Article
Cardiac & Cardiovascular Systems
Gregory N. Milburn, Faruk Moonschi, Ashley M. White, Mindy Thompson, Katherine Thompson, Emma J. Birks, Kenneth S. Campbell
Summary: This study aims to examine the effects of freezing on the contractile function of chemically permeabilized myocardium. The results showed that freezing had minimal impact on maximum isometric force, passive force, and Hill coefficients, but it did affect the pCa(50), causing a slight decrease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Plant Sciences
M. L. Romo-Perez, C. H. Weinert, B. Egert, B. L. Franzisky, S. E. Kulling, C. Zoerb
Summary: The study found that onion plants have the ability to exclude Na+ after moderate Na2SO4 treatment, foliar application does not lead to Na+ accumulation in the bulbs, while soil application results in Na+ accumulation in the leaves and bulbs, with no significant impact on the metabolite profile of onions.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Dermatology
Masataka Ota, Takashi Sasaki, Tamotsu Ebihara, Emiko Yokosawa, Yumi Murakami, Hiroshi Matsunaka, Yuko Chinuki, Masayuki Amagai, Eishin Morita
Summary: The study found that loss-of-function mutations of the filaggrin (FLG) gene do not affect the severity of atopic dermatitis (AD) or skin barrier function, and have little impact on the amount of FLG protein and total amino acids in the stratum corneum of lesional skin. The results suggest that the production of FLG in skin lesions is influenced by the activation of Th2-dominant inflammatory cells along with FLG abnormalities.
JOURNAL OF DERMATOLOGY
(2021)
Article
Ecology
T. J. T. Mills, T. M. Nelson, L. A. Pearson, B. A. Neilan
Summary: Bacteria in the guts of pollinating insects are crucial for nutrient acquisition, digestion, and resistance to pests and diseases. This study investigates the gut microbiome of the Australian native stingless bee, Tetragonula carbonaria, and the impact of colony transplantation on gut health. Although some differences were observed between bees from natural and manufactured hives, a core microbiome dominated by Lactobacillus spp., unclassified Acetobacteraceae spp., and Bombella spp. was maintained. The study suggests that hive transplantation has a limited negative impact on the overall health and resilience of the colony.
Article
Medicine, General & Internal
Sevgi Bilgen, Dilek Erdogan Ari, Emel Ozveri
Summary: The coadministration of ondansetron and tramadol did not affect tramadol consumption or the presence of pain, nausea, and vomiting in patients undergoing laparoscopic cholecystectomy.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2022)
Review
Critical Care Medicine
Yun Yan, Yu Chen, Xijing Zhang
Summary: GI dysfunction is common in critical care, with opioids playing a role in its development. Opioid antagonists may be used to treat GI dysmotility in ICU settings.
Article
Multidisciplinary Sciences
Smitha Soman, Somdeb Chattopadhyay, Siya Ram, Vinay Kumar Nandicoori, G. Aneeshkumar Arimbasseri
Summary: Mycobacterium tuberculosis exhibits strong biases for amino acid and codon usage, which are influenced by the high GC content of its genome. Despite carrying only a single copy of each tRNA gene, the relative levels of tRNAs in the Mtb tRNA pool vary significantly. The translation machinery and tRNA pool of Mtb co-evolve with codon usage to optimize translation efficiency.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Abigail E. Powell, Duo Xu, Gillie A. Roth, Kaiming Zhang, Wah Chiu, Eric A. Appel, Peter S. Kim
Summary: Ebola virus is a highly pathogenic virus that has caused numerous outbreaks. The existing vaccine requires ultra-low temperature storage, posing logistical challenges. By designing and characterizing two new vaccines, researchers found that some protein subunit antigens did not elicit enhanced antibody responses when displayed on multivalent scaffolds, providing insights for the design of future Ebola virus vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Komal Zafar, Muhammad Wasim, Batool Fatima, Dilshad Hussain, Rubaida Mehmood, Muhammad Najam-ul-Haq
