Article
Multidisciplinary Sciences
Esra'a Samara, Zaher Nazzal, Shayma Naghnaghia, Rowa' AL-Ramahi
Summary: This study investigated the prevalence of potentially inappropriate medication (PIM) and its associated factors among elderly patients attending primary health care clinics in the West Bank. The results showed that over one-third of the participants were using PIM, with polypharmacy and diabetes being the main predicting variables.
Article
Public, Environmental & Occupational Health
Tzvetan Krustev, Petya Milushewa, Konstantin Tachkov, Konstantin Mitov, Guenka Petrova
Summary: This study evaluates the use of STOPP/START criteria in identifying potentially inappropriate medication and potential prescribing omissions in older patients with cardiovascular diseases in Bulgaria. The study finds a high percentage of potentially inappropriate medication among older patients receiving polypharmacy.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Raquel Diez, Raquel Cadenas, Julen Susperregui, Ana M. Sahagun, Nelida Fernandez, Juan J. Garcia, Matilde Sierra, Cristina Lopez
Summary: Inappropriate prescribing in the elderly is a risk factor for adverse drug reactions, hospitalization, and mortality. This study aimed to examine and compare the prevalence of potentially inappropriate medications in nursing home residents and determine the prevalence of potential prescribing omissions. The results showed that benzodiazepines and proton pump inhibitors were the most frequent inappropriate medications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Huanyu Zhang, Eliza L. Y. Wong, Eng-kiong Yeoh, Bosco H. M. Ma
Summary: The study developed a Hong Kong-specific PIM assessing tool based on published criteria and verified it through a modified Delphi method. The final PIM list included 164 statements applicable to older adults, serving as a measure to improve local prescribing quality. Further research should validate its impact on health outcomes in clinical settings.
Article
Environmental Sciences
Kyungwon Yoon, Jung-Tae Kim, Won-Gun Kwack, Donghyun Kim, Kyung-Tae Lee, Seungwon Yang, Sangmin Lee, Yeo-Jin Choi, Eun-Kyoung Chung
Summary: This study found that DPIMs were commonly used in elderly patients with dementia in Korea, with benzodiazepines being the most frequently prescribed. Female patients using polypharmacy with multiple comorbidities should be closely monitored to minimize unnecessary DPIM use.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Yuping Wang, Jie Zhu, Luchen Shan, Ling Wu, Cunchuan Wang, Wah Yang
Summary: This study investigated the occurrence and risk factors of potentially inappropriate medications (PIM) in older diabetic kidney disease (DKD) patients during hospitalization, and explored the association with polypharmacy. The results showed that PIM was common during hospitalization and that polypharmacy was an independent risk factor for PIM.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gerontology
Lesley Charles, Elena Kumar, Eimad Elghol, Bonnie Dobbs, Peter George Jaminal Tian, Oksana Babenko
Summary: This study investigated the prevalence of potentially inappropriate medication (PIM) use among elderly patients, finding rates of 45% and 57.3% at two different clinics. A substantial portion of patients had at least one medication stopped or modified, suggesting a need for increased physician awareness in order to reduce PIM use further.
CANADIAN JOURNAL ON AGING-REVUE CANADIENNE DU VIEILLISSEMENT
(2022)
Article
Pharmacology & Pharmacy
Ying Zhang, Zhaoyan Chen, Fangyuan Tian
Summary: The study found a high prevalence of potentially inappropriate medications among older Chinese outpatients, with the Chinese criteria having a higher detection rate than the Beers criteria. The main risk factors for potentially inappropriate medication use in older patients include age, number of diseases, and number of medications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Monira Alwhaibi, Bander Balkhi
Summary: This study examines the gender-based variation in prescribing potentially inappropriate medication (PIM) among older adults in Saudi Arabia. The results show that older women have a higher prevalence of PIM utilization compared to men, and women tend to use cardiovascular and gastrointestinal drugs more frequently.
