Cellular immune dysfunction in immune thrombocytopenia (ITP)

Rituximab causes a polarization of B cells that augments its therapeutic function in NK-cell-mediated antibody-dependent cellular cytotoxicity

(2013) D. Rudnicka et al.   BLOOD

Childhood Immune Thrombocytopenia—Who Will Spontaneously Recover?

(2013) Joanne Yacobovich et al.   SEMINARS IN HEMATOLOGY

Decreased expression of indoleamine 2,3-dioxygenase 1 in dendritic cells contributes to impaired regulatory T cell development in immune thrombocytopenia

(2012) Lucia Catani et al.   ANNALS OF HEMATOLOGY

Immune Regulatory Function of B Cells

(2012) Claudia Mauri et al.   Annual Review of Immunology

Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

(2012) R. Aslam et al.   BLOOD

Bregging rights in ITP

(2012) J. W. Semple   BLOOD

Splenic proliferative lymphoid nodules distinct from germinal centers are sites of autoantigen stimulation in immune thrombocytopenia

(2012) C. Daridon et al.   BLOOD

Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD

(2012) C. Leon et al.   BLOOD

MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation

(2012) E. C. Smith et al.   BLOOD

CD16+ monocytes control T-cell subset development in immune thrombocytopenia

(2012) H. Zhong et al.   BLOOD

Defective regulatory B-cell compartment in patients with immune thrombocytopenia

(2012) X. Li et al.   BLOOD

DNA Methyltransferase 3B Gene Promoter and Interleukin-1 Receptor Antagonist Polymorphisms in Childhood Immune Thrombocytopenia

(2012) Margarita Pesmatzoglou et al.   Clinical & Developmental Immunology

The immunopathogenesis of immune thrombocytopenia

(2012) John W. Semple et al.   CURRENT OPINION IN HEMATOLOGY

Stromal-derived factor-1 gene variations in pediatric patients with primary immune thrombocytopenia

(2012) Fan-Chen Ku et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Overexpression of RORγt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice

(2012) Keigyou Yoh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B cells and CD22 are dispensable for the immediate antiinflammatory activity of intravenous immunoglobulins in vivo

(2012) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1

(2012) Inessa Schwab et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Critical role of CD4+CD25+ regulatory T cells in preventing murine autoantibody-mediated thrombocytopenia

(2012) Tetsuya Nishimoto et al.   EXPERIMENTAL HEMATOLOGY

The clinical significance of circulating B cells secreting anti-glycoprotein IIb/IIIa antibody and platelet glycoprotein IIb/IIIa in patients with primary immune thrombocytopenia

(2012) Jian-fang Chen et al.   Hematology

Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia

(2012) Yu Hu et al.   HUMAN IMMUNOLOGY

Effects of High-Dose Dexamethasone on Regulating Interleukin-22 Production and Correcting Th1 and Th22 Polarization in Immune Thrombocytopenia

(2012) Jiang Cao et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Bmi-1 Regulates Autoreactive CD4+ T Cell Survival in Immune Thrombocytopenia Patients

(2012) Li Ma et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Decreased plasma cytokines are associated with low platelet counts in aplastic anemia and immune thrombocytopenic purpura

(2012) X. FENG et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The Ratio of Treg/Th17 Cells Correlates with the Disease Activity of Primary Immune Thrombocytopenia

(2012) Lili Ji et al.   PLoS One

Sialylation-independent mechanism involved in the amelioration of murine immune thrombocytopenia using intravenous gammaglobulin

(2012) Danila Leontyev et al.   TRANSFUSION

Dendritic cells a double-edge sword in autoimmune responses

(2012) Giada Amodio et al.   Frontiers in Immunology

B Cell Activating Factor Gene Polymorphisms in Patients With Risk of Idiopathic Thrombocytopenic Purpura

(2011) Samah M. Abdel-Hamid et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Increased number of B-cells in the red pulp of the spleen in ITP

