Article
Veterinary Sciences
Ga-Won Lee, Min-Hee Kang, Jin-Ha Jeon, Doo-Won Song, Woong-Bin Ro, Heyong-Seok Kim, Hee-Myung Park
Summary: This study suggests that imatinib may be an effective adjunctive therapy with prednisolone and chlorambucil treatment for dogs with treatment-resistant chronic lymphocytic leukemia (CLL).
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Medicine, General & Internal
Amarpreet Devi, Lieze Thielemans, Eleni E. Ladikou, Taran K. Nandra, Timothy Chevassut
Summary: Lymphocytosis is a common blood-test finding that requires clinical evaluation to determine whether it is benign or malignant. Most chronic lymphocytic leukemia (CLL) patients are identified incidentally through routine blood tests. Patient outcomes are influenced by genetic predisposition and various prognostic markers. Chemo-immunotherapy is an effective treatment strategy for the majority of patients, and novel oral therapies are being developed.
Article
Virology
Jeremy Barben, Alain Putot, Anca-Maria Mihai, Jeremie Vovelle, Patrick Manckoundia
Summary: This is a unique case report demonstrating the association between CLL transformation and hMPV infection. Due to the poor physical condition of the patient, CLL was not treated.
Article
Oncology
Michael Asger Andersen, Klaus Rostgaard, Carsten Utoft Niemann, Henrik Hjalgrim
Summary: The study found that CLL patients have increased susceptibility to infections for decades before diagnosis, and a similar pattern was observed in the offspring of CLL patients. The duration of this time window is consistent with immune dysfunction and/or certain infections playing a causal role in CLL pathogenesis, potentially mediating the association between constitutional infection susceptibility and CLL risk.
Article
Pathology
Anya K. Hotinski, Oliver G. Best, Bryone J. Kuss
Summary: Chronic lymphocytic leukaemia (CLL) is a clonally complex disease with high intra-tumoural and inter-patient heterogeneity, requiring accurate prognostic tests. The emergence of new targeted agents in recent years has also created a need for improved predictive tests in therapy.
Article
Hematology
Phillip. C. C. Nguyen, Vuong Nguyen, Kylie Baldwin, Yamuna Kankanige, Piers Blombery, Neil Came, David. A. A. Westerman
Summary: Undetectable measurable residual disease (MRD) in chronic lymphocytic leukaemia (CLL) can be assessed using computational analysis. This study developed a computational pipeline using FlowSOM to detect MRD in CLL samples. The results showed high correlation with expert analysis, with high concordance in binary classification of typical CLL samples. This demonstrates the feasibility and value of automated MFC analysis in a diagnostic laboratory.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Pathology
Christopher B. Ryder, Kwadwo A. Oduro, Erika M. Moore
Summary: This study evaluated the clinicopathologic characteristics of isolated BM CLL-type MBL in patients who did not meet criteria for CLL/SLL. The results showed that most patients had low-level marrow involvement and did not progress to CLL/SLL, but some patients received treatment due to cytopenias.
Article
Immunology
Jennifer A. Whitaker, Sameer A. Parikh, Tait D. Shanafelt, Neil E. Kay, Richard B. Kennedy, Diane E. Grill, Krista M. Goergen, Timothy G. Call, Saad S. Kendarian, Wei Ding, Gregory A. Poland
Summary: Among patients with chronic lymphocytic leukemia (CLL) and monoclonal B cell lymphocytosis (MBL), the immunogenicity of high-dose influenza vaccine is lower compared to healthy adults, with MBL patients showing greater immunogenicity against influenza B compared to CLL patients.
Review
Hematology
Akihiro Ohmoto, Shigeo Fuji
Summary: Adult T-cell leukemia/lymphoma (ATLL) has aggressive clinical behaviors. A progression model from asymptomatic human T-cell leukemia virus type 1 carrier to aggressive ATLL has been proposed. Indolent ATLL has unsatisfactory long-term prognosis and warrants further treatment strategies, including precision medicine. Unlike indolent ATLL, several molecular-targeted agents have dramatically improved chronic lymphocytic leukemia (CLL) prognosis.
Article
Hematology
Gonzalo Blanco, Anna Puiggros, Barbara Sherry, Lara Nonell, Xavier Calvo, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, Gerardo Ferrer, Florencia Palacios, Magdalena Arnal, Maria Rodriguez-Rivera, Eva Gimeno, Eugenia Abella, Kanti R. Rai, Pau Abrisqueta, Francesc Bosch, Alexandre Calon, Ana Ferrer, Nicholas Chiorazzi, Blanca Espinet
Summary: Studies have revealed differences in the inflammatory environment between MBL and CLL, highlighting an active role for antigen stimulation in the very early stages of the disease, potentially related to malignant B-cell transformation.
EXPERIMENTAL HEMATOLOGY
(2021)
Article
Oncology
Ferenc Takacs, Lili Kotmayer, Agnes Czeti, Gabor Szaloki, Tamas Laszlo, Gabor Mikala, Agnes Mark, Andras Masszi, Peter Farkas, Mark Plander, Julia Weisinger, Judit Demeter, Sandor Fekete, Laszlo Szerafin, Beata Margit Deak, Erika Szaleczky, Adrienn Sulak, Zita Borbenyi, Gabor Barna
Summary: This study suggests that the increased expression of CD27 and CD86 may be associated with ibrutinib resistance, and monitoring these phenotypic changes could play a role in patient follow-up.
PATHOLOGY & ONCOLOGY RESEARCH
(2022)
Article
Genetics & Heredity
Qiuyi Zhang, Ying Gao, Shuchun Lin, Lynn R. Goldin, Yonghong Wang, Holly Stevenson, Daniel C. Edelman, Keith Killian, Gerald Marti, Paul S. Meltzer, Song Xiang, Neil E. Caporaso
Summary: This study investigated the DNA methylation aberrations in malignant B lymphocytes of CLL patients and identified differentially methylated positions (DMPs) and differentially methylated and expressed genes (DMEGs) associated with CLL by integrating public databases. The direction of each DMEG in CLL was observed based on DMPs in the promoter and the body region, and the methylation heterogeneity of CLL subgroups and the effect of B cell maturation on CLL were explored. The findings suggest the importance of DNA methylation in the pathogenesis of CLL and provide potential markers for diagnostic and therapeutic purposes.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Jayalakshmi Balakrishna, Neil Basumallik, Robert Matulonis, Drake Scott, Dalia Salem, Gregory Jasper, Adrian Wiestner, Maryalice Stetler-Stevenson, Gerald Marti, Clare Sun, Constance M. Yuan
Summary: This study demonstrates the prognostic utility of antigen quantitation in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and monoclonal B-cell lymphocytosis (MBL), and finds that different protein expressions are associated with immunoglobulin status, cytogenetic abnormalities, and time to first treatment.
LEUKEMIA & LYMPHOMA
(2021)
Review
Oncology
Giulia Benintende, Federico Pozzo, Idanna Innocenti, Francesco Autore, Alberto Fresa, Giovanni D'Arena, Valter Gattei, Luca Lurenti
Summary: Measurable residual disease (MRD) refers to the presence of cancer cells that remain after treatment in patients with no clinically detectable disease. It is a highly sensitive parameter that indicates disease burden and predicts survival in these patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Shenmiao Yang, Abraham M. Varghese, Nitin Sood, Carlos Chiattone, Norah O. Akinola, Xiaojun Huang, Robert Peter Gale
Summary: East Asians, Asian Indians, and Amerindians have a significantly lower incidence rate of chronic lymphocytic leukemia compared to persons of European descent, suggesting a genetic rather than environmental basis for this disparity. These populations have different genetic admixtures with archaic hominins, potentially explaining the varying CLL incidences among them, as well as differences in clinical and molecular covariates of CLL. Further research is needed to determine the exact reasons behind these population variances in CLL and other lymphomas and cancers.
Review
Hematology
Grzegorz Nowakowski, Matthew J. Maurer, James R. Cerhan, Debarshi Dey, Laurie H. Sehn
Summary: Comparative effectiveness studies using real-world data can provide complementary evidence on treatment effectiveness. By balancing baseline covariates using propensity score methods, closely matched patient-level cohorts can be generated for robust comparative analyses.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Oncology
Terry Boyle, Geffen Kleinstern, Paige M. Bracci, James R. Cerhan, Yolanda Benavente, Delphine Casabonne, Brian C-H Chiu, Thomas M. Habermann, Elizabeth A. Holly, Mark Liebow, Aaron Norman, Ora Paltiel, Dennis Robinson, Nathaniel Rothman, Rania Abu Seir, Susan L. Slager, Paul J. Villeneuve, Sophia S. Wang, Dennis D. Weisenburger, John J. Spinelli
Summary: This study, which pooled data from nine case-control studies, found that moderate-to-vigorous intensity physical activity can reduce the risk of non-Hodgkin lymphoma.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Freddy A. Barragan, Lauren J. Mills, Andrew R. Raduski, Erin L. Marcotte, Kelsey E. Grinde, Logan G. Spector, Lindsay A. Williams
Summary: Black children have lower incidence yet worse survival in B-cell acute lymphoblastic leukemia (B-ALL). Genetic ancestry and differentially expressed genes associated with ancestry play a role in death risk. The impact of reported race/ethnicity on death risk varies after adjusting for genetic ancestry genes. Other factors also contribute to B-ALL survival.
