Article
Chemistry, Multidisciplinary
Jiaxuan Xia, Chen Chen, Meichen Dong, Ying Zhu, Anni Wang, Shiyi Li, Ru Zhang, Chunbo Feng, Xinnan Jiang, Xinchun Xu, Jianxin Wang
Summary: It has been discovered that utilizing ginsenoside Rg3 instead of cholesterol and PEG in liposome preparation can prolong the blood circulation time of liposomes and avoid triggering the accelerated blood clearance phenomenon and immune responses.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Multidisciplinary
Anne M. Talkington, Morgan D. McSweeney, Timothy Wessler, Marielle K. Rath, Zibo Li, Tao Zhang, Hong Yuan, Jonathan E. Frank, M. Gregory Forest, Yanguang Cao, Samuel K. Lai
Summary: PEGylation is commonly used to prolong the circulation time of protein therapeutics and nanomedicines. However, individuals exposed to PEGylated therapeutics may develop antibodies specific to PEG, increasing the risk of hypersensitivity and accelerated drug clearance. In this study, a PBPK model was developed to investigate the impact of anti-PEG antibodies on the pharmacokinetics and biodistribution of PEGylated drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Yi-Chen Lin, Bing-Mae Chen, Trieu Thi My Tran, Tien-Ching Chang, Talal Salem Al-Qaisi, Steve R. Roffler
Summary: Methoxy polyethylene glycol (mPEG) is often attached to various biologically active molecules to improve their compatibility in the body. However, the presence of anti-PEG antibodies can lead to accelerated drug clearance and negatively impact drug effectiveness and safety. This study examined how different types of antibodies against the PEG backbone or terminal methoxy group affect the clearance and distribution of pegylated compounds. The results show that the impact of these antibodies depends on the structure and number of PEG chains in the compound.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Phim-on Khunsuk, Chitsuda Pongma, Tanapat Palaga, Voravee P. Hoven
Summary: Lipid nanoparticles (LNPs) are key in delivering mRNA into cells for protein translation. However, the use of poly(ethylene glycol) (PEG) in LNPs can lead to PEG allergies. In this study, a non-PEG lipid was developed and conjugated with an antifouling zwitterionic polymer to create LNPs with superior mRNA transfection efficiency.
Article
Chemistry, Multidisciplinary
Richard d'Arcy, Farah El Mohtadi, Nora Francini, Carlisle R. DeJulius, Hyunmoon Back, Arianna Gennari, Mike Geven, Maria Lopez-Cavestany, Zulfiye Yesim Turhan, Fang Yu, Jong Bong Lee, Michael R. King, Leonid Kagan, Craig L. Duvall, Nicola Tirelli
Summary: This study developed an 'active-stealth' polymer, PTGG, which is less immunogenic in human plasma than PEG, has antioxidant and anti-inflammatory properties, and better protects proteins from denaturation. Experimental results showed that PTGG-protein conjugates were superior to PEG analogues in terms of activity and stability.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Mareike F. S. Deuker, Volker Mailaender, Svenja Morsbach, Katharina Landfester
Summary: Poly(ethylene glycol) (PEG) is commonly used to reduce unspecific protein adsorption and prolong nanocarrier circulation time, but the presence of anti-PEG antibodies in the bloodstream can counteract its stealth effect. This study found a high concentration and prevalence of anti-PEG antibodies in the German population, which led to higher uptake in macrophages and accelerated blood clearance of PEGylated nanocarriers.
NANOSCALE HORIZONS
(2023)
Article
Pharmacology & Pharmacy
Shirleide Santos Nunes, Juliana de Oliveira Silva, Renata Salgado Fernandes, Sued Eustaquio Mendes Miranda, Elaine Amaral Leite, Marcelo Alexandre de Farias, Rodrigo Villares Portugal, Geovanni Dantas Cassali, Danyelle M. Townsend, Monica Cristina Oliveira, Andre Luis Branco de Barros
Summary: PEGylated liposomes are widely studied as drug delivery systems, but their interaction with cells may be hindered by the addition of PEG. This study compared the characteristics and drug delivery capabilities of PEGylated and non-PEGylated liposomes. The results showed that non-PEGylated liposomes had better cellular uptake and were more effective in controlling tumor growth.
