Article
Immunology
Grzegorz Majka, Henryk Mazurek, Magdalena Strus, Marta Ciszek-Lenda, Rafal Szatanek, Agnieszka Pac, Edyta Golinska, Janusz Marcinkiewicz
Summary: The high concentration of sputum bacteria in cystic fibrosis patients with advanced lung disease is associated with increased levels of inflammatory markers and low levels of certain cytokines. Specific inflammatory biomarkers including blood CRP, NLR, and sputum elastase, IL-6, IL-8, and IL-10 are recommended for monitoring the disease.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kiera H. Harwood, Rachel M. McQuade, Andrew Jarnicki, Elena K. Schneider-Futschik
Summary: Cystic fibrosis is caused by a defect in the CFTR protein, resulting in respiratory complications and a highly inflammatory environment in the lungs. Neutrophil infiltration plays a critical role in driving inflammation through various pathways. Understanding these mechanisms can lead to the development of new therapeutic targets for CF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Critical Care Medicine
Daniel P. Cook, Christopher M. Thomas, Ashley Y. Wu, Mark Rusznak, Jian Zhang, Weisong Zhou, Jacqueline-Yvonne Cephus, Katherine N. Gibson-Corley, Vasiliy V. Polosukhin, Allison E. Norlander, Dawn C. Newcomb, David A. Stoltz, R. Stokes Peebles
Summary: Type 2 inflammation is observed in cystic fibrosis patients. This study reveals that CFTR deficiency leads to increased expression and release of IL-33, and deletion of IL-33 reduces allergen-induced inflammation in the CF lung.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Chemistry, Medicinal
Sara Consalvi, Giovanna Poce, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Paola Patrignani, Annalisa Bruno, Maurizio Anzini, Vincenzo Calderone, Alma Martelli, Lara Testai, Antonio Giordani, Mariangela Biava
Summary: This review discusses the rational for further studies of COX-2 inhibitors-NO releaser hybrids (NO-Coxibs) in the pharmacological treatment of airway inflammation in Cystic Fibrosis (CF), indicating that previous research results may provide suitable candidates for the treatment of CF.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Cell Biology
Monica Averna, Paola Melotti, Claudio Sorio
Summary: Cystic fibrosis is characterized by pulmonary bacterial colonization and hyperinflammation. White blood cells in CF patients are directly impacted by altered CFTR expression/function, impairing their ability to resolve infections and inflammation. Specific CFTR modulators have been introduced clinically, providing a tool for disease management and investigation into CF pathophysiology. These drugs improve lung function, quality of life, and may correct the dysregulated immune function that characterizes CF. Analysis of CFTR expression and function in leukocytes can provide insights into CF pathogenesis and potential clinical applications.
Article
Biochemistry & Molecular Biology
Berengere Villeret, Reem Ghinnagow, Saade Kheir, Maelys Born-Bony, Jay K. Kolls, Ignacio Garcia-Verdugo, Jean-Michel Sallenave
Summary: This study reveals the importance of lymphocytes in fighting against Pseudomonas aeruginosa infection. The bacterium down-regulates IL-23 and IL-22 protein accumulation in the lungs, but up-regulates their RNA production. Adenovirus-mediated over-expression of IL-1, IL-23, and IL-7 can rescue mice from Pseudomonas aeruginosa-induced lethality, suggesting its potential value in locally immunosuppressed individuals like cystic fibrosis patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Xiao Liu, Jingjing Huang, Yuan Jiang, Zhengyu Cao, Maoxiong Wu, Runlu Sun, Zhiteng Chen, Peng Yu, Jianyong Ma, Yangxin Chen, Yuling Zhang, Jingfeng Wang
Summary: This study investigated the inflammatory biomarker profiles of psychological treatment-naive individuals and found that levels of IL-6 and IL-8 were positively correlated with symptoms of depression, suggesting they may play a role in the pathogenesis of psychological disorders. However, these associations were not significant after multiple testing. Larger and longitudinal studies are needed to confirm these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Economics
Sarah Acaster, Clara Mukuria, Donna Rowen, John E. Brazier, Claire E. Wainwright, Bradley S. Quon, Jamie Duckers, Alexandra L. Quittner, Yiyue Lou, Patrick R. Sosnay, Lisa J. McGarry
Summary: This study developed a preference-based utility measure for cystic fibrosis (CF) based on the CFQ-R questionnaire, which is the first disease-specific scoring algorithm for CF. It allows for estimation of disease-specific utilities and can be used in cost-effectiveness analysis.