Article
Economics
Martha J. Bailey, Susan H. Leonard, Joseph Price, Evan Roberts, Logan Spector, Mengying Zhang
Summary: This paper describes the digitization of almost 185,000 causes of death for Ohio by combining handwriting recognition, data cleaning algorithms, and semi-automated classification of causes. The methods used in this research can be applied to other collections of handwritten data.
EXPLORATIONS IN ECONOMIC HISTORY
(2023)
Article
Oncology
Kurt S. Bantilan, Neil E. Kay, Sameer A. Parikh, Kari G. Rabe, Timothy G. Call, Jose F. Leis, Wei Ding, Susan L. Slager, Jacob D. Soumerai, Lindsey E. Roeker, Anthony Mato, Andrew D. Zelenetz
Summary: We aimed to develop a prognostic model to determine who would benefit from first-line chemoimmunotherapy (CIT) vs targeted therapy in chronic lymphocytic leukemia (CLL). Our study found that time from diagnosis to second treatment (TT2T) was a better predictor of overall survival (OS) than time from diagnosis to first treatment (TT1T) in CLL. We developed a risk score model consisting of three predictors (unmutated IGHV, beta(2)-microglobulin >297 nmol/L, and Rai stage I-IV) that was prognostic for TT2T and OS. TT2T shows potential as a surrogate for OS in CLL, but further validation is needed.
LEUKEMIA & LYMPHOMA
(2023)
Article
Medicine, General & Internal
Jennifer M. Geris, Mark R. Schleiss, Anthony J. Hooten, Erica Langer, Nelmary Hernandez-Alvarado, Michelle A. Roesler, Jeannette Sample, Lindsay A. Williams, David S. Dickens, Rajen J. Mody, Yaddanapudi Ravindranath, Kate L. Gowans, Matthew G. Pridgeon, Logan G. Spector, Heather H. Nelson
Summary: Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer and a leading cause of death in children. Congenital cytomegalovirus (cCMV) has been identified as a potential risk factor for ALL. This study compared the prevalence of cCMV infection between ALL cases and matched controls, and found that cCMV was associated with increased risk of hyperdiploid ALL.
Article
Hematology
Emelie Curovic Rotbain, Cristine Allmer, Klaus Rostgaard, Michael Asger Andersen, Noomi Vainer, Caspar da Cunha-Bang, Sameer A. Parikh, Kari G. Rabe, Henrik Hjalgrim, Henrik Frederiksen, Susan L. Slager, Carsten Utoft Niemann
Summary: Age-related comorbid conditions, such as type 2 diabetes, are common in patients with chronic lymphocytic leukemia (CLL). This study analyzed two separate cohorts to assess the impact of type 2 diabetes on CLL patient outcomes. The results showed that CLL patients with type 2 diabetes had shorter overall survival, were less likely to receive treatment, and had an increased risk of death due to infections. These findings highlight the need for additional interventions and research to address the treatment needs of CLL patients with co-occurring type 2 diabetes.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rachel Zmora, Logan Spector, John Bass, Amanda Thomas, Jessica Knight, Kamakshi Lakshminarayan, James St Louis, Lazaros Kochilas
Summary: The study found that procedure-specific center volume is inversely associated with early postoperative mortality for infantile congenital heart surgery (CHS) but has no measurable effect on later mortality.
