Review
Medicine, General & Internal
Sergio de Jesus Romero-Tapia, Crystell Guadalupe Guzman Priego, Blanca E. Del-Rio-Navarro, Manuel Sanchez-Solis
Summary: This review summarizes the close association between viral infection and the onset, progression, and exacerbation of asthma, discussing related protective and risk factors, as well as treatment options. It also presents recent research on the innate immunological pathways and changes in the epithelial barrier. The review emphasizes the importance of genetics and epigenetics in asthma and virus susceptibility, and describes the involvement of viral etiology in bronchiolitis, childhood wheezing, and asthma. The most frequently related respiratory viruses and their mechanisms of action are mentioned.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Mauricio T. Caballero, Ashish Satav, Christopher J. Gill, Saad B. Omer, Rachel C. Pieciak, Abdul Momin Kazi, Eric Af Simoes, Fernando P. Polack
Summary: The study found that there are obstacles and challenges in conducting research in developing countries to determine the factors associated with community mortality due to RSV, including obtaining family consent for testing, sampling at the household level, supporting grieving parents, developing tailored strategies for challenging settings, and integrating data from different sources.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Andrew Nishimoto, Nicholas Wohlgemuth, Jason Rosch, Stacey Schultz-Cherry, Valerie Cortez, Hannah M. Rowe
Summary: Bacterial, fungal, and helminthic species within the microbiome of mammalian hosts have significant effects on health and disease. Pathogenic viruses have evolved to interact with and potentially exploit or evade the microbiome during infection. Recent research has highlighted both synergistic and antagonistic interactions between the microbiome and pathogenic viruses, showcasing the complexity of their relationship.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Ivan Sanz-Munoz, Sonia Tamames-Gomez, Javier Castrodeza-Sanz, Jose Maria Eiros-Bouza, Raul Ortiz de Lejarazu-Leonardo
Summary: Non-pharmaceutical interventions have successfully reduced the spread of viruses, but may also lead to decreased circulation of pathogens, lowering herd immunity.
Review
Cell Biology
Qianyu Feng, Hongwei Zhao, Lili Xu, Zhengde Xie
Summary: N6-methyladenosine modification is a crucial RNA modification in eukaryotes, especially in relation to diseases caused by viruses. Studies have shown that m(6)A modification plays diverse regulatory roles in the life cycle of viruses.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Infectious Diseases
Andre Almeida, Matteo Boattini, Eirini Christaki, Torcato Moreira Marques, Ines Moreira, Lourenco Cruz, Valentina Tosatto, Diogo Antao, Gabriele Bianco, Marco Iannaccone, Cristina Costa, Georgios Tsiolakkis, Elina Khattab, Diamanto Kasapi, Ana Teresa Ferreira, Rossana Cavallo, Rita Corte-Real
Summary: The study found that Influenza A H1N1 was independently associated with a higher risk of death and IMV, while RSV was associated with older age and more comorbidities.
Review
Virology
Ralph A. Tripp, John Stambas
Summary: Vaccines targeting viral surface glycoproteins play a crucial role in disease prevention for respiratory viral diseases, with technological advances providing solutions for current and emerging pathogens. Understanding the structural basis for antibody neutralization guides the selection of vaccine targets for respiratory viruses like RSV.
Article
Hematology
Yae-Jean Kim, Alpana Waghmare, Hu Xie, Leona Holmberg, Steven A. Pergam, Keith R. Jerome, Wendy M. Leisenring, Chikara Ogimi, Angela P. Campbell, Janet A. Englund, Michael Boeckh
Summary: Pretransplant respiratory virus infections have a negative impact on hematopoietic cell transplantation outcomes. The controversy remains regarding the impact and need for delay of transplantation for pretransplant infection with human rhinovirus (HRV) or endemic human coronavirus (HCoV). In this study, it was found that pretransplant upper respiratory tract infection with HRV and endemic HCoV was not associated with increased mortality or fewer days alive and out of hospital (DAOH). However, for allogeneic recipients receiving myeloablative conditioning, lower respiratory tract disease (LRD) due to any respiratory virus, including HRV alone, was associated with increased overall mortality and fewer DAOH.
