Article
Medicine, General & Internal
Liu Yang, Chaobin Wang, Miao Liu, Shu Wang
Summary: Adenoid cystic carcinoma (ACC) is a rare type of breast cancer, and the role of adjuvant treatments for this type of cancer remains controversial. A study found that adjuvant chemotherapy (CT) and radiotherapy (RT) did not significantly improve overall survival (OS) and breast cancer-specific survival (BCSS) in patients with ACC of the breast. However, adjuvant RT may be beneficial for overall survival in patients who underwent breast-conserving surgery.
Article
Endocrinology & Metabolism
Feng Yu, Xue Li, Yanhui Ji, Jian Tan, Guizhi Zhang, Peng Wang, Yajing He, Renfei Wang
Summary: Early RAT is associated with greater biochemical response but has no impact on SIR. Delayed initial RAT (>= 3 months after thyroidectomy) related to IR in intermediate- to high-risk DTC.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Ming-Hung Chang, Kuo-Hwa Chiang, Jiunn-Min Shieh, Kuo-Chen Cheng, Chung-Han Ho
Summary: Miliary lung metastasis is not a dominant indicator for outcome evaluation in patients with non-small cell lung cancer harboring EGFR mutation under TKI prescription. Other strong prognostic indicators include performance status, liver metastasis, EGFR type, and generation of TKI.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Guangxi Wang, Mantang Qiu, Xudong Xing, Juntuo Zhou, Hantao Yao, Mingru Li, Rong Yin, Yan Hou, Yang Li, Shuli Pan, Yuqing Huang, Fan Yang, Fan Bai, Honggang Nie, Shuangshuang Di, Limei Guo, Zhu Meng, Jun Wang, Yuxin Yin
Summary: Lung cancer, the leading cause of cancer-related deaths, can be improved by early detection. A study found dysregulated lipid metabolism in different cell types of early-stage lung cancers. By identifying nine important lipids, a targeted assay was developed with high specificity in detecting early-stage lung cancer. This method demonstrated high sensitivity and specificity in screening and clinical cohorts. Overall, this method shows promise in early lung cancer detection and cancer prevention for high-risk populations.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Takuya Matsui, Noriaki Sakakura, Shin Koyama, Keita Nakanishi, Eiichi Sasaki, Seiichi Kato, Waki Hosoda, Yoshiko Murakami, Hiroaki Kuroda, Yasushi Yatabe
Summary: Invasive mucinous adenocarcinoma (IMA) is a rare subtype of invasive lung adenocarcinoma with differences in lymph node metastasis and KRAS mutations compared to non-IMA. Patients with IMA have a higher rate of intrapulmonary recurrence postoperatively, leading to significantly worse prognosis among those with lung recurrence compared to non-IMA patients. Overall survival rates at 5 years did not differ significantly between the two groups.
ANNALS OF THORACIC SURGERY
(2021)
Article
Oncology
Toshirou Nishida, Shinsuke Sato, Masato Ozaka, Yujiro Nakahara, Yoshito Komatsu, Masato Kondo, Haruhiko Cho, Seiichi Hirota, Tatsuo Kagimura, Yukinori Kurokawa, Yuko Kitagawa
Summary: Long-term adjuvant therapy appears to have better prognostic effects for high-risk gastrointestinal stromal tumor patients, delaying recurrence.
Article
Otorhinolaryngology
Di Zhang, Lixi Li, Tingyu Wen, Fei Ma
Summary: This study aimed to explore the clinical characteristics, prognostic factors, and value of adjuvant therapy for major salivary duct carcinoma (SDC). The study found that age, tumor size, and lymph node involvement were independent prognostic factors, and adjuvant radiotherapy could improve survival rates for patients with tumors larger than 4 cm.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Oncology
Yangxun Pan, Ze Yuan, Jiongliang Wang, Siegmund Ngai, Zhiwen Hu, Liyang Sun, Zhenyun Yang, Dandan Hu, Minshan Chen, Zhongguo Zhou, Yaojun Zhang
Summary: This study evaluated the efficacy and safety of postoperatively adjuvant therapy in treating uHCC patients who received FOLFOX-HAIC-based conversion therapy. The results showed that adjuvant therapy was associated with improved survival outcomes compared with non-adjuvant therapy, especially for patients with macrovascular invasion and positive hepatitis B surface antigen.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Genetics & Heredity
Jae Kwang Yun, Sugyeong Kim, Hongyul An, Geun Dong Lee, Hyeong Ryul Kim, Yong-Hee Kim, Dong Kwan Kim, Seung-Il Park, Sehoon Choi, Youngil Koh
Summary: Preoperative clonal hematopoiesis (CH) in non-small cell lung cancer (NSCLC) patients can negatively impact survival outcomes through adjuvant therapy.