Article
Pharmacology & Pharmacy
Yu Ishima, Nio Yamazaki, Victor T. G. Chuang, Taro Shimizu, Hidenori Ando, Tatsuhiro Ishida
Summary: This study evaluates the effect of MAL-PEG-DSPE liposomes (PL-MAL) on the accelerated blood clearance (ABC) phenomenon compared to PL-OCH3. The results show that PL-MAL induces ABC phenomenon independent of IgM antibodies against PEG. These findings are valuable for further studies using ligand-bound liposomes.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Review
Oncology
Nicoletta Luxi, Alexia Giovanazzi, Alessandra Arcolaci, Patrizia Bonadonna, Maria Angiola Crivellaro, Paola Maria Cutroneo, Carmen Ferrajolo, Fabiana Furci, Lucia Guidolin, Ugo Moretti, Elisa Olivieri, Giuliana Petrelli, Giovanna Zanoni, Gianenrico Senna, Gianluca Trifiro
Summary: This paper conducted a literature review and database search on the frequency, risk factors, and underlying mechanisms of COVID-19 vaccine-related allergies. It found that mRNA-based vaccines using novel platforms have an increased risk of severe allergic reactions. The paper also summarized the prevention and management recommendations from scientific societies and regulatory agencies.
Article
Chemistry, Multidisciplinary
Morgan D. McSweeney, Limei Shen, Alexander C. DeWalle, Jordan B. Joiner, Elizabeth C. Ciociola, Dharmendra Raghuwanshi, Matthew S. Macauley, Samuel K. Lai
Summary: This study explored the effectiveness of prophylaxis with free PEG or tolerogenic PEGylated liposomes as a strategy to reduce the amount of APA induced by subsequently administered PEGylated liposomes. The results showed that a single administration of free PEG alone was capable of markedly reducing the APA response to PEG-liposomes for up to 2 months, which was comparable to, and often exceeded, interventions with different tolerogenic PEG-liposomes. These findings support further research on free PEG prophylaxis as a potential strategy to mitigate the APA response to sensitizing PEGylated therapeutics.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Materials Science, Multidisciplinary
Min Liu, Siyi Liu, Jingya Xiu, Jiulong Zhang, Yihui Deng, Xiuli Zhao
Summary: Poly(ethylene glycol) (PEG) is widely used for nanocarrier decoration due to its long circulation characteristics. However, the applications of linear PEG-modified nanocarriers have been hindered by the accelerated blood clearance (ABC) phenomenon caused by anti-PEG antibodies (APAs), which can induce significant changes in pharmacokinetics, biological distributions, and trigger complement activation-related pseudoallergies (CARPA). Y-type PEG-lipid derivatives were found to have weaker immunogenicity and can avoid the ABC phenomenon and reduce APAs levels. These Y-type PEG-modified nanocarriers also improve the therapeutic effect of tumor treatment. This research promotes the development of Y-type PEG-decorated nanocarriers and provides a basis for their clinical application.
APPLIED MATERIALS TODAY
(2023)
Article
Nanoscience & Nanotechnology
Dezhi Sui, Yujie Wang, Wenliang Sun, Lu Wei, Changzhi Li, Yangxu Gui, Zhaowei Qi, Xinrong Liu, Yanzhi Song, Yihui Deng
Summary: Cationic liposomes have been utilized as delivery platforms for mRNA vaccines. Poly(ethylene glycol) (PEG)-lipid derivatives are commonly used to enhance stability and reduce toxicity. However, these derivatives often trigger the production of anti-PEG antibodies. This study investigated the role of PEG-lipid derivatives on PEGylated cationic liposomes and their impact on photothermal therapy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Yuri Sugimoto, Tadaharu Suga, Naoya Kato, Mizuki Umino, Asako Yamayoshi, Hidefumi Mukai, Shigeru Kawakami
Summary: This study developed a microfluidic post-insertion method for the clinical application and large-scale preparation of targeted liposomes.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Medicine, Research & Experimental
Shirleide Santos Nunes, Sued Eustaquio Mendes Miranda, Juliana de Oliveira Silva, Renata Salgado Fernandes, Janaina de Alcantara Lemos, Carolina de Aguiar Ferreira, Danyelle M. Townsend, Geovanni Dantas Cassali, Monica Cristina Oliveira, Andre Luis Branco de Barros
Summary: A folate-coated pH-sensitive liposome drug delivery system for Irinotecan was developed to improve tumor therapy without potential adverse events. The system showed better antitumor activity compared to the pH-dependent system alone or free drug, with no evidence of systemic toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, Research & Experimental
Tien-Ching Chang, Bing-Mae Chen, Jer-Yuan Wu, Tian-Lu Cheng, Steve Roffler
Summary: Antibodies that bind polyethylene glycol (PEG) can accelerate the clearance of pegylated medicines, with higher affinity antibodies leading to greater clearance and reduced drug efficacy. The molar ratio of high affinity anti-PEG antibodies to PEG-EPO correlates with accelerated blood clearance in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)