An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma

Phenotypes and Karyotypes of Human Malignant Mesothelioma Cell Lines

(2013) Vandana Relan et al.   PLoS One

Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells

(2012) Peter S Harris et al.   BMC CANCER

A Phase I Open-Label Dose-Escalation Study of Intravenous BI 2536 Together With Pemetrexed in Previously Treated Patients With Non–Small-Cell Lung Cancer

(2012) Peter M. Ellis et al.   Clinical Lung Cancer

Excision Repair Cross Complementation Group 1 and Thymidylate Synthase Expression in Patients With Mesothelioma

(2012) Steven C.H. Kao et al.   Clinical Lung Cancer

The ticking time-bomb of asbestos: Its insidious role in the development of malignant mesothelioma

(2012) Anthony Linton et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Phase i study of the Plk1 inhibitor BI 2536 administered intravenously on three consecutive days in advanced solid tumours

(2012) A. Frost et al.   Current Oncology

MiR-100 resensitizes docetaxel-resistant human lung adenocarcinoma cells (SPC-A1) to docetaxel by targeting Plk1

(2011) Bing Feng et al.   CANCER LETTERS

Low Calretinin Expression and High Neutrophil-To-Lymphocyte Ratio Are Poor Prognostic Factors in Patients with Malignant Mesothelioma Undergoing Extrapleural Pneumonectomy

(2011) Steven Chuan-Hao Kao et al.   Journal of Thoracic Oncology

Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy

(2011) Ivan Bièche et al.   Molecular Cancer

Validation of tissue microarray technology in malignant pleural mesothelioma

(2011) Steven C.H. Kao et al.   PATHOLOGY

Elevated expression of Rad18 regulates melanoma cell proliferation

(2011) Ronald P.C. Wong et al.   Pigment Cell & Melanoma Research

Overexpressions of Cyclin B1, cdc2, p16 and p53 in Human Breast Cancer: The Clinicopathologic Correlations and Prognostic Implications

(2011) Seoung Wan Chae et al.   YONSEI MEDICAL JOURNAL

Polo-like kinase1 (Plk1) knockdown enhances cisplatin chemosensitivity via up-regulation of p73α in p53 mutant human epidermoid squamous carcinoma cells

(2010) Shilpa Tyagi et al.   BIOCHEMICAL PHARMACOLOGY

An Open-Label, Phase I Study of the Polo-like Kinase-1 Inhibitor, BI 2536, in Patients with Advanced Solid Tumors

(2010) R.-D. Hofheinz et al.   CLINICAL CANCER RESEARCH

Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies

(2010) Christophe Le Tourneau et al.   EUROPEAN JOURNAL OF CANCER

The Efficacy and Safety of BI 2536, a Novel Plk-1 Inhibitor, in Patients with Stage IIIB/IV Non-small Cell Lung Cancer Who Had Relapsed after, or Failed, Chemotherapy: Results from an Open-Label, Randomized Phase II Clinical Trial

(2010) Martin Sebastian et al.   Journal of Thoracic Oncology

Identification of Potential Therapeutic Targets in Malignant Mesothelioma Using Cell-Cycle Gene Expression Analysis

(2009) Solange Romagnoli et al.   AMERICAN JOURNAL OF PATHOLOGY

Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol

(2009) Ilija Androic et al.   BMC CANCER

Cdc2 as prognostic marker in stage UICC II colon carcinomas

(2009) Alexander Meyer et al.   EUROPEAN JOURNAL OF CANCER

Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence

(2009) Ann Byrne et al.   EXPERIMENTAL CELL RESEARCH

Malignant pleural mesothelioma: Genome-wide expression patterns reflecting general resistance mechanisms and a proposal of novel targets

(2009) Oluf Dimitri Røe et al.   LUNG CANCER

Small Molecule Targeting the Hec1/Nek2 Mitotic Pathway Suppresses Tumor Cell Growth in Culture and in Animal

(2008) G. Wu et al.   CANCER RESEARCH

Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicinin vivoin a breast cancer xenograft model

(2008) Maria Virginia C.L. Appleyard et al.   INTERNATIONAL JOURNAL OF CANCER

Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo

(2008) E. Diaz-Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells

(2008) Mohamed Salah I Abaza et al.   WORLD JOURNAL OF GASTROENTEROLOGY