Article
Oncology
Katie M. O'Brien, Shelley S. Tworoger, Holly R. Harris, Britton Trabert, Clarice R. Weinberg, Renee T. Fortner, Aimee A. D'Aloisio, Andrew M. Kaunitz, Nicolas Wentzensen, Dale P. Sandler
Summary: A large pooled analysis of data from four large, prospective cohorts found no clear association between genital powder use and uterine cancer risk. Even for long-term users, the increase in risk was small and not statistically significant.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Endocrinology & Metabolism
Susanne F. Awad, Amine A. Toumi, Kholood A. Al-Mutawaa, Salah A. Alyafei, Muhammad A. Ijaz, Shamseldin A. H. Khalifa, Suresh B. Kokku, Amit C. M. Mishra, Benjamin Poovelil, Mounir B. Soussi, Katie G. El-Nahas, Abdulla O. Al-Hamaq, Julia A. Critchley, Mohammed H. Al-Thani, Laith J. Abu-Raddad
Summary: This study aimed to forecast the burden of type 2 diabetes mellitus (T2DM) in Qatar and found that the prevalence, number of cases, and incidence will increase sharply between 2021 and 2050. Obesity is one of the main risk factors and there are variations in the disease burden among different nationality groups.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Oncology
Ignacio Zapardiel, Myriam Gracia Segovia, Ronalds Macuks, Rosanna Mancari, Patriciu Achimas-Cadariu, Giacomo Corrado, Arnoldas Bartusevicius, Vladyslav Sukhin, Juan C. Muruzabal, Pluvio J. Coronado Martin, Barbara Gardella, Jurgen M. Piek, Nicole Concin, Clemente Arab, Dimitrios Papatheodorou, Stephan Polterauer, Sara Iacoponi, Teresa Nieto, Martha C. Lopez-Sanclemente, Hanna Trukhan, Maria M. Gil, Irina Bakinovskaya, Alena Dalamanava, Marc Cucurull, Dzmitry Rovski, Laura Baquedano, Luis Chiva, Marcin Mardas, Siarhei Anatolievich Mavrichev, Jaroslav Klat, Carlos A. Lopez de la Manzanara, Yusuf Yildirim, SARCUT Study Grp
Summary: This retrospective study analyzed 683 patients with uterine sarcoma to identify and evaluate the impact of different prognostic factors on overall survival and disease-free survival. The results showed variations in 5-year overall survival and disease-free survival rates among different subtypes of uterine sarcoma. The presence of residual disease after surgery was identified as the most significant factor affecting overall survival.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Review
Endocrinology & Metabolism
Nami Mohammadian Khonsari, Patricia Khashayar, Ehsan Shahrestanaki, Roya Kelishadi, Sahar Mohammadpoor Nami, Motahar Heidari-Beni, Zahra Esmaeili Abdar, Ozra Tabatabaei-Malazy, Mostafa Qorbani
Summary: This systematic review and meta-analysis showed that normal weight obesity (NWO) increased the odds of cardiometabolic risk factors (CMRFs). These findings indicate the inadequacy of BMI measurement and emphasize the need for body fat assessment for a better obesity risk assessment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Melkamu A. Zeru, Endalamaw Tesfa, Aweke A. Mitiku, Awoke Seyoum, Tesfaye Abera Bokoro
Summary: This study aimed to assess the prevalence and risk factors of type-2 DM in Ethiopian population. The pooled prevalence of DM in Ethiopia was 6.5%, with identified risk factors including older age, illiteracy, cigarette smoking, MBI >= 25, family history of DM, history of hypertension, and physical inactivity. Awareness of these risk factors is crucial for effective prevention and management of type-2 DM in this population.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Yingting Cao, Quan Huynh, Nitin Kapoor, Panniyammakal Jeemon, Gabrielli Thais de Mello, Brian Oldenburg, Kavumpurathu Raman Thankappan, Thirunavukkarasu Sathish
Summary: This study examined the association between dietary patterns and cardiometabolic risk factors in high-risk individuals for diabetes in India. The findings showed that a snack-fruit pattern was associated with increased triglycerides, while a rice-meat-refined wheat pattern was associated with elevated Hb1Ac and central obesity.