Review
Biochemistry & Molecular Biology
Aleksandra Vilotic, Mirjana Nacka-Aleksic, Andrea Pirkovic, Zanka Bojic-Trbojevic, Dragana Dekanski, Milica Jovanovic Krivokuca
Summary: This review summarizes the role of interleukin-6 (IL-6) and interleukin-8 (IL-8) in healthy and pathological pregnancies. The authors provide an overview of the expression of these cytokines during pregnancy and discuss their involvement in pregnancy establishment, parturition, and various pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Hai-Bo Tan, Yan-Qiu Zheng, Yu-Pei Zhuang
Summary: IL-17A plays a role in DKD that is not only negative; it can alleviate inflammation and fibrosis caused by DKD by regulating autophagy or macrophage phenotype, and contradictory expression of IL-17A has been observed in human DKD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Environmental Sciences
Ersilia Nigro, Rita Polito, Ausilia Elce, Giuseppe Signoriello, Paola Iacotucci, Vincenzo Carnovale, Monica Gelzo, Federica Zarrilli, Giuseppe Castaldo, Aurora Daniele
Summary: Regular physical activity plays a key role in modulating inflammatory processes in cystic fibrosis (CF) patients, by regulating the secretion of pro-inflammatory cytokines and ameliorating lung function. TNF alpha may serve as a marker of the effects of physical activity in the management of CF patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Allergy
Sara Manti, Giuseppe Fabio Parisi, Maria Papale, Gian Luigi Marseglia, Amelia Licari, Salvatore Leonardi
Summary: Type 2 inflammation is recognized as a critical contributor to cystic fibrosis, and understanding its pathways can help identify targets for treating inflammation and fibrosis in patients with CF.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)
Review
Immunology
Lanxuan Wei, David Abraham, Voon Ong
Summary: IL-17 is a pro-inflammatory cytokine that plays an important role in host defense. It activates transcription and stabilizes mRNAs through multiple pathways, mainly acting on stromal cells to promote the secretion of other immunomodulatory factors and support the growth and differentiation of immune cells. IL-17 has a dual role in immune reactions and inflammatory diseases, and it also plays a significant role in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Matteo Puccetti, Marilena Pariano, Claudia Stincardini, Paulina Wojtylo, Aurelie Schoubben, Emilia Nunzi, Maurizio Ricci, Luigina Romani, Stefano Giovagnoli
Summary: In this study, a novel treatment approach for cystic fibrosis (CF) was proposed, using an inhalable dry powder formulation of anakinra. The new formulation showed improved aerodynamic properties, pharmacological activity, and therapeutic efficacy compared to systemic delivery. Peripheral side effects were significantly reduced, demonstrating the potential of anakinra repurposing through the pulmonary route in CF.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Immunology
Franziska E. Uhl, Lotte Vanherle, Anja Meissner
Summary: Heart failure (HF) affects 64 million people worldwide. Pulmonary manifestations of HF, including lung inflammation and vascular structure changes, contribute to the poor quality of life for many HF patients. This study investigates the role of cystic fibrosis transmembrane regulator (CFTR) in lung inflammation during HF and suggests that pharmacological correction of CFTR expression could alleviate HF-associated lung inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Hafiz Arbab Sakandar, Weining Huang, Stan Kubow, Faizan Ahmed Sadiq, Muhammad Imran
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2020)
Article
Microbiology
Mohd Baasir Gaisawat, Chad W. MacPherson, Julien Tremblay, Amanda Piano, Michele M. Iskandar, Thomas A. Tompkins, Stan Kubow
Article
Food Science & Technology
Sana Gammoh, Muhammad H. Alu'datt, Carole C. Tranchant, Doa'a Ghazi Al-U'datt, Mohammad N. Alhamad, Taha Rababah, Stan Kubow, Malik S. Y. Haddadin, Zaid Ammari, Sofyan Maghaydah, Haya Banat
LWT-FOOD SCIENCE AND TECHNOLOGY
(2020)
Article
Endocrinology & Metabolism
Tongzhu Meng, Stan Kubow, Daiva E. Nielsen
Summary: This study investigated the associations between CD36 gene variants and fat consumption in different BMI categories. The results showed that CD36 variants were associated with fat intake and food categories, which may play a role in subsequent associations with chronic disease biomarkers. Associations differed by BMI status and dietary fat type.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Food Science & Technology
Muhammad H. Alu'datt, Doa'a G. F. Al-u'datt, Mohammad N. Alhamad, Carole C. Tranchant, Taha Rababah, Sana Gammoh, Rami M. Althnaibat, Mohammad G. Daradkeh, Stan Kubow
Summary: This study demonstrated that peptide fractions isolated from cow milk jameed exhibited various antioxidant, anti-ACE, and anti-alpha-amylase activities, which can be influenced by different drying methods and salt content adjustments. Lowering the salt content or changing the drying method enhanced the bioactivities of certain peptide fractions.
