The potential role of Aurora kinase inhibitors in haematological malignancies

Effects of AZD1152, a selective Aurora B kinase inhibitor, on Burkitt's and Hodgkin's lymphomas

(2011) Naoki Mori et al.   BIOCHEMICAL PHARMACOLOGY

Aurora inhibitor MLN8237 in combination with docetaxel enhances apoptosis and anti-tumor activity in mantle cell lymphoma

(2011) Wenqing Qi et al.   BIOCHEMICAL PHARMACOLOGY

Combining Histone Deacetylase Inhibitor Vorinostat with Aurora Kinase Inhibitors Enhances Lymphoma Cell Killing with Repression of c-Myc, hTERT, and microRNA Levels

(2011) L. Kretzner et al.   CANCER RESEARCH

Antimyeloma Activity of a Multitargeted Kinase Inhibitor, AT9283, via Potent Aurora Kinase and STAT3 Inhibition Either Alone or in Combination with Lenalidomide

(2011) L. Santo et al.   CLINICAL CANCER RESEARCH

From cell biology to therapy: ENMD-2076 in the treatment of multiple myeloma

(2011) Shuhong Zhang et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Aurora kinase inhibitors as anti-cancer therapy

(2010) Warren Lok et al.   ANTI-CANCER DRUGS

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state

(2010) J. den Hollander et al.   BLOOD

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

(2010) G. Gorgun et al.   BLOOD

Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma

(2010) Xiaojing Wang et al.   BRITISH JOURNAL OF HAEMATOLOGY

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Retracted: Aurora kinase inhibitor AZD1152 negatively affects the growth and survival of HTLV-1-infected T lymphocytes in vitro

(2010) Mariko Tomita et al.   INTERNATIONAL JOURNAL OF CANCER

Influence of pharmacogenetic variability on the pharmacokinetics and toxicity of the aurora kinase inhibitor danusertib

(2010) Neeltje Steeghs et al.   INVESTIGATIONAL NEW DRUGS

p53: The Attractive Tumor Suppressor in the Cancer Research Field

(2010) Toshinori Ozaki et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Aurora kinase inhibitors: novel small molecules with promising activity in acute myeloid and Philadelphia-positive leukemias

(2010) A S Moore et al.   LEUKEMIA

The FLT3 Internal Tandem Duplication Mutation Is a Secondary Target of the Aurora B Kinase Inhibitor AZD1152-HQPA in Acute Myelogenous Leukemia Cells

(2010) M. Grundy et al.   MOLECULAR CANCER THERAPEUTICS

ENMD-2076 Is an Orally Active Kinase Inhibitor with Antiangiogenic and Antiproliferative Mechanisms of Action

(2010) G. C. Fletcher et al.   MOLECULAR CANCER THERAPEUTICS

Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface

(2010) Julie P.I. Welburn et al.   MOLECULAR CELL

Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase

(2010) D. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targets and effectors of the cellular response to aurora kinase inhibitor MK-0457 (VX-680) in imatinib sensitive and resistant chronic myelogenous leukemia

(2009) Nicholas J. Donato et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma

(2009) D. Hose et al.   BLOOD

KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation

(2009) Y. Shiotsu et al.   BLOOD

In vitroanti-myeloma activity of the Aurora kinase inhibitor VE-465

(2009) Joseph M. Negri et al.   BRITISH JOURNAL OF HAEMATOLOGY

Mitotic drivers—inhibitors of the Aurora B Kinase

(2009) Nicholas Keen et al.   CANCER AND METASTASIS REVIEWS

Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen

(2009) John McLaughlin et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

(2009) Arne Lindqvist et al.   JOURNAL OF CELL BIOLOGY

Discovery and Development of Aurora Kinase Inhibitors as Anticancer Agents

(2009) John R. Pollard et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of Aurora B kinase in non-Hodgkin lymphoma

(2009) Takayuki Ikezoe et al.   LABORATORY INVESTIGATION

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

(2009) Mark E. Burkard et al.   PLOS BIOLOGY

Polo-Like Kinase 1 Directs Assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF Complex to Initiate Cleavage Furrow Formation

(2009) Benjamin A. Wolfe et al.   PLOS BIOLOGY

Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I

(2008) A. Gontarewicz et al.   BLOOD

A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response

(2008) K. W. Pratz et al.   BLOOD

The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma

(2008) Robert P. Evans et al.   BRITISH JOURNAL OF HAEMATOLOGY

Frequent overexpression of Aurora Kinase A in upper gastrointestinal adenocarcinomas correlates with potent antiapoptotic functions

(2008) Altaf A. Dar et al.   CANCER

Plk1 regulates mitotic Aurora A function through βTrCP-dependent degradation of hBora

(2008) Eunice H. Y. Chan et al.   CHROMOSOMA

Aurora Kinases as Anticancer Drug Targets

(2008) O. Gautschi et al.   CLINICAL CANCER RESEARCH

Aurora A Is Essential for Early Embryonic Development and Tumor Suppression

(2008) Lin-Yu Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells

(2008) Robert Evans et al.   LEUKEMIA & LYMPHOMA

Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery

(2008) Libor Macůrek et al.   NATURE

The aurora kinase A regulates GSK-3β in gastric cancer cells

(2008) A A Dar et al.   ONCOGENE

Battling the Hematological Malignancies: The 200 Years' War

(2008) M. A. Lichtman   ONCOLOGIST

The chromosomal passenger complex and the spindle assembly checkpoint: kinetochore-microtubule error correction and beyond

(2008) Gerben Vader et al.   Cell Division

Aurora kinases as targets for cancer therapy

(2007) Giannis Mountzios et al.   CANCER TREATMENT REVIEWS