Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model

Increased CDA Expression/Activity in Males Contributes to Decreased Cytidine Analog Half-Life and Likely Contributes to Worse Outcomes with 5-Azacytidine or Decitabine Therapy

(2013) R. Z. Mahfouz et al.   CLINICAL CANCER RESEARCH

Defining a Gene Promoter Methylation Signature in Sputum for Lung Cancer Risk Assessment

(2012) S. Leng et al.   CLINICAL CANCER RESEARCH

Therapeutic Liposomal Dry Powder Inhalation Aerosols for Targeted Lung Delivery

(2012) Lauren Willis et al.   LUNG

Combination Therapy with Vidaza and Entinostat Suppresses Tumor Growth and Reprograms the Epigenome in an Orthotopic Lung Cancer Model

(2011) Steven A. Belinsky et al.   CANCER RESEARCH

Regional particle size dependent deposition of inhaled aerosols in rats and mice

(2011) Philip J. Kuehl et al.   INHALATION TOXICOLOGY

Aerosolized Gemcitabine in Patients with Carcinoma of the Lung: Feasibility and Safety Study

(2011) Etienne Lemarie et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Phase I Study of Oral Azacitidine in Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, and Acute Myeloid Leukemia

(2011) Guillermo Garcia-Manero et al.   JOURNAL OF CLINICAL ONCOLOGY

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non-Small Cell Lung Cancer

(2011) R. A. Juergens et al.   Cancer Discovery

Intratracheally Administered 5-Azacytidine Is Effective Against Orthotopic Human Lung Cancer Xenograft Models and Devoid of Important Systemic Toxicity

(2010) Sameer Mahesh et al.   Clinical Lung Cancer

Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis

(2010) M Tessema et al.   ONCOGENE

Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers

(2009) Mathewos Tessema et al.   CARCINOGENESIS

Combination Chemotherapeutic Dry Powder Aerosols via Controlled Nanoparticle Agglomeration

(2009) Nashwa El-Gendy et al.   PHARMACEUTICAL RESEARCH

Aerosolized Chemotherapy

(2008) Frederic Gagnadoux et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

The BH3-only protein Bik/Blk/Nbk inhibits nuclear translocation of activated ERK1/2 to mediate IFNγ-induced cell death

(2008) Yohannes A. Mebratu et al.   JOURNAL OF CELL BIOLOGY