Article
Health Care Sciences & Services
Donald A. Redelmeier, Jonathan S. Zipursky
Summary: This review introduces a cautionary framework for investigators considering dose-response relationships in observational research and highlights the potential pitfalls in interpreting and analyzing such relationships.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Review
Microbiology
Melisa Elsie Kasimin, Suriyani Shamsuddin, Arnold Marshall Molujin, Mohd Khalizan Sabullah, Jualang Azlan Gansau, Roslina Jawan
Summary: Food preservation is a method used to slow down food spoilage and reduce the risk of foodborne illness. Researchers are increasingly focusing on biopreservation techniques, which utilize lactic acid bacteria and their antimicrobial substances to extend shelf life and maintain nutritional value. Enterococcus, a type of lactic acid bacteria, produces a bacteriocin called enterocin that inhibits the growth of pathogenic bacteria. This report highlights the application of Enterococcus in biopreservation of meat and meat-based products, as well as the effects of enzymes, temperature, and pH on the stability of bacteriocin. Industry procedures for meat preservation are also discussed, including their benefits and drawbacks.
Article
Neurosciences
Tim Hirschfeld, Johanna Prugger, Tomislav Majic, Timo T. Schmidt
Summary: This study presents the first meta-analysis on the dose-response relationship of altered states of consciousness induced by LSD. The results show a sigmoid-like increase of effects with a plateau at around 100 μg, with the most strongly modulated factors being changes in perception and illusory imagination. The findings also highlight the role of non-pharmacological factors and individual differences in shaping subjective experiences.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Shunyao Wu, Xinmin Li, Yu Xia, Hua Liang
Summary: The study proposes a test for assessing nonlinear dose-response models based on a Cramer-von Mises statistic and provides a bootstrap resampling technique for calculating critical values. Empirical results demonstrate good power performance of the test in small sample sizes.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2021)
Article
Food Science & Technology
Lulu Han, Iwao Sakane, Masashi Mizuno
Summary: The combination of IC-1 and luteolin has shown synergistic anti-allergic effects by reducing IgE content and inhibiting mast cell degranulation during the allergy state.
Article
Food Science & Technology
Lynne T. Haber, John F. Reichard, Alice K. Henning, Peter Dawson, R. Sharon Chinthrajah, Sayantani B. Sindher, Andrew Long, Melissa J. Vincent, Kari C. Nadeau, Bruce C. Allen
Summary: Risk-based labeling using minimal eliciting doses in sensitized populations may replace precautionary allergen labeling for food allergens. Data on peanut allergens from double-blind placebo-controlled food challenges in the US show a complex hierarchical structure accounting for variability across individuals and study locations. Estimating the dose-response distribution could contribute to improved food labeling guidelines for managing food allergies.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Merel A. van der Most, Ignacio Miro Estruch, Nico W. van den Brink
Summary: Antidepressant prescriptions have increased globally, raising concerns about their impact on non-target organisms. Antidepressants can affect organism behavior, which can have population-level effects. They have also shown non-monotonic dose-response curves, but current studies often lack the resolution to detect relevant non-monotonicity. This study examined the behavioral effects of fluoxetine and sertraline, selective serotonin reuptake inhibitors, and the pesticide chlorpyrifos on Caenorhabditis elegans, using a wide range of concentrations. The results showed a triphasic dose-response relationship for activity and chemotaxis with fluoxetine, but not with sertraline or chlorpyrifos.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Food Science & Technology
Jana Vyrostkova, Ivana Regecova, Eva Dudrikova, Slavomir Marcincak, Maria Vargova, Mariana Kovacova, Jana Mal'ova
Summary: This study calculated the antibiotic resistance profiles of Enterococcus faecium, E. faecalis, and E. durans isolated from traditional sheep and goat cheeses in a border area of Slovakia with Hungary. E. faecalis showed higher resistance compared to E. durans and E. faecium, with high resistance to rifampicin and vancomycin. E. durans and E. faecium also exhibited resistance, with a high percentage of multidrug-resistant strains.
