Article
Peripheral Vascular Disease
Vibhu Parcha, Gargya Malla, Rajat Kalra, Peng Li, Ambarish Pandey, Khurram Nasir, Garima Arora, Pankaj Arora
Summary: The study evaluated the use of coronary artery calcium (CAC) score to guide hypertension therapy in individuals without cardiovascular disease. Results showed that among those with CAC>0, there was a higher risk of incident cardiovascular events in individuals with elevated BP or low-risk stage 1 hypertension, as well as in those with high-risk stage 1 or stage 2 hypertension. The study suggests that utilizing CAC score may help personalize cardiovascular risk reduction strategies in individuals where current guidelines do not recommend treatment.
Article
Peripheral Vascular Disease
Hokyou Lee, Yuichiro Yano, So Mi Jemma Cho, Ji Eun Heo, Dong-Wook Kim, Sungha Park, Donald M. Lloyd-Jones, Hyeon Chang Kim
Summary: Treatment and control rates for high blood pressure are unsatisfactory among young adults, with poor adherence to pharmacological treatment associated with higher risk for future cardiovascular events.
Article
Health Care Sciences & Services
Syed Karam Mustafa Gardezi, William W. Aitken, Mohammad Hashim Jilani, Jerzy Wilinski
Summary: Medication non-adherence is a significant healthcare barrier, particularly in asymptomatic diseases like hypertension. Poor adherence to blood pressure (BP) medications is associated with increased cardiovascular (CV) deaths. Even a small increase in adherence rate could lead to a substantial decrease in preventable CV deaths.
Article
Critical Care Medicine
Andrey Zinchuk, Jen-Hwa Chu, Jiasheng Liang, Yeliz Celik, Sara Op de Beeck, Nancy S. Redeker, Andrew Wellman, H. Klar Yaggi, Yuksel Peker, Scott A. Sands
Summary: This study found that a low ArTH, as well as very low and high <(V)over dot> comp, are associated with worse long-term CPAP adherence in patients with CAD and OSA. Physiological traits, along with established determinants, may help predict and improve CPAP adherence.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jeffrey Chidester, Daniel Bennett, Chris Mathew, Tiffany Denkins, Rebecca Vigen, Tayo Addo, Sandeep Das
Summary: A telephone-based reminder system was developed to improve DAPT adherence post-PCI, leading to directed interventions in nearly 1 in 10 patients contacted. However, the system did not significantly improve PDC levels compared to a contemporary sample, highlighting the ongoing difficulty in detecting barriers to adherence.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Ibtisam M. Al-Zaru, Ghada Shahrour, Dina Masha'al, Audai A. Hayajneh
Summary: The study found no significant relationship between depression and adherence to healthy lifestyle behaviors among CAD patients in Jordan. Factors such as gender, smoking status, and number of cardiac catheterization procedures were identified as significant predictors of patient adherence to healthy lifestyle behaviors. Physical activity, maintaining a healthy diet, and weight loss were the least adopted lifestyle behaviors among the patients, while quitting smoking and medication compliance were the most commonly adopted behaviors.
Article
Nursing
Ugur Dogan, Nimet Ovayolu
Summary: The aim of this study was to investigate the effect of training provided by nurses to coronary artery patients on treatment adherence. The results showed that planned training positively contributed to treatment adherence and anthropometric measurements in the patients.
JOURNAL OF CLINICAL NURSING
(2022)
Review
Cardiac & Cardiovascular Systems
Davide Capodanno, Dominick J. Angiolillo
Summary: Coronary artery disease (CAD) is a major cause of death worldwide, and antiplatelet therapy plays a crucial role in its prevention and treatment. While antiplatelet drugs are effective in reducing thrombotic events, they also carry a risk of bleeding complications. Personalized antiplatelet therapy has emerged as a strategy to optimize the balance between safety and efficacy by tailoring treatment to individual patients' needs and risk profiles. Accurate risk stratification can help in selecting the most appropriate antiplatelet therapy and prevent serious outcomes.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Fei Gao, Yue Ping Li, Xiao Teng Ma, Zhi Jian Wang, Dong Mei Shi, Yu Jie Zhou
Summary: The study indicates that the combination treatment of PCSK9 inhibitors and statins significantly reduces the rate of coronary artery calcification progression.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Health Care Sciences & Services
Gary Chun-Yun Kang
Summary: This study aimed to determine the efficacy of technology-based interventions in improving adherence to antihypertensive medications. The results showed that several interventions significantly improved adherence and had a positive impact on blood pressure control. However, randomized controlled trials on technological interventions in this area are still limited.
Article
Public, Environmental & Occupational Health
Y. Feng, M. Han, R. Qie, S. Huang, Q. Li, C. Guo, G. Tian, Y. Zhao, X. Yang, Y. Li, X. Wu, Q. Zhou, Y. Zhang, Y. Wu, D. Liu, F. Hu, M. Zhang, Y. Yang, X. Shi, L. Sun, D. Hu
Summary: This study found a negative association between adherence to antihypertensive medications and the risk of recurrence of cardiovascular disease events, with higher adherence associated with lower risk. Additionally, for every 20% increase in adherence, the risk of cardiovascular disease events decreased by 9%. Results of sensitivity analysis and subgroup analysis were consistent.
Review
Medicine, General & Internal
Stefano Cacciatore, Luigi Spadafora, Marco Bernardi, Mattia Galli, Matteo Betti, Francesco Perone, Giulia Nicolaio, Emanuele Marzetti, Anna Maria Martone, Francesco Landi, Elad Asher, Maciej Banach, Olivier Hanon, Giuseppe Biondi-Zoccai, Pierre Sabouret, C. Noel Bairey Merz
Summary: Coronary artery disease is a common condition in older adults but managing it is challenging due to the complexity of patient characteristics including frailty burden, comorbidities, and body composition abnormalities. The aim of this narrative review is to emphasize the importance of assessing frailty in guiding therapeutic decision-making and tailoring coronary artery disease management to the specific needs of older adults, taking into account age-related changes and potential drug interactions. The review also discusses gaps in evidence and offers perspectives on optimizing coronary artery disease management in older adults.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Laura J. Davidson, Joseph C. Cleveland, Frederick G. Welt, Saif Anwaruddin, Robert O. Bonow, Michael S. Firstenberg, Mario F. Gaudino, Bernard J. Gersh, Kendra J. Grubb, Ajay J. Kirtane, Jacqueline E. Tamis-Holland, Alexander G. Truesdell, Stephan Windecker, Roza A. Taha, Chris Malaisrie
Summary: The treatment of left main coronary artery disease requires complex decision-making. This article proposes a practical approach to treatment, including medical therapy, percutaneous coronary intervention, and coronary artery bypass grafting. It emphasizes the importance of shared decision-making that meets the needs and preferences of individual patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ziwei Xi, Jianan Li, Hong Qiu, Tingting Guo, Yong Wang, Yang Li, Jianfeng Zheng, Kefei Dou, Bo Xu, Yongjian Wu, Shubin Qiao, Weixian Yang, Yuejin Yang, Runlin Gao
Summary: This study demonstrates that in patients with SCAD undergoing complex PCI, ticagrelor can significantly reduce the risk of adverse cardiovascular events compared to clopidogrel, without an increased risk of major bleeding.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Waseem Hijazi, Yuanchao Feng, Danielle A. Southern, Derek Chew, Neil Filipchuk, Bryan Har, Matthew James, Stephen Wilton, Piotr J. Slomka, Daniel Berman, Robert J. H. Miller
Summary: This study evaluated the impact of SPECT MPI testing on medical therapy prescription for coronary artery disease (CAD). The results showed that abnormal perfusion and coronary artery calcium burden were associated with prescription of ASA and statin medications.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Pharmacology & Pharmacy
Sylvie Perreault, Alice Dragomir, Robert Cote, Aurelie Lenglet, Simon de Denus, Marc Dorais, Brian White-Guay, James Brophy, Mireille E. Schnitzer, Marie-Pierre Dube, Jean-Claude Tardif
Summary: This study compares the effectiveness and safety of different doses of direct oral anticoagulants (DOACs) with warfarin or other DOACs for patients with atrial fibrillation (AF). The results show that low-dose dabigatran has better effectiveness but worse safety compared to warfarin, while low-dose apixaban has better safety than warfarin.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Veronique Bouchard, Annie Robitaille, Sylvie Perreault, Marie-Christyne Cyr, Jean -Claude Tardif, David Busseuil, Bianca D'Antono
Summary: This study examined the impact of psychological distress on outpatient care utilization in patients with coronary artery disease (CAD). The results showed a significant correlation between depressive symptoms and outpatient care utilization, particularly in CAD patients. Further research is needed to determine whether psychosocial interventions can have an impact on healthcare utilization.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Sylvie Perreault, Robert Cote, Alice Dragomir, Brian White-Guay, Aurelie Lenglet, Marc Dorais
Summary: There was no significant difference in the effectiveness or safety outcome between low-dose and standard-dose rivaroxaban in patients with atrial fibrillation. However, low-dose apixaban was associated with a greater risk of stroke/systemic embolism and death without a reduction in bleeding rates.
