Review
Nutrition & Dietetics
Abeer M. Aljaadi, Angela M. Devlin, Tim J. Green
Summary: Riboflavin is an essential vitamin that is involved in multiple redox reactions and metabolism of other B vitamins. Deficiency of riboflavin may contribute to anemia, particularly in women and children. While riboflavin deficiency is commonly observed in low-income countries, it may also be a concern in middle- and high-income countries.
Review
Nutrition & Dietetics
Helene McNulty, Kristina Pentieva, Mary Ward
Summary: Riboflavin, in its cofactor forms FAD and FMN, is crucial for energy metabolism, cellular antioxidant potential, and metabolic interactions with other micronutrients. Severe riboflavin deficiency causes clinical symptoms like cheilosis, stomatitis, glossitis, dermatitis, and severe anemia. Subclinical deficiency, more common globally, can have adverse health consequences, including anemia and hypertension. This review examines the causes, detection, and consequences of riboflavin deficiency, and highlights research, public health, and policy priorities.
ANNUAL REVIEW OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Harry Jarrett, Helene McNulty, Catherine F. Hughes, Kristina Pentieva, J. J. Strain, Adrian McCann, Liadhan McAnena, Conal Cunningham, Anne M. Molloy, Albert Flynn, Sinead M. Hopkins, Geraldine Horigan, Ciara O'Connor, Janette Walton, Breige A. McNulty, Michael J. Gibney, Yvonne Lamers, Mary Ward
Summary: The concentration of vitamin B-6 is lower in older adults, and riboflavin levels affect the status of vitamin B-6, especially in older individuals. The combination of the MTHFR 677TT genotype with riboflavin deficiency leads to a decrease in vitamin B-6 levels. Intake of vitamin B-6, supplement use, and EGRac are associated with PLP levels.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Joelle J. E. Janssen, Bart Lagerwaard, Arie G. Nieuwenhuizen, Silvie Timmers, Vincent C. J. de Boer, Jaap Keijer
Summary: A single bout of exercise significantly increased EGR activity in both high-fit and low-fit females, but did not affect EGRAC, indicating that vitamin B2 status was not affected. The exercise response on EGRAC and EGR did not differ between high-fit and low-fit females.
Article
Biochemistry & Molecular Biology
Magdalena Chelchowska, Joanna Gajewska, Jadwiga Ambroszkiewicz, Joanna Mazur, Mariusz Oltarzewski, Tomasz M. Maciejewski
Summary: This study found that smoking increases oxidative stress levels and reduces the balance of glutathione in both mothers and newborns. Lower levels of reductase were observed in smoking groups, while GPx-3 levels were decreased in newborns exposed to tobacco smoke in utero. This suggests that oxidative stress from tobacco smoke can negatively impact glutathione homeostasis and antioxidant balance in newborns.
Article
Biochemistry & Molecular Biology
Laura G. Sherlock, Durganili Balasubramaniyan, Lijun Zheng, Miguel Zarate, Thomas Sizemore, Cassidy Delaney, Trent E. Tipple, Clyde J. Wright, Eva Nozik-Grayck
Summary: Maternal selenium deficiency leads to decreased neonatal selenium levels and increased risk for neonatal morbidities. The impact of maternal selenium deficiency varies across different organs and selenoproteins. Research suggests that neonates experience earlier depletion of selenoenzyme activity in the liver and circulation after maternal selenium deficiency, indicating a potential escalation of risk to the neonate with prolonged maternal selenium deficiency.
Article
Nutrition & Dietetics
Georgina Gomez, Irina Kovalskys, Ana Carolina B. Leme, Dayana Quesada, Attilio Rigotti, Lilia Yadira Cortes Sanabria, Martha Cecilia Yepez Garcia, Maria Reyna Liria-Dominguez, Marianella Herrera-Cuenca, Regina Mara Fisberg, Agatha Nogueira Previdelli, Viviana Guajardo, Gerson Ferrari, Mauro Fisberg, Juan Carlos Brenes
Summary: The study found that individuals with low socioeconomic status in Latin America tended to consume less fruits, vegetables, whole grains, fiber, and fish and seafood, but more legumes. However, diet quality and body mass index were observed to improve with higher socioeconomic status. Additionally, women in low socioeconomic status were more likely to have abdominal obesity and excess weight compared to those in middle and high socioeconomic statuses.