Article
Genetics & Heredity
Matthew J. Harder, Julie Hix, Wendy M. Reeves, Michael T. Veeman
Summary: By studying a pair of shadow enhancers for the Brachyury gene in Ciona, it was found that they had significant differences in sensitivity and cooperativity to the shared regulator. Additionally, subtle differences in sensitivity to this upstream signal were identified in different notochord precursor cells.
Article
Microbiology
Jessica Esther Agius, David Norton Phalen, Karrie Rose, John-Sebastian Eden
Summary: Whole genome analysis of a novel species of enterococci, Enterococcus lacertideformus, revealed its pathogenic nature and biofilm-forming capabilities. Evolutionary analysis showed limitations in nutrient acquisition and utilization in the bacterium.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Pediatrics
Zhiguang Zhang, Madison Predy, Kylie D. Hesketh, Lesley Pritchard, Valerie Carson
Summary: This study found that tummy time preference, bout frequency, and bout length increased during the first 6 months of life. There was a linear dose-response relationship between tummy time duration and infant development, with varying threshold doses for different developmental outcomes.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmed A. Alsultan, Caren van Roekel, Maarten W. Barentsz, Maarten L. J. Smits, Britt Kunnen, Miriam Koopman, Arthur J. A. T. Braat, Rutger C. G. Bruijnen, Bart de Keizer, Marnix G. E. H. Lam
Summary: The study demonstrated a significant dose-response relationship in CRLM patients treated with glass Y-90 radioembolization, showing predictive value for treatment outcomes. Toxicity was mostly limited to grades 1 and 2, with a low incidence of radioembolization-induced liver disease.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Eleftheria Alevronta, Viktor Skokic, Gail Dunberger, Cecilia Bull, Karin Bergmark, Rebecka Jornsten, Gunnar Steineck
Summary: The study found steep dose-response curves for the small intestine, with estimated dose-response parameters. The sigmoid colon and small intestine had the highest AUC values. The DVHs for the small intestine showed good separation between survivors with and without excessive mucus discharge at low to intermediate doses, which was not true for the sigmoid colon.
Review
Toxicology
J. M. Coulson, B. W. Hughes
Summary: Aluminium exposure is associated with bone disease and neurotoxicity, with higher concentrations leading to neurotoxicity in patients with chronic kidney disease. Depending on the source of exposure, different individuals may develop different symptoms and require specific attention.
CLINICAL TOXICOLOGY
(2022)
Article
Engineering, Environmental
Raisa Estefania Nunez-Salas, Jorge Rodriguez-Chueca, Aracely Hernandez-Ramirez, Encarnacion Rodriguez, Maria de Lourdes Maya-Trevino
Summary: This study compared the photocatalytic inactivation of E. coli and Enterococcus sp. strains using boron-doped ZnO (B-ZnO) with ZnO and TiO2. Under darkness, B-ZnO showed better performance, while under solar simulated irradiation, all three materials exhibited significant disinfection effects. The desirability function confirmed B-ZnO as the best material with enhanced photocatalytic antimicrobial activity against both strains.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Otorhinolaryngology
Zhenxiao Huang, Bing Zhou, Dehui Wang, Hongrui Zang, Huankang Zhang, Huan Wang, Shenqing Wang, Lei Cheng, Jinrang Li, Wenying Wu, Huifang Zhou, Huili Wu
Summary: This study compared the efficacy of bioabsorbable steroid-eluting sinus stents with absorbable Nasopore packs after endoscopic sinus surgery for chronic rhinosinusitis. Results showed that steroid-eluting stents significantly reduced the need for postoperative surgical intervention and polyp formation compared to Nasopore, and were effective in preventing severe adhesions. Both the stents and Nasopore packs were effective in maintaining ethmoid sinus patency and preventing middle turbinate lateralization. Further prospective cohort studies with long-term outcomes are needed.