Article
Endocrinology & Metabolism
Mary M. Barker, Francesco Zaccardi, Emer M. Brady, Gaurav S. Gulsin, Andrew P. Hall, Joseph Henson, Zin Zin Htike, Kamlesh Khunti, Gerald P. McCann, Emma L. Redman, David R. Webb, Emma G. Wilmot, Tom Yates, Jian Yeo, Melanie J. Davies, Jack A. Sargeant
Summary: The diagnosis of type 2 diabetes at a younger age is associated with a worse cardiovascular risk profile, including higher body weight, BMI, waist circumference, and body fat percentage.
WORLD JOURNAL OF DIABETES
(2022)
Article
Medicine, General & Internal
Li Wang, Xiaoguang Li, Zhaoxin Wang, Michael P. Bancks, Mercedes R. Carnethon, Philip Greenland, Ying-Qing Feng, Hui Wang, Victor W. Zhong
Summary: The study based on NHANES data from US adults reveals a significant increase in the prevalence of diabetes between 1999-2000 and 2017-2018. Only around 21% of adults with diagnosed diabetes achieved all three risk factor control goals in 2015-2018.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Obstetrics & Gynecology
Alexandra Huss, Maximilian Klar, Mir Fuad Hasanov, Ingolf Juhasz-Boss, Michaela Bossart
Summary: This study identifies tumor histology, age at diagnosis, and progesterone receptor status as prognostic factors for uterine sarcoma. For leiomyosarcoma patients, age, surgical margins, FIGO stage, and chemotherapy application are also important for overall survival.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Public, Environmental & Occupational Health
Periyasamy Kuppusamy, Ranjan Kumar Prusty, Deepali Prakash Kale
Summary: Nearly half of all pregnancies in India have one or more high-risk factors, and the risks are higher among vulnerable populations. Addressing the leading high-risk factors should be a priority in health policy and programs.
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Endocrinology & Metabolism
Danielle K. Longmore, Jessica E. Miller, Siroon Bekkering, Christoph Saner, Edin Mifsud, Yanshan Zhu, Richard Saffery, Alistair Nichol, Graham Colditz, Kirsty R. Short, David P. Burgner
Summary: In adults hospitalized with COVID-19, overweight, obesity, and diabetes were associated with increased odds of requiring respiratory support but were not associated with death. In patients with diabetes, the odds of severe COVID-19 were not increased above the BMI-associated risk.
Review
Endocrinology & Metabolism
Yu Lu, Jing Tao
Summary: Diabetes and excess body weight are associated with negative outcomes in bladder cancer prognosis. Diabetic patients have higher risks compared to non-diabetics, while overweight patients do not show significant differences compared to normal BMI individuals. However, obese individuals have higher risks for disease progression and recurrence compared to normal BMI patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Sujata, Ramna Thakur
Summary: The study highlights that women and men with similar backgrounds and biological conditions can be affected differently by diabetes, with factors such as dietary habits and socio-economic status playing important roles in influencing the prevalence of the disease.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Megan Delisle, Bader Alshamsan, Kalki Nagaratnam, Denise Smith, Ying Wang, Amirrtha Srikanthan
Summary: Leiomyosarcoma (LMS) is an aggressive soft tissue sarcoma with a poor prognosis. Approximately 40% of patients will develop metastatic disease. This systematic review and pooled survival analysis found that patients with LMS metastases in the lungs, liver, spine, and brain can undergo metastasectomy with acceptable survival.
