Article
Nutrition & Dietetics
Wen Xu, Ming Zhong, Tingting Pan, Hongping Qu, Erzhen Chen
Summary: This study found that gut microbiota and short-chain fatty acid levels are associated with enteral nutrition tolerance in critically ill patients. On the first day of enteral nutrition initiation, the tolerance group had higher microbiota diversity and operational taxonomic units than the intolerance group. On the third day, the genus Escherichia-Shigella was significantly elevated in the tolerance group. The levels of short-chain fatty acids decreased more significantly in the intolerance group.
Article
Microbiology
Sayaka Katagiri, Yujin Ohsugi, Takahiko Shiba, Kanako Yoshimi, Kazuharu Nakagawa, Yuki Nagasawa, Aritoshi Uchida, Anhao Liu, Peiya Lin, Yuta Tsukahara, Takanori Iwata, Haruka Tohara
Summary: This study evaluated the oral/gut microbial communities in children receiving enteral nutrition with or without homemade blenderized tube feeding. The results showed that homemade blenderized tube feeding significantly increased the diversity and relative abundance of specific bacteria in the gut microbiome of children, reducing health risks. In addition, more complex network structures of microbial communities were observed in the oral cavity and gut of children receiving homemade blenderized tube feeding. In conclusion, homemade blenderized tube feeding not only provides satisfaction and enjoyment during meals with the family, but also alters the gut microbial composition to a healthy state.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Sara Sila, Marko Jelic, Ivana Trivic, Arjana Tambic Andrasevic, Sanja Kolacek, Iva Hojsak
Summary: This study investigated the changes in the intestinal microbiota of children with Crohn's disease (CD) before, during, and after exclusive enteral nutrition (EEN). Stool samples were collected at different time points and a molecular approach was used for analysis. The study found that the microbiota composition changed significantly after two months of EEN discontinuation and remained mostly unchanged over a year of follow-up.
Review
Food Science & Technology
Lili Jiang, Dandan Han, Youling Hao, Zhuan Song, Zhiyuan Sun, Zhaolai Dai
Summary: Serotonin produced by EC cells in the gut is crucial for maintaining gut function and homeostasis. The interactions between dietary factors, gut microbiota, and gut serotonin play important roles in gut metabolism and immune function, but the underlying mechanisms are not fully understood.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Immunology
Jiawei Zhang, Jiaxin Deng, Juan Li, Yuping Su, Jiancong Hu, Dezheng Lin, Mingli Su, Yongcheng Chen, Sen Liao, Xuhao Bai, Miwei Lv, Tian Xu, Qinghua Zhong, Xuefeng Guo
Summary: This study reveals that the changes in the composition of intestinal flora in elderly COVID-19 patients receiving different nutritional support strategies are associated with different clinical outcomes. The abundance of Enterococcus_faecium in elderly COVID-19 patients receiving PN is significantly increased and closely related to poor clinical outcomes. It highlights the potential of microbiome-centric interventions to mitigate and manage COVID-19 in older adults with different nutritional support options.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Multidisciplinary Sciences
Avner Leshem, Eran Elinav
Summary: Studying the impact of diet on gut microbes can lead to targeted dietary strategies for improved human health, as shown in a recent clinical trial.
Review
Nutrition & Dietetics
Edoardo Muratore, Davide Leardini, Francesco Baccelli, Francesco Venturelli, Arcangelo Prete, Riccardo Masetti
Summary: Allogeneic hematopoietic stem cell transplantation is a potentially curative strategy, but it is associated with complications and mortality. The disruption of gut microbiota has been linked to these complications, and nutritional strategies are being considered as effective methods of modulating the gut microbiota and improving clinical outcomes.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Yao Lv, Yue Lou, Ana Liu, Qi Cheng, Gan Yang, Cuifang Xu, Youyou Luo, Jingan Lou, Jindan Yu, Youhong Fang, Hong Zhao, Kerong Peng, Yan Ni, Jie Chen
Summary: Exclusive enteral nutrition (EEN) treatment can improve gut microbiome and bile acid (BA) metabolism of patients with Crohn's disease (CD). The study involved 27 newly diagnosed pediatric CD patients and 27 healthy controls. The findings suggest that EEN treatment can restore GM structure and secondary BA metabolism, and the abundance of Firmicutes bacteria and the balance of primary and secondary BAs are associated with CD severity and mucosal inflammation.
CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Shuai Jiang, Dejiang Xue, Miao Zhang, Qian Li, Hui Liu, Di Zhao, Guanghong Zhou, Chunbao Li
Summary: This study aimed to investigate the digestion of myoglobin diet in vitro and its relationship with gut microbiota and intestinal barrier. The in vitro study showed that myoglobin diets had a higher alpha-helix content and lower digestibility. The results from feeding C57BL/6J mice with different levels of myoglobin in the diet for 3 and 8 weeks revealed that increasing myoglobin content led to a significant increase in the relative abundance of Akkermansia muciniphila. Additionally, the content of short chain fatty acids exhibited a trend of increase and then decrease as myoglobin content increased at 3 weeks. A low-myoglobin diet upregulated the gene expression related to colonic mucin and tight junction proteins by increasing the proportion of beneficial microbiota, while a high-myoglobin diet had adverse effects.
Article
Nutrition & Dietetics
Esther G. Neelis, Barbara A. E. de Koning, Jessie M. Hulst, Rodanthi Papadopoulou, Caroline Kerbiriou, Edmond H. H. M. Rings, Rene M. H. Wijnen, Ben Nichols, Konstantinos Gerasimidis
Summary: Children with intestinal failure receiving parenteral nutrition show alterations in gut microbiota composition and function, with depletion of beneficial SCFAs and species and an increase in potentially harmful pathobionts. Nutrient intake and enteral nutrition have significant impacts on microbial community structure.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Saurabh Mehta, Samantha L. Huey, Daniel McDonald, Rob Knight, Julia L. Finkelstein
Summary: The gut microbiome in infants and children can be influenced by diet, impacting immune function, cognitive development, and overall health. Further research is needed to gather comprehensive data and conclusions.
ANNUAL REVIEW OF NUTRITION, VOL 41, 2021
(2021)
Review
Nutrition & Dietetics
Peter Cronin, Susan A. Joyce, Paul W. O'Toole, Eibhlis M. O'Connor
Summary: Dietary fiber is crucial for nutrition and health, but modern dietary practices have led to a decrease in fiber consumption, potentially contributing to the rise of gut diseases. Changes in gut microbiota composition and function due to different types of dietary fiber could alter glucose and lipid metabolism.
Review
Nutrition & Dietetics
Valentina V. Huwiler, Melanie Scalise, Katja A. Schonenberger, Stefan Muhlebach, Zeno Stanga, Maria L. Balmer
Summary: This narrative review examines the role of dietary fibre in enteral nutrition for preventing and treating sepsis, with a focus on critically ill patients. It discusses the implications for clinical practice and identifies future research directions.
Article
Medicine, Research & Experimental
Cheng Li
Summary: Human responses to the same diets vary due to complex diet-host-microbiota interactions. Recent advances show that quantifying this interaction could lead to personalized nutrition strategies for improving individual health. The gut microbiome, compared to host related factors, can be easily modulated by dietary exposures and plays a crucial role in human health. However, limitations in processing and analyzing 'big-data' on the human microbiome hinder the translation of diet-host-microbiota interactions into tools for personalized health improvement. This review aims to summarize recent advances in understanding diet-host-microbiota interactions to aid in the development of personalized nutrition strategies.
Review
Nutrition & Dietetics
Secundino Cigarran Guldris, Juan Antonio Latorre Catala, Ana Sanjurjo Amado, Nicolas Menendez Granados, Eva Pineiro Varela
Summary: Fibre consumption is beneficial for patients with chronic kidney disease by preventing risk factors, improving intestinal microbiota composition, and reducing metabolic acidosis and inflammation. Western dietary practices increase mortality risk in CKD patients due to low fibre, high animal protein, saturated fat, sodium, and sugar intake. On the other hand, diets with higher fibre and vegetable protein intake, such as Mediterranean, vegetarian, or PLADO, have a preventive effect on risk factors and influence CKD progression.
Article
Nutrition & Dietetics
Valeria Dipasquale, Katia Lecoeur, Madeleine Aumar, Dominique Guimber, Stephanie Coopman, Audrey Nicolas, Audrey Lecoufle, Audrey Van Malleghem, Dominique Turck, Delphine Ley, Frederic Gottrand
Summary: This study examined the tube-weaning practice of a group of pediatric gastroenterologists managing children receiving prolonged enteral nutrition. The results showed significant practice variation, with most respondents using individualized weaning programs and preferring home-based weaning attempts. The study highlights the need for standardized tube-weaning programs based on increased knowledge about different weaning modalities.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Pediatrics
Aurelie Pham, Emmanuelle Ecochard-Dugelay, Arnaud Bonnard, Enora Le Roux, Thomas Gelas, Veronique Rousseau, Nadege Thomassin, Isabelle Cabon-Boudard, Audrey Nicolas, Audrey Guinot, Julie Rebeuh, Aurelie Le Mandat, Djamal-Dine Djeddi, Virginie Fouquet, Aurelie Boucharny, Sabine Irtan, Julie Lemale, Aurelie Comte, Laure Bridoux-Henno, Claire Dupont-Lucas, Georges Dimitrov, Anne Turquet, Corinne Borderon, Cecile Pelatan, Emilie Chaillou Legault, Camille Jung, Stephanie Willot, Louise Montalva, Delphine Mitanchez, Frederic Gottrand, Marc Bellaiche
Summary: Feeding disorders are common in children with oesophageal atresia, with no typical profile of patients at risk. A national cohort study in France found 42% of children experienced feeding disorders, and systematic screening for these disorders is recommended to improve patient care and outcomes.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Article
Food Science & Technology
Ratih W. Wisnuwardani, Stefaan De Henauw, Maria Forsner, Frederic Gottrand, Inge Huybrechts, Antonios G. Kafatos, Mathilde Kersting, Viktoria Knaze, Yannis Manios, Esther Nova, Denes Molnar, Joseph A. Rothwell, Augustin Scalbert, Stefania Sette, Kurt Widhalm, Luis A. Moreno, Nathalie Michels
Summary: European adolescents had low dietary polyphenol intake, and there was no linear association between dietary polyphenols and serum total antioxidant capacity. Future studies should use polyphenol biomarkers and additional antioxidant measures to confirm these findings.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Pediatrics
Charlotte Flatres, Madeleine Aumar, Delphine Ley, Rony Sfeir, Audrey Nicolas, Michel Bonnevalle, Alain Duhamel, Frederic Gottrand
Summary: This study demonstrates a high prevalence of acid gastroesophageal reflux disease (GERD) in late infancy and supports the recommendation of systematic checking for acid GERD when treatment with proton pump inhibitors (PPI) is stopped.
PEDIATRIC RESEARCH
(2022)
Article
Nutrition & Dietetics
Lucie Marousez, Norbert Sprenger, Marie De Lamballerie, Sarahi Jaramillo-Ortiz, Lea Tran, Edwina Micours, Frederic Gottrand, Michael Howsam, Frederic J. Tessier, Delphine Ley, Jean Lesage
Summary: This study evaluated the impact of HHP processing on human milk components and found that HHP treatment preserves HMOs and avoids the formation of Maillard reaction products. In contrast, Holder pasteurization significantly increased the levels of Maillard reaction products.
CLINICAL NUTRITION
(2022)
Article
Pediatrics
Sophia Elmehdi, Delphine Ley, Madeleine Aumar, Stephanie Coopman, Dominique Guimber, Audrey Nicolas, Matthieu Antoine, Dominique Turck, Maeva Kyheng, Frederic Gottrand
Summary: This study evaluated the feasibility of endoscopic gastrojejunal tube (GJT) placement in infants and children and assessed the associated complications. The results showed that endoscopic GJT placement is feasible in children, even in low-weight infants. Although complications were frequent, the majority were minor.
JOURNAL OF PEDIATRICS
(2022)
Article
Cardiac & Cardiovascular Systems
S. M. Flieh, M. L. Miguel-Berges, I Huybrechts, M. J. Castillo, M. Gonzalez-Gross, A. Marcos, F. Gottrand, C. Le Donne, K. Widhalm, D. Molnar, P. Stehle, A. Kafatos, J. Dallongeville, E. Gesteiro, S. Abbeddou, L. A. Moreno, E. M. Gonzalez-Gil
Summary: The study found associations between larger portion sizes of vegetables and dairy products with higher VO2 max, while larger portion sizes of margarines and vegetable oils were associated with lower VO2 max. Additionally, larger portion sizes of certain food groups were linked to higher metabolic risk scores.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Nutrition & Dietetics
Jules Morcel, Laurent Beghin, Nathalie Michels, Jeremy Vanhelst, Julien Labreuche, Elodie Drumez, Angela Polito, Marika Ferrari, Laura Censi, Dominique Deplanque, Maria Luisa Miguel-Berges, Thais De Ruyter, Stefaan De Henauw, Luis A. Moreno, Frederic Gottrand
Summary: Cardiovascular diseases are the leading cause of death worldwide. The BELINDA study aims to evaluate cardiovascular risk and its association with risk factors during adolescence. By following up on the HELENA study, this research collects comprehensive clinical and biological data, and identifies differences in BMI and maternal education level among the participating population.
Article
Nutrition & Dietetics
Carla Morales-Ferre, Ignasi Azagra-Boronat, Malen Massot-Cladera, Sebastian Tims, Karen Knipping, Johan Garssen, Jan Knol, Angels Franch, Margarida Castell, Francisco J. Perez-Cano, Maria J. Rodriguez-Lagunas
Summary: In this study, the effects of a Lactofidus(TM), short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS) mixture, and their combination on RV infection in a rat model for early life diarrhea were analyzed. The supplementations significantly reduced the incidence and severity of diarrhea and showed various effects on immunoglobulin profiles, gut microbiota, and intestinal gene expression.
Article
Pediatrics
Agate Bourg, Frederic Gottrand, Benoit Parmentier, Julie Thomas, Anne Lehn, Christian Piolat, Arnaud Bonnard, Rony Sfeir, Julie Lienard, Veronique Rousseau, Myriam Pouzac, Agnes Liard, Philippe Buisson, Aurore Haffreingue, Louis David, Sophie Branchereau, Veronique Carcauzon, Nicolas Kalfa, Marc -David Leclair, Hubert Lardy, Sabine Irtan, Francois Varlet, Thomas Gelas, Diana Potop, Marie Auger-Hunault
Summary: This study evaluated the outcomes of long gap esophageal atresia (EA) compared to non-long gap EA/tracheo-esophageal fistula (TEF) at the ages of 1 and 6 years. The study also assessed whether the initial treatment (delayed primary anastomosis of native esophagus vs. esophageal replacement) influenced mortality and morbidity at these ages. The results showed that the long gap EA group had more complications and longer hospital stay at age 1 year, and digestive complications were more frequent in the long gap group at age 6 years. The study concluded that long gap strongly influenced digestive morbidity at age 6 years.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Cell Biology
Hannah R. R. Wardill, Ana Rita Da Silva Ferreira, Himanshu Kumar, Emma H. H. Bateman, Courtney B. B. Cross, Joanne M. M. Bowen, Rick Havinga, Hermie J. M. Harmsen, Jan Knol, Bram Dorresteijn, Miriam van Dijk, Jeroen van Bergenhenegouwen, Wim J. E. Tissing
Summary: Cytotoxicity is the main mechanism of chemotherapy's anti-cancer effects, but it also causes damage to healthy tissues. The gastrointestinal tract is particularly affected, resulting in gastrointestinal mucositis and various side effects. This study found that a specific diet can protect the intestinal mucosa from chemotherapy toxicity without compromising its anti-tumor effects.
CELL DEATH & DISEASE
(2023)
Article
Nutrition & Dietetics
Lucie Marousez, Lea Chantal Tran, Edwina Micours, Matthieu Antoine, Frederic Gottrand, Jean Lesage, Delphine Ley
Summary: Inadequate perinatal nutrition can affect the maturity of the intestinal barrier and the development of the intestinal microbiota in mice. Supplementing with prebiotic fiber appears to improve gut microbiota establishment in postnatal-growth-restricted mice and can lead to changes in intestinal morphology and microbial composition.
Review
Gastroenterology & Hepatology
Paolo Lionetti, Eytan Wine, Rinat Ran Ressler, Gerard J. Minor, Giles Major, Boutaina Zemrani, Frederic Gottrand, Claudio Romano
Summary: Children who require enteral nutrition often experience gastrointestinal symptoms. Fiber-containing enteral formulas can improve bowel function, promote healthy gut microbiota growth, and improve immune homeostasis. However, there is a lack of guidance in clinical practice.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Miguel Seral-Cortes, Sergio Sabroso-Lasa, Marcela Gonzalez-Gross, Carlos Quesada-Gonzalez, Peter Stehle, Frederic Gottrand, Ascension Marcos, Ligia Esperanza-Diaz, Yannis Manios, Odysseas Androutsos, Kurt Widhalm, Denes Molnar, Inge Huybrechts, Manon Muntaner, Aline Meirhaeghe, Diego R. Salazar-Tortosa, Jonatan Ruiz, Luis Mariano Esteban, Idoia A. Labayen, Luis Moreno, HELENA Study Grp
Summary: The study aimed to develop an ALT-specific genetic risk score to evaluate hepatic damage risk in European adolescents. The unweighted and weighted genetic risk scores were found to be significantly associated with ALT levels, and the predictive ability was further improved by integrating BMI as a clinical factor.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Florine Ruthmann, Nadia Guerouaou, Francis Vasseur, Maria-Claire Migaud, Dominique Deplanque, Frederic Gottrand, Laurent Beghin, Odile Viltart
Summary: Recent studies have found associations between emotional disorders, cognitive impairments, and cardiovascular disorders at the subclinical level. This exploratory study aimed to investigate these relationships in the general population. The results suggest that anxiety and depression are differentially related to cognitive and endothelial functions, but the relationship between cognitive performance and endothelial function was not significant.