Article
Biochemistry & Molecular Biology
Magdalena Chelchowska, Justyna Jurczewska, Joanna Gajewska, Joanna Mazur, Dorota Szostak-Wegierek, Ewa Rudnicka, Jadwiga Ambroszkiewicz
Summary: Metabolic disorders in women with PCOS may lead to increased oxidative stress and reproductive failure. This study evaluated the levels of antioxidant parameters and proteins involved in cellular redox in the serum of PCOS patients. It found that abdominal obesity, as indicated by the VAT/SAT ratio and WHR, was associated with higher concentrations of oxidative markers and lower cellular redox index. The study suggests that oxidative stress associated with abdominal obesity may disrupt cellular processes and activate antioxidant enzymes. Further research is needed to confirm these associations in a larger group of PCOS patients.
Article
Nutrition & Dietetics
Kerry S. Jones, Sarah R. Meadows, Karen Chamberlain, Damon A. Parkington, Dave Collins, Polly Page, Albert Koulman
Summary: In adults, delaying the processing of chilled whole blood for 24 hours had minimal impact on the measured concentrations of most micronutrients and some clinical biomarkers compared to processing within 2 hours, indicating that adherence to a 2-hour processing protocol may be unnecessary for these analytes.
JOURNAL OF NUTRITION
(2021)
Article
Medicine, Research & Experimental
N. Semenova, I. M. Madaeva, A. S. Brichagina, S. Kolesnikov, L. Kolesnikova
Summary: This study found that women with insomnia in the perimenopausal period had higher glutathione reductase activity and lower GSSG level and GSH/GSSG ratio. In the postmenopausal period, there was lower glutathione reductase activity, increased GSSG level, and decreased GSH/GSSG ratio compared to the perimenopause. These findings are important for the treatment of insomnia in menopausal women to correct free radical balance and prevent oxidative stress.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Nutrition & Dietetics
Kenneth H. Brown, Sophie E. Moore, Sonja Y. Hess, Christine M. McDonald, Kerry S. Jones, Sarah R. Meadows, Mari S. Manger, Jennifer Coates, Silvia Alayon, Saskia J. M. Osendarp
Summary: Micronutrient deficiencies can have negative impacts on health and functionality, especially among children and women in low- and middle-income countries. The lack of information is due to limited understanding of the importance of micronutrients by policymakers, high costs and logistical constraints involved in data collection and analysis, and inadequate professional capacity for implementing related surveys.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Agriculture, Dairy & Animal Science
Marketa Prokesova, Milena Busova, Mahyar Zare, Hung Quang Tran, Eliska Kucerova, Anna Pavlovna Ivanova, Tatyana Gebauer, Vlastimil Stejskal
Summary: The study evaluated the effects of humic substances on juvenile Clarias gariepinus, finding that different HS diets had minimal impact on growth and production parameters, but showed some positive effects on health status and antioxidant parameters, especially in the HS3 group.
Article
Nutrition & Dietetics
Martina Rooney, Catherine F. Hughes, J. J. Strain, Michelle Clements, Helene McNulty, Mary Ward
Summary: This study provides the first evidence that brachial and central blood pressure are significantly higher in adults with the variant MTHFR 677TT genotype, and this phenomenon is more pronounced in women.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Biochemistry & Molecular Biology
Laura G. Sherlock, William C. McCarthy, Maya R. Grayck, Mack Solar, Andres Hernandez, Lijun Zheng, Cassidy Delaney, Trent E. Tipple, Clyde J. Wright, Eva S. Nozik
Summary: Exposure to selenium deficiency during pregnancy and lactation can impair weight gain and lung growth in offspring. Selenium deficiency reduces the levels and activity of multiple selenoproteins in the neonatal lung, affecting oxidative stress and cell signaling.
Article
Public, Environmental & Occupational Health
Martin Romero-Martinez, Tonatiuh Barrientos-Gutierrez, Lucia Cuevas-Nasu, Sergio Bautista-Arredondo, M. Arantxa Colchero, Elsa B. Gaona-Pineda, Jesus Martinez-Barnetche, Celia Alpuche-Aranda, Luz M. Gomez-Acosta, Laura R. Mendoza-Alvarado, Eduardo Lazcano-Ponce, Juan Rivera-Dommarco, Teresa Shamah-Levy
Summary: Ensanut 2021 is a probabilistic household survey conducted as part of the continuous Ensanut 2020-2024 project, aiming to estimate the seroprevalence of SARS-CoV-2 antibodies at both regional and national levels by collecting data from at least 12,060 complete household interviews and 9,837 samples, and to accumulate information for state inferences in 2024.