Article
Ophthalmology
Eileen c. Bowden, A. N. J. A. L. E. E. Choudhury, Steven j. Gedde, William j. Feuer, Panos g. Christakis, E. L. E. O. N. O. R. E. Savatovsky, Y. I. N. G. Han, Iqbal i. k. Ahmed, Donald l. Budenz
Summary: This study aims to identify the risk factors associated with failure of tube shunt surgery. The results showed that lower preoperative intraocular pressure, neovascular glaucoma, Ahmed implantation, and younger age were predictors of tube shunt failure.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Oncology
Tuo Lan, Yikyung Park, Graham A. Colditz, Jingxia Liu, Molin Wang, Kana Wu, Edward Giovannucci, Siobhan Sutcliffe
Summary: While the results were not entirely consistent, the study found that a high plant-based dietary pattern during adolescence may be associated with a slightly reduced risk of prostate cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Holly Michelle Crowe, Elizabeth Elliott Hatch, Tanran R. Wang, Charles Robert Horsburgh, Ellen Margrethe Mikkelsen, Wendy Kuohung, Lauren Anne Wise, Amelia Kent Wesselink
Summary: Periconceptional antibiotic use was not significantly associated with the risk of spontaneous abortion in this study, possibly due to multiple factors.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Oncology
Kelly Offermans, Josien C. A. Jenniskens, Colinda C. J. M. Simons, Iryna Samarska, Gregorio E. Fazzi, Kim M. Smits, Leo J. Schouten, Matty P. Weijenberg, Heike I. Grabsch, Piet A. van den Brandt
Summary: In this study, the authors found that metabolic Warburg-subtypes can predict the survival benefit from adjuvant therapy in colorectal cancer patients. Patients with moderate metabolic Warburg-subtype had a survival benefit from adjuvant therapy, while patients with low metabolic Warburg-subtype did not.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Gastroenterology & Hepatology
Junjie Huang, Don Eliseo Lucero-Prisno III, Lin Zhang, Wanghong Xu, Sunny H. H. Wong, Siew C. C. Ng, Martin C. S. Wong
Summary: Globally, gastrointestinal cancers account for over one-fourth of all cancer incidence and one-third of cancer-related mortality. East Asia has the highest burden of gastrointestinal cancers, including stomach, liver, oesophageal, and gallbladder cancers, which is attributed to population growth, aging, and westernization of lifestyles. The increasing incidence of young-onset colorectal cancer is also observed in East Asia. To effectively reduce the burden of gastrointestinal cancers in this region, efforts should be made to modify unhealthy lifestyles, promote vaccination against hepatitis virus, control infections, increase colorectal cancer screening, enhance early cancer detection, and improve cancer survivorship through organized rehabilitation programs.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Wei-Yuan Yao, Leah Li, Hui-Ru Jiang, Yong-Fu Yu, Wang-Hong Xu
Summary: The aim of this study was to investigate the transgenerational associations between exposure to famine in early life and obesity. The results showed that maternal exposure to famine was associated with higher risk of obesity in children, while paternal exposure was associated with lower risk. Understanding the transgenerational associations is important for reducing obesity risk in future generations.
Article
Oncology
Liu Lihua, Talar S. Habeshian, Zhang Juanjuan, Noah C. Peeri, Du Mengmeng, Immaculata De Vivo, Veronica Wendy Setiawan
Summary: The incidence of endometrial cancer, especially early-onset cases, is increasing, with striking differences in demographic and tumor characteristics as well as racial and ethnic patterns. This study utilized data from the Cancer in North America (CiNA) Analytic File to examine trends in invasive endometrial cancer incidence by age and ethnicity. The faster increase in early-onset cases, particularly among non-White women, suggests a possible association with the rising obesity epidemic in younger generations.
