Article
Geriatrics & Gerontology
Marco Narici, Jamie McPhee, Maria Conte, Martino V. Franchi, Kyle Mitchell, Sara Tagliaferri, Elena Monti, Giuseppe Marcolin, Philip J. Atherton, Kenneth Smith, Bethan Phillips, Jonathan Lund, Claudio Franceschi, Marcello Maggio, Gillian S. Butler-Browne
Summary: The study introduced an ultrasound imaging method for diagnosing sarcopenia based on changes in muscle geometric proportions. The ultrasound sarcopenic index (USI) was proposed as a novel marker for the loss of muscle mass associated with sarcopenia, providing a useful 'signature of sarcopenia' and allowing for stratification of individuals according to muscle sarcopenia presence and severity. The USI was found to be a useful clinical tool for confirming the diagnosis of sarcopenia, with DXA-derived skeletal muscle index (SMI) showing significant correlation with USI.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Nutrition & Dietetics
Mary F. O'Leary, Sarah R. Jackman, Vlad R. Sabou, Matthew I. Campbell, Jonathan C. Y. Tang, John Dutton, Joanna L. Bowtell
Summary: Shatavari may improve muscle function and contractility via myosin conformational change, warranting further investigation in larger and more diverse cohorts.
Article
Physiology
Ryan Neil Marshall, James McKendry, Benoit Smeuninx, Alex Peter Seabright, Paul T. Morgan, Carolyn Greig, Leigh Breen
Summary: Ageing is associated with changes in skeletal muscle oxidative metabolism, which may be influenced by physical activity status. The effect of resistance exercise training on skeletal muscle mitochondrial regulation is unclear.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jason Tallis, Sharn Shelley, Hans Degens, Cameron Hill
Summary: Obesity and aging have negative impacts on skeletal muscle function, with their combined effects yet to be thoroughly explored. Poor muscle function is associated with chronic diseases, poor quality of life, and all-cause mortality, highlighting the importance of studying and intervening in these effects for overall health and physical function.
Article
Food Science & Technology
Min-Kyeong Lee, Hyeon Hak Jeong, Myeong-Jin Kim, Heeyeon Ryu, Jiwon Baek, Bonggi Lee
Summary: Glucocorticoid excess is a critical factor contributing to muscle atrophy, while applying mechanical load and providing adequate nutrients can prevent and improve muscle wasting.
Review
Nutrition & Dietetics
Cong Wu, Katsuhiko Suzuki
Summary: Flavonoids may have a great potential to treat sarcopenia by improving skeletal muscle mass, muscle strength, and physical performance in older adults.
Article
Nutrition & Dietetics
Fengchan Xi, Yong You, Weiwei Ding, Tao Gao, Yang Cao, Shanjun Tan, Wenkui Yu
Summary: This study aimed to investigate the relationship between longitudinal changes in skeletal muscle mass and poor prognosis and nutritional intake in acutely hospitalized patients with abdominal trauma. The results showed that the loss of skeletal muscle mass was associated with poor prognosis and nutritional intake in these patients.
FRONTIERS IN NUTRITION
(2023)
Article
Neurosciences
Xiaoyan Zhang, Hawley E. Kunz, Kevin Gries, Corey R. Hart, Eric C. Polley, Ian R. Lanza
Summary: Healthy older adults exhibit lower cardiorespiratory fitness (V?O2peak) compared to young individuals, mainly due to changes in central hemodynamics. While total physical activity levels do not differ by age, moderate-to-vigorous physical activity is lower in older adults. Moderate-to-vigorous physical activity is associated with V?O2peak and muscle oxidative capacity, but cannot fully explain the age-related decline in fitness.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biology
Marcel A. Vieira-Lara, Marleen B. Dommerholt, Wenxuan Zhang, Maaike Blankestijn, Justina C. Wolters, Fentaw Abegaz, Albert Gerding, Ydwine T. van der Veen, Rachel Thomas, Ronald P. van Os, Dirk-Jan Reijngoud, Johan W. Jonker, Janine K. Kruit, Barbara M. Bakker
Summary: The study revealed that aged mice are more susceptible to insulin resistance when on a high-fat diet. Intramuscular lipid accumulation, particularly C18:0-containing ceramides and diacylglycerols, was induced by the high-fat diet in aged mice. Computational modelling identified CPT1B as a crucial factor influencing the response to the high-fat diet in aged animals.
Article
Biology
Alistair M. Senior, Veronique Legault, Francis B. Lavoie, Nancy Presse, Pierrette Gaudreau, Valerie Turcot, David Raubenheimer, David G. Le Couteur, Stephen J. Simpson, Alan A. Cohen
Summary: Using a multidimensional approach to study the effects of nutrient intake on physiological dysregulation in an aged population, key patterns of specific nutrients associated with minimal biological ageing were identified.
Review
Geriatrics & Gerontology
Hongfu Jin, Wenqing Xie, Peiwu Hu, Kun Tang, Xiuhua Wang, Yuxiang Wu, Miao He, Dengjie Yu, Yusheng Li
Summary: Sarcopenia is an age-related disease that significantly impacts the quality of life and prognosis of elderly individuals. Studies have shown that melatonin has potential in combating sarcopenia by protecting muscle cell mitochondria, maintaining muscle fiber numbers, and increasing muscle strength.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Physiology
Osvaldo Delbono, Zhong-Min Wang, Maria Laura Messi
Summary: Brainstem noradrenergic neuron clusters play a crucial role in regulating cognition and skeletal muscle function. They are highly heterogeneous and project to different areas in the brain and spinal cord. Understanding the vulnerability of these neurons to protein deposition and aging can help detect neurodegeneration early on and predict disease progression.
Article
Nutrition & Dietetics
Colleen S. Deane, Ushnah S. U. Din, Tanvir S. Sian, Ken Smith, Amanda Gates, Jonathan N. Lund, John P. Williams, Ricardo Rueda, Suzette L. Pereira, Philip J. Atherton, Bethan E. Phillips
Summary: Acute curcumin supplementation enhances the effect of oral nutritional supplement on microvascular blood flow in healthy older adults, without affecting muscle glucose uptake, vascular function, or blood flow.
Article
Geriatrics & Gerontology
Mindaugas Kvedaras, Petras Minderis, Leonardo Cesanelli, Agne Cekanauskaite, Aivaras Ratkevicius
Summary: Old mice are less susceptible to muscle wasting during fasting compared to adult mice, showing less weight loss and muscle wasting, as well as a smaller decline in metabolic rate and fat mass.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Cell Biology
Giuseppe Sirago, Maria A. Pellegrino, Roberto Bottinelli, Martino V. Franchi, Marco Narici
Summary: Physical inactivity is a major risk factor for chronic diseases, leading to loss of muscle mass and strength. While studies have focused on understanding the mechanisms of muscle loss, less attention has been given to the contribution of somatomotor control changes.
