Article
Multidisciplinary Sciences
Astrid Borretzen, Lars A. R. Reisaeter, Anders Ringheim, Karsten Gravdal, Svein A. Haukaas, Kristine E. Fasmer, Ingfrid H. S. Haldorsen, Christian Beisland, Lars A. Akslen, Ole J. Halvorsen
Summary: This study investigated microvascular proliferation in prostate cancer and its relation to quantitative imaging parameters, clinico-pathological features, and prognosis. The study found that blood flow and ADC were associated with microvascular density, while pMVD, GMP, and ADC were associated with adverse clinico-pathological factors and prognosis.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ying-Tso Chen, Chia-Li Chung, Yu-Wen Cheng, Chien-Ju Lin, Tzu-Ting Tseng, Shu-Shong Hsu, Hung-Pei Tsai, Aij-Lie Kwan
Summary: This study aimed to investigate the prognostic role of TXNDC11 in glioblastoma (GBM). The results showed that high expression of TXNDC11 was significantly associated with higher tumor grade and poor prognosis in GBM. TXNDC11 silencing inhibited GBM cell proliferation, migration, invasion, and promoted apoptosis, while its over-expression had the opposite effects. Furthermore, TXNDC11 knockdown regulated the expression of N-cadherin, E-cadherin, and Cyclin D1 in GBM cells. In vivo experiments demonstrated that TXNDC11-silenced GBM cells led to slower tumor growth and prolonged survival time. These findings suggest that TXNDC11 is a potential oncogene and therapeutic target in GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
M. C. B. Hughes, M. Malt, K. Khosrotehrani, B. M. Smithers, A. C. Green
Summary: The study found a significant association between the quality of patients' diets before diagnosis and melanoma thickness, with patients with higher diet quality being less likely to be diagnosed with thick melanoma.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Oncology
Yasaman Rezaie, Fahimeh Fattahi, Baharnaz Mashinchi, Kambiz Kamyab Hesari, Sahar Montazeri, Elham Kalantari, Zahra Madjd, Leili Saeednejad Zanjani
Summary: This study investigated the potential role of Talin-1 as a prognosis biomarker in skin tumors. The results showed that Talin-1 expression levels were significantly different in melanoma and non-melanoma skin cancer tissues, and were associated with clinicopathological parameters and survival outcomes.
Article
Biochemistry & Molecular Biology
Akos Janos Varga, Istvan Balazs Nemeth, Lajos Kemeny, Janos Varga, Laszlo Tiszlavicz, Dinesh Kumar, Steven Dodd, Alec W. M. Simpson, Tunde Buknicz, Rob Beynon, Deborah Simpson, Tibor Krenacs, Graham J. Dockray, Andrea Varro
Summary: Micro-environmental factors play an important role in the progression of melanoma. Gastrin concentration is significantly associated with melanoma thickness and metastasis. Gastrin promotes migration and invasion of melanoma cells through CCK2 receptors, and also affects adjacent stromal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Makoto Sano, Ryota Takahashi, Hideaki Ijichi, Kazunaga Ishigaki, Tomoharu Yamada, Koji Miyabayashi, Gen Kimura, Suguru Mizuno, Hiroyuki Kato, Hiroaki Fujiwara, Takuma Nakatsuka, Yasuo Tanaka, Jinsuk Kim, Yohei Masugi, Yasuyuki Morishita, Mariko Tanaka, Tetsuo Ushiku, Yousuke Nakai, Keisuke Tateishi, Yukimoto Ishii, Hiroyuki Isayama, Harold L. Moses, Kazuhiko Koike
Summary: PDAC is the deadliest cancer and frequently associated with CAT. This study found that inhibition of VCAM-1 can effectively treat PDAC and CAT in mice, leading to extended survival time. Increase of plasma ANP and sVCAM-1 may serve as diagnostic markers for CAT in PDAC.
Article
Biochemistry & Molecular Biology
Lucia Longhitano, Giuseppe Broggi, Sebastiano Giallongo, Maria Failla, Lidia Puzzo, Teresio Avitabile, Daniele Tibullo, Alfio Distefano, Valeria Pittala, Michele Reibaldi, Guido Nicola Zanghi, Antonio Longo, Andrea Russo, Rosario Caltabiano, Giovanni Li Volti, Nicolo Musso
Summary: The study revealed the important role of HO-1 in regulating uveal melanoma progression, with an increase of HO-1 promoting cellular proliferation and wound healing ability of tumor cells, suggesting HO-1 protein expression may serve as a potential prognostic and therapeutic factor in UM patients.
