is needed using larger populations and standardized scales to assess the clinical efficacy of antioxidants.
Article
Biochemistry & Molecular Biology
Lara Marie DeAngelis, Nicola Cirillo, Alexis Perez-Gonzalez, Michael McCullough
Summary: This study used multiplex immunohistochemistry (mIHC) to investigate the presence and abundance of mucosal-associated invariant T (MAIT) cells in oral lichen planus (OLP) tissue samples, as well as their relationship with Candida infection and symptoms. The results showed the presence of MAIT cell phenotypes in OLP tissue, with significant differences in the percentage of positive cells between different OLP groups. The relative abundance of triple-stained cells also varied significantly. Reduced percentage of certain cells was observed in symptomatic OLP with and without Candida, suggesting a potential role of these cells in OLP pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Won Jung, Sungil Jang
Summary: Oral lichen planus is a chronic inflammatory disease with an unknown cause. Dysbiosis in the oral microbiome and functional abnormalities in the oral mucosa play important roles in its development.
Review
Chemistry, Multidisciplinary
Ingrida Cema, Jagriti Kakar, Madara Dzudzilo, Modra Murovska
Summary: Oral lichen planus (OLP) is an autoimmune lesion mediated by T cells and activated by an unknown antigen. Epstein-Barr virus (EBV) can act as both an exogenous and an endogenous antigen in the pathogenesis of OLP. In the development of the autoimmune process, factors such as cytokines, chemokines, autoantibodies, self-reactive B and T cells, and dysregulation of antigen-presenting cells play a role.
APPLIED SCIENCES-BASEL
(2023)
