Article
Chemistry, Physical
Linna Liang, Wendi Huo, Bei Wang, Lingzhi Cao, Haoran Huo, Yixin Liu, Yi Jin, Xinjian Yang
Summary: Tumor multidrug resistance is a major cause of chemotherapy failure, and reversing tumor multidrug resistance is crucial for increasing the sensitivity of tumor cells to chemodrugs. The self-assembled DNAzyme nanoflowers can efficiently reverse multidrug resistance, enhance drug loading capacity, and suppress P-glycoprotein expression.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Jianfei Wang, Xubin Suo, Han Zhang
Summary: This study aimed to overcome the resistance of lung cancer cells to paclitaxel by preparing P-glycoprotein antibody-conjugated paclitaxel PEG-coated immunoliposomes (Pab-PTX-L). The results showed that Pab-PTX-L had nano-sized particles with high encapsulation efficiency of paclitaxel and exhibited better cellular uptake, cell viability inhibition, and apoptosis induction in paclitaxel-resistant lung cancer cells. Moreover, Pab-PTX-L demonstrated good tumor-targeting and antitumor effects in mouse experiments.
Article
Biochemistry & Molecular Biology
Eric Chekwube Aniogo, Blassan P. George, Heidi Abrahamse
Summary: The study utilized photodynamic therapy to treat MCF-7 cells overexpressed with P-glycoprotein, resulting in cell apoptosis with increased externalisation of phosphatidylserine protein and changes in apoptotic protein expression.
Article
Biochemistry & Molecular Biology
Jason W. Y. Kan, Clare S. W. Yan, Iris L. K. Wong, Xiaochun Su, Zhen Liu, Tak Hang Chan, Larry M. C. Chow
Summary: Biotransformation of flavonoid dimer FD18 resulted in an active metabolite FM04, which exhibited improved druggability and was more potent in reversing P-gp-mediated PTX resistance. FM04 sensitized cancer cells to multiple anticancer drugs by inhibiting P-gp transport activity and stimulating P-gp ATPase. In addition, FM04 enhanced the intestinal absorption of PTX and showed significant antitumor activity in mouse models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Michela Levi, Luisa Vera Muscatello, Barbara Brunetti, Cinzia Benazzi, Federico Parenti, Francesca Gobbo, Giancarlo Avallone, Barbara Bacci, Elisa Zambon, Paola Valenti, Giuseppe Sarli
Summary: Multidrug resistance in neoplastic cells is primarily mediated by P-glycoprotein and breast cancer resistance protein, with canine mammary carcinomas showing high intrinsic expression levels of both. However, no significant association was found between the expression of these proteins and immunophenotypes, Ki67 index, histological grade, or tumor-related death in this study.
Article
Biochemistry & Molecular Biology
Wenqin Sun, Iris L. K. Wong, Helen Ka-Wai Law, Xiaochun Su, Terry C. F. Chan, Gege Sun, Xinqing Yang, Xingkai Wang, Tak Hang Chan, Shengbiao Wan, Larry M. C. Chow
Summary: Tea polyphenol derivative EC31 is a potent and nontoxic P-gp inhibitor that can reverse multidrug resistance and enhance the efficacy of anticancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Chung-Pu Wu, Cheng-Yu Hung, Megumi Murakami, Yu-Shan Wu, Chun-Ling Lin, Yang-Hui Huang, Tai-Ho Hung, Jau-Song Yu, Suresh Ambudkar
Summary: In this study, we investigate the role of P-glycoprotein (P-gp) in the reduced sensitivity of cancer cells to the anaplastic lymphoma kinase (ALK) inhibitor ensartinib. Our results demonstrate that P-gp overexpression decreases the intracellular accumulation and cytotoxic activity of ensartinib in cancer cells. These findings highlight the importance of understanding the mechanisms of ensartinib resistance mediated by P-gp.
Article
Plant Sciences
Sara Abdelfatah, Madeleine Boeckers, Maitane Asensio, Onat Kadioglu, Anette Klinger, Edmond Fleischer, Thomas Efferth
Summary: The study identified isopetasin and S-isopetasin as novel P-gp inhibitors, which can overcome multidrug resistance and induce ROS generation and apoptosis in cancer cells.
