☆ 4.7 Article

A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas

BRITISH JOURNAL OF CANCER (2012)

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BRITISH JOURNAL OF CANCER
Volume 107, Issue 6, Pages 994-1000

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NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2012.302

Keywords

thyroid; radiation; gene expression; Chernobyl

Categories

Oncology

Funding

  1. European Union GENRISK-T project [FP6-36495]
  2. Fonds de la Recherche Scientifique Medicale
  3. Fondation contre le Cancer
  4. Fondation Van Buuren
  5. Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agriculture/Fonds de la Recherche Scientifique grant

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BACKGROUND: Papillary thyroid cancer (PTC) incidence increased dramatically in children after the Chernobyl accident, providing a unique opportunity to investigate the molecular features of radiation-induced thyroid cancer. In contrast to the previous studies that included age-related confounding factors, we investigated mRNA expression in PTC and in the normal contralateral tissues of patients exposed and non-exposed to the Chernobyl fallout, using age-and ethnicity-matched non-irradiated cohorts. METHODS: Forty-five patients were analysed by full-genome mRNA microarrays. Twenty-two patients have been exposed to the Chernobyl fallout; 23 others were age-matched and resident in the same regions of Ukraine, but were born after 1 March 1987, that is, were not exposed to I-131. RESULTS: A gene expression signature of 793 probes corresponding to 403 genes that permitted differentiation between normal tissues from patients exposed and from those who were not exposed to radiation was identified. The differences were confirmed by quantitative RT-PCR. Many deregulated pathways in the exposed normal tissues are related to cell proliferation. CONCLUSION: Our results suggest that a higher proliferation rate in normal thyroid could be related to radiation-induced cancer either as a predisposition or as a consequence of radiation. The signature allows the identification of radiation-induced thyroid cancers. British Journal of Cancer (2012) 107, 994-1000. doi:10.1038/bjc.2012.302 www.bjcancer.com Published online 24 July 2012 (C) 2012 Cancer Research UK

