SH2B3 (LNK)mutations from myeloproliferative neoplasms patients have mild loss of function against wild type JAK2 and JAK2 V617F

Genetic Alterations Activating Kinase and Cytokine Receptor Signaling in High-Risk Acute Lymphoblastic Leukemia

(2012) Kathryn G. Roberts et al.   CANCER CELL

14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells

(2012) Jing Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Possible new LNK mutations in myeloproliferative neoplasms

(2011) Jung-Sook Ha et al.   AMERICAN JOURNAL OF HEMATOLOGY

A nonsynonymous LNK polymorphism associated with idiopathic erythrocytosis

(2011) Mary Frances McMullin et al.   AMERICAN JOURNAL OF HEMATOLOGY

Adaptor protein Lnk binds to PDGF receptor and inhibits PDGF-dependent signaling

(2011) Saskia Gueller et al.   EXPERIMENTAL HEMATOLOGY

Clonal hierarchy and allelic mutation segregation in a myelofibrosis patient with two distinct LNK mutations

(2011) T L Lasho et al.   LEUKEMIA

LNK can also be mutated outside PH and SH2 domains in myeloproliferative neoplasms with and without V617FJAK2 mutation

(2011) C. Hurtado et al.   LEUKEMIA RESEARCH

Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis

(2011) Chung Yeng Looi et al.   PLoS One

Genetic and Epigenetic Complexity in Myeloproliferative Neoplasms

(2011) N. C. P. Cross   Hematology-American Society of Hematology Education Program

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms

(2010) S. T. Oh et al.   BLOOD

BCR-ABL but Not JAK2 V617F Inhibits Erythropoiesis through the Ras Signal by Inducing p21CIP1/WAF1

(2010) Masahiro Tokunaga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lnk constrains myeloproliferative diseases in mice

(2010) Alexey Bersenev et al.   JOURNAL OF CLINICAL INVESTIGATION

Adaptor protein Lnk inhibits c-Fms-mediated macrophage function

(2010) Saskia Gueller et al.   JOURNAL OF LEUKOCYTE BIOLOGY

LNK mutation studies in blast-phase myeloproliferative neoplasms and in chronic-phase disease with TET2, IDH, JAK2 or MPL mutations

(2010) A Pardanani et al.   LEUKEMIA

Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F

(2009) Sigal Gery et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

(2009) Masashi Sanada et al.   NATURE

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

(2009) Daniel F Gudbjartsson et al.   NATURE GENETICS

Adaptor protein Lnk associates with Tyr568in c-Kit

(2008) Saskia Gueller et al.   BIOCHEMICAL JOURNAL

Lnk adaptor protein down-regulates specific Kit-induced signaling pathways in primary mast cells

(2008) C. Simon et al.   BLOOD