ANNALS OF THORACIC SURGERY
(2023)
Letter
Oncology
Nicholas J. Boddicker, Sameer A. Parikh, Aaron D. Norman, Kari G. Rabe, Rosalie Griffin, Timothy G. Call, Dennis P. Robinson, Janet E. Olson, Angela Dispenzieri, Vincent Rajkumar, Shaji Kumar, Neil E. Kay, Curtis A. Hanson, James R. Cerhan, David Murray, Esteban Braggio, Tait D. Shanafelt, Celine M. Vachon, Susan L. Slager
Article
Oncology
Cristina Correia, Matthew J. J. Maurer, Samantha J. J. McDonough, Paula A. A. Schneider, Paige E. E. Ross, Anne J. J. Novak, Andrew L. L. Feldman, James R. R. Cerhan, Susan L. L. Slager, Thomas E. E. Witzig, Bruce W. W. Eckloff, Hu Li, Grzegorz S. S. Nowakowski, Scott H. H. Kaufmann
Summary: The identification of follicular lymphoma (FL) patients with low disease burden but high risk for early progression is unclear. In a study on newly diagnosed FLs, BCL2 mutations with high variant allele frequency (VAF) were found to be associated with increased transformation risk and shorter event-free survival. However, other sequenced genes did not contribute significantly to the prognostic value of the panel. Nonsynonymous BCL2 mutations with VAF = 20% were consistently associated with decreased event-free survival and overall survival.
BLOOD CANCER JOURNAL
(2023)
Article
Hematology
Rosalie Griffin, Julia E. Wiedmeier-Nutor, Sameer A. Parikh, Chantal E. McCabe, Daniel R. O'Brien, Nicholas J. Boddicker, Geffen Kleinstern, Kari G. Rabe, Laura Bruins, Sochilt Brown, Cecilia Bonolo de Campos, Wei Ding, Jose F. Leis, Paul J. Hampel, Timothy G. Call, Daniel L. Van Dyke, Neil E. Kay, James R. Cerhan, Huihuang Yan, Susan L. Slager, Esteban Braggio
Summary: TP53 aberrations are important in CLL and HCMBL, and multi-hit TP53 state is associated with increased risk of requiring therapy and death. Both TP53 mutations and del(17p) provide important prognostic information that should be measured in HCMBL and CLL.
Letter
Hematology
Samuel R. Kosydar, Sameer A. Parikh, Scott C. Lester, Kari G. Rabe, Wei Ding, Jessica F. Burlile, Saad S. Kenderian, Yucai Wang, Eli Muchtar, Amber B. Koehler, Susan M. Schwager, Susan L. Slager, Neil E. Kay, Timothy G. Call, William G. Breen, Paul J. Hampel
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: Many studies have found associations between neighborhood deprivation and disease, emphasizing the importance of social determinants of health. However, when studying diseases with long latency periods such as cancers, considering the timing of exposures for deprivation becomes more important.
ENVIRONMENTAL RESEARCH
(2023)
Article
Oncology
Philip J. Lupo, Tiffany M. Chambers, Beth A. Mueller, Jacqueline Clavel, John D. Dockerty, David R. Doody, Friederike Erdmann, Sameera Ezzat, Tommaso Filippini, Johnni Hansen, Julia E. Heck, Claire Infante-Rivard, Alice Y. Kang, Corrado Magnani, Carlotta Malagoli, Catherine Metayer, Helen D. Bailey, Ana M. Mora, Evangelia Ntzani, Eleni Th Petridou, Maria S. Pombo-de-Oliveira, Wafaa M. Rashed, Eve Roman, Joachim Schuz, Catharina Wesseling, Logan G. Spector, Michael E. Scheurer
Summary: The study explores the associations between nonchromosomal birth defects and childhood leukemia using data from the Childhood Cancer and Leukemia International Consortium. The results suggest possible novel genetic and environmental factors associated with birth defects that may also increase leukemia susceptibility.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Cindy Im, Noha Sharafeldin, Yan Yuan, Zhaoming Wang, Yadav Sapkota, Zhanni Lu, Logan G. Spector, Rebecca M. Howell, Michael A. Arnold, Melissa M. Hudson, Kirsten K. Ness, Leslie L. Robison, Smita Bhatia, Gregory T. Armstrong, Joseph P. Neglia, Yutaka Yasui, Lucie M. Turcotte
Summary: This study evaluated SMNs among long-term childhood cancer survivors of European and African genetic ancestry, finding that a polygenic risk score (PRS) could significantly impact SMN risk in survivors who did not receive radiation therapy and were treated with specific chemotherapies.
JOURNAL OF CLINICAL ONCOLOGY
(2023)