Article
Immunology
Xin Wang, Xiaochen Yin, Boya Zhang, Chenfeng Liu, Yahua Lin, Xiaofen Huang, Yufang Li, Chenguang Shen, Weibin Zheng, Guofeng Fu, Junyu Chen, Yanling Wen, Wei Zhang, Bo-Sheng Pan, Mujin Fang, Zizheng Zheng, Zheng Zhang, Quan Yuan, Guo Fu, Shaowei Li, Jun Zhang, Yixin Chen, Ningshao Xia, Qinjian Zhao
Summary: Immunization with an aluminium-zinc hybrid particulate adjuvant (FH-001) alone can quickly induce a broadly protective immune response to resist multiple deadly respiratory viruses. Alveolar macrophages and the type I interferon pathway play essential roles in the prophylactic effect of FH-001.
EMERGING MICROBES & INFECTIONS
(2022)
Review
Immunology
Sara Manti, Salvatore Leonardi, Fariba Rezaee, Terri J. Harford, Miriam K. Perez, Giovanni Piedimonte
Summary: Maternal infections during pregnancy can have significant consequences for the developing fetus. The maternal immune system undergoes complex changes to tolerate the fetus, but this does not suppress susceptibility to respiratory pathogens. Infections such as influenza, RSV, and SARS-CoV-2 can lead to acute and chronic complications in neonates and children.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Firas El Chaer, Daniel R. Kaul, Janet A. Englund, Michael Boeckh, Marjorie V. Batista, Susan K. Seo, Paul A. Carpenter, David Navarro, Hans H. Hirsch, Michael G. Ison, Genovefa A. Papanicolaou, Roy F. Chemaly
Summary: The Practice Guidelines Committee of the American Society of Transplantation and Cellular Therapy partnered with its Transplant Infectious Disease Special Interest Group to update the guidelines for hematopoietic cell transplantation. They adopted a new approach of publishing each topic in a concise format of FAQs, tables, and figures. In the seventh guideline, they focused on respiratory syncytial virus (RSV) and provided answers to FAQs regarding epidemiology, clinical diagnosis, prophylaxis, and treatment.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Virology
Sebastien Barral, Aline Mamin, Carole Dantin, Stavroula Masouridi-Levrat, Yves Chalandon, Laurent Kaiser, Diem-Lan Vu
Summary: This retrospective observational study found that rhinovirus infections are the most common in allo-HSCT patients, including pre-transplant infections. However, the mortality rate due to pre-transplant RVIs is low.
Article
Microbiology
Parsa Hodjat, Paul A. Christensen, Sishir Subedi, David W. Bernard, Randall J. Olsen, S. Wesley Long
Summary: The study found that non-COVID respiratory viruses returned rapidly after the relaxation of COVID-19 control measures, highlighting the importance for both physicians and the public to pay attention. Clinicians and the public now need to consider both COVID-19 and other respiratory pathogens when dealing with symptomatic respiratory illnesses in patients.
MICROBIOLOGY SPECTRUM
(2021)
Review
Microbiology
Kyle L. Macauslane, Cassandra L. Pegg, Kirsty R. Short, Benjamin L. Schulz
Summary: Acute respiratory infections (ARIs) are a major cause of death and disability, with the greatest impact on children, pregnant women, and the elderly. Respiratory viruses are the main culprits behind ARIs. The unfolded protein response (UPR) is a defense mechanism activated in response to viral infection, and it plays a role in the pathogenesis of respiratory diseases. Many respiratory viruses manipulate the UPR during infection, affecting both the host and the pathogens. Modulating the UPR may have therapeutic potential in virally induced respiratory diseases.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vladimir Kukushkin, Oganes Ambartsumyan, Alexei Subekin, Anna Astrakhantseva, Vladimir Gushchin, Alexandra Nikonova, Anastasia Dorofeeva, Vitaly Zverev, Anna Keshek, Nadezda Meshcheryakova, Olga Zaborova, Alexandra Gambaryan, Elena Zavyalova
Summary: In light of recurring epidemics and pandemics, rapid and reliable virus identification techniques are needed. Polymerase chain reaction with reverse transcription is a reliable and sensitive, though not rapid, tool. The antibody-based strip is a rapid, though not reliable, and sensitive tool. Alternative tools are being developed to meet all the customer's needs, such as surface-enhanced Raman spectroscopy (SERS) which allows single molecule detection in minutes. A multiplex lithographic SERS aptasensor was developed to detect several respiratory viruses in one pot within 17 min by using labeled aptamers anchored onto metal surfaces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)