Article
Oncology
Keting Li, Wentao Hao, Xianben Liu, Yin Li, Haibo Sun, Shilei Liu, Wenqun Xing, Yan Zheng
Summary: This study compared the efficacy of adjuvant chemotherapy and postoperative observation in patients with esophageal squamous cell carcinoma (ESCC) after neoadjuvant chemotherapy. The results showed that adjuvant chemotherapy did not improve overall survival (OS) in these patients, but it may benefit certain groups of patients.
Article
Biochemistry & Molecular Biology
Xiangmei Zhang, Xiaoyan Fan, Xin Li, Yaping Wang, Yulong Zhang, You Li, Jidong Zhao, Dongwei He
Summary: TACC3 is overexpressed in LUAD and may serve as an independent risk factor for worse prognosis in these patients.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Oncology
Kunwei Peng, Huijiao Cao, Yafei You, Wenzhuo He, Chang Jiang, Lei Wang, Yanan Jin, Liangping Xia
Summary: For patients with T1N0M0 lung large cell neuroendocrine carcinoma (LCNEC), lobectomy and lymph nodes dissection are associated with significantly prolonged survival. Adjuvant chemotherapy may not contribute to extended survival in patients with smaller tumors (less than 2 cm).
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Ruhan Zhao, Yunnan Dai, Xinyang Li, Cuimin Zhu
Summary: By retrospectively analyzing patients with lung cancer combined with liver metastases, multiple independent prognostic factors were identified. A personalized prognostic nomogram was established and validated, providing guidance for the development of patient treatment plans.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Andrew X. Zhu, Farshid Dayyani, Chia-Jui Yen, Zhenggang Ren, Yuxian Bai, Zhiqiang Meng, Hongming Pan, Paul Dillon, Shivani K. Mhatre, Vincent E. Gaillard, Sairy Hernandez, Robin Kate Kelley, Bruno Sangro
Summary: This study investigated the potential of on-treatment alpha-fetoprotein (AFP) response as a surrogate biomarker for prognosis in hepatocellular carcinoma patients receiving atezolizumab + bevacizumab. The results showed that AFP cutoffs of >= 75% decrease and <= 10% increase from baseline at 6 weeks could distinguish responders and patients with disease control. These AFP cutoffs were associated with longer overall survival and progression-free survival in patients, particularly those with hepatitis B virus etiology.
CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Xuchen Huang, Sainan Li, Wei Gao, Jiajie Shi, Meng Cheng, Yunzhe Mi, Yueping Liu, Meixiang Sang, Ziyi Li, Cuizhi Geng
Summary: The aim of this study was to investigate the potential of KIF20A as a prognostic marker for female patients with estrogen receptor (ER)-positive breast cancer (BC) treated with tamoxifen (TAM). Online tools were used to analyze the correlation between KIF20A gene expression and patient survival. Immunohistochemistry (IHC) was performed to assess KIF20A expression levels in patients from our center, and Cox regression analysis was used to evaluate the prognostic value of KIF20A for disease-free survival (DFS) and overall survival (OS).
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Respiratory System
M. Mesa-Guzman, J. Gonzalez, A. B. Alcaide, J. Berto, J. P. de-Torres, A. Campo, L. M. Seijo, M. M. Ocon, J. C. Pueyo, G. Bastarrika, M. D. Lozano, R. Pio, L. M. Montuenga, M. Garcia-Granero, J. Zulueta
ARCHIVOS DE BRONCONEUMOLOGIA
(2021)
Article
Oncology
Vicente Fresquet, Maria J. Garcia-Barchino, Marta Larrayoz, Jon Celay, Carmen Vicente, Marta Fernandez-Galilea, Maria J. Larrayoz, Maria J. Calasanz, Carlos Panizo, Alexandra Junza, Jiahuai Han, Celia Prior, Puri Fortes, Ruben Pio, Julen Oyarzabal, Alvaro Martinez-Baztan, Bruno Paiva, Maria J. Moreno-Aliaga, Maria D. Odero, Xabier Agirre, Oscar Yanes, Felipe Prosper, Jose A. Martinez-Climent
Summary: Epigenetic therapies induce viral mimicry in cancer cells, reshaping mitochondrial metabolism and driving caspase-independent tumor cell death, leading to increased sensitivity to BCL2 inhibitor drugs.
Article
Medical Laboratory Technology
D. A. N. I. E. L. AJONA, A. N. A. REMIREZ, C. R. I. S. T. I. N. A. SAINZ, C. R. I. S. T. I. N. A. BERTOLO, A. L. V. A. R. O. GONZALEZ, N. E. R. E. A. VARO, M. A. R. I. A. D. LOZANO, J. A. V. I. E. R. J. ZULUETA, M. I. G. U. E. L. MESA-GUZMAN, A. N. A. C. MARTIN, R. O. S. A. PEREZ-PALACIOS, J. O. S. E. L. U. I. S. PEREZ-GRACIA, P. I. E. R. R. E. P. MASSION, L. U. I. S. M. MONTUENGA, R. U. B. E. N. PIO
Summary: This study developed a diagnostic model based on quantification of plasma markers, showing good diagnostic performance in detecting various lung tumor types with high specificity and positive predictive value. The model was effective in assessing lung cancer risk and nodule malignancy, significantly increasing the risk of lung cancer in asymptomatic individuals and discriminating benign and malignant pulmonary nodules with very good specificity.
TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Esther Redin, Irati Garmendia, Teresa Lozano, Diego Serrano, Yaiza Senent, Miriam Redrado, Maria Villalba, Carlos E. De Andrea, Francisco Exposito, Daniel Ajona, Sergio Ortiz-Espinosa, Ana Remirez, Cristina Bertolo, Cristina Sainz, Juana Garcia-Pedrero, Ruben Pio, Juan Lasarte, Jackeline Agorreta, Luis M. Montuenga, Alfonso Calvo
Summary: YES1 protein expression is associated with increased numbers of Tregs in patients with NSCLC. Dasatinib synergizes with anti-PD-1 to impair tumor growth in NSCLC experimental models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Cora Palanca-Ballester, Aitor Rodriguez-Casanova, Susana Torres, Silvia Calabuig-Farinas, Francisco Exposito, Diego Serrano, Esther Redin, Karmele Valencia, Eloisa Jantus-Lewintre, Angel Diaz-Lagares, Luis Montuenga, Juan Sandoval, Alfonso Calvo
Summary: In addition to genetic changes, cancer is also characterized by epigenetic alterations that can be used for diagnosis, prognosis, and predicting drug response. These changes can be detected in early stages of cancer and through liquid biopsies, offering valuable information for personalized treatment. Validation and standardization of epigenetic biomarkers are needed for their successful transfer from research to clinical practice.
Article
Cell Biology
Karmele Valencia, Cristina Sainz, Cristina Bertolo, Gabriel de Biurrun, Jackeline Agorreta, Arantza Azpilikueta, Marta Larrayoz, Graziella Bosco, Carolina Zandueta, Miriam Redrado, Esther Redin, Francisco Exposito, Diego Serrano, Mirari Echepare, Daniel Ajona, Ignacio Melero, Ruben Pio, Roman Thomas, Alfonso Calvo, Luis M. Montuenga
Summary: There is a lack of adequate mouse models and cell lines for studying lung squamous cell carcinoma (LUSC). In this study, two models of transplantable LUSC cell lines were generated and characterized, revealing similar genetic and transcriptomic patterns. The immune landscape and response to immune checkpoint inhibition were also compared. Furthermore, the metastatic potential of these models showed organotropism similar to LUSC in humans. Overall, these valuable cell line tools recapitulate the complexity of the human disease.
DISEASE MODELS & MECHANISMS
(2022)
Article
Oncology
Borja Ruiz-Fernandez de Cordoba, Haritz Moreno, Karmele Valencia, Naiara Perurena, Pablo Ruedas, Thomas Walle, Alberto Pezonaga-Torres, Juan Hinojosa, Elisabet Guruceaga, Antonio Pineda-Lucena, Marta Abengozar-Muela, Denis Cochonneau, Carolina Zandueta, Susana Martinez-Canarias, Alvaro Teijeira, Daniel Ajona, Sergio Ortiz-Espinosa, Xabier Morales, Carlos Ortiz de Solorzano, Marta Santisteban, Luis Ramos-Garcia, Laura Guembe, Vratislav Strnad, Dominique Heymann, Sandra Hervas-Stubbs, Ruben Pio, Maria E. Rodriguez-Ruiz, Carlos E. de Andrea, Silvestre Vicent, Ignacio Melero, Fernando Lecanda, Rafael Martinez-Monge
Summary: Locoregional failure in breast cancer patients after surgery and irradiation is linked to a poor prognosis. The ENPP1/HP axis is exploited by tumor cells to promote local recurrence by suppressing immune cells. Blocking this axis offers new opportunities for therapeutic intervention.