ENT-EAR NOSE & THROAT JOURNAL
(2022)
Article
Developmental Biology
Song-Qun Hu, Hui-Min Xu, Fuping Qian, Chang-Sheng Chen, Xin Wang, Dong Liu, Lei Cheng
Summary: The role of IRF7 in hair cell development in zebrafish was investigated, suggesting it may be a member of the deafness gene family. Knockdown of irf7 led to alterations in the expression of multiple genes, ultimately affecting the development of hair cells.
DEVELOPMENTAL NEUROBIOLOGY
(2022)
Article
Oncology
Hai-Bing Chen, Xiao-Yang Gong, Wang Li, Dong-Sheng Chen, Le-le Zhao, Si Li, Ming-Zhe Xiao, Lei Cheng, Xi Chen
Summary: This study identified TP53 as the most frequently mutated gene in patients with sarcomatoid carcinoma of the head and neck, with mutations in genes related to cell cycling, chromatin remodeling, and histone modification also being common. Alterations in receptor tyrosine kinases (RTKs) were found in some patients, with PIK3CA being the most frequently mutated gene. The tumor mutation burden (TMB) value was significantly higher in PIK3CA mutation patients compared to wild-type patients.
Article
Respiratory System
Chengshuo Wang, Lei Cheng, Huabin Li, Zheng Liu, Hongfei Lou, Jianbo Shi, Ying Sun, Dehui Wang, Qintai Yang, Hongmeng Yu, Changqing Zhao, Dongdong Zhu, Fengli Cheng, Yan Li, Bo Liao, Meiping Lu, Cuida Meng, Shen Shen, Yueqi Sun, Rui Zheng, Luo Zhang
Summary: Corticosteroids are effective in treating chronic rhinosinusitis, but concerns about potential side effects persist. Transnasal nebulization may offer a balanced solution, yet there is currently no consensus or guidelines on its use. Chinese experts have developed a consensus on the application of steroid transnasal nebulization in treating CRS, focusing on efficacy and safety considerations.
JOURNAL OF THORACIC DISEASE
(2021)
Review
Pharmacology & Pharmacy
Min Zhang, Jing-Zi Ni, Lei Cheng
Summary: Intranasal corticosteroids (INCSs) have a favorable safety profile and high local-systemic balance of bioavailability with a low incidence of adverse events in the treatment of pediatric allergic rhinitis (AR). However, the use of INCSs should be individualized based on patient response and adverse effects. Evaluation of the benefits and risks of INCSs is necessary to ensure clinical efficacy and prevent potential events.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Otorhinolaryngology
Yu Zhang, Qilei Zhang, Xinyang Wu, Geping Wu, Xingkai Ma, Lei Cheng
Summary: This study found that Bicalutamide, an androgen receptor antagonist, has therapeutic effects on an animal model of allergic rhinitis, reducing allergic lesions and suppressing PI3K/PKB activity in mast cells. These results provide important implications for the prevention and treatment of allergic rhinitis.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Immunology
Ruo-Xi Chen, Meng-Di Dai, Qing-Zhao Zhang, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Xin-Jie Zhu, Zhong-Fei Wu, Zheng-Dong Zhang, Lei Cheng
Summary: This study explored the genetic association of allergic rhinitis (AR) with single nucleotide polymorphisms (SNPs) in the Toll-like receptor (TLR) signaling pathway. It found that genetic polymorphisms in TLR2 and CD14, as well as gene-gene interactions, were associated with susceptibility to AR in this Han Chinese population. However, the results regarding gene-environment interactions were limited.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Allergy
Xin-Yuan Chen, Xin-Jie Zhu, Min Chen, Mei-Ping Lu, Mei-Lin Wang, Min Yin, Ruo-Xi Chen, Zhong-Fei Wu, Dong-Yun Bu, Zheng-Dong Zhang, Lei Cheng
Summary: This study found that the SNP rs79525962 in the GARP gene is associated with the risk of persistent allergic rhinitis (PER) sensitized to house dust mites. Different genotypes may result in alterations in the secondary structure of GARP.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Review
Food Science & Technology
Jialu Shi, Youfa Wang, Lei Cheng, Jin Wang, Vijaya Raghavan
Summary: Food allergy has become a global public health issue, especially in developed countries. Recent studies have shown that dysbiosis in the gut microbiota is strongly linked to the increasing prevalence of food allergy. Modulating the gut microbial composition is crucial in regulating the immunogenicity of food antigens. Therefore, probiotics, prebiotics, synbiotics, and postbiotics have attracted significant attention as innovative strategies for preventing and treating food allergy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Immunology
Yi-Fan Yang, Rui Zheng, Xiang Gu, Fang Gao, Min Chen, Mu-Long Du, Zheng-Dong Zhang, Mei-Ping Lu, Lei Cheng
Summary: This study found that two SNPs in the ferroptosis-related genes ENPP2 and EPAS1 are significantly associated with the risk of house dust mite-induced allergic rhinitis. These genetic variants may serve as potential predictors of susceptibility to house dust mite-induced allergic rhinitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Lin Lin, Lei Cheng
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Medicine, General & Internal
Xiao-Ying Zhao, Ming Chen, Lei Cheng
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Otorhinolaryngology
Ying-Ying Zhang, Min Zhang, Jia-Qi Zhang, Qiu-Qi Li, Mei-Ping Lu, Lei Cheng
Summary: Combining AIT with omalizumab can significantly improve the efficacy and safety of AIT in treating allergic diseases, increasing tolerance to allergens and reducing severe systemic adverse events.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Review
Allergy
Chengshuo Wang, Yixiao Bao, Jianjun Chen, Xiaoyang Chen, Lei Cheng, Yin Shi Guo, Chuangli Hao, He Lai, Huabin Li, Jing Li, Changshan Liu, Yun Liu, Zheng Liu, Hongfei Lou, Wei Lv, Guangmin Nong, Qianhui Qiu, Xiumin Ren, Jie Shao, Yi-Hong Shen, Li Shi, Xi-Cheng Song, Yuxin Song, Suping Tang, Hongtian Wang, Xiangdong Wang, Xueyan Wang, Zhenlin Wang, Qingyu Wei, Hua Xie, Zhimin Xing, Rui Xu, Yu Xu, Qintai Yang, Hongmei Yao, Jing Ye, Yiwen You, Hongmeng Yu, Yongmei Yu, Huanping Zhang, Gehua Zhang, Yuan Zhang, Yuxiang Zhi, Weikang Zhou, Li Zhu, Xinhua Zhu, Ruonan Chai, Dehua Chen, Kai Guan, Zizhen Huang, Yanran Huang, Tingting Ma, Yuemei Ma, Yifan Meng, Lei Ren, Jianxing Wang, Nan Wang, Mo Xian, Rong Xiang, Ming Zheng, Luo Zhang
Summary: The prevalence of allergic rhinitis in China has been increasing, with allergen immunotherapy (AIT) being the only curative intervention that aims to improve the immune system and induce immune tolerance. Experts have developed the first English version AIT guidelines for China, leading to progress in basic research and clinical practice, particularly in the use of biomarkers and understanding of AIT during the COVID-19 pandemic.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2022)
Review
Allergy
Hao Chen, Jing Li, Lei Cheng, Zhongshan Gao, Xiaoping Lin, Rongfei Zhu, Lin Yang, Ailin Tao, Haiyu Hong, Wei Tang, Yinshi Guo, Huaiqiu Huang, Jinlyu Sun, He Lai, Cheng Lei, Guanghui Liu, Li Xiang, Zhuanggui Chen, Han Ma, Alson Wai-ming Chan, Chuangli Hao, Baoqing Sun
Summary: The prevalence of allergic diseases has been increasing in China in recent years, with allergen identification being key to diagnosis. While various allergy diagnostic methods are available, they are not standardized, making diagnostics more complex due to cross-sensitization and co-sensitization. This consensus aims to standardize allergen diagnostic methods and provide guidance for healthcare professionals, and was prepared by a panel of experts from professional allergy associations in China.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2021)