Article
Multidisciplinary Sciences
Sylvie Perreault, Mireille E. Schnitzer, Eliane Disso, Jakub Qazi, Laurie-Anne Boivin-Proulx, Marc Dorais
Summary: Polypharmacy is associated with increased mortality risk in patients with heart failure, while cardiovascular and non-cardiovascular polypharmacy do not show significant associations. Certain heart conditions and health problems are associated with increased mortality risk, while the use of certain medications can lower the risk.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Laurie-Anne Boivin-Proulx, Brian J. Potter, Marc Dorais, Sylvie Perreault
Summary: This study investigated the changes in antithrombotic medication prescription patterns among patients with atrial fibrillation undergoing percutaneous coronary intervention. The results showed that the publication of guidelines in 2016 had a positive impact on the prescription of oral anticoagulation therapy. However, a substantial treatment gap still existed even after the guidelines were published.
Article
Oncology
Alice Dragomir, Nawar Touma, Jason Hu, Sylvie Perreault, Armen G. Aprikian
Summary: This study evaluated the risk of cardiovascular disease (CVD) associated with gonadotropin-releasing hormone (GnRH) agonists versus GnRH antagonist in patients with prostate cancer. The results showed that the use of GnRH antagonist decreased the risk of heart failure in patients with prior CVD, and decreased the risk of ischemic heart disease in patients without prior CVD but increased the risk of arrhythmia.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Cardiac & Cardiovascular Systems
Rahul Aggarwal, Christian T. Ruff, Saverio Virdone, Sylvie Perreault, Ajay K. Kakkar, Michael G. Palazzolo, Marc Dorais, Gloria Kayani, Daniel E. Singer, Eric Secemsky, Jonathan Piccini, Usman A. Tahir, Changyu Shen, Robert W. Yeh
Summary: A clinical risk score was developed and validated to personalize bleeding risk assessment for individuals with atrial fibrillation taking direct-acting oral anticoagulants (DOACs). The risk score showed superior performance compared to existing clinical decision tools and can help stratify patients based on their expected bleeding risk.
Meeting Abstract
Cardiac & Cardiovascular Systems
Laurie-Anne Boivin Proulx, Marc Dorais, Sylvie Perreault
Meeting Abstract
Cardiac & Cardiovascular Systems
Laurie-Anne Boivin Proulx, Aurelie Langlet, Catherine Legault, Marc Dorais, Sylvie Perreault
Meeting Abstract
Cardiac & Cardiovascular Systems
Laurie-Anne Boivin Proulx, Aurelie Langlet, Marc Dorais, Sylvie Perreault
Meeting Abstract
Cardiac & Cardiovascular Systems
Laurie-Anne Boivin Proulx, Brian J. Potter, Sylvie Perreault
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Laurie-Anne Boivin-Proulx, Brian J. Potter, Marc Dorais, Sylvie Perreault
Summary: Obese patients are often excluded from clinical trials comparing the effectiveness and safety of direct oral anticoagulants in atrial fibrillation patients. However, this study found that the use of direct oral anticoagulants in obese atrial fibrillation patients showed similar effectiveness and safety compared to warfarin use.
Meeting Abstract
Economics
S. Perreault, M. Schnitzer, E. Disso, J. Qazi, M. Dorais
Meeting Abstract
Economics
S. Perreault, A. Dragomir, A. Lenglet, M. Dorais
Meeting Abstract
Economics
A. Lenglet, J. Qazi, M. Dorais, S. Perreault