Article
Oncology
Sergio Ortiz-Espinosa, Xabier Morales, Yaiza Senent, Diego Alignani, Beatriz Tavira, Irati Macaya, Borja Ruiz, Haritz Moreno, Ana Remirez, Cristina Sainz, Alejandro Rodriguez-Pena, Alvaro Oyarbide, Mikel Ariz, Maria P. Andueza, Karmele Valencia, Alvaro Teijeira, Kai Hoehlig, Axel Vater, Barbara Rolfe, Trent M. Woodruff, Jose Maria Lopez-Picazo, Silvestre Vicent, Grazyna Kochan, David Escors, Ignacio Gil-Bazo, Jose Luis Perez-Gracia, Luis M. Montuenga, John D. Lambris, Carlos Ortiz de Solorzano, Fernando Lecanda, Daniel Ajona, Ruben Pio
Summary: This study reveals that C5a can enhance the capacity of PMN-MDSCs to promote tumor growth and metastasis by inducing the formation of NETs. The formation of NETs is dependent on the production of HMGB1 by cancer cells. Inhibiting C5a, C5aR1, or NETosis can reduce the number of circulating tumor cells and the metastatic burden in a mouse lung metastasis model. The translational relevance of these findings is supported by the stimulation of migration and NETosis in PMN-MDSCs obtained from lung cancer patients.
Review
Oncology
Ana Belen Herrera-Campos, Esteban Zamudio-Martinez, Daniel Delgado-Bellido, Monica Fernandez-Cortes, Luis M. Montuenga, F. Javier Oliver, Angel Garcia-Diaz
Summary: The tumor microenvironment (TME) characterized by low oxygen supply (hypoxia) is associated with aggressive cancer phenotypes and poor prognosis. Supplemental oxygen, or hyperoxia, has been shown to improve the efficacy of cancer therapies by reducing tumor hypoxia and promoting antitumor immunity. However, prolonged exposure to high oxygen levels can cause lung injury and inflammation, which may have negative consequences. Further studies are needed to optimize the use of hyperoxia in cancer treatment and prevent its side effects.
Article
Biotechnology & Applied Microbiology
Alejandro Rodriguez-Pena, Estibaliz Armendariz, Alvaro Oyarbide, Xabier Morales, Sergio Ortiz-Espinosa, Borja Ruiz-Fernandez de Cordoba, Denis Cochonneau, Inaki Cornago, Dominique Heymann, Josepmaria Argemi, Delia D'Avola, Bruno Sangro, Fernando Lecanda, Ruben Pio, Ivan Cortes-Dominguez, Carlos Ortiz-de-Solorzano
Summary: This paper presents a double spiral microfluidic device based on inertial separation for efficient enrichment and isolation of circulating tumor cells (CTCs). The device has a fine-tunable cut-off value and better separation results than existing technologies.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Irati Garmendia, Esther Redin, Luis M. Montuenga, Alfonso Calvo
Summary: YES1, a nonreceptor tyrosine kinase, is considered as an emerging target in solid tumors. It is overexpressed in many tumor types, promoting cell proliferation and invasiveness. Novel specific inhibitors of YES1 have shown impressive antitumor effects in pre-clinical models. Inhibiting YES1 in tumors with high expression of this protein is a promising strategy against cancer.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Oncology
Yaiza Senent, Beatriz Tavira, Ruben Pio, Daniel Ajona
Summary: Tumor progression is influenced by the interaction between tumor cells and their surrounding tumor microenvironment (TME), and the complement system plays a key role in this process. However, tumors can exploit the complement system to promote chronic inflammation, activate cancer-related pathways, and inhibit anti-tumor immune responses. Myeloid-derived suppressor cells are recognized as major regulators of tumor-associated complement activities.
Review
Oncology
Lucia Suarez, Maria E. Rodriguez-Ruiz, Ana Rouzaut
Summary: The introduction of immunotherapy has significantly improved the survival of cancer patients. However, many patients still do not respond to immunotherapy due to resistance from the tumor stroma. The study of lymphatic tumor vasculature and the effects of radiotherapy on lymphatic endothelial cells can provide new approaches to enhance anti-tumor response.
Review
Oncology
Nerea Otegui, Maeva Houry, Imanol Arozarena, Diego Serrano, Esther Redin, Francisco Exposito, Sergio Leon, Karmele Valencia, Luis Montuenga, Alfonso Calvo
Summary: Immunotherapy for NSCLC is effective for some patients, but less than half of them will benefit from it. Detection of PD-L1 in tumors is currently the only validated predictive biomarker. Genetic and metabolic alterations in tumor cells can affect the tumor microenvironment and the response to immunotherapy. Novel strategies based on these alterations may improve the efficacy of immunotherapy for lung cancer patients.
Editorial Material
Oncology
Karmele Valencia, Luis M. Montuenga, Alfonso Calvo
Summary: The influence of sex on immunotherapy response in patients with non-small cell lung cancer (NSCLC) is inconclusive. However, a recent study suggests that the existence of a 17 beta-estradiol/ER alpha/PDL1 signaling loop in NSCLC is a key factor determining the response to immunotherapy, opening up new therapeutic options.
CLINICAL CANCER RESEARCH
(2023)