Identifying the translational gap in the evaluation of drug-induced QTcinterval prolongation

Assessing the Probability of Drug-Induced QTc-Interval Prolongation During Clinical Drug Development

(2011) A S Y Chain et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Comparison of 5 methods of QT interval measurements on electrocardiograms from a thorough QT/QTc study: effect on assay sensitivity and categorical outliers

(2011) Vaibhav Salvi et al.   JOURNAL OF ELECTROCARDIOLOGY

Heart rate correction models to detect QT interval prolongation in novel pharmaceutical development

(2011) Michael Markert et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Investigating dynamic protocol-dependence of hERG potassium channel inhibition at 37°C: Cisapride versus dofetilide

(2010) James T. Milnes et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

A pharmacokinetic–pharmacodynamic model for cardiovascular safety assessment of R1551

(2010) Angèle Fleury et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Assessment of QTc-prolonging potential of BX471 in healthy volunteers. A ‘thorough QTcstudy’ following ICH E14 using various QT correction methods

(2009) Marc Vandemeulebroecke et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Simultaneous optimal experimental design on dose and sample times

(2009) Joakim Nyberg et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Thorough QT/QTc Study in Patients With Advanced Parkinson's Disease: Cardiac Safety of Rotigotine

(2008) M Malik et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research

(2008) M DANHOF et al.   TRENDS IN PHARMACOLOGICAL SCIENCES