Article
Immunology
Pengju Yang, Mei Luan, Weizhe Li, Mengtian Niu, Qiannan He, Yixin Zhao, Jianan Chen, Binyue Mao, Kuanhou Mou, Pan Li
Summary: This study utilized single cell RNA sequencing to investigate the mechanisms of peripheral immune responses in vitiligo patients, identifying differences in transcriptome profiles of various immune cell populations. The findings provide new insights into the pathogenesis of vitiligo and may aid in the identification of potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Xinya Xu, Min Jiang, Chengfeng Zhang, Zhuhui Qiao, Wenjie Liu, Yan Le, Jiaqiang Wu, Wenjuan Ma, Leihong Flora Xiang
Summary: The study revealed similarities in clinical features and immune characteristics between segmental vitiligo and mild-to-moderate nonsegmental vitiligo, while showing significant differences from severe nonsegmental vitiligo. Classifying active vitiligo based on disease extent may be more clinically meaningful for guiding immunomodulatory treatment.
PIGMENT CELL & MELANOMA RESEARCH
(2022)
Article
Dermatology
Engi Seif E. Shaker, Sherihan H. Allam, Maaly M. Mabrouk, Nashwa M. Elgharbawy, Shady Fikry Abdel Salaam
Summary: This study is the first to consider the correlation between lipid disturbances and vitiligo disease activity. The results demonstrate that simvastatin can improve lipid profile and reduce vitiligo activity in patients with non-segmental vitiligo and dyslipidemia.
DERMATOLOGIC THERAPY
(2022)
Article
Multidisciplinary Sciences
Narumol Silpa-archa, Surachanee Likittanasombat, Chalermkwan Apinuntham, Chutipon Pruksaeakanan, Norramon Charoenpipatsin, Chayada Chaiyabutr, Chanisada Wongpraparut
Summary: Bimatoprost ophthalmic solution 0.03% combined with NB-UVB was found to be a safe and effective treatment for non-segmental vitiligo in non-face/neck areas. A study compared the efficacy and safety of combination therapy with NB-UVB phototherapy, bimatoprost monotherapy, and placebo. Significant improvement in VASI score was observed in non-segmental vitiligo patients treated with combination therapy.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Ki-Heon Jeong, Su Kang Kim, Jong-Kil Seo, Min Kyung Shin, Mu-Hyoung Lee
Summary: Non-segmental vitiligo (NSV) is the most common type of vitiligo characterized by the loss of melanocytes. Genetic factors, specifically polymorphisms in the GZMB gene, have been found to be associated with autoimmune diseases and play a role in NSV susceptibility. Several SNPs in the GZMB gene showed significant association with NSV, suggesting a potential link between GZMB polymorphisms and NSV development.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Mazda Farshad, Frederic Cornaz, Jose Miguel Spirig, Reto Sutter, Nadja A. Farshad-Amacker, Jonas Widmer
Summary: The location and cranio-caudal extent of spondylophytes are crucial for their biomechanical effects, and a classification system can help in clinical decision-making. Non-bridging spondylophytes primarily act as tensile structures, while spondylophytes with osseous bridging contribute significantly in most loading conditions.
Article
Medicine, General & Internal
Yildiz Hayran, Gul Ozge Ergen, Fusun Ozmen
Summary: The study revealed that HLA-A*02 increased, HLA-A*11 and HLA-DRB1*01 decreased susceptibility to vitiligo in Turkish patients, along with a potential relationship between HLA and TAC.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Review
Pharmacology & Pharmacy
Jacqueline R. R. Hwang, Marcia S. S. Driscoll
Summary: This review evaluates the pharmacokinetics, efficacy, and safety of topical ruxolitinib for the treatment of nonsegmental vitiligo. The therapy has shown significant improvements in clinical outcomes and has been approved by the FDA as the first treatment for repigmentation in nonsegmental vitiligo. Clinicians should consider the benefits of ruxolitinib as a time-efficient and low-risk alternative to conventional therapies.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Dermatology
Abd El-Aziz Ibrahim El-Taweel, Amira Mohamed Noureldin Abdelrahman, Sarah Sabry, Rehab Mohammed Salem
Summary: This study found that serum levels of TWEAK were significantly higher in vitiligo patients compared to control subjects, with elevated levels in segmental vitiligo. TWEAK showed promising sensitivity and specificity in diagnosing and differentiating vitiligo, indicating its potential role as a therapeutic target in the condition.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Editorial Material
Immunology
Helena Zenedin Marchioro, Caio Cesar Silva de Castro, Aline Salete Turatti Chiesorin, Elaine Weiss Bindi, Isabella Gizzi Jiacomini, Helio Amante Miot
Summary: This study revealed a remarkable prevalence of immune-mediated inner ear disease (IMIED) in adult patients with non-segmental vitiligo (NSV) associated with sensorineural hearing loss (SNHL). The study used audiometry and serological measurement of anti-Hsp70 antibody to evaluate the prevalence of IMIED in NSV patients. The results showed a significant association between SNHL and IMIED in NSV patients, with higher levels of serum anti-Hsp70 antibodies in IMIED cases.
AUTOIMMUNITY REVIEWS
(2023)
Article
Immunology
Meiyu Wu, Lu Wang, Haijing Wu, Ming Yang, Zhenghao He, Yiran Chen, Huiming Zhang
Summary: This study found that Leptin can promote the progression of vitiligo by enhancing the cytotoxic function of CD8(+) T cells. This suggests that Leptin may become a new target for vitiligo treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Marcella Willemsen, Nicoline F. Post, Nathalie O. P. van Uden, Vidhya S. Narayan, Saskia Chielie, E. Helen Kemp, Marcel W. Bekkenk, Rosalie M. Luiten
Summary: Studies have shown differences in immune cell profiles between patients with segmental vitiligo (SV) and non-segmental vitiligo (NSV), with increased systemic immune activation and decreased regulatory T cells in NSV but not in SV. SV patients also show less involvement of B-cell immunity compared to NSV patients. This indicates distinct immune pathways in the pathogenesis of SV and NSV.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Dermatology
Ariela A. Souroujon, Ilana Guttman, Nathalie Levin, Galia Capuano, Cesar Alejandro Reyes Salcedo, Paulina Garcia
Summary: This systematic review analyzes the effectiveness of autologous cell transplant as a therapeutic approach for stable segmental vitiligo. Autologous cell transplant has emerged as a promising modality for managing vitiligo, with cultivated cells having better results. This review highlights the importance of autologous cell transplant as a new and reliable tool for the treatment of stable segmental vitiligo.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Immunology
Kaiqiao He, Wei Wu, Xinju Wang, Wei Dai, Sijia Wang, Chunying Li, Shuli Li
Summary: This study found that serum levels of S100B, S100A9, and HMGB1 may serve as biomarkers for diagnosing and assessing the activity/severity of non-segmental vitiligo (NSV). The combination of these markers can improve the accuracy of diagnosis and assessment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Physics, Multidisciplinary
Qiuxia Sun, Yu Zhang, Lu Sun, Qing Li, Peng Gao, Hao He
Summary: This study classifies and analyzes the traffic performance characteristics of urban trunk roads to assist travelers in avoiding peak hours and congested routes, as well as to help traffic managers develop refined management strategies. The research reveals that trunk roads generally have good conditions, with weekends showing better traffic conditions overall compared to weekdays. Significant differences exist in the change trajectory of TPI data and spatial distribution among different types of trunk roads.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2021)