(2011) Bob Olsson et al.   ANNALS OF HEMATOLOGY

Immunologic effects of rituximab on the human spleen in immune thrombocytopenia

(2011) S. Audia et al.   BLOOD

The role of vanin-1 and oxidative stress-related pathways in distinguishing acute and chronic pediatric ITP

(2011) B. Zhang et al.   BLOOD

The neonatal Fc receptor (FcRn) is not required for IVIg or anti-CD44 monoclonal antibody-mediated amelioration of murine immune thrombocytopenia

(2011) A. R. Crow et al.   BLOOD

The role of PTPN22 gene polymorphism in childhood immune thrombocytopenic purpura

(2011) Shahira K. Anis et al.   BLOOD COAGULATION & FIBRINOLYSIS

FcγRIIa and FcγRIIIa genetic polymorphisms in a group of pediatric immune thrombocytopenic purpura in Egypt

(2011) Tayseer K. Eyada et al.   BLOOD COAGULATION & FIBRINOLYSIS

The KIR2DS2/DL2 genotype is associated with adult persistent/chronic and relapsed immune thrombocytopenia independently of FCGR3a-158 polymorphisms

(2011) Jamie P. Nourse et al.   BLOOD COAGULATION & FIBRINOLYSIS

Elevated plasma IL-22 levels correlated with Th1 and Th22 cells in patients with immune thrombocytopenia

(2011) Jiang Cao et al.   CLINICAL IMMUNOLOGY

Circulating plasmacytoid dendritic cells in patients with primary and Helicobacter pylori-associated immune thrombocytopenia

(2011) Akio Saito et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Circulating CD4+CD161+CD196+ Th17 cells are not increased in immune thrombocytopenia

(2011) D. Sollazzo et al.   HAEMATOLOGICA

The levels of IL-17A and of the cytokines involved in Th17 cell commitment are increased in patients with chronic immune thrombocytopenia

(2011) A. M. C. Rocha et al.   HAEMATOLOGICA

CNR2 functional variant (Q63R) influences childhood immune thrombocytopenic purpura

(2011) F. Rossi et al.   HAEMATOLOGICA

Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults

(2011) Ameet Sarpatwari et al.   Hematology

Decreased expression of MBD2 and MBD4 gene and genomic-wide hypomethylation in patients with primary immune thrombocytopenia

(2011) Zhen-ping Chen et al.   HUMAN IMMUNOLOGY

Effects of CD70 and CD11a in Immune Thrombocytopenia Patients

(2011) Li Ma et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Role of CD4+CD25+ T Cells in Children With Idiopathic Thrombocytopenic Purpura

(2011) Laila El-Morsi Aboul-Fotoh et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Increased expressions of DNA methyltransferases contribute to CD70 promoter hypomethylation and over expression of CD70 in ITP

(2011) Li Ma et al.   MOLECULAR IMMUNOLOGY

Investigation of TNF-alpha, TGF-beta 1, IL-10, IL-6, IFN-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic thrombocytopenic purpura

(2011) M. Pehlivan et al.   PLATELETS

CD72 gene expression in immune thrombocytopenia

(2011) Hu Zhou et al.   PLATELETS

Pathway of Toll-Like Receptor 7/B Cell Activating Factor/B Cell Activating Factor Receptor Plays a Role in Immune Thrombocytopenia In Vivo

(2011) Qing Yang et al.   PLoS One

Increased Number of Tc17 and Correlation with Th17 Cells in Patients with Immune Thrombocytopenia

(2011) Yu Hu et al.   PLoS One

Management of Immune Thrombocytopenic Purpura in Children

(2011) Amy Lee Bredlau et al.   PEDIATRIC DRUGS

Animal models of immune thrombocytopenia (ITP)

(2010) John W. Semple   ANNALS OF HEMATOLOGY

Extreme lymphoproliferative disease and fatal autoimmune thrombocytopenia in FasL and TRAIL double-deficient mice

(2010) L. M. Sedger et al.   BLOOD

Drug-induced thrombocytopenia: development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG

(2010) S. X. Liang et al.   BLOOD

Improved regulatory T-cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents

(2010) W. Bao et al.   BLOOD

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

Thrombopoietic agents

(2010) Roberto Stasi et al.   BLOOD REVIEWS

Recent progress in understanding the pathogenesis of immune thrombocytopenia

(2010) John W Semple et al.   CURRENT OPINION IN HEMATOLOGY

TLR7 regulates dendritic cell-dependent B-cell responses through BlyS in immune thrombocytopenic purpura

(2010) Huiming Yu et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Low-dose rituximab combined with short-term glucocorticoids up-regulates Treg cell levels in patients with immune thrombocytopenia

(2010) Zhenyu Li et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Overview of the immune response

(2010) David D. Chaplin   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Regulatory T-cells in systemic lupus erythematosus-associated thrombocytopenia: a comparison with idiopathic thrombocytopenic purpura

(2010) S.-H. Park et al.   LUPUS

An FcγRIIb transmembrane polymorphism in Chinese ITP patients

(2010) Jianhui Xu et al.   PLATELETS

Rituximab in Autoimmune Hematologic Diseases: Not Just a Matter of B Cells

(2010) Roberto Stasi   SEMINARS IN HEMATOLOGY

Surveillance of Antigen-Presenting Cells by CD4+CD25+ Regulatory T Cells in Autoimmunity

(2009) Sébastien André et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy

(2009) L. Chow et al.   BLOOD

International consensus report on the investigation and management of primary immune thrombocytopenia

(2009) D. Provan et al.   BLOOD

The ITP syndrome: pathogenic and clinical diversity

(2009) D. B. Cines et al.   BLOOD

A Th17-like developmental process leads to CD8+Tc17 cells with reduced cytotoxic activity

(2009) Magdalena Huber et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura

(2009) J. Zhang et al.   HAEMATOLOGICA

Immune Thrombocytopenia in Patients with Connective Tissue Disorders and the Antiphospholipid Antibody Syndrome

(2009) Daniel G. Arkfeld et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Infections, Antigen-Presenting Cells, T Cells, and Immune Tolerance: Their Role in the Pathogenesis of Immune Thrombocytopenia

(2009) John W. Semple   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Innate immunity

(2009) Stuart E. Turvey et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CD20-depleting therapy in autoimmune diseases: from basic research to the clinic

(2009) F. Perosa et al.   JOURNAL OF INTERNAL MEDICINE

Controversies in the diagnosis and management of childhood acute immune thrombocytopenic purpura

(2009) George B. Segel et al.   PEDIATRIC BLOOD & CANCER

Profile of Th17 cytokines (IL-17, TGF-β, IL-6) and Th1 cytokine (IFN-γ) in patients with immune thrombocytopenic purpura

(2008) Daoxin Ma et al.   ANNALS OF HEMATOLOGY

De novo induction of platelet-specific CD4+CD25+ regulatory T cells from CD4+CD25- cells in patients with idiopathic thrombocytopenic purpura

(2008) X.-L. Zhang et al.   BLOOD

Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab

(2008) R. Stasi et al.   BLOOD

Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1

(2008) B. Olsson et al.   BLOOD

Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura

(2008) J. Yu et al.   BLOOD

Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group

(2008) F. Rodeghiero et al.   BLOOD

Dendritic cells and cytokines in human inflammatory and autoimmune diseases

(2008) P BLANCO et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Th17 cells in human disease

(2008) Laura A. Tesmer et al.   IMMUNOLOGICAL REVIEWS

CTLA-4{middle dot}Ig converts naive CD4+CD25- T cells into CD4+CD25+ regulatory T cells

(2008) M. Razmara et al.   INTERNATIONAL IMMUNOLOGY

Bmi1 regulates memory CD4 T cell survival via repression of theNoxagene

(2008) Masakatsu Yamashita et al.   JOURNAL OF EXPERIMENTAL MEDICINE