JOURNAL OF FOOD SCIENCE
(2021)
Article
Nutrition & Dietetics
Christina E. Larder, Michele M. Iskandar, Stan Kubow
Summary: The study found that collagen hydrolysates (CHs) may induce prebiotic effects in the ascending colon, which could impact osteoarthritis (OA) and metabolic diseases. Different CHs produce distinct microbial metabolites post-digestion, emphasizing the need for further research to determine the physiological significance of these metabolites.
Review
Nutrition & Dietetics
Bahareh Barkhidarian, Lucas Roldos, Michele M. Iskandar, Ahmad Saedisomeolia, Stan Kubow
Summary: Probiotics have the potential to improve micronutrient status in healthy subjects, but studies show varying degrees of efficacy. Further clinical trials are needed to determine the most effective strains of probiotics, doses, and durations of interventions.
Article
Food Science & Technology
Mohammad Alrosan, Thuan-Chew Tan, Azhar Mat Easa, Sana Gammoh, Stan Kubow, Muhammad H. Alu'datt
Summary: Plant proteins have gained attention for their health benefits, cost-effectiveness, and versatile applications in the food industry. Combining quinoa proteins with lentil proteins at pH 12 resulted in soluble protein complexes with increased solubility and resistance to aggregation. The interaction between the two proteins led to changes in protein structure and surface morphology, with electrostatic interactions, hydrophobic forces, and hydrogen bonding playing key roles in protein-protein interactions. The study demonstrated that pH cycling is a robust approach for assessing the emulsion and foaming properties of food proteins.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Rheumatology
Ali Mobasheri, Armaghan Mahmoudian, Ursule Kalvaityte, Ilona Uzieliene, Christina E. Larder, Michele M. Iskandar, Stan Kubow, Paulo Cesar Hamdan, Cyro Scala de Almeida Jr, Lacey J. Favazzo, Luc J. C. van Loon, Pieter J. Emans, Perola G. Plapler, Michael J. Zuscik
Summary: OA is the most common form of arthritis causing pain and disability, with no approved disease modifying drugs. Collagen hydrolyzates are increasingly popular as supplements for joint health, but their efficacy in treating advanced joint disease remains uncertain. The White Paper aims to encourage research and development of collagen-based supplements for musculoskeletal diseases, emphasizing the need for scientific innovation and collaboration.
CURRENT RHEUMATOLOGY REPORTS
(2021)
Review
Immunology
Samira Tarashi, Mohammad Saber Zamani, Mir Davood Omrani, Abolfazl Fateh, Arfa Moshiri, Ahmad Saedisomeolia, Seyed Davar Siadat, Stan Kubow
Summary: This review provides an overview of the protective and harmful roles of extracellular vesicles (EVs) derived from commensal and pathogenic bacteria in host-bacterial and interbacterial interactions. Bacterial EVs have important impacts on human health and metabolic homeostasis by regulating microbiota-host crosstalk and intestinal homeostasis.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Review
Food Science & Technology
Tim Lorenz, Michele M. Iskandar, Vahid Baeghbali, Michael O. Ngadi, Stan Kubow
Summary: Dysphagia is a swallowing condition commonly caused by stroke, predominantly affecting the elderly. Texture-modified diets are often prescribed but can lead to malnutrition. 3D food printing shows potential to enhance the appeal of texture-modified diets, although its ultra-processed nature raises concerns about nutrition and the gut microbiome.
Article
Nutrition & Dietetics
Dalal Alkazemi, Noora Alsouri, Tasleem Zafar, Stan Kubow
Summary: Magnesium plays a key role in the development of metabolic disorders, and hypomagnesemia may be involved in the pathogenesis of metabolic syndrome (MetS) and its components. Hypomagnesemia is significantly associated with MetS and its components in adults living in Kuwait.
Article
Food Science & Technology
Raphael Aidoo, Vincent Abe-Inge, Ebenezer M. Kwofie, Jamie I. Baum, Stan Kubow
Summary: This study investigates the environmental and nutritional performances of different dietary scenarios and finds a non-linear relationship between these two factors. The results suggest that including 10% legumes, 0.11% red meat, 0.28% processed meat, and 2.81% white meat in a composite diet can significantly reduce global warming and achieve a high diet quality.
NPJ SCIENCE OF FOOD
(2023)
Article
Biochemistry & Molecular Biology
Christina E. Larder, Michele M. Iskandar, Stan Kubow
Summary: The study found differences in the absorption and metabolism of bioactive peptides in collagen hydrolysates in the human body, further research is needed on the mechanisms and effects related to the liver.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Article
Psychology, Clinical
Mariam Ebrahim, Dalal Alkazemi, Tasleem A. Zafar, Stan Kubow
JOURNAL OF EATING DISORDERS
(2019)