Article
Medicine, General & Internal
Ebony King, Mohsen Bazargan, Nana Entsuah, Sayaka W. W. Tokumitsu, Cheryl Wisseh, Edward K. K. Adinkrah
Summary: This study aimed to investigate the prevalence of potentially inappropriate medication (PIM) use among underserved older Latino adults. The results showed that one-third of the participants had at least one use of PIM, over half of the sample had polypharmacy, and 46% of the sample took drugs to be used with caution. Regression analysis revealed that PIM use was associated with the number of prescription medications, chronic conditions, sleep difficulty, lack of access to primary care, financial strain, and poor self-rated health.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Aslinur Albayrak, Halil Demirbas
Summary: This study investigated the use of multiple medications and potentially inappropriate medications (PIMs) among elderly patients in a community pharmacy in Turkey, as well as the medication regimen complexity. The results showed that many elderly patients had polypharmacy and were using PIMs, highlighting the need for pharmacist intervention to reduce inappropriate medication use.
Article
Pharmacology & Pharmacy
Fangyuan Tian, Zhaoyan Chen, Rui Tang, Qiyi Feng, Fengbo Wu
Summary: Objectives: This study aimed to evaluate the long- and short-term effects of an expert consensus on the prevalence of polypharmacy and potentially inappropriate medication (PIM) use in elderly lung cancer patients with multimorbidity. The results showed that although the prevalence of polypharmacy decreased after the publication of the expert consensus, the trend of polypharmacy remained upward. The prevalence of PIM use decreased abruptly after the intervention but still showed an upward long-term trend.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Lina Tao, Xiaoyu Qu, Huan Gao, Jinghui Zhai, Yueming Zhang, Yanqing Song
Summary: This study aimed to investigate the prevalence of polypharmacy and potentially inappropriate medications (PIMs) in older inpatients. Findings showed that 91.58% of patients were taking 5 or more medications simultaneously, with 30.08% of patients being subjected to one or more PIMs. Hyperpolypharmacy and older age were identified as independent factors associated with PIM use.
Review
Public, Environmental & Occupational Health
Bastiaan T. G. M. Sallevelt, Toine C. G. Egberts, Corlina J. A. Huibers, Jimmy Ietswaart, A. Clara Drenth-van Maanen, Emma Jennings, Cian O'Mahony, Katharina Tabea Jungo, Martin Feller, Nicolas Rodondi, Francois-Xavier Sibille, Anne Spinewine, Eugene P. van Puijenbroek, Ingeborg Wilting, Wilma Knol
Summary: The study aimed to assess the detectability of medication errors (MEs) with a STOPP/START-based in-hospital medication review in older people with polypharmacy and multimorbidity prior to a potentially preventable drug-related hospital admission (DRA). The results showed that a significant portion of MEs were not detectable during the medication review, and the recommendations made during the review were not implemented.
Article
Medicine, General & Internal
Henrik Rudolf, Ulrich Thiem, Kaysa Aust, Dietmar Krause, Renate Klaassen-Mielke, Wolfgang Greiner, Hans J. Trampisch, Nina Timmesfeld, Petra Thuermann, Eike Hackmann, Tanja Barkhausen, Ulrike Junius-Walker, Stefan Wilm
Summary: The RIME trial aimed to investigate whether special training and the use of the PRISCUS card could reduce the occurrence of potentially inappropriate medications and undesired drug-drug interactions in elderly patients in primary care. However, the results showed that these interventions did not significantly lower the percentage of patients with PIM or DDI.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Li-Nien Chien, Yi-Fan Li, Rong-Sen Yang, Tsung-Han Yang, Yi-Han Chen, Wei-Jia Huang, Hsin-Yi Tsai, Chun-Yi Li, Ding-Cheng Chan
Summary: This study compared the clinical outcomes and health resource use between hip fracture patients receiving hospital-based FLS care and those receiving UC in Taiwan. Results showed that the FLS group exhibited better trends in certain indicators during the 2-year follow-up.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Geriatrics & Gerontology
Jaw-Shiun Tsai, San-Yuan Wang, Chin-Hao Chang, Chin-Ying Chen, Chiung-Jung Wen, Guan-Yuan Chen, Ching-Hua Kuo, Y. Jane Tseng, Ching-Yu Chen
Summary: Through analyzing plasma metabolites in elderly and young adult groups, traumatic acid was identified as a potential plasma biomarker of sarcopenia, with concentrations positively correlated with sarcopenia and related factors. Further studies are needed to validate the results and explore underlying mechanisms.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Geriatrics & Gerontology
Yi-Chun Chou, Hsiao-Hui Tsou, Ding-Cheng Derrick Chan, Chiung-Jung Wen, Feng-Ping Lu, Kun-Pei Lin, Meng-Chen Wu, Yung-Ming Chen, Jen-Hau Chen
Summary: This study translated the Clinical Frailty Scale (CFS) into traditional Chinese (CFS-C) and evaluated its reliability and validity in a geriatric population in Taiwan. The results showed that CFS-C had acceptable validity and reliability and was correlated with other geriatric assessments.
Article
Toxicology
Yao-Pang Chung, Te- Weng, Ding-Cheng Chan, Rong-Sen Yang, Shing-Hwa Liu
Summary: This study found that TBT exposure can induce human chondrocyte senescence and accelerate mouse articular cartilage aging. TBT affects signaling pathways and has an impact on cell secretory phenotype, leading to changes in protein expression and mRNA expression.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Immunology
Yi-Chia Huang, Hsiao-Chen Tu, Han-Yueh Kuo, Pei-Lan Shao, Yu-Nong Gong, Hui-Ying Weng, Hung -Yu Shu, Chiung-Hui Kuo, Po-Hsien Kuo, Chien -Hui Chien, Chen-Chi Wu, Ding-Cheng (Derrick) Chan, Meng-Kun Tsai, Shih-Feng Tsai, Chong-Jen Yu
Summary: This case study investigated an outbreak in a COVID-19-designated hospital and a hospital-based skilled nursing facility. The analysis of PCR tests and other studies revealed multiple clusters of COVID-19 infections, suggesting the potential for airborne transmission.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Chirn-Bin Chang, Rong-Sen Yang, Wei-Jia Huang, Yi-Chun Chou, Chiung-Jung Wen, Ting-Chun Huang, Ming-Chang Chen, Ding-Cheng Chan
Summary: This study investigates whether there are urban-rural differences in refracture, mortality, prescription pattern, and associated factors of vertebral fractures after receiving assistance from an FLSs. The results show that the mortality rate is higher in the rural group, but there is no urban-rural difference in the 1-year refracture rate. The types of osteoporosis medications prescribed for both groups are similar, but participants in the rural group are less likely to change their medications and have lower adherence rate. Rating: 8 points.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Tsung-Han Yang, Chen-Yu Wang, Shau-Huai Fu, Ding-Cheng Chan, Ho-Min Chen, Jou-Wei Lin, Chun-Feng Huang, Jen-Jia Yang, Chih-Hsing Wu, Jawl-Shan Hwang, Rong-Sen Yang
Summary: This study investigated the 11-year trend during the adjustment period of the National Health Insurance reimbursement, and found that there was an immediate drop in the prescription of osteoporosis medications after the implementation of a new policy, which took 5 years to recover to the previous level.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Chen-Yu Wang, Tsung-Han Yang, Shau-Huai Fu, Jawl-Shan Hwang, Ho-Min Chen, Jou-Wei Lin, Chih-Cheng Hsu, Yin-Fan Chang, Chih-Hsing Wu, Ding-Cheng Chan, Rong-Sen Yang
Summary: This study aimed to investigate the 11-year secular trend of adherence to new AOMs therapy and evaluate the change in urbanization areas after reimbursement criteria were implemented. The results showed that high adherence to AOMs increased after the new reimbursement scheme, particularly in high-urbanization areas.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Yu-Chieh Tsai, Yung-Ming Chen, Chiung-Jung Wen, Meng-Chen Wu, Yi-Chun Chou, Jen-Hau Chen, Kun-Pei Lin, Ding-Cheng Chan, Feng-Ping Lu
Summary: The 30-day hospital readmission rate is significantly related to advanced age, and the predictive ability of existing models for readmission risk in the oldest population is uncertain. In addition to multimorbidity, a history of falls and frailty are associated with higher readmission risk in older adults.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Chun-Feng Huang, Jung-Fu Chen, Ian R. Reid, Wing P. Chan, Peter Robert Ebeling, Bente Langdahl, Shih-Te Tu, Toshio Matsumoto, Ding-Cheng Chan, Yoon-Sok Chung, Fang-Ping Chen, E. Michael Lewiecki, Keh-Sung Tsai, Rong-Sen Yang, Seng Bin Ang, Ko-En Huang, Yin-Fan Chang, Chung-Hwan Chen, Joon-Kiong Lee, Hsin-I Ma, Weibo Xia, Ambrish Mithal, David L. Kendler, Cyrus Cooper, Jawl-Shan Hwang, Chih-Hsing Wu
Summary: Postmenopausal women are at a high risk of osteoporotic fractures due to rapid bone loss. To prevent this, experts in the Asia-Pacific region have developed a set of statements for the prevention of fractures in postmenopausal women. They advocate for reimbursement of pharmaceutical therapy for women with a high risk of fractures and emphasize the need for more clinical experience and data to improve intervention strategies.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Ta-Wei Tai, Chun-Feng Huang, Huei-Kai Huang, Rong-Sen Yang, Jung-Fu Chen, Tien-Tsai Cheng, Fang-Ping Chen, Chung-Hwan Chen, Yin-Fan Chang, Wei-Chieh Hung, Der-Sheng Han, Ding-Cheng Chan, Ching-Chou Tsai, I-Wen Chen, Wing P. Chan, Husan-Jui Chang, Jawl-Shan Hwang, Chih-Hsing Wu
Summary: This updated guideline aims to reduce the risk of osteoporotic fractures and improve the quality of care for patients with osteoporosis in Taiwan by providing practical recommendations based on the latest evidence.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Biotechnology & Applied Microbiology
Chen-Yu Lin, Te- Weng, Jui-Zhi Loh, Ding-Cheng Chan, Chih-Kang Chiang, Kuan-Yu Hung, Shing-Hwa Liu
Summary: Low-intensity pulsed ultrasound (LIPUS) is a therapeutic ultrasound that can aid in bone fracture repair and soft tissue healing. This study aimed to investigate the protective potential of LIPUS on CKD-associated muscle wasting. The results showed that LIPUS treatment effectively improved muscle strength, prevented muscle mass loss, and reduced muscle atrophy-related protein expression in CKD mice.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2023)
Article
Geriatrics & Gerontology
Ting-Fu Lai, Yung Liao, Ming-Chun Hsueh, Kun-Pei Lin, Ding-Cheng Chan, Yung-Ming Chen, Chiung-Jung Wen
Summary: This study aimed to investigate the effects of replacing sedentary behavior with light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) on the muscle function of older adults. The results showed that replacing sedentary behavior with LPA was associated with improvements in handgrip strength, TUG test findings, and gait speed, while replacing sedentary behavior with MVPA was associated with better gait speed and 5XSST findings.
Article
Public, Environmental & Occupational Health
Ting-Fu Lai, Yung Liao, Chien-Yu Lin, Ming-Chun Hsueh, Mohammad Javad Koohsari, Ai Shibata, Koichiro Oka, Ding-Cheng Chan
Summary: This study examined the association of breaks in sedentary time with physical function outcomes in older adults. The results showed that breaks in sedentary time during the day were associated with gait speed, basic functional mobility, and lower-limb strength. Specifically, breaks in sedentary time during the evening were associated with better lower extremity strength. Therefore, interrupting sedentary time, especially in the evening, can help maintain and improve physical function in older adults.
ARCHIVES OF PUBLIC HEALTH
(2023)