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Nahal-Bose, Hitoshi Nakagama, Hidewaki Nakagawa, Hiromi Nakamura, Toru Nakamura, Kaoru Nakano, Tannistha Nandi, Jyoti Nangalia, Mia Nastic, Arcadi Navarro, Fabio C. P. Navarro, David E. Neal, Gerd Nettekoven, Felicity Newell, Steven J. Newhouse, Yulia Newton, Alvin Wei Tian Ng, Anthony Ng, Jonathan Nicholson, David Nicol, Yongzhan Nie, G. Petur Nielsen, Morten Muhlig Nielsen, Serena Nik-Zainal, Michael S. Noble, Katia Nones, Paul A. Northcott, Faiyaz Notta, Brian D. O'Connor, Peter O'Donnell, Maria O'Donovan, Sarah O'Meara, Brian Patrick O'Neill, J. Robert O'Neill, David Ocana, Angelica Ochoa, Layla Oesper, Christopher Ogden, Hideki Ohdan, Kazuhiro Ohi, Lucila Ohno-Machado, Karin A. Oien, Akinyemi I. Ojesina, Hidenori Ojima, Takuji Okusaka, Larsson Omberg, Choon Kiat Ong, Stephan Ossowski, German Ott, B. F. Francis Ouellette, Christine P'ng, Marta Paczkowska, Salvatore Paiella, Chawalit Pairojkul, Marina Pajic, Qiang Pan-Hammarstroem, Elli Papaemmanuil, Irene Papatheodorou, Nagarajan Paramasivam, Ji Wan Park, Joong-Won Park, Keunchil Park, Kiejung Park, Peter J. Park, Joel S. Parker, Simon L. Parsons, Harvey Pass, Danielle Pasternack, Alessandro Pastore, Ann-Marie Patch, Iris Pauporte, Antonio Pea, John V. Pearson, Chandra Sekhar Pedamallu, Jakob Skou Pedersen, Paolo Pederzoli, Martin Peifer, Nathan A. Pennell, Charles M. Perou, Marc D. Perry, Gloria M. Petersen, Myron Peto, Nicholas Petrelli, Robert Petryszak, Stefan M. Pfister, Mark Phillips, Oriol Pich, Hilda A. Pickett, Todd D. Pihl, Nischalan Pillay, Sarah Pinder, Mark Pinese, Andreia V. Pinho, Esa Pitkaenen, Xavier Pivot, Elena Pineiro-Yanez, Laura Planko, Christoph Plass, Paz Polak, Tirso Pons, Irinel Popescu, Olga Potapova, Aparna Prasad, Shaun R. Preston, Manuel Prinz, Antonia L. Pritchard, Stephenie D. Prokopec, Elena Provenzano, Xose S. Puente, Sonia Puig, Montserrat Puiggros, Sergio Pulido-Tamayo, Gulietta M. Pupo, Colin A. Purdie, Michael C. Quinn, Raquel Rabionet, Janet S. Rader, Bernhard Radlwimmer, Petar Radovic, Benjamin Raeder, Keiran M. Raine, Manasa Ramakrishna, Kamna Ramakrishnan, Suresh Ramalingam, Benjamin J. Raphael, W. Kimryn Rathmell, Tobias Rausch, Guido Reifenberger, Jueri Reimand, Jorge Reis-Filho, Victor Reuter, Iker Reyes-Salazar, Matthew A. Reyna, Sheila M. Reynolds, Esther Rheinbay, Yasser Riazalhosseini, Andrea L. Richardson, Julia Richter, Matthew Ringel, Markus Ringner, Yasushi Rino, Karsten Rippe, Jeffrey Roach, Lewis R. Roberts, Nicola D. Roberts, Steven A. Roberts, A. Gordon Robertson, Alan J. Robertson, Javier Bartolome Rodriguez, Bernardo Rodriguez-Martin, F. German Rodriguez-Gonzalez, Michael H. A. Roehrl, Marius Rohde, Hirofumi Rokutan, Gilles Romieu, Ilse Rooman, Tom Roques, Daniel Rosebrock, Mara Rosenberg, Philip C. Rosenstiel, Andreas Rosenwald, Edward W. Rowe, Romina Royo, Steven G. Rozen, Yulia Rubanova, Mark A. Rubin, Carlota Rubio-Perez, Vasilisa A. Rudneva, Borislav C. Rusev, Andrea Ruzzenente, Gunnar Raetsch, Radhakrishnan Sabarinathan, Veronica Y. Sabelnykova, Sara Sadeghi, S. Cenk Sahinalp, Natalie Saini, Mihoko Saito-Adachi, Gordon Saksena, Adriana Salcedo, Roberto Salgado, Leonidas Salichos, Richard Sallari, Charles Saller, Roberto Salvia, Michelle Sam, Jaswinder S. Samra, Francisco Sanchez-Vega, Chris