AGEING RESEARCH REVIEWS
(2023)
Review
Food Science & Technology
Caroline R. Hill, Armaghan Shafaei, Lois Balmer, Joshua R. Lewis, Jonathan M. Hodgson, A. Harvey Millar, Lauren C. Blekkenhorst
Summary: Sulfur is an essential element for plant and human health, and its incorporation into the food chain relies heavily on plant uptake. The dietary requirements for sulfur are based on the synthesis of proteins, enzymes, co-enzymes, vitamins, and hormones. While sulfur-containing amino acids are abundant in animal sources, the variety and quantity of sulfur-containing compounds in plants also have wide-ranging effects on human health. The role of sulfur in redox biochemistry protects against oxidative stress and inflammation, which is consistent with cardiometabolic dysfunction and many chronic metabolic diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Cardiac & Cardiovascular Systems
Reindolf Anokye, Ben Jackson, James Dimmock, Joanne M. Dickson, Lauren C. Blekkenhorst, Jonathan M. Hodgson, Joshua R. Lewis, Mandy Stanley
Summary: This article aims to investigate the psychological distress and changes in health-related quality of life (HRQoL) following cardiovascular risk assessment and communication of results to asymptomatic adults. Through a review of relevant studies, the findings on these aspects are found to be mixed.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Clinical Neurology
Jackson Luker, Richard Woodman, David Schultz
Summary: This study describes the prevalence and annual incidence rates of MND in South Australia between 2017 and 2019. The results show that the crude prevalence and incidence of MND in South Australia were considerably higher than global estimates. This may reflect higher rates of the disease or higher rates of case ascertainment compared to the GBD project.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2023)
Article
Endocrinology & Metabolism
Pratik Pokharel, Cecilie Kyro, Anja Olsen, Anne Tjonneland, Kevin Murray, Lauren C. Blekkenhorst, Catherine P. Bondonno, Jonathan M. Hodgson, Nicola P. Bondonno
Summary: The study examined the relationship between vegetable/potato intake and incident type 2 diabetes (T2D) and investigated whether the relationship between vegetable intake and incident T2D is mediated by baseline BMI. The findings showed that higher vegetable intake can help reduce the risk of T2D, partly by reducing BMI.
Article
Geriatrics & Gerontology
Abadi K. Gebre, Marc Sim, Jack Dalla Via, Alexander J. Rodriguez, Kun Zhu, John T. Schousboe, Jonathan M. Hodgson, Catherine P. Bondonno, Richard L. Prince, Joshua R. Lewis
Summary: In older women, cardiovascular disease, especially cerebrovascular disease, is associated with an increased risk of long-term falls. These findings emphasize the need to recognize increased falls risk in patients with cardiovascular disease.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Sport Sciences
Caitlin Attwell, Alannah McKay, Marc Sim, Cory Dugan, Joanna Nicholas, Luke Hopper, Peter Peeling
Summary: The study aimed to compare the effect of oral iron supplementation in the morning versus evening on increasing iron stores in ballet and contemporary dancers. Results showed that both morning and evening supplementation effectively increased serum ferritin (sFer) levels in dancers with sub-optimal iron status. There was no significant difference in the effectiveness between the two supplementation timings. This study demonstrates the importance of proper iron supplementation in improving iron status in dancers.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Review
Nutrition & Dietetics
Katherine M. Livingstone, Jonathan C. Rawstorn, Stephanie R. Partridge, Stephanie L. Godrich, Sarah A. McNaughton, Gilly A. Hendrie, Lauren C. Blekkenhorst, Ralph Maddison, Yuxin Zhang, Scott Barnett, John C. Mathers, Maria Packard, Laura Alston
Summary: This study systematically reviewed digital interventions to increase vegetable intake in adults. The findings suggest that a minority of digital interventions were effective, and their effectiveness was associated with the use of behavior change theories and stakeholder involvement in intervention design. The results highlight the need for better utilization of behavior change theories and comprehensive design methods in digital interventions, as well as addressing both behavior change and food environment influences on vegetable intake.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Article
Biochemistry & Molecular Biology
George C. Mayne, Richard J. Woodman, David I. Watson, Tim Bright, Susan Gan, Reginald V. Lord, Michael J. Bourke, Angelique Levert-Mignon, Isabell Bastian, Tanya Irvine, Ann Schloithe, Marian Martin, Lorraine Sheehan-Hennessy, Damian J. Hussey
