Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 143, Issue 1, Pages 71-74Publisher
WILEY
DOI: 10.1111/j.1365-2141.2008.07301.x
Keywords
splenic marginal zone lymphoma; transformation; clinical features; outcome; prognosis
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In a series of 48 patients with splenic marginal zone lymphoma (SMZL) with circulating villous lymphocytes, we describe the clinical and laboratory features of nine cases that transformed to high-grade B-cell lymphoma. These patients had a significantly greater incidence of peripheral lymph node involvement at diagnosis when compared to SMZL patients who did not transform (P < 0.03). While transformation in the bone marrow is frequently refractory to therapy and associated with poor outcome in SMZL, lymph node transformation responds well to chemotherapy with durable progression-free and overall survival.
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