Sander, Grant Sanders, Rajiv Sarin, Iman Sarrafi, Aya Sasaki-Oku, Torill Sauer, Guido Sauter, Robyn P. M. Saw, Maria Scardoni, Christopher J. Scarlett, Aldo Scarpa, Ghislaine Scelo, Dirk Schadendorf, Jacqueline E. Schein, Markus B. Schilhabel, Matthias Schlesner, Thorsten Schlomm, Heather K. Schmidt, Sarah-Jane Schramm, Stefan Schreiber, Nikolaus Schultz, Steven E. Schumacher, Roland F. Schwarz, Richard A. Scolyer, David Scott, Ralph Scully, Raja Seethala, Ayellet V. Segre, Iris Selander, Colin A. Semple, Yasin Senbabaoglu, Subhajit Sengupta, Elisabetta Sereni, Stefano Serra, Dennis C. Sgroi, Mark Shackleton, Nimish C. Shah, Sagedeh Shahabi, Catherine A. Shang, Ping Shang, Ofer Shapira, Troy Shelton, Ciyue Shen, Hui Shen, Rebecca Shepherd, Ruian Shi, Yan Shi, Yu-Jia Shiah, Tatsuhiro Shibata, Juliann Shih, Eigo Shimizu, Kiyo Shimizu, Seung Jun Shin, Yuichi Shiraishi, Tal Shmaya, Ilya Shmulevich, Solomon I. Shorser, Charles Short, Raunak Shrestha, Suyash S. Shringarpure, Craig Shriver, Shimin Shuai, Nikos Sidiropoulos, Reiner Siebert, Anieta M. Sieuwerts, Lina Sieverling, Sabina Signoretti, Katarzyna O. Sikora, Michele Simbolo, Ronald Simon, Janae V. Simons, Jared T. Simpson, Peter T. Simpson, Samuel Singer, Nasa Sinnott-Armstrong, Payal Sipahimalani, Tara J. Skelly, Marcel Smid, Jaclyn Smith, Karen Smith-McCune, Nicholas D. Socci, Heidi J. Sofia, Matthew G. Soloway, Lei Song, Anil K. Sood, Sharmila Sothi, Christos Sotiriou, Cameron M. Soulette, Paul N. Span, Paul T. Spellman, Nicola Sperandio, Andrew J. Spillane, Oliver Spiro, Jonathan Spring, Johan Staaf, Peter F. Stadler, Peter Staib, Stefan G. Stark, Lucy Stebbings, olafur Andri Stefansson, Oliver Stegle, Lincoln D. Stein, Alasdair Stenhouse, Chip Stewart, Stephan Stilgenbauer, Miranda D. Stobbe, Michael R. Stratton, Jonathan R. Stretch, Adam J. Struck, Joshua M. Stuart, Henk G. Stunnenberg, Hong Su, Xiaoping Su, Ren X. Sun, Stephanie Sungalee, Hana Susak, Akihiro Suzuki, Fred Sweep, Monika Szczepanowski, Holger Sueltmann, Takashi Yugawa, Angela Tam, David Tamborero, Benita Kiat Tee Tan, Donghui Tan, Patrick Tan, Hiroko Tanaka, Hirokazu Taniguchi, Tomas J. Tanskanen, Maxime Tarabichi, Roy Tarnuzzer, Patrick Tarpey, Morgan L. Taschuk, Kenji Tatsuno, Simon Tavare, Darrin F. Taylor, Amaro Taylor-Weiner, Jon W. Teague, Bin Tean Teh, Varsha Tembe, Javier Temes, Kevin Thai, Sarah P. Thayer, Nina Thiessen, Gilles Thomas, Sarah Thomas, Alan Thompson, Alastair M. Thompson, John F. F. Thompson, R. Houston Thompson, Heather Thorne, Leigh B. Thorne, Adrian Thorogood, Grace Tiao, Nebojsa Tijanic, Lee E. Timms, Roberto Tirabosco, Marta Tojo, Stefania Tommasi, Christopher W. Toon, Umut H. Toprak, David Torrents, Giampaolo Tortora, Joerg Tost, Yasushi Totoki, David Townend, Nadia Traficante, Isabelle Treilleux, Jean-Remi Trotta, Lorenz H. P. Truemper, Ming Tsao, Tatsuhiko Tsunoda, Jose M. C. Tubio, Olga Tucker, Richard Turkington, Daniel J. Turner, Andrew Tutt, Masaki Ueno, Naoto T. Ueno, Christopher Umbricht, Husen M. Umer, Timothy J. Underwood, Lara Urban, Tomoko Urushidate, Tetsuo Ushiku, Liis Uuskuela-Reimand, Alfonso Valencia, David J. van den Berg, Steven Van Laere, Peter Van Loo, Erwin G. Van Meir, Gert G. van den Eynden, Theodorus van der Kwast, Naveen Vasudev, Miguel Vazquez, Ravikiran Vedururu, Umadevi Veluvolu, Shankar Vembu, Lieven P. C. Verbeke, Peter Vermeulen, Clare Verrill, Alain Viari, David Vicente, Caterina Vicentini, K. Vijayraghavan, Juris Viksna, Ricardo E. Vilain, Izar Villasante, Anne Vincent-Salomon, Tapio Visakorpi, Douglas Voet, Paresh Vyas, Ignacio Vazquez-Garcia, Nick M. Waddell, Nicola Waddell, Claes Wadelius, Lina Wadi, Rabea Wagener, Jeremiah A. Wala, Jian Wang, Jiayin Wang, Linghua Wang, Qi Wang, Wenyi Wang, Yumeng Wang, Zhining Wang, Paul M. Waring, Hans-Joerg Warnatz, Jonathan Warrell, Anne Y. Warren, Sebastian M. Waszak, David C. Wedge, Dieter Weichenhan, Paul Weinberger, John N. Weinstein, Joachim Weischenfeldt, Daniel J. Weisenberger, Ian Welch, Michael C. Wendl, Johannes Werner, Justin P. Whalley, David A. Wheeler, Hayley C. Whitaker, Dennis Wigle, Matthew D. Wilkerson, Ashley Williams, James S. Wilmott, Gavin W. Wilson, Julie M. Wilson, Richard K. Wilson, Boris Winterhoff, Jeffrey A. Wintersinger, Maciej Wiznerowicz, Stephan Wolf, Bernice H. Wong, Tina Wong, Winghing Wong, Youngchoon Woo, Scott Wood, Bradly G. Wouters, Adam J. Wright, Derek W. Wright, Mark H. Wright, Chin-Lee Wu, Dai-Ying Wu, Guanming Wu, Jianmin Wu, Kui Wu, Yang Wu, Zhenggang Wu, Liu Xi, Tian Xia, Qian Xiang, Xiao Xiao, Rui Xing, Heng Xiong, Qinying Xu, Yanxun Xu, Hong Xue, Shinichi Yachida, Sergei Yakneen, Rui Yamaguchi, Takafumi N. Yamaguchi, Masakazu Yamamoto, Shogo Yamamoto, Hiroki Yamaue, Fan Yang, Huanming Yang, Jean Y. Yang, Liming Yang, Lixing Yang, Shanlin Yang, Tsun-Po Yang, Yang Yang, Xiaotong Yao, Marie-Laure Yaspo, Lucy Yates, Christina Yau, Chen Ye, Kai Ye, Venkata D. Yellapantula, Christopher J. Yoon, Sung-Soo Yoon, Fouad Yousif, Jun Yu, Kaixian Yu, Willie Yu, Yingyan Yu, Ke Yuan, Yuan Yuan, Denis Yuen, Christina K. Yung, Olga Zaikova, Jorge Zamora, Marc Zapatka, Jean C. Zenklusen, Thorsten Zenz, Nikolajs Zeps, Cheng-Zhong Zhang, Fan Zhang, Hailei Zhang, Hongwei Zhang, Hongxin Zhang, Jiashan Zhang, Jing Zhang, Junjun Zhang, Xiuqing Zhang, Xuanping Zhang, Yan Zhang, Zemin Zhang, Zhongming Zhao, Liangtao Zheng, Xiuqing Zheng, Wanding Zhou, Yong Zhou, Bin Zhu, Hongtu Zhu, Jingchun Zhu, Shida Zhu, Lihua Zou, Xueqing Zou, Anna Defazio, Nicholas van As, Carolien H. M. van Deurzen, Marc J. van de Vijver, L. Van't Veer, Christian von Mering

NATURE GENETICS (2023)

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Article Oncology

Systematic in vitro analysis of therapy resistance in glioblastoma cell lines by integration of clonogenic survival data with multi-level molecular data

Leon Emanuel Schnoeller, Daniel Piehlmaier, Peter Weber, Nikko Brix, Daniel Felix Fleischmann, Alexander Edward Nieto, Martin Selmansberger, Theresa Heider, Julia Hess, Maximilian Niyazi, Claus Belka, Kirsten Lauber, Kristian Unger, Michael Orth

Summary: Despite previous efforts, glioblastoma remains a highly devastating disease with poor prognosis. In this study, we integrated data from multiple molecular levels to identify therapy resistance and potential targets for treatment. Our findings suggest new candidates for combination therapy and provide proof-of-concept for multi-level data integration. The generated dataset offers valuable resources for researchers in the field of glioblastoma therapy resistance.

RADIATION ONCOLOGY (2023)

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