Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen

Determination of clinically therapeutic endoxifen concentrations based on efficacy from human MCF7 breast cancer xenografts

(2013) Inna Y. Gong et al.   BREAST CANCER RESEARCH AND TREATMENT

CYP2D6 Genotype Should Not Be Used for Deciding About Tamoxifen Therapy in Postmenopausal Breast Cancer

(2013) James M. Rae et al.   JOURNAL OF CLINICAL ONCOLOGY

Concordance Between CYP2D6 Genotypes Obtained From Tumor-Derived and Germline DNA

(2013) James M. Rae et al.   JNCI-Journal of the National Cancer Institute

The use of the 13C-dextromethorphan breath test for phenotyping CYP2D6 in breast cancer patients using tamoxifen: association with CYP2D6 genotype and serum endoxifen levels

(2012) F. L. Opdam et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Individualization of Tamoxifen Treatment for Breast Carcinoma

(2012) L Binkhorst et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Tamoxifen Use in Postmenopausal Breast Cancer: CYP2D6 Matters

(2012) Hiltrud Brauch et al.   JOURNAL OF CLINICAL ONCOLOGY

CYP2D6 and UGT2B7 Genotype and Risk of Recurrence in Tamoxifen-Treated Breast Cancer Patients

(2012) James M. Rae et al.   JNCI-Journal of the National Cancer Institute

CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women with Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial

(2012) Meredith M. Regan et al.   JNCI-Journal of the National Cancer Institute

Physiologically based pharmacokinetic modeling of tamoxifen and its metabolites in women of different CYP2D6 phenotypes provides new insight into the tamoxifen mass balance

(2012) Kristin Josefine Ruth Dickschen   Frontiers in Pharmacology

Prediction-Corrected Visual Predictive Checks for Diagnosing Nonlinear Mixed-Effects Models

(2011) Martin Bergstrand et al.   AAPS Journal

Activity Levels of Tamoxifen Metabolites at the Estrogen Receptor and the Impact of Genetic Polymorphisms of Phase I and II Enzymes on Their Concentration Levels in Plasma

(2011) T E Mürdter et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Tamoxifen Metabolite Concentrations, CYP2D6 Genotype, and Breast Cancer Outcomes

(2011) L Madlensky et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Development and validation of a quantitative assay for the determination of tamoxifen and its five main phase I metabolites in human serum using liquid chromatography coupled with tandem mass spectrometry

(2011) S.F. Teunissen et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Dextromethorphan As a Phenotyping Test to Predict Endoxifen Exposure in Patients on Tamoxifen Treatment

(2011) Anne-Joy M. de Graan et al.   JOURNAL OF CLINICAL ONCOLOGY

Genotype-Guided Tamoxifen Dosing Increases Active Metabolite Exposure in Women With Reduced CYP2D6 Metabolism: A Multicenter Study

(2011) William J. Irvin et al.   JOURNAL OF CLINICAL ONCOLOGY

Assessment of Activity Levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 Genes by Population Pharmacokinetics of Dextromethorphan

(2010) K Abduljalil et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Endoxifen, a New Cornerstone of Breast Cancer Therapy: Demonstration of Safety, Tolerability, and Systemic Bioavailability in Healthy Human Subjects

(2010) A Ahmad et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Piraña and PCluster: A modeling environment and cluster infrastructure for NONMEM

(2010) Ron J. Keizer et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE

Simultaneous quantification of dextromethorphan and its metabolites dextrorphan, 3-methoxymorphinan and 3-hydroxymorphinan in human plasma by ultra performance liquid chromatography/tandem triple-quadrupole mass spectrometry

(2010) Walter J. Loos et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Impaired Tamoxifen Metabolism Reduces Survival in Familial Breast Cancer Patients

(2008) W. G. Newman et al.   CLINICAL CANCER RESEARCH

Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: The npde add-on package for R

(2008) Emmanuelle Comets et al.   COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE