Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL

Translating TRAIL-receptor targeting agents to the clinic

(2012) Martha W. den Hollander et al.   CANCER LETTERS

Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL

(2012) Eva Szegezdi et al.   MOLECULAR & CELLULAR PROTEOMICS

Targeting the Apoptotic Pathway in Chondrosarcoma Using Recombinant Human Apo2L/TRAIL (Dulanermin), a Dual Proapoptotic Receptor (DR4/DR5) Agonist

(2012) V. Subbiah et al.   MOLECULAR CANCER THERAPEUTICS

Knockdown of MADD and c-FLIP overcomes resistance to TRAIL-induced apoptosis in ovarian cancer cells

(2011) Liang-Cheng Li et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis

(2011) E W Duiker et al.   BRITISH JOURNAL OF CANCER

Randomized Phase II Study of Dulanermin in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Advanced Non–Small-Cell Lung Cancer

(2011) Jean-Charles Soria et al.   JOURNAL OF CLINICAL ONCOLOGY

Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants

(2011) C R Reis et al.   Cell Death & Disease

Disruption of the MDM2–p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway

(2011) R Koster et al.   Cell Death & Disease

LBY135, a novel anti-DR5 agonistic antibody induces tumor cell-specific cytotoxic activity in human colon tumor cell lines and xenografts

(2010) Jing Li et al.   DRUG DEVELOPMENT RESEARCH

The role of c-FLIPL in ovarian cancer: Chaperoning tumor cells from immunosurveillance and increasing their invasive potential

(2010) Ahmed El-Gazzar et al.   GYNECOLOGIC ONCOLOGY

Effect of TRA-8 Anti-Death Receptor 5 Antibody in Combination With Chemotherapy in an Ex Vivo Human Ovarian Cancer Model

(2010) Peter J. Frederick et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Phase I Dose-Escalation Study of Recombinant Human Apo2L/TRAIL, a Dual Proapoptotic Receptor Agonist, in Patients With Advanced Cancer

(2010) Roy S. Herbst et al.   JOURNAL OF CLINICAL ONCOLOGY

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

(2010) Inge A M de Graaf et al.   Nature Protocols

Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase toward Its Death Receptors†

(2009) Carlos R. Reis et al.   BIOCHEMISTRY

Nutlin-3 enhances tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through up-regulation of death receptor 5 (DR5) in human sarcoma HOS cells and human colon cancer HCT116 cells

(2009) Takeshi Hori et al.   CANCER LETTERS

Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model

(2009) E. W. Duiker et al.   CLINICAL CANCER RESEARCH

Therapeutic Potential of Mdm2 Inhibition in Malignant Germ Cell Tumours

(2009) Sebastian Bauer et al.   EUROPEAN UROLOGY

The extrinsic apoptosis pathway and its prognostic impact in ovarian cancer

(2009) Evelien W. Duiker et al.   GYNECOLOGIC ONCOLOGY

TRAIL receptor signalling and modulation: Are we on the right TRAIL?

(2008) Devalingam Mahalingam et al.   CANCER TREATMENT REVIEWS

Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5

(2008) C Adams et al.   CELL DEATH AND DIFFERENTIATION

A robustex vivomodel for evaluation of induction of apoptosis by rhTRAIL in combination with proteasome inhibitor MG132 in human premalignant cervical explants

(2008) Brigitte M.T. Hougardy et al.   INTERNATIONAL JOURNAL OF CANCER

DR4-selective Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Variants Obtained by Structure-based Design

(2008) Vicente Tur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY