A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder

Pharmacokinetic profile of fesoterodine

(2011) B. Malhotra et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Trospium chloride has no effect on memory testing and is assay undetectable in the central nervous system of older patients with overactive bladder

(2010) D. Staskin et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

The Design and Development of Fesoterodine as a Prodrug of 5- Hydroxymethyl Tolterodine (5-HMT), the Active Metabolite of Tolterodine

(2009) B. Malhotra et al.   CURRENT MEDICINAL CHEMISTRY

The Role of P-Glycoprotein in Limiting Brain Penetration of the Peripherally Acting Anticholinergic Overactive Bladder Drug Trospium Chloride

(2009) J. Geyer et al.   DRUG METABOLISM AND DISPOSITION

Basic Mechanisms of Urgency: Preclinical and Clinical Evidence

(2009) Martin C. Michel et al.   EUROPEAN UROLOGY

Drug interactions at the blood-brain barrier: Fact or fantasy?☆

(2009) Sara Eyal et al.   PHARMACOLOGY & THERAPEUTICS

Unbound Drug Concentration in Brain Homogenate and Cerebral Spinal Fluid at Steady State as a Surrogate for Unbound Concentration in Brain Interstitial Fluid

(2008) X. Liu et al.   DRUG METABOLISM AND DISPOSITION

The Effects of Antimuscarinic Treatments in Overactive Bladder: An Update of a Systematic Review and Meta-Analysis

(2008) Christopher R. Chapple et al.   EUROPEAN UROLOGY

Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome

(2008) Martin C Michel   EXPERT OPINION ON PHARMACOTHERAPY

In Vivo Quantitative Autoradiographic Analysis of Brain Muscarinic Receptor Occupancy by Antimuscarinic Agents for Overactive Bladder Treatment

(2008) S. Maruyama et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Progress in Brain Penetration Evaluation in Drug Discovery and Development

(2008) X. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Subcellular localization of transporters along the rat blood–brain barrier and blood–cerebral-spinal fluid barrier by in vivo biotinylation

(2008) L.M. Roberts et al.   NEUROSCIENCE