Article
Biology
Maria-Vittoria Sepporta, Viviane Praz, Katia Balmas Bourloud, Jean-Marc Joseph, Nicolas Jauquier, Nicolo' Riggi, Katya Nardou-Auderset, Audrey Petit, Jean-Yves Scoazec, Herve Sartelet, Raffaele Renella, Annick Muhlethaler-Mottet
Summary: TWIST1 and TWIST2 have opposite effects in neuroblastoma, with TWIST1 associated with poor survival and metastasis, and TWIST2 correlating with good prognosis. Suppression of TWIST1 reduces tumor growth and metastasis, and affects multiple signaling and cell-cell interaction pathways.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
N. Bhaskaran, E. Schneider, F. Faddoul, A. Paes da Silva, R. Asaad, A. Talla, N. Greenspan, A. D. Levine, D. McDonald, J. Karn, M. M. Lederman, P. Pandiyan
Summary: Residual systemic inflammation and mucosal immune dysfunction persist in people living with HIV despite antiretroviral therapy, and an unusual population of regulatory T cells expressing Amphiregulin and unable to suppress CD4 T cells may be contributing to disrupted oral immune protection in HIV patients.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Leidan Zhang, Yuqing Wei, Di Wang, Juan Du, Xinyue Wang, Bei Li, Meiqing Jiang, Mengyuan Zhang, Na Chen, Meiju Deng, Chuan Song, Danying Chen, Liang Wu, Jiang Xiao, Hongyuan Liang, Hongxin Zhao, Yaxian Kong
Summary: Persistent immune activation plays a crucial role in CD4(+) T cell depletion and AIDS progression during HIV infection. Foxp3(+) DNT cells accumulate in untreated HIV-infected individuals and are correlated with CD4(+) T cell count, immune activation, and systemic inflammation. These findings suggest that Foxp3(+) DNT cells may serve as a potential target for controlling immune activation during HIV infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Ajit J. Nirmal, Zoltan Maliga, Tuulia Vallius, Brian Quattrochi, Alyce A. Chen, Connor A. Jacobson, Roxanne J. Pelletier, Clarence Yapp, Raquel Arias-Camison, Yu-An Chen, Christine G. Lian, George F. Murphy, Sandro Santagata, Peter K. Sorger
Summary: This study investigates immune evasion and immunoediting in primary melanoma using high-plex imaging, 3D high-resolution microscopy, and spatially resolved microregion transcriptomics. The results show significant changes in cellular neighborhoods involving tumor, immune, and stromal cells during the progression of precursor states, melanoma in situ, and invasive tumor. Immunossuppression is already detectable in precursor regions, and a suppressive environment is formed along the tumor-stromal boundary during invasion, involving cytokine gradients, MHC-II expression, and PD1-PDL1-mediated cell contacts.
Article
Biology
Nil Vanli, Jinghao Sheng, Shuping Li, Zhengping Xu, Guo-Fu Hu
Summary: RNASE4 serves as a biomarker for prostate cancer and can predict aggressiveness of the disease and enhance diagnosis accuracy. It also promotes tumor cell proliferation and angiogenesis.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Guangtong Deng, Furong Zeng, Yi He, Yu Meng, Huiyan Sun, Juan Su, Shuang Zhao, Yan Cheng, Xiang Chen, Mingzhu Yin
Summary: This study reveals the role of the EEF2K/p-STAT3/SPP1 pathway in melanoma progression, which may serve as a target for novel combination therapy for melanoma.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jonas Feldheim, David Wend, Mara J. Lauer, Camelia M. Monoranu, Martin Glas, Christoph Kleinschnitz, Ralf-Ingo Ernestus, Barbara M. Braunger, Patrick Meybohm, Carsten Hagemann, Malgorzata Burek
Summary: This study found that high expression of PCDHGC3 is associated with longer progression-free survival (PFS) in glioma patients. Knockout of PCDHGC3 decreased the growth rate but increased the migration rate of glioma cells, and also affected the expression of genes involved in the WNT signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Manik Garg, Dominique-Laurent Couturier, Jeremie Nsengimana, Nuno A. Fonseca, Matthew Wongchenko, Yibing Yan, Martin Lauss, Goeran B. Jonsson, Julia Newton-Bishop, Christine Parkinson, Mark R. Middleton, D. Timothy Bishop, Sarah McDonald, Nikki Stefanos, John Tadross, Ismael A. Vergara, Serigne Lo, Felicity Newell, James S. Wilmott, John F. Thompson, Georgina V. Long, Richard A. Scolyer, Pippa Corrie, David J. Adams, Alvis Brazma, Roy Rabbie
Summary: The study shows that a 121 metastasis-associated gene signature identified using differential expression analysis is significantly associated with progression-free and overall survival in melanoma patients. Machine learning models trained with these signature genes outperformed models using clinical covariates or published prognostic signatures in predicting metastases. The signature negatively correlated with immune cell infiltration and could potentially help stratify early-stage melanoma patients for further evaluation in clinical trials.
NATURE COMMUNICATIONS
(2021)
Review
Dermatology
Christian Kromer, Mario Fabri, Christoph Schlapbach, Marco H. Schulze, Uwe Gross, Michael P. Schoen, Timo Buhl
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2019)
Review
Immunology
Leonhard von Meyenn, Nicole Leonie Bertschi, Christoph Schlapbach
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
S. Morteza Seyed Jafari, Karolina Gadaldi, Laurence Feldmeyer, Nikhil Yawalkar, Luca Borradori, Christoph Schlapbach
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Dermatology
Cecilia Bazzini, Nadja Begre, Bertand Favre, Takashi Hashimoto, Michael Hertl, Christoph Schlapbach, Luca Borradori
JOURNAL OF DERMATOLOGICAL SCIENCE
(2020)
Article
Immunology
Bettina Stolp, Flavian Thelen, Xenia Ficht, Lukas M. Altenburger, Nora Ruef, V. V. G. Krishna Inavalli, Philipp Germann, Nicolas Page, Federica Moalli, Andrea Raimondi, Kirsten A. Keyser, S. Morteza Seyed Jafari, Francesca Barone, Matthias S. Dettmer, Doron Merkler, Matteo Iannacone, James Sharpe, Christoph Schlapbach, Oliver T. Fackler, U. Valentin Nagerl, Jens V. Stein
SCIENCE IMMUNOLOGY
(2020)
Letter
Dermatology
A. D. Gloor, L. Feldmeyer, A. Rammlmair, C. Schlapbach, D. Wallach, L. Borradori
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Dermatology
Michael P. Schoen, Carola Berking, Tilo Biedermann, Timo Buhl, Luise Erpenbeck, Kilian Eyerich, Stefanie Eyerich, Kamran Ghoreschi, Matthias Goebeler, Ralf J. Ludwig, Knut Schaekel, Bastian Schilling, Christoph Schlapbach, Georg Stary, Esther von Stebut, Kerstin Steinbrink
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2020)
Letter
Dermatology
A. D. Gloor, M. van Rhyn, C. Schlapbach
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Dermatology
Michael P. Schoen, Carola Berking, Tilo Biedermann, Timo Buhl, Luise Erpenbeck, Kilian Eyerich, Stefanie Eyerich, Kamran Ghoreschi, Matthias Goebeler, Ralf J. Ludwig, Knut Schaekel, Bastian Schilling, Christoph Schlapbach, Georg Stary, Esther Stebut, Kerstin Steinbrink
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2020)
Article
Dermatology
O. Steck, N. L. Bertschi, F. Luther, J. van den Berg, D. J. Winkel, A. Holbro, C. Schlapbach
Summary: This study explored the clinical and immunological effects of type 2 cytokine blockade with dupilumab as supportive treatment in Sezary syndrome. The results showed rapid and sustained reduction in itch, improvement in skin and lymph node involvement, and a reduction in Th2 bias with dupilumab treatment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Editorial Material
Hematology
Christoph Schlapbach
Summary: Mycosis fungoides (MF) and S 'ezary syndrome (SS) are the most common forms of cutaneous T-cell lymphoma (CTCL). The clinical presentation of CTCL is similar to inflammatory skin diseases, but the mechanism behind the inflammatory changes caused by malignant CTCL T cells in the skin has been unclear. A recent study in Blood has found that CTCL T cells secrete cytokines IL-13, IL-22, and OSM, which activate JAK-STAT signaling in surrounding keratinocytes, leading to impaired skin barrier function. These findings provide a mechanistic rationale for cytokine and/or JAK targeting in MF and SS.
Letter
Dermatology
Simone L. Boll, Carole A. Zahn, Christoph Schlapbach
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Medicine, General & Internal
S. Morteza Seyed Jafari, Robert E. Hunger, Christoph Schlapbach
FRONTIERS IN MEDICINE
(2020)
Meeting Abstract
Dermatology
L. von Meyenn, C. Micosse, C. Adam, B. Homey, D. Simon, B. Snijder, M. Schmidt, C. Schlapbach
EXPERIMENTAL DERMATOLOGY
(2019)
Article
Immunology
Claire Micosse, Leonhard von Meyenn, Oliver Steck, Enja Kipfer, Christian Adam, Cedric Simillion, S. Morteza Seyed Jafari, Peter Olah, Nikhil Yawlkar, Dagmar Simon, Luca Borradori, Stefan Kuchen, Daniel Yerly, Bernhard Homey, Curdin Conrad, Berend Snijder, Marc Schmidt, Christoph Schlapbach
SCIENCE IMMUNOLOGY
(2019)