Inducing apoptosis in chemotherapy-resistant B-lineage acute lymphoblastic leukaemia cells by targeting HSPA5, a master regulator of the anti-apoptotic unfolded protein response signalling network

Chaperone-Targeting Cytotoxin and Endoplasmic Reticulum Stress-Inducing Drug Synergize to Kill Cancer Cells

(2015) Joseph M. Backer et al.   NEOPLASIA

The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78

(2010) G. Roue et al.   BLOOD

Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL

(2010) E. Rosati et al.   BLOOD

Association of elevated GRP78 expression with increased astrocytoma malignancy via Akt and ERK pathways

(2010) Lu-Hua Zhang et al.   BRAIN RESEARCH

Gene expression profiles of infant acute lymphoblastic leukaemia and its prognostically distinct subsets

(2010) Sanjive Qazi et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic

(2010) Fatih M. Uckun et al.   BRITISH JOURNAL OF HAEMATOLOGY

Targeted Nanoparticles That Deliver a Sustained, Specific Release of Paclitaxel to Irradiated Tumors

(2010) Ralph J. Passarella et al.   CANCER RESEARCH

Dominant expression of survival signals of endoplasmic reticulum stress response in Hodgkin lymphoma

(2010) Kung-Chao Chang et al.   CANCER SCIENCE

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Mouse sarcoma L1 cell line holoclones have a stemness signature

(2010) J. Miloszewska et al.   CELL PROLIFERATION

Bruton's tyrosine kinase as a molecular target in treatment of leukemias and lymphomas as well as inflammatory disorders and autoimmunity

(2010) Fatih M Uckun et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas

(2010) Fatih M Uckun et al.   Expert Review of Anticancer Therapy

JAK3 pathway is constitutively active in B-lineage acute lymphoblastic leukemia

(2010) Fatih M Uckun et al.   Expert Review of Anticancer Therapy

Roles of GRP78 in physiology and cancer

(2010) Lu-Hua Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

GRP78 up-regulation is associated with androgen receptor status, Hsp70-Hsp90 client proteins and castrate-resistant prostate cancer

(2010) Shaun S Tan et al.   JOURNAL OF PATHOLOGY

Akt is the downstream target of GRP78 in mediating cisplatin resistance in ER stress-tolerant human lung cancer cells

(2010) Yidan Lin et al.   LUNG CANCER

Crystal Structures of the ATPase Domains of Four Human Hsp70 Isoforms: HSPA1L/Hsp70-hom, HSPA2/Hsp70-2, HSPA6/Hsp70B', and HSPA5/BiP/GRP78

(2010) Magdalena Wisniewska et al.   PLoS One

STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress

(2010) F. M. Uckun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD22 EXON 12 deletion as a pathogenic mechanism of human B-precursor leukemia

(2010) F. M. Uckun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78

(2009) U. K. Misra et al.   APOPTOSIS

Polo-like-kinase 1 (PLK1) as a molecular target to overcome SYK-mediated resistance of B-lineage acute lymphoblastic leukaemia cells to oxidative stress

(2009) Fatih M. Uckun et al.   BRITISH JOURNAL OF HAEMATOLOGY

Blockade of GRP78 sensitizes breast cancer cells to microtubules-interfering agents that induce the unfolded protein response

(2009) Jiao Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Outcome of Patients Treated for Relapsed or Refractory Acute Lymphoblastic Leukemia: A Therapeutic Advances in Childhood Leukemia Consortium Study

(2009) Richard H. Ko et al.   JOURNAL OF CLINICAL ONCOLOGY

Ligation of cancer cell surface GRP78 with antibodies directed against its COOH-terminal domain up-regulates p53 activity and promotes apoptosis

(2009) U. K. Misra et al.   MOLECULAR CANCER THERAPEUTICS

A cell-penetrating peptidic GRP78 ligand for tumor cell-specific prodrug therapy

(2008) Yoshiyuki Yoneda et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Ten-year survival of children with acute lymphoblastic leukemia: A report from the Children's Oncology Group

(2008) Michael E. Trigg et al.   LEUKEMIA & LYMPHOMA