JNCI CANCER SPECTRUM
(2023)
Article
Oncology
Sontoria D. King, Swathi Veliginti, Martijn C. G. J. Brouwers, Zhewen Ren, Wei Zheng, Veronica W. Setiawan, Lynne R. Wilkens, Xiao-Ou Shu, Alan A. Arslan, Laura E. Beane Freeman, Paige M. Bracci, Federico Canzian, Mengmeng Du, Steven J. Gallinger, Graham G. Giles, Phyllis J. Goodman, Christopher A. Haiman, Manolis Kogevinas, Charles Kooperberg, Loic LeMarchand, Rachel E. Neale, Kala Visvanathan, Emily White, Demetrius Albanes, Gabriella Andreotti, Ana Babic, Sonja I. Berndt, Lauren K. Brais, Paul Brennan, Julie E. Buring, Kari G. Rabe, William R. Bamlet, Stephen J. Chanock, Charles S. Fuchs, J. Michael Gaziano, Edward L. Giovannucci, Thilo Hackert, Manal M. Hassan, Verena Katzke, Robert C. Kurtz, I. -Min Lee, Nuria Malats, Neil Murphy, Ann L. Oberg, Irene Orlow, Miquel Porta, Francisco X. Real, Nathaniel Rothman, Howard D. Sesso, Debra T. Silverman, Ian M. Thompson Jr, Jean Wactawski-Wende, Xiaoliang Wang, Nicolas Wentzensen, Herbert Yu, Anne Zeleniuch-Jacquotte, Kai Yu, Brian M. Wolpin, Eric J. Duell, Donghui Li, Rayjean J. Hung, Sandra Perdomo, Marjorie L. McCullough, Neal D. Freedman, Alpa Patel, Ulrike Peters, Elio Riboli, Malin Sund, Anne Tjonneland, Jun Zhong, Stephen K. Van den Eeden, Peter Kraft, Harvey A. Risch, Laufey T. Amundadottir, Alison P. Klein, Rachael Z. Stolzenberg-Solomon, Samuel O. Antwi
Summary: This study used Mendelian randomization (MR) to investigate the relationship between genetic predisposition to nonalcoholic fatty liver disease (NAFLD) and risk for pancreatic cancer. The results showed no association between genetically predicted NAFLD and pancreatic cancer risk, suggesting that any association between NAFLD and pancreatic cancer might be due to metabolic disturbances rather than a causal relationship.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Public, Environmental & Occupational Health
Summer Harvey, Nicolas Wentzensen, Kimberly Bertrand, Amanda Black, Louise A. Brinton, Chu Chen, Laura Costas, Luigino Dal Maso, Immaculata De Vivo, Mengmeng Du, Montserrat Garcia-Closas, Marc T. Goodman, Jessica Gorzelitz, Lisa Johnson, James Lacey, Linda Liao, Loren Lipworth, Jolanta Lissowska, Anthony B. Miller, Kelli O'Connell, Tracy A. O'Mara, Xiao Ou, Julie R. Palmer, Alpa Patel, Sonia Paytubi, Beatriz Pelegrina, Stacey Petruzella, Anna Prizment, Thomas Rohan, Sven Sandin, Veronica Wendy Setiawan, Rashmi Sinha, Britton Trabert, Penelope M. Webb, Lynne R. Wilkens, Wanghong Xu, Hannah P. Yang, Wei Zheng, Megan A. Clarke
Summary: This study evaluated the associations between obesity in young adulthood and adulthood with endometrial cancer risk. The results showed that obesity in both periods was positively associated with endometrial cancer risk, and weight gain was also positively associated with this risk while weight loss was inversely associated.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Sara Lindstrom, Lu Wang, Helian Feng, Arunabha Majumdar, Sijia Huo, James Macdonald, Tabitha Harrison, Constance Turman, Hongjie Chen, Nicholas Mancuso, Theo Bammler, Steve Gallinger, Stephen B. Gruber, Marc J. Gunter, Loic Le Marchand, Victor Moreno, Kenneth Offit, Immaculata De Vivo, Tracy A. O'Mara, Amanda B. Spurdle, Ian Tomlinson, Rebecca Fitzgerald, Puya Gharahkhani, Ines Gockel, Janusz Jankowski, Stuart Macgregor, Johannes Schumacher, Jill Barnholtz-Sloan, Melissa L. Bondy, Richard S. Houlston, Robert B. Jenkins, Beatrice Melin, Margaret Wrensch, Paul Brennan, David C. Christiani, Mattias Johansson, James Mckay, Melinda C. Aldrich, Christopher Amos, Maria Teresa Landi, Adonina Tardon, D. Timothy Bishop, Florence Demenais, Alisa M. Goldstein, Mark M. Iles, Peter A. Kanetsky, Matthew H. Law, Laufey T. Amundadottir, Rachael Stolzenberg-Solomon, Brian M. Wolpin, Alison Klein, Gloria Petersen, Harvey Risch, Stephen J. Chanock, Mark P. Purdue, Ghislaine Scelo, Paul Pharoah, Siddhartha Kar, Rayjean J. Hung, Bogdan Pasaniuc, Peter Kraft
Summary: This study quantified the shared genetic contribution to risk of different cancers and identified novel cancer susceptibility loci using data from 12 cancer genome-wide association studies. The results suggest that some genetic risk variants are shared among cancers, but most of cancer heritability is specific to certain tissues. Cross-disease analysis allows for increased statistical power and the identification of new susceptibility regions. Future studies are likely to discover additional regions associated with the risk of multiple cancer types.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Pathology
Bartholomeus G. H. Latten, Bela Kubat, Piet A. van den Brandt, Axel zur Hausen, Leo J. Schouten
Summary: The autopsy rate is declining while major discrepancies exist between autopsies and clinical diagnoses. This study aims to investigate the relationship between the cause of death, a history of cancer, and the autopsy rate. The findings of this study are important in understanding the impact of cancer on autopsies and can help counteract the decline in the medical autopsy.
Article
Oncology
Selena Odeh, Iryna V. Samarska, Andres Matoso, Jeroen A. A. Van De Pol, Marcella M. L. L. Baldewijns, Christina A. A. Hulsbergen-Van De Kaa, Jaleesa Van Der Meer, Guido Roemen, Erik Geelkens, Manon Van Engeland, Axel Zur Hausen, Leo J. Schouten, Kim M. Smits
Summary: The aim of this study was to re-evaluate renal cell carcinoma cases from a large population-based cohort in the Netherlands, using new classifications, in order to identify newly recognized subtypes. The cases were initially evaluated using previous classifications and data on clinicopathological characteristics were obtained. Two urogenital pathologists reviewed digital slides according to new grading and classification systems. No new RCC subtypes were identified in the cases. Restaging and regrading showed the possibility of reporting newer features in an old sample collection.
Article
Medicine, General & Internal
Tuo Lan, Mei Wang, Matthew J. J. Ehrhardt, Shu Jiang, Jennifer Q. Q. Lanctot, Gregory T. T. Armstrong, Melissa M. M. Hudson, Graham A. A. Colditz, Leslie L. L. Robison, Yikyung Park
Summary: This study examines the associations between dietary patterns and cardiovascular disease risk in adult survivors of childhood cancer. The findings suggest that adhering to healthy dietary patterns, such as the Healthy Eating Index (HEI-2015), DASH, and aMED, may lower the risk of cardiovascular disease, particularly in women. These results indicate that a diet rich in plant foods and moderate in animal foods should be recommended for the management and prevention of cardiovascular disease in childhood cancer survivors.
Article
Oncology
Gertraud Maskarinec, Sayaka M. Brown, Jordyn Lee, David Bogumil, Catherine Walsh, Christopher A. Haiman, Veronica Wendy Setiawan, Yurii B. Shvetsov, Loic Le Marchand
Summary: This study found an association between T2D and NHL incidence in several subgroups but not in the total population, and identified excess body weight in early life as a predictor of NHL incidence.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Environmental Sciences
Laura Deen, Alice Clark, Karin Sorig Hougaard, Kajsa Ugelvig Petersen, Marie Frederiksen, Lauren A. Wise, Amelia K. Wesselink, Harald William Meyer, Jens Peter Bonde, Sandra Sogaard Tottenborg
Summary: This study found an association between indoor air exposure to PCBs and T2D incidence, but there was no clear dose-response relationship between exposure and risk.
ENVIRONMENTAL RESEARCH
(2023)
Article
Oncology
Jason Tasoulas, Douglas R. Farquhar, Siddharth Sheth, Trevor Hackman, Wendell G. Yarbrough, Chris B. Agala, Alzina Koric, Luca Giraldi, Eleonora Fabianova, Jolanta Lissowska, Beata Swiatkowska, Marta Vilensky, Victor Wunsch-Filho, Marcos Brasilino de Carvalho, Rossana Veronica Mendoza Lopez, Ivana Holcatova, Diego Serraino, Jerry Polesel, Cristina Canova, Lorenzo Richiardi, Jose P. Zevallos, Andy Ness, Miranda Pring, Steve J. Thomas, Tom Dudding, Yuan-Chin Amy Lee, Mia Hashibe, Paolo Boffetta, Andrew F. Olshan, Kimon Divaris, Antonio L. Amelio
Summary: Good oral health, as defined by maintaining natural teeth and frequent dental visits, appears to be associated with improved overall survival among head and neck squamous cell carcinoma patients.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)