Article
Oncology
S. Morteza Seyed Jafari, Flavia Folini-Huesser, Simone Cazzaniga, Robert E. Hunger
Summary: The study aimed to investigate the long-term efficacy of imiquimod 5% cream for the management of lentigo maligna (LM), with a focus on disease recurrence and prognostic factors of disease-free survival (DFS). If surgical excision is not possible due to age/comorbidities or critical cosmetic localization, imiquimod could provide optimal outcomes with a low risk of relapse.
Article
Dermatology
Cristian Navarrete-Dechent, Saud Aleissa, Karen Connolly, Brian P. Hibler, Stephen W. Dusza, Anthony M. Rossi, Erica Lee, Kishwer S. Nehal
Summary: This study evaluated the association between clinical size of lentigo maligna (LM) and invasion, finding that the clinical area of LM correlated with the margin needed for complete removal. However, due to limitations such as referral bias, invasion in LM cannot be accurately estimated based on clinical area alone.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Review
Dermatology
Silvia Vaienti, Paolo Calzari, Gianluca Nazzaro
Summary: Topical imiquimod may be a therapeutic option for the treatment of melanoma in situ and lentigo maligna melanoma, but further evidence from controlled studies is needed.
DERMATOLOGY AND THERAPY
(2023)
Article
Dermatology
Lilian K. F. L. Rocha, Ricardo E. Vilain, Richard A. Scolyer, Serine N. Lo, Martin Drummond, Phoebe Star, Gerald B. Fogarty, Angela M. Hong, Pascale Guitera
Summary: A retrospective analysis was conducted on AIMP lesions at two melanoma centers between 2005 and 2015, with 34 patients included. Predictors of subsequent MIS included certain DS and RCM features, while clinical predictors of worse outcome included previous history of MIS at the same site. Non-surgical treatment had a high failure rate for AIMP, with recommendations for close monitoring and treatment based on specific features identified in DS and RCM. Early surgery is recommended for MIS cases that recur as AIMP, despite the small number of patients in the study.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
J. Zoutendijk, S. Koljenovic, M. Wakkee, A. L. Mooyaart, T. Nijsten, R. R. van den Bos
Summary: This study investigated the use of clinical and dermoscopic mapping to increase the detection rate of lentigo maligna melanoma (LMM). The results showed that 8.6% of biopsy-proven LM were actually LMM, and the clinical guidance of dermatologists did not increase the detection rate of LMM.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Anouk Soenen, Morgane Vourc'h, Amir Khammari, Jean-Michel Nguyen, Celine Bossard, Marie Denis Musquer, Beatrice Vergier, Brigitte Dreno
Summary: The study demonstrates that Imiquimod treatment can significantly improve the condition of lentigo maligna (LM), and reflectance confocal microscopy (RCM) is an effective method for assessing the treatment response.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Emi Dika, Martina Lambertini, Annalisa Patrizi, Cosimo Misciali, Federica Scarfi, Giovanni Pellacani, Victor Desmond Mandel, Francesca Di Tullio, Ignazio Stanganelli, Johanna Chester, Shaniko Kaleci, Daniela Massi, Vincenzo De Giorgi, Elisa Cinotti, Pietro Rubegni, Jean Luc Perrot, Francesca Farnetani
Summary: The study aims to identify dermatoscopic features associated with folliculotropism in LMs/LMMs. Grey circles may indicate folliculotropism in LM lesions, while light/dark brown pseudonetwork and light brown structureless areas in LMMs may indicate diffuse distribution of malignant melanocytes in the follicular units.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Dermatology
R. Kwak, C. Joyce, A. E. Werchniak, J. Y. Lin, H. C. Tsibris
Summary: Adjuvant imiquimod treatment can reduce LM recurrence rates in cases with background melanocytic dysplasia or close margins. Positive surgical margins are associated with decreased clinical clearance, while the presence of an inflammatory response during treatment is associated with increased clearance. Close clinical follow-up is necessary for LM cases with positive surgical margins due to higher recurrence rates.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Oncology
Yannick S. Elshot, Biljana Zupan-Kajcovski, Wouter Ouwerkerk, W. Martin C. Klop, Peter J. F. M. Lohuis, Mijke Bol, Marianne B. Crijns, Marcel. W. Bekkenk, Menno A. de Rie, Alfons J. M. Balm
Summary: This study retrospectively reviewed the clinical characteristics and prognostic outcomes of 345 patients with cutaneous head and neck melanoma. The results showed that head and neck melanoma subtype had lower Breslow thickness, higher diagnostic sampling errors, and increased risk of local recurrence compared to non-head and neck melanoma. However, the subtype did not independently affect survival after considering other variables such as patient age and Breslow thickness.
Article
Oncology
Patrick O. Emanuel, Rajan Patel, Jonathan Zwi, Du Cheng, Mark Izzard
Summary: Intraoperative frozen section margin assessment is effective in treating head and neck lentigo maligna, achieving clearance rates similar to Mohs surgery.
Article
Dermatology
Mai P. Hoang, Pawel Karpinski, Miguel Zuniga-Castillo, Ruth K. Foreman, Kevin S. Emerick, Arthur J. Sober
Summary: Histologic margin status is the strongest predictor of progression for lentigo maligna melanoma. Patients with positive or close/<3 mm histologic margins should consider a re-excision due to the increased risk of relapse.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Dermatology
Magdalena Misiak-Galazka, Joanna Czuwara, Adam Galazka, Anna Czaplicka, Lidia Rudnicka
Summary: This article presents a case where interval treatment with topical imiquimod was implemented for severe inflammatory response in a patient with lentigo maligna. The treatment resulted in total clearance of the lesion without relapse during a 2-year follow-up.
DERMATOLOGY AND THERAPY
(2022)
Review
Dermatology
Ajay N. Sharma, Delila P. Foulad, Linda Doan, Patrick K. Lee, Natasha Atanaskova Mesinkovska
Summary: This study compares the efficacy of Mohs micrographic surgery (MMS) with traditional surgical and nonsurgical therapies for lentigo maligna (LM) and lentigo maligna melanoma (LMM). Results indicate that MMS has a lower recurrence rate compared to other treatment options, making it a successful choice for these conditions. Further clinical trials are needed to better understand the role of MMS in the treatment algorithm for LM and LMM.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Review
Dermatology
Tatiana Abrantes, Allison Robbins, Benjamin Kahn, Sara Yumeen, R. Scott Bukoski, Oliver Wisco, Leslie Robinson-Bostom, John Kawaoka, Tiffany Libby, Hayley Goldbach, Dillon Imbriano, Leonardo Lizbinski, Megan Tran, Samer Wahood, Aakash Mehta, Thomas Miner
Summary: This study comprehensively defines and describes the surgical techniques used to treat MMIS-LM and discusses the advantages and disadvantages of each technique. The results highlight the importance of understanding the methodology and terminology for these surgical procedures and tissue processing methods in order to provide optimal patient care.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Dermatology
Julia Eckardt, Victoria Behrens, Katrin Kofler, Stephan Forchhammer, Hans-Martin Haefner, Lukas Kofler
Summary: This study investigated the haematoxylin-eosin staining and immunohistochemistry of tumour margins in lentigo maligna melanoma and lentigo maligna. The additional use of immunohistochemistry reduced the risk of local recurrence after micrographic-controlled surgery.
EUROPEAN JOURNAL OF DERMATOLOGY
(2022)