SALUD PUBLICA DE MEXICO
(2021)
Article
Nutrition & Dietetics
Salma F. Ahmad Fuzi, Sohail Mushtaq
BRITISH JOURNAL OF NUTRITION
(2019)
Article
Nutrition & Dietetics
Charlotte M. Buckley, Sophie Austin, Bernard M. Corfe, Mark A. Green, Alexandra M. Johnstone, Emma J. Stevenson, Elizabeth A. Williams, Jeffrey M. Brunstrom
JOURNAL OF NUTRITION
(2019)
Article
Nutrition & Dietetics
Elizabeth A. Williams, Madeleine Parker, Aisling Robinson, Sophie Pitt, Allan A. Pacey
EUROPEAN JOURNAL OF NUTRITION
(2020)
Letter
Nutrition & Dietetics
Salma F. Ahmad Fuzi, Sohail Mushtaq
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Esme R. Tuttiett, Dan J. Green, Emma J. Stevenson, Thomas R. Hill, Bernard M. Corfe, Elizabeth A. Williams
Summary: This study aimed to investigate the effects of short-term protein supplementation on energy and nutrient intake and appetite in middle-older age adults. The results showed that a 20 g/day whey protein supplement given outside of meal-times did not alter habitual dietary intakes, hunger or appetite in this population.
Article
Biochemical Research Methods
Stephen A. Wise, Johanna E. Camara, Carolyn Q. Burdette, Grace Hahm, Federica Nalin, Adam J. Kuszak, Joyce Merkel, Ramon A. Durazo-Arvizu, Emma L. Williams, Christian Popp, Christian Beckert, Jan Schultess, Glen Van Slooten, Carole Tourneur, Camille Pease, Ravi Kaul, Alfredo Villarreal, Marcelo Cidade Batista, Heather Pham, Alex Bennett, Eugene Jansen, Dilshad Ahmed Khan, Mark Kilbane, Patrick J. Twomey, James Freeman, Neil Parker, Sohail Mushtaq, Christine Simpson, Pierre Lukas, Etienne Cavalier, Christopher T. Sempos
Summary: The study conducted by VDSP evaluated the performance of ligand binding assays for measuring serum total 25-hydroxyvitamin D, finding that only half of the assays met the established criteria. Multiple regression analysis showed that most assays underestimated certain vitamin D metabolites, with some assays potentially having cross-reactivity issues.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemical Research Methods
Johanna E. Camara, Stephen A. Wise, Andrew N. Hoofnagle, Emma L. Williams, Graham D. Carter, Julia Jones, Carolyn Q. Burdette, Grace Hahm, Federica Nalin, Adam J. Kuszak, Joyce Merkel, Ramon A. Durazo-Arvizu, Pierre Lukas, Etienne Cavalier, Christian Popp, Christian Beckert, Jan Schultess, Glen Van Slooten, Carole Tourneur, Camille Pease, Ravi Kaul, Alfredo Villarreal, Fiona Ivison, Ralf Fischer, Jody M. W. van den Ouweland, Chung S. Ho, Emmett W. K. Law, Jean-Nicolas Simard, Renaud Gonthier, Brett Holmquist, Marcelo Cidade Batista, Heather Pham, Alex Bennett, Sarah Meadows, Lorna Cox, Eugene Jansen, Dilshad Ahmed Khan, Kimberly Robyak, Michael H. Creer, Mark Kilbane, Patrick J. Twomey, James Freeman, Neil Parker, Jinyun Yuan, Robert Fitzgerald, Sohail Mushtaq, Michael W. Clarke, Norma Breen, Christine Simpson, Christopher T. Sempos
Summary: The study conducted by VDSP evaluated the commutability of SRMs and PT/EQA samples for the determination of serum total 25(OH)D. Results showed that some SRM and PT/EQA samples were deemed non-commutable with specific assays within certain concentration ranges.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Claire E. Williams, Elizabeth A. Williams, Bernard M. Corfe
Summary: This study suggests that vitamin D supplementation does not improve IBS symptoms in a UK community setting. While there was an increase in vitamin D levels in the intervention group compared to the placebo group, no significant differences were found in the change of IBS symptom severity and quality of life improvement between the two trial arms.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Nutrition & Dietetics
Mary Ni Lochlainn, Natalie J. Cox, Thomas Wilson, Richard P. G. Hayhoe, Sheena E. Ramsay, Antoneta Granic, Masoud Isanejad, Helen C. Roberts, Daisy Wilson, Carly Welch, Christopher Hurst, Janice L. Atkins, Nuno Mendonca, Katy Horner, Esme R. Tuttiett, Yvie Morgan, Phil Heslop, Elizabeth A. Williams, Claire J. Steves, Carolyn Greig, John Draper, Clare A. Corish, Ailsa Welch, Miles D. Witham, Avan A. Sayer, Sian Robinson
Summary: Frailty, a syndrome of increasing importance in the context of the global aging population, is considered to have poor nutritional status as a key contributing factor. Observational evidence suggests that dietary quality, including patterns like the Mediterranean diet, may play a protective role in frailty risk. Further research and well-designed trials are needed to determine the causal effects of nutrition on frailty risk and progression, and how dietary changes can be utilized for prevention and treatment.
