Article
Immunology
Cuipeng Qiu, Yaru Duan, Bofei Wang, Jianxiang Shi, Peng Wang, Hua Ye, Liping Dai, Jianying Zhang, Xiao Wang
Summary: The study found a positive correlation between the high expression of PDLIM1 autoantibodies in OC patients and high expression of PDLIM1 in tissues, indicating the potential of autoantibodies against PDLIM1 as a novel serological biomarker for OC, serving as a complementary measure to CA125 and improving the accuracy of OC detection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Seyin Zou, Jie Li, Junping Yan, Jinhong Xu, Maorui Lin, Donglin Cao
Summary: The distribution of serum thrombospondin-2 (THBS2) displayed significant heterogeneity among various cancers compared to healthy controls in China. Most cancer patients showed decreased serum THBS2 levels, except for hepatoma and lymphoma patients who exhibited relatively high levels. Ovarian cancer patients with low THBS2 expression may have a higher risk of developing metastasis.
CLINICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Martin Salzmann, Alexander H. Enk, Jessica C. Hassel
Summary: Our study examined the usefulness of the S100 protein in monitoring the progression of uveal melanoma. We found that S100 levels in the blood varied depending on the stage of the disease and the expression of S100 in metastases. Patients with strong S100 expression in metastases always had rising S100 levels in their blood, while patients without S100 expression in metastases never showed rising S100 levels. Therefore, S100 levels can be predicted by examining S100 expression in metastases and may be useful in monitoring disease progression.
Article
Biochemistry & Molecular Biology
Alexey A. Lipengolts, Yulia A. Finogenova, Vsevolod A. Skribitsky, Kristina E. Shpakova, Adi Anaki, Menachem Motiei, Alevtina S. Semkina, Maxim A. Abakumov, Anna V. Smirnova, Elena Y. Grigorieva, Rachela Popovtzer
Summary: In this study, core/shell Fe3O4@Au theranostic nanoparticles were developed with the aim of providing bimodal CT and MRI enhancement. These nanoparticles showed significant enhancement of tumors and tumor blood vessels and accumulated in the liver and spleen. They were found to be non-toxic and effective contrast agents for CT and MRI diagnostics, with potential applications in cancer diagnostics and beyond.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Alexander Wong, Hayden Gunraj, Vignesh Sivan, Masoom A. Haider
Summary: Prostate cancer is the second most common cancer in men worldwide and early screening is crucial. Correlated diffusion imaging (CDI) shows promise as a screening tool. In the largest study of its kind, hyperintensity in CDIs is found to be a strong indicator of PCa presence and performs well in cancerous tissue delineation.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Panpan Yang, Kuanzheng Mao, Yisha Gao, Zhen Wang, Jun Wang, Yufei Chen, Chao Ma, Yun Bian, Chengwei Shao, Jianping Lu
Summary: This study compared the measurement of tumor size using CT and MRI in pancreatic cancer patients undergoing neoadjuvant therapy. The results showed no significant difference in tumor size measured by CT and MRI before and after neoadjuvant therapy. CT and MRI have similar performance in assessing tumor size in pancreatic cancer.
Article
Oncology
Chao Ran, Jian Sun, Yunhui Qu, Na Long
Summary: This study aimed to explore the clinical value of MRI and tumor serum markers in preoperative diagnosis of cervical cancer lymph node metastasis and para-uterine invasion. The results showed that MRI combined with serum SCCA can more accurately identify cervical cancer lymph node metastasis and para-uterine invasion compared with MRI alone. Tumor marker combined with MRI diagnosis is an important auxiliary method for cervical cancer treatment.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Ayumu Matsuoka, Shinichi Tate, Kyoko Nishikimi, Tastuya Kobayashi, Satoyo Otsuka, Makio Shozu
Summary: This study found that preoperative serum follicle-stimulating hormone (FSH) levels are an extremely useful marker for differentiating granulosa cell tumors (GCTs) from other ovarian tumors. The GCT group had significantly lower serum FSH levels compared to the non-GCT group, while serum sex steroid hormone levels were significantly higher. Furthermore, serum FSH levels showed high sensitivity and specificity and served as a reliable indicator for distinguishing GCTs from other ovarian tumors.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Guohua Shen, Rang Wang, Lili Pan, Anren Kuang
Summary: Glomus tumors are vascular neoplasms arising from glomus bodies, typically found in tissues concentrated with these bodies. We reported the MRI and FDG PET/CT findings of a glomus tumor presenting as an axillary mass in a 25-year-old woman.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Woo Yeon Hwang, Dong Hoon Suh, Kidong Kim, Yong Beom Kim, Jae Hong No
Summary: This study evaluated the prognostic value of HE4 as a tumor marker in cervical cancer. The results showed that high levels of HE4 expression were associated with poor overall survival, indicating a poor prognosis for cervical cancer patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Benjamin J. Dewey, Benjamin M. Howe, Robert J. Spinner, Geoffrey B. Johnson, Mark A. Nathan, Doris E. Wenger, Stephen M. Broski
Summary: This study found that schwannomas may exhibit features associated with malignant peripheral nerve sheath tumors on MRI and FDG PET/CT imaging, including irregular margins, internal non-enhancement, perilesional edema, and heterogeneous FDG uptake. A significant proportion of lesions showed FDG activity above previously thought useful cutoff levels in differentiating malignant from benign peripheral nerve sheath tumors.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Riordan Azam, David Lim, Belinda Curpen, Anne-Marie Mulligan, Nicole Look Hong
Summary: Current imaging techniques show poor correlation with final surgical pathology, leading to potential uncertainty in surgical excision and exclusion of non-surgical management candidates. Triple-negative breast cancer (TNBC) is a good candidate for ongoing trials due to stronger correlations between pathology and imaging.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Genetics & Heredity
Parisa Vasefifar, Rouhollah Motafakkerazad, Leili Aghebati Maleki, Souzan Najafi, Farid Ghrobaninezhad, Basira Najafzadeh, Hajar Alemohammad, Mohammad Amini, Amir Baghbanzadeh, Behzad Baradaran
Summary: Cancer stem cells (CSCs) play a crucial role in tumor initiation and development, as well as in chemoresistance and metastasis. Nanog, a cell surface marker, is upregulated in various cancers and contributes to the stemness, self-renewal, metastasis, invasiveness, and chemoresistance of cancer cells. The function of Nanog in multiple cancers is of significant importance for cancer treatment.
Article
Oncology
Taichi Matsubara, Shinkichi Takamori, Naoki Haratake, Takatoshi Fujishita, Ryo Toyozawa, Kensaku Ito, Mototsugu Shimokawa, Masafumi Yamaguchi, Takashi Seto, Tatsuro Okamoto
Summary: This study compared the clinical and prognostic significance of three immune-nutritional parameters for non-small cell carcinoma (NSCLC) and found that the CRP-albumin ratio (CAR) is an independent prognostic factor in predicting postoperative survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Jumei Hao, Jing Sang, Xiajuan Xu, Aihua Bao
Summary: This study analyzed the diagnostic value of computed tomography (CT), magnetic resonance imaging (MRI) combined with serum lactate dehydrogenase (LDH), neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), and N-myc (MYCN) in the diagnosis of pediatric neuroblastoma. The results showed that the sensitivity of CT and MRI combined with serum LDH, NSE, CEA, and MYCN was significantly higher than that of the three alone.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