Summary: In this study, a CoNiWO4 nanocomposite was used as an electrochemical sensor for simultaneous detection of tramadol and serotonin. The nanocomposite was synthesized using a hydrothermal method and characterized through various techniques. The sensor was developed by depositing CoNiWO4-NPs onto a glassy carbon electrode surface and employed different electrochemical techniques for detection. The prepared sensor showed a linear range, LOD, and LOQ for serotonin and tramadol, and was successfully applied for determination in biological samples.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Astrid Pechmann, Max Behrens, Katharina Doernbrack, Adrian Tassoni, Sabine Stein, Sibylle Vogt, Daniela Zoeller, Gunther Bernert, Tim Hagenacker, Ulrike Schara-Schmidt, Inge Schwersenz, Maggie C. Walter, Matthias Baumann, Manuela Baumgartner, Marcus Deschauer, Astrid Eisenkoelbl, Marina Flotats-Bastardas, Andreas Hahn, Veronka Horber, Ralf A. Husain, Sabine Illsinger, Jessika Johannsen, Cornelia Koehler, Heike Koelbel, Monika Mueller, Arpad von Moers, Kurt Schlachter, Gudrun Schreiber, Oliver Schwartz, Martin Smitka, Elisabeth Steiner, Eva Stoegmann, Regina Trollmann, Katharina Vill, Claudia Weiss, Gert Wiegand, Andreas Ziegler, Hanns Lochmueller, Janbernd Kirschner
Summary: This study presents real-world evidence on the effects of nusinersen treatment in patients with early-onset spinal muscular atrophy. The findings demonstrate significant improvements in motor function, particularly in children under the age of 2. However, the improvements in bulbar and respiratory function are not equivalent to those in motor function.
Article
Multidisciplinary Sciences
Jade Parker-Character, David R. Hager, Tanner B. Call, Zachary S. Pickup, Scott A. Turnbull, Evan M. Marshman, Shaleen B. Korch, John M. Chaston, Gerald B. Call
Summary: This study investigated the relationship between the microbiota and Parkinson's disease using a Drosophila melanogaster model, finding that the microbiota had a negative impact on the eclosion process in PD model flies. Analysis revealed differences in microbiota composition between control and PD model flies, consistent with human studies. Results from fecal transfer and mono-association experiments suggest a host genotype-microbiota interaction.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Bin Song, Jacob W. Feldmann, Shibo Cao, Melissa Feitosa, Youngbin Kong, Woori Kim, Altana Schweitzer, Pierre Leblanc, Jeffrey S. Schweitzer, Kwang-Soo Kim
Summary: The ak mouse is a suitable model for studying both motor and non-motor symptoms of Parkinson's disease (PD), including fine motor deficits, olfactory function deficits, and gastrointestinal dysfunction. It can also be used for the development of novel disease-modifying therapeutics.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Endocrinology & Metabolism
Kelly L. Roszko, Tiffany Y. Hu, Lori C. Guthrie, Beth A. Brillante, Michaele Smith, Michael T. Collins, Rachel Gafni
Summary: Patients with hypoparathyroidism experience poor quality of life, including fatigue and brain fog. Treatment with PTH 1-34 had limited and non-sustained effects on improving quality of life, inconclusive changes in fatigue experience, and no change in the 6-minute walk test.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Neurosciences
Joyce Karoline Friosi de Carvalho, Lais da Silva Pereira-Rufino, Carlos Eduardo Panfilio, Regiane Dias Amorim Silva, Isabel Cristina Cespedes
Summary: Alcohol misuse by the elderly causes significant physical limitations, leading to worsened functional capacity in walking and various motor abilities, ultimately reducing their quality of life in physical, mental, and social aspects.
NEUROSCIENCE LETTERS
(2021)
Article
Behavioral Sciences
Ji-Ae Yu, JuHyung Park
Summary: The effects of First-Person Perspective Action Observation training and Third-Person Perspective Action Observation training on upper extremity function and activities of daily living in stroke patients were investigated. Both trainings significantly improved the upper extremity function and daily activities, with First-Person Perspective Action Observation training being more effective.
BRAIN AND BEHAVIOR
(2022)
