Article
Health Care Sciences & Services
Dmitry A. Verbenko, Arfenya E. Karamova, Olga G. Artamonova, Dmitry G. Deryabin, Alexander Rakitko, Alexandr Chernitsov, Anna Krasnenko, Artem Elmuratov, Victoria S. Solomka, Alexey A. Kubanov
Summary: The study on apremilast treatment for plaque psoriasis patients revealed genetic associations with treatment outcomes, suggesting potential for predictive modeling in targeted therapy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Anja Linde, Eva Gerdts, Kare Steinar Tveit, Ester Kringeland, Helga Midtbo
Summary: Psoriasis patients on infliximab treatment had a lower prevalence of cardiac organ damage compared to controls, and hypertension was identified as the major covariable for subclinical cardiac organ damage in psoriasis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zi-Tong Chen, Rong-Fen Chen, Xiao-Long Li, Qiao Wang, Wei-Wei Ren, Dan-Dan Shan, Yu-Jing Zhao, Li-Ping Sun, Hui-Xiong Xu, Yu-Ling Shi, Le-Hang Guo
Summary: Objective is to identify patients in the subclinical psoriatic arthritis (Sub-PsA) phase by ultrasound (US) and provide a solution to screen them.
EUROPEAN RADIOLOGY
(2023)
Article
Cell Biology
Chih-Jung Chang, Jing Zhang, Yu-Ling Tsai, Chun-Bing Chen, Chun-Wei Lu, Yu-Ping Huo, Huey-Ming Liou, Chao Ji, Wen-Hung Chung
Summary: The study revealed differences in the bacterial communities within plasma-derived extracellular vesicles (EVs) of patients with moderate to severe psoriasis compared to healthy controls, showcasing a lower diversity and richness in the psoriasis group. Specific amplicon sequence variant (ASV) alterations were observed according to health conditions, with distinct taxonomic differences between groups. This suggests that plasma EVs could serve as an indicator for assessing the microbiome composition of psoriasis patients.
Article
Medicine, Research & Experimental
April W. Armstrong, Timothy Fitzgerald, Robert R. McLean, Amanda Teeple, Jonathan P. Uy, Mobolaji Olurinde, Katelyn Rowland, Lin Guo, Ying Shan, Kristina Callis Duffin
Summary: Prior studies have shown that guselkumab improves disease activity and patient-reported outcomes in patients with moderate-to-severe plaque psoriasis. However, the real-world effectiveness of guselkumab in different subgroups (such as body mass index categories) is still an active area of research.
ADVANCES IN THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Cristina Membrive-Jimenez, Cristina Perez-Ramirez, Salvador Arias-Santiago, Antonio Giovanni Richetta, Laura Ottini, Laura Elena Pineda-Lancheros, Maria del Carmen Ramirez-Tortosa, Alberto Jimenez-Morales
Summary: This study evaluated the influence of single-nucleotide polymorphisms on the drug survival of biological therapies in patients with moderate-to-severe psoriasis. The results suggest that SNPs in the HLA-C, TNF, TLR5, CD84, PDE3A, and SLCO1C1 genes may serve as biomarkers for drug survival, enabling personalized medicine and improving patient quality of life while reducing healthcare costs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Pablo Coto-Segura, Cristina Segu-Verges, Antonio Martorell, David Moreno-Ramirez, Guillem Jorba, Valentin Junet, Filippo Guerri, Xavier Daura, Baldomero Oliva, Carlos Cara, Olaya Suarez-Magdalena, Sonya Abraham, Jose Manuel Mas
Summary: This study used computational modeling to investigate the response variability of moderate-to-severe psoriasis patients to CZP treatment. By generating virtual populations and simulating different dosing regimens, the researchers identified drug efficacy differences in diverse subpopulations and revealed mechanisms of action for different dosing schemes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qian Li, Ju Qiao, Hongzhong Jin, Benchao Chen, Zhimei He, Guoqin Wang, Xiang Ni, Max Wang, Michelle Xia, Baiyong Li, Rui Chen, Pei Hu
Summary: This study characterized the PK/PD of AK111 in Chinese moderate-to-severe plaque psoriasis patients. The results showed that AK111 has similar PK characteristics to typical IgG1 antibodies and inhibits the formation of psoriatic plaques. The findings can provide reference for further clinical development and dosage optimization.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Ran Pan, Xiaolun Wang, Min Shu, Jaydeep Das, Manik Kalra, Zhidong Wang
Summary: The efficacy of SEC in the treatment of patients with moderate-to-severe plaque psoriasis is well demonstrated through NMA.
CHINESE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Cristina Membrive-Jimenez, Sayleth Vieira-Maroun, Noelia Marquez-Pete, Yasmin Cura, Cristina Perez-Ramirez, Jesus Tercedor-Sanchez, Alberto Jimenez-Morales, Maria del Carmen Ramirez-Tortosa
Summary: This study found that polymorphisms in ABCC1, ABCG2, and FOXP3 genes are associated with the development of MTX toxicity in PS patients. These polymorphisms may serve as biomarkers for predicting toxicity risk in MTX treatment.