Article
Cell Biology
Chung-Pu Wu, Megumi Murakami, Yu-Shan Wu, Ya-Chen Chi, Sung-Han Hsiao, Yang-Hui Huang, Tai-Ho Hung, Suresh Ambudkar
Summary: The study explored the potential of using branebrutinib to resensitize P-gp-overexpressing multidrug-resistant cancer cells to chemotherapy by inhibiting the drug transport function of P-gp. Results showed that branebrutinib could reverse P-gp-mediated MDR at sub-toxic concentrations while maintaining cytotoxicity against drug-sensitive parental cell lines and P-gp-overexpressing multidrug-resistant variants. This new pharmacological action of branebrutinib against P-gp activity warrants further investigation in future drug combination studies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jing-Yi Chen, Chieh-Ju Sung, Ssu-Chi Chen, Yi-Ping Hsiang, Yung-Chia Hsu, Yu-Ning Teng
Summary: Cancer drug resistance is a challenging issue for patients, especially in the later stages of treatment. In this study, researchers investigated the effects of vitamin E TPGS on drug efflux transporters and its ability to reverse multidrug resistance in cancer. The results showed that vitamin E TPGS significantly inhibited the efflux function of transporters P-gp, MRP1, and BCRP, without affecting protein expression levels. It was also found to be a competitive inhibitor on chemotherapeutic drug efflux in different over-expressing cell lines. Furthermore, vitamin E TPGS was able to enhance cell membrane fluidity and reverse multidrug resistance in breast cancer cells. This study suggests that vitamin E TPGS could be a promising modulator for overcoming drug resistance in cancer treatment.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ko-Hua Yu, Chan-Yen Kuo, I-Ting Wu, Ching-Ho Chi, Keng-Chang Tsai, Ping-Chung Kuo, Jing-Wen Zeng, Chin-Chuan Hung, Hsin-Yi Hung
Summary: Multidrug resistance is a significant challenge in cancer chemotherapy, but arctigenin derivatives show potential in reversing this resistance, especially when combined with paclitaxel.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Priya Mondal, Jagadish Natesh, Abdul Ajees Abdul Salam, Syed Musthapa Meeran
Summary: This study identified a potential bioactive compound, mahanimbine, from curry leaves that showed strong binding affinity with P-gp and modulated its activity. The compound was extracted using a novel and simple method and its structure and mass were confirmed. Mahanimbine was found to stimulate P-gp ATPase activity and enhance the intracellular accumulation of P-gp substrates. It also synergistically enhanced the efficiency of the chemotherapeutic drug gefitinib in lung cancer cells. Overall, mahanimbine could be further developed as a potential candidate to overcome chemoresistance in lung cancer.
BIOORGANIC CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Sofija Jovanovic Stojanov, Epole N. Ntungwe, Jelena Dinic, Ana Podolski-Renic, Milica Pajovic, Patricia Rijo, Milica Pesic
Summary: Coleon U, a natural compound not recognized as a substrate of P-glycoprotein, has equal efficacy against sensitive and multidrug-resistant cancer cells. It delays the decrease in P-glycoprotein activity by decreasing mitochondrial membrane potential and inhibiting P-glycoprotein expression.
Review
Pharmacology & Pharmacy
Jinyun Dong, Li Yuan, Can Hu, Xiangdong Cheng, Jiang -Jiang Qin
Summary: Multidrug resistance (MDR) is a major threat in chemotherapy, and the overexpression of ATP-binding cassette (ABC) transporters, particularly P-glycoprotein (P-gp)/ABCB1, plays a role in MDR. Targeting P-gp with small molecule inhibitors is an effective approach, but no clinically useful inhibitors have been identified so far. Therefore, further research is needed to overcome MDR.
PHARMACOLOGY & THERAPEUTICS
(2023)
Retraction
Oncology
S. Mohana, M. Ganesan, N. Rajendra Prasad, D. Ananthakrishnan, D. Velmurugan
Summary: A correction to this paper has been published and is accessible through the original article.