Summary: We developed an efficient method for estimating confidence intervals for biomarker models' prediction errors. Combining this method with StaVarSel significantly improved the predictive capacity of serum miRNA biomarkers for detecting disease states at risk of progressing to oesophageal adenocarcinoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jocelyn Tan, Carrie-Anne Ng, Nicolas H. Hart, Timo Rantalainen, Marc Sim, David Scott, Kun Zhu, Beth Hands, Paola Chivers
Summary: Bone health is compromised in children and adolescents with low motor competence (LMC). This study found that LMC is associated with decreased bone mineral density (BMD) at load-bearing bone sites, particularly in males. Engaging in osteogenic physical activity can increase BMD, but factors like diversity and movement quality may also contribute to BMD differences based on LMC status.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Food Science & Technology
Catherine P. Bondonno, Liezhou Zhong, Nicola P. Bondonno, Marc Sim, Lauren C. Blekkenhorst, Alex Liu, Anjana Rajendra, Pratik Pokharel, Dorit W. Erichsen, Oliver Neubauer, Kevin D. Croft, Jonathan M. Hodgson
Summary: Vegetables, meat, and water are the main sources of dietary nitrate, which has been regulated and monitored due to concerns over cancer risk. However, evidence suggests that nitrate from vegetables can actually protect against cardiovascular disease and other chronic illnesses. The potential formation of carcinogenic N-nitrosamines from nitrate is still a concern.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Health Care Sciences & Services
Nicholas L. Scarfo, Sayeh Dehghanian, Mai Duong, Richard J. Woodman, Pravin Shetty, Henry Lu, Cameron J. Phillips
Summary: This study investigated the perspectives of general practitioners on discharge summaries of their patients. The results showed that general practitioners preferred to receive discharge summaries within 48 hours and believed that late arrival negatively impacted patient care. They also expressed the desire to be notified about patient admissions and discharges, and supported patients receiving their own copy of the discharge summary. General practitioners considered the ideal length of discharge summaries to be less than 4 pages and emphasized the importance of providing rationale for medication changes. Overall, accuracy and effective communication were highlighted as key concerns.
AUSTRALIAN HEALTH REVIEW
(2023)
Review
Food Science & Technology
Caroline R. Hill, Alex Haoci Liu, Lyn Mccahon, Liezhou Zhong, Armaghan Shafaei, Lois Balmer, Joshua R. Lewis, Jonathan M. Hodgson, Lauren C. Blekkenhorst
Summary: Higher intakes of cruciferous and allium vegetables are associated with a lower risk of cardiometabolic-related outcomes. This scoping review explores the potential roles of S-methyl cysteine sulfoxide (SMCSO) found in these vegetables and its mechanisms of action. Animal studies suggest that SMCSO has anti-hyperglycemic, anti-hypercholesterolemic, antioxidant, anticancer, and antibacterial properties. More research, especially human studies, is needed to further understand the health benefits of SMCSO, particularly for cardiometabolic and inflammatory-based pathologies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Endocrinology & Metabolism
Jack Dalla Via, Abadi K. Gebre, Cassandra Smith, Zulqarnain Gilani, David Suter, Naeha Sharif, Pawel Szulc, John T. Schousboe, Douglas P. Kiel, Kun Zhu, William D. Leslie, Richard L. Prince, Joshua R. Lewis, Marc Sim
Summary: Abdominal aortic calcification (AAC), a measure of vascular disease, is associated with increased cardiovascular risk and poorer prognosis. An automated machine-learning algorithm has been developed for assessing AAC, which is associated with long-term incident fractures and falls.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Peripheral Vascular Disease
Jin Nuo Joan Tsang, Stephen Bacchi, Joshua G. Kovoor, Aashray K. Gupta, Brandon Stretton, Samuel Gluck, Toby Gilbert, Yogesh Sharma, Richard Woodman, Arduino A. Mangoni
Summary: The study investigated the prevalence of elevated blood pressure and its association with in-hospital mortality in Australian medical inpatients. The results showed that elevated systolic blood pressure levels were common in this group, and a negative association was observed between systolic blood pressure values ≥ 140 mmHg and in-hospital mortality. Further research is needed to determine the clinical significance and optimal management of blood pressure elevations in this population.
JOURNAL OF CLINICAL HYPERTENSION
(2023)