Article
Dermatology
Alexa B. Kimball, Lyn Guenther, Sunil Kalia, Elke M. G. J. de Jong, Kimberly Parnell Lafferty, Dan Y. Chen, Wayne Langholff, Neil H. Shear
Summary: This cohort study reported pregnancy outcomes among women with psoriasis in the Psoriasis Longitudinal Assessment and Registry (PSOLAR), with most pregnancies associated with biologic exposure having similar outcomes to those without biologic exposure.
Article
Dermatology
R. Curmin, S. Guillo, Y. De Rycke, H. Bachelez, M. Beylot-Barry, N. Beneton, O. Chosidow, A. Dupuy, P. Joly, D. Jullien, M. A. Richard, M. Viguier, E. Sbidian, C. Paul, E. Mahe, F. Tubach
Summary: This study described the switching patterns of biologic treatments and showed how they changed over time, particularly with the availability of new biologic agents.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Multidisciplinary Sciences
Mohammad Esmaeil Barbati, Frank Hildebrand, Hagen Andruszkow, Rolf Lefering, Michael J. Jacobs, Houman Jalaie, Alexander Gombert
Summary: This study examines the etiology, frequency, and impact of abdominal vascular injuries in polytrauma patients, highlighting the potentially underestimated significance of venous injuries. Venous trauma was associated with higher in-hospital mortality compared to arterial injuries, emphasizing the importance of further investigation and assessment in patients with suspected abdominal vascular injuries.
SCIENTIFIC REPORTS
(2021)
Review
Health Care Sciences & Services
Cristina Membrive Jimenez, Cristina Perez Ramirez, Almudena Sanchez Martin, Sayleth Vieira Maroun, Salvador Antonio Arias Santiago, Maria del Carmen Ramirez Tortosa, Alberto Jimenez Morales
Summary: Biopharmaceutical treatments for moderate-to-severe psoriasis can vary in effectiveness and toxicity among individual patients, suggesting the potential for personalized treatment approaches in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Dermatology
Mie S. Liljendahl, Nikolai Loft, Tri-Long Nguyen, Lone Skov, Alexander Egeberg
Summary: This study provides the first estimation of the proportion of patients with moderate-to-severe psoriasis in Denmark who are eligible for systemic therapy but do not receive it. The results showed that a large number of patients with moderate-to-severe psoriasis are candidates for systemic therapy but do not receive it. Furthermore, the study found that the time on conventional systemic therapy has become shorter and more patients are initiating biologics as second-line therapy.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Oncology
Helena Tufvesson Stiller, Rasmus Mikiver, Srinivas Uppugunduri, Marcus Schmitt-Egenolf
Summary: This study investigates how Swedish melanoma patients perceive information provided in routine clinical practice and explores the correlation between satisfaction with information, symptoms and functioning scales, and quality of life. The results show that patients lack sufficient information and age affects the perception of it. It is of utmost importance to tailor the information to suit the individual needs of a given patient, as satisfaction with the information received correlates with the patient's well-being.
Article
Dermatology
Sofia Lofvendahl, Jenny M. Norlin, Marcus Schmitt-Egenolf
Summary: This study estimated the prevalence and incidence of generalized pustular psoriasis (GPP) in the Swedish general population, as well as the prevalence of psoriasis vulgaris within the GPP population. The results indicated that the estimated GPP population in Sweden falls within the range of previous estimates, but the estimates were sensitive to the criteria used to define GPP cases.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Sofia Lofvendahl, Jenny M. Norlin, Marcus Schmitt-Egenolf
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Dermatology
Sofia Lofvendahl, Jenny M. Norlin, Marcus Schmitt-Egenolf
Summary: The economic burden of palmoplantar pustulosis, a chronic relapsing skin condition commonly occurring with psoriasis vulgaris, was estimated in this study. Using data from Swedish registers, healthcare resource use for patients with palmoplantar pustulosis was compared with controls from the general population and patients with psoriasis vulgaris. The study found higher costs for patients with palmoplantar pustulosis compared to the general population, and identified comorbidity burden in palmoplantar pustulosis.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Dermatology
Jenny M. Norlin, Sofia Lofvendahl, Marcus Schmitt-Egenolf
Summary: This study analyzed the treatment response of IL-17/IL-23 inhibitors in clinical practice for patients with psoriasis and the proportions of patients who reached the treatment targets of PASI <3 and DLQI <=5. The results showed that 66% of patients achieved both targets, 23% achieved one target, and 11% did not achieve any target, with no statistically significant difference in treatment outcomes between IL-17 and IL-23 inhibitor treatment groups.