Article
Biochemical Research Methods
Christopher T. Sempos, Emma L. Williams, Graham D. Carter, Julia Jones, Johanna E. Camara, Carolyn Q. Burdette, Grace Hahm, Federica Nalin, David L. Duewer, Adam J. Kuszak, Joyce Merkel, Andrew N. Hoofnagle, Pierre Lukas, Etienne Cavalier, Ramon A. Durazo-Arvizu, Peter M. Crump, Christian Popp, Christian Beckert, Jan Schultess, Glen Van Slooten, Carole Tourneur, Camille Pease, Ravi Kaul, Alfredo Villarreal, Fiona Ivison, Ralf Fischer, Jody M. W. van den Ouweland, Chung S. Ho, Emmett W. K. Law, Jean-Nicolas Simard, Renaud Gonthier, Brett Holmquist, Marcelo Cidade Batista, Sarah Meadows, Lorna Cox, Eugene Jansen, Dilshad Ahmed Khan, Kimberly Robyak, Michael H. Creer, Mark Kilbane, Patrick J. Twomey, James Freeman, Neil Parker, Jinyun Yuan, Robert Fitzgerald, Sohail Mushtaq, Michael W. Clarke, Norma Breen, Christine Simpson, Stephen A. Wise
Summary: This study compared the results of DEQAS human serum samples shipped under frozen and ambient conditions, finding significant differences in certain 25(OH)D assays depending on the handling/transport conditions. The LC-MS/MS methods showed stability during shipment at ambient conditions, whereas some ligand binding assays exhibited discrepancies.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Tarimoboere Agbalalah, Sohail Mushtaq
Summary: This study investigated the effect of vitamin D-3 supplementation on vascular function and cardiometabolic disease risk markers. The results showed that vitamin D-3 supplementation significantly improved plasma 25(OH)D concentrations, but had limited effects on cardiometabolic disease risk markers.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Review
Nutrition & Dietetics
Ghadah Alnooh, Tourkiah Alessa, Essra Noorwali, Salwa Albar, Elizabeth Williams, Luc P. P. de Witte, Mark S. S. Hawley
Summary: This study evaluated smartphone apps for supporting the DASH diet, focusing on their quality, likely effectiveness, and data privacy/security. A systematic search and analysis were conducted, revealing limited availability of apps for DASH diet self-management. Only two apps, NOOM and DASH To TEN, were identified as suitable options with adequate quality and security.
Article
Nutrition & Dietetics
Esme R. Tuttiett, Elysa Ioannou, Hanneke A. H. Wijnhoven, Bernard M. Corfe, Elizabeth A. Williams
Summary: This study aimed to modify and validate a protein screening tool for assessing lower protein intake in a UK population. The modified tool showed good discriminative accuracy in a sample of UK adults.
JOURNAL OF NUTRITIONAL SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
Stephanie Watkins, Ellen Freeborn, Sohail Mushtaq
Summary: This study developed and validated a FFQ for assessing dietary vitamin D intake in healthy adults in the UK, which showed strong correlation and agreement with a 4 d-FD. Significant correlation was also found between plasma 25(OH)D concentrations and vitamin D intake measured by the FFQ and 4 d-FD.
PUBLIC HEALTH NUTRITION
(2021)
Article
Geriatrics & Gerontology
Susan Morris, James D. Cater, Mark A. Green, Alexandra M. Johnstone, Jeffrey M. Brunstrom, Emma J. Stevenson, Elizabeth A. Williams, Bernard M. Corfe