Letter
Allergy
MyungJa Ro, Sun-Young Kwon, Jae-Hong Kim
Article
Biochemistry & Molecular Biology
JaeIn Park, Jae-Hyun Jang, Jae-Hong Kim
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2019)
Article
Multidisciplinary Sciences
Sun-Young Kwon, MyungJa Ro, Jae-Hong Kim
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Sun-Young Kwon, Jae-Hong Kim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Jinhong Cho, Jinyoung Park, Sang Chul Shin, Jae-Hong Kim, Eunice EunKyeong Kim, Eun Joo Song
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Oncology
Jinhong Cho, Jinyoung Park, Sang Chul Shin, Mihue Jang, Jae-Hong Kim, Eunice EunKyeong Kim, Eun Joo Song
Article
Andrology
Soyun Han, Takashi Baba, Shogo Yanai, Dong Jun Byun, Ken-ichirou Morohashi, Jae-Hong Kim, Man Ho Choi
Summary: The study compared the metabolic pathways of steroids in fetal and adult mouse testes using GC-MS technology, revealing a significant increase in steroid levels in fetal testes. Metabolic ratios and specific steroidogenic pathways differed between fetal and adult mouse testes.
Article
Biochemistry & Molecular Biology
Dong-Wook Kwak, Donghwan Park, Jae-Hong Kim
Summary: The study demonstrated that blocking BLT1 or BLT2 signaling pathways significantly suppressed airway inflammation and IL-17 production, thereby alleviating neutrophil-dominant airway inflammation. The 5-/12-LO enzymes and the BLT1/BLT2-linked cascade play crucial roles in neutrophil-dominant airway inflammation and IL-17 synthesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Construction & Building Technology
Dong Jin Jeong, Taehwan Kim, Jong-Hyun Ryu, Jae Hong Kim
Summary: This paper presents a model for calculating the adiabatic temperature rise in concrete based on isothermal calorimetry of its paste binder, which is simpler and more practical. The model is verified by comparing its prediction results with measurements, and it can be a promising method for practically predicting the temperature profile of mass concrete using isothermal calorimetry.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Dong-Wook Kwak, Donghwan Park, Jae-Hong Kim
Summary: The study shows that BLT1 and BLT2 play a role in stimulating NLRP3 inflammasome and IL-1 beta synthesis, contributing significantly to neutrophil-dominant asthmatic airway inflammation.
Article
Biochemistry & Molecular Biology
Donghwan Park, MyungJa Ro, A-Jin Lee, Dong-Wook Kwak, Yunro Chung, Jae-Hong Kim
Summary: The study found that BLT2, a receptor for leukotriene B-4 with low affinity, plays a role in sepsis, a systemic inflammatory response syndrome caused by infection. Levels of BLT2 ligands and synthesizing enzymes for LTB4 and 12(S)-HETE were significantly increased in lung and liver tissues in a septic mouse model. Blocking BLT2 suppressed the production of sepsis-associated cytokines and alleviated lung inflammation in the sepsis group, suggesting that BLT2 may be a potential therapeutic target for sepsis patients.
MOLECULES AND CELLS
(2021)
Article
Biochemistry & Molecular Biology
Donghwan Park, Dong-Wook Kwak, Jae-Hong Kim
Summary: This study found that levels of ligands for BLT1/2 were significantly increased in bronchoalveolar lavage fluid after house dust mites challenge, and blocking BLT1 or BLT2, as well as 5-lipoxygenase or 12-lipoxygenase, suppressed T(H)2 cytokines production and alleviated lung inflammation in a mouse model of eosinophilic airway inflammation induced by house dust mites. These results suggest that the 5-/12-LO-BLT1/2 cascade plays a role in mediating T(H)2 cytokine production in house dust mite-induced airway inflammation, indicating that BLT1/2 may be a potential therapeutic target for patients with house dust mite-induced allergic asthma.
Meeting Abstract
Immunology
Donghwan Park, DongWook Kwak, Jae-Hong Kim
JOURNAL OF IMMUNOLOGY
(2020)
Meeting Abstract
Immunology
DongWook Kwak, Donghwan Park, Jae-Hyun Jang, Jae-Hong Kim
JOURNAL OF IMMUNOLOGY
(2020)
Article
Allergy
MyungJa Ro, A-Jin Lee, Jae-Hong Kim