Article
Endocrinology & Metabolism
Kristoffer Nilsson, Emelie Andersson, Sofie Persson, Kristina Karlsdotter, Josefin Skogsberg, Staffan Gustavsson, Johan Jendle, Katarina Steen Carlsson
Summary: This study performed a model-based analysis to evaluate the health benefits and costs of increased implementation of empagliflozin for people with type 2 diabetes and established cardiovascular disease in Sweden. The results indicated that the broader implementation of empagliflozin would lead to further benefits, such as increased life years gained and reduced incidence of cardiovascular deaths and heart failures, even in the short term.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Sofie Persson, Kristoffer Nilsson, Kristina Karlsdotter, Josefin Skogsberg, Staffan Gustavsson, Johan Jendle, Katarina Steen Carlsson
Summary: This study aimed to assess the impact of established cardiovascular disease (eCVD) on hospital-based care, work absence, associated costs, and mortality in patients with type 2 diabetes. The results showed that eCVD posed a significant burden on both individuals with type 2 diabetes and society, highlighting the importance of efficient management to reduce risks and delay onset.
DIABETES OBESITY & METABOLISM
(2023)
Article
Dermatology
Sofia Lofvendahl, Jenny M. Norlin, Marcus Schmitt-Egenolf
Summary: This study compared the comorbidity burden of Swedish patients with palmoplantar pustulosis (PPP) with the general population and patients with psoriasis vulgaris (PV). The results showed a significantly higher comorbidity burden in PPP patients compared to the general population, with increased odds for diseases in different categories (metabolic, cerebrovascular, cardiovascular, psychiatric). Although PPP and PV patients had similar overall comorbidity burdens, the comorbidity profiles differed significantly. Comorbidities such as type 2 diabetes and chronic obstructive pulmonary disorder, which had a high prevalence (> 5%) in PPP and higher odds than PV, may be of particular importance for the specific comorbidity burden of PPP.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Oncology
Helena Tufvesson Stiller, Marcus Schmitt-Egenolf, Helena Fohlin, Srinivas Uppugunduri
Summary: A nationwide survey in Sweden examined the experiences of cancer patients during the Covid-19 pandemic. The study found that fewer patients visited health services, but those who did seek help had similar experiences. Waiting times were shorter and emotional support improved, but support for significant others declined. Most patients received their results in a meeting with their physician, but there was an increasing interest in receiving results by phone.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Endocrinology & Metabolism
Katarina Steen Carlsson, Mads Faurby, Kristoffer Nilsson, Michael Lyng Wolden
Summary: Individuals with type 2 diabetes are at high risk of developing atherosclerotic cardiovascular disease (ASCVD), which brings significant costs, morbidity, and mortality. The study supports the structured assessment of ASCVD risk in these patients and the broader implementation of guideline-recommended treatments.
Editorial Material
Medicine, General & Internal
Marcus Schmitt-Egenolf
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dermatology
Sofia Lofvendahl, Jenny M. Norlin, Oskar Ericson, Malin Hanno, Marcus Schmitt-Egenolf
Summary: This study analyzed the sick leave situation in patients with generalized pustular psoriasis and found that the number of sick leave days was significantly higher in these patients compared to the control groups. The study also indicated that the sick leave days were already higher prior to diagnosis, suggesting delayed diagnosis and/or a comorbidity burden.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Cardiac & Cardiovascular Systems
Katarina Steen Carlsson, Kristoffer Nilsson, Michael Lyng Wolden, Mads Faurby
Summary: This study aims to investigate the direct and indirect costs, early retirement, cardiovascular events, and mortality in people with atherosclerotic cardiovascular disease (ASCVD) and matched controls over a 5-year period in Sweden. The results showed that individuals with ASCVD had significantly higher costs compared to the controls, with indirect costs and inpatient admissions being major cost drivers. ASCVD patients were also more likely to experience additional ASCVD events, such as stroke and myocardial infarction, and enter early retirement.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Katarina Steen Carlsson, Mads Faurby, Kristoffer Nilsson, Michael Lyng Wolden
Summary: This study aimed to examine the impact of chronic heart failure (CHF) on cardiovascular events, mortality, early retirement, and economic costs in Sweden. The results showed that individuals with CHF had a higher risk of stroke, myocardial infarction, mortality, and early retirement compared to the control group. The study also found that inpatient admissions and work absence were major contributors to the economic costs associated with CHF.
Article
Medicine, General & Internal
Jenny M. Norlin, Sofia Loefvendahl, Marcus Schmitt-Egenolf, Stamatis Gregoriou, Emmanuel Andres
Summary: This study investigated the influence of socioeconomic factors on access to biologics for psoriasis. The findings showed that, after adjusting for disease severity and lifestyle factors, the higher-income group had better access to biologics compared to the middle-income group.
JOURNAL OF CLINICAL MEDICINE
(2023)
