Article
Biotechnology & Applied Microbiology
Qian Ouyang, Yajuan Xu, Yanjie Ban, Jingjing Li, Yanjun Cai, Bo Wu, Yingqi Hao, Zongzong Sun, Miao Zhang, Mengqi Wang, Wentao Wang, Yinkai Zhao
Summary: This study evaluated the efficacy of probiotics combined with prebiotics in the treatment of small intestinal bacterial overgrowth (SIBO) in pregnant women with subclinical hypothyroidism (SCH). The results demonstrated that the treatment with probiotics and prebiotics could reduce the incidence of SIBO and inflammation levels, and improve gastrointestinal symptoms in pregnant women with SCH. Rating: 8 out of 10.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Review
Integrative & Complementary Medicine
Melissa A. Nickles, Aliza Hasan, Anastasia Shakhbazova, Sarah Wright, Cynthia J. Chambers, Raja K. Sivamani
Summary: The review evaluates the role of alternative therapies in the treatment of small intestinal bacterial overgrowth (SIBO), finding preliminary evidence supporting their use but highlighting the need for large-scale, randomized, placebo-controlled trials to further evaluate their effectiveness.
JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
(2021)
Review
Medicine, General & Internal
Barbara Skrzydlo-Radomanska, Bozena Cukrowska
Summary: Small Intestinal Bacterial Overgrowth (SIBO) is a form of dysbiosis that involves excessive bacterial colonization in the small intestine, with some bacteria more typical of the colon microbiota. The prevalence of SIBO has been estimated to range from 2.5% to 22%, increasing with age and comorbidities. The availability of noninvasive breath tests has led to an increase in diagnosed SIBO cases. This review provides an overview of the pathophysiology, manifestations, diagnostics, and recommended management of SIBO.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Daniel Bushyhead, Eamonn M. M. Quigley
Summary: The concept of small intestinal bacterial overgrowth (SIBO) explains the cause of maldigestion and malabsorption. With the development of diagnostic testing, the methods for diagnosing SIBO have evolved from small bowel culture to breath tests and culture-independent microbial analytics. The availability of breath tests has led to an expansion in the diagnosis of SIBO and the associated clinical symptoms. However, issues with the specificity of breath tests have raised doubts about the role of SIBO in certain clinical scenarios. The hope is to use modern molecular microbiology to study the human small intestinal microbiome in order to provide an objective basis for diagnosing SIBO.
Review
Biochemistry & Molecular Biology
Adela Danau, Laura Dumitrescu, Antonia Lefter, Delia Tulba, Bogdan Ovidiu Popescu
Summary: There is a close connection between the gut microbiota and the brain via the gut-brain axis, with Small Intestinal Bacterial Overgrowth (SIBO) potentially playing a role in the progression of Parkinson's disease (PD). SIBO can be eradicated with antibiotics, but may reappear if predisposing factors persist, highlighting its potential impact on the development of PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Xin Feng, Xiao-Qing Li
Summary: This systematic review and meta-analysis found that the prevalence of SIBO in diabetic patients was 29%, and the risk of SIBO in diabetic patients was 2.91 times higher than that in patients without diabetes. The prevalence of SIBO in diabetes was higher in studies using jejunal aspirate culture for diagnosis and in studies conducted in Western countries.
Article
Gastroenterology & Hepatology
Rafael Martin-Masot, Manuel Molina Arias, Juan Jose Diaz Martin, Maria Luz Cilleruelo Pascual, Carolina Gutierrez Junquera, Ester Donat, Enriqueta Roman Riechmann, Victor M. Navas-Lopez
Summary: There is high variability in the management of SIBO among pediatric population in Spain, with a significant proportion of patients being diagnosed without predisposing conditions and treated with antibiotics and/or probiotics.
REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS
(2021)
Article
Nutrition & Dietetics
Cezary Chojnacki, Paulina Konrad, Aleksandra Blonska, Marta Medrek-Socha, Karolina Przybylowska-Sygut, Jan Chojnacki, Tomasz Poplawski
Summary: This study aims to evaluate selected metabolites of the tryptophan kynurenine pathway in depressive patients with small intestinal bacterial overgrowth (SIBO). The study found that patients with SIBO had higher levels of kynurenine and quinolinic acid, and these levels were associated with abdominal symptoms and mental disorders.
Article
Gastroenterology & Hepatology
Daniel Bushyhead, Eamonn M. Quigley
Summary: The concept of SIBO has undergone significant changes and challenges, with uncertainty and controversy surrounding its diagnosis. This review aims to discuss the current pathophysiology of SIBO.
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2021)
Review
Gastroenterology & Hepatology
Ayesha Shah, Parag Thite, Teressa Hansen, Bradley J. Kendall, David S. Sanders, Mark Morrison, Michael P. Jones, Gerald Holtmann
Summary: This study found a link between small intestinal bacterial overgrowth (SIBO) and celiac disease (CeD) through a systematic review and meta-analysis. The prevalence of SIBO is higher in CeD patients, and antibiotic therapy for SIBO positive CeD patients leads to improvement in gastrointestinal symptoms.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Qinyan Yao, Zihan Yu, Qingguo Meng, Jihua Chen, Yaxin Liu, Wenxuan Song, Xiangfeng Ren, Jinjie Zhou, Xin Chen
Summary: Obesity is a global public health problem with increasing occurrence worldwide. It is associated with many diseases and conditions such as NAFLD, T2DM, and IR. The gut microbiota has been recognized as an important factor in regulating host health and diseases. SIBO, a type of intestinal dysbiosis, has been found to be related to obesity and its related diseases. However, the causal relationship between SIBO and obesity and the specific mechanisms are not well understood. This review discusses the interaction between SIBO and obesity, its mechanisms, and potential interventions, aiming to discover new therapeutic targets and treatment options for obesity and its related diseases.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Michel Bouchoucha, Marinos Fysekidis, Celine Lekhal, Bakhtiar Daniel Bejou, Jean-Marc Sabate, Robert Benamouzig
Summary: The study aimed to evaluate the efficacy of COLIGENTA for SIBO symptomatology and breath test normalization, showing that a 10-day treatment of COLIGENTA led to a significant improvement in SIBO clinical conditions and can be used as the first or second treatment line.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Multidisciplinary Sciences
Anna Mollar, Vannina G. Marrachelli, Eduardo Nunez, Daniel Monleon, Vicent Bodi, Juan Sanchis, David Navarro, Julio Nunez
Summary: In patients with heart failure, the intestinal bacterial metabolites TMAO and Butyrate are independently associated with the exhaled concentrations of hydrogen after a breath test, with a positive association for TMAO and a negative one for Butyrate.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Nicolas Richard, Charlotte Desprez, Fabien Wuestenberghs, Anne-Marie Leroi, Guillaume Gourcerol, Chloe Melchior
Summary: The study investigated the efficacy of different antibiotics in treating small intestinal bacterial overgrowth. Remission was observed in over half of the patients after one course of antibiotics, with rotating antibiotics showing more effectiveness than a single antibiotic. Remission was associated with significant improvements in quality of life and bloating.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Clinical Neurology
Karol Kowalski, Agata Mulak
Summary: The study found a higher prevalence of SIBO in AD patients, but no significant association with cognitive impairment, comorbidities, or medications. AD patients had higher zonulin levels compared to controls, but this was not related to the presence of SIBO.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Article
Multidisciplinary Sciences
Alexandr Parlesak, Inge Tetens, Jorgen Dejgard Jensen, Sinne Smed, Mojca Gabrijelcic Blenkus, Mike Rayner, Nicole Darmon, Aileen Robertson
Article
Medicine, General & Internal
Peter Scarborough, Asha Kaur, Linda Cobiac, Paul Owens, Alexandr Parlesak, Kate Sweeney, Mike Rayner
Article
Nutrition & Dietetics
Esa-Pekka A. Nykanen, Hanna E. Dunning, Richmond N. O. Aryeetey, Aileen Robertson, Alexandr Parlesak
Article
Public, Environmental & Occupational Health
Mahesh Sarki, Alexandr Parlesak, Aileen Robertson
PUBLIC HEALTH NUTRITION
(2019)
Review
Multidisciplinary Sciences
Kamila Ismailova, Pratiksha Poudel, Alexandr Parlesak, Peder Frederiksen, Berit L. Heitmann
Article
Environmental Sciences
Patricia Eustachio Colombo, Emma Patterson, Liselotte Schafer Elinder, Anna Karin Lindroos, Ulf Sonesson, Nicole Darmon, Alexandr Parlesak
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Nutrition & Dietetics
Abdi Bekele Gurmu, Esa-Pekka A. Nykanen, Fikadu Reta Alemayehu, Aileen Robertson, Alexandr Parlesak
Article
Nutrition & Dietetics
Kristyna Faksova, Zuzana Derflerova Brazdova, Aileen Robertson, Alexandr Parlesak
Article
Nutrition & Dietetics
Patricia Eustachio Colombo, Emma Patterson, Anna Karin Lindroos, Alexandr Parlesak, Liselotte Schafer Elinder
Article
Nutrition & Dietetics
Janne Lauk, Eha Nurk, Aileen Robertson, Alexandr Parlesak
Article
Green & Sustainable Science & Technology
Liselotte Schafer Elinder, Patricia Eustachio Colombo, Emma Patterson, Alexandr Parlesak, Anna Karin Lindroos
Article
Nutrition & Dietetics
Patricia Eustachio Colombo, James Milner, Pauline F. D. Scheelbeek, Anna Taylor, Alexandr Parlesak, Thomas Kastner, Owen Nicholas, Liselotte S. Elinder, Alan D. Dangour, Rosemary Green
Summary: Fruit and vegetable consumption in the UK is low, impacting public health significantly. Meeting the 5-a-day target can increase life expectancy and reduce greenhouse gas emissions, with prioritizing vegetables leading to greater reductions. Choosing UK-produced vegetables can reduce water footprints.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Patricia Eustachio Colombo, Liselotte Schafer Elinder, Emma Patterson, Alexandr Parlesak, Anna Karin Lindroos, Susanne Andermo
Summary: The study highlights the importance of increasing knowledge among pupils and kitchen staff for successful implementation of sustainable school meals. Staff training in cooking sustainable meals is crucial, and barriers among pupils can be addressed by introducing plant-based meals gradually and paying attention to seasoning, naming, and aesthetics. Leadership support and involvement of stakeholders at various levels are key to transitioning to sustainable school meals on a large scale.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2021)
Article
Nutrition & Dietetics
Patricia Eustachio Colombo, Liselotte Schafer Elinder, Anna Karin Lindroos, Alexandr Parlesak
Summary: Low-carbon diets can have positive effects on climate change and health, as shown by the study on climate-friendly, nutritionally adequate, affordable, and culturally acceptable diets for Swedish adolescents. The optimized diets differed from the EAT-Lancet diet, indicating the importance of cultural dietary context in shaping sustainable diets.
Article
Nutrition & Dietetics
Talia Masino, Patricia Eustachio Colombo, Kia Reis, Inge Tetens, Alexandr Parlesak
Summary: This study aimed to identify culturally acceptable nutritional solutions for German adults that are both climate friendly and health promoting. Linear programming was applied to optimize the food supply for different dietary patterns considering nutritional adequacy, health promotion, GHGEs, affordability, and cultural acceptability. The vegan diet was the only one that stayed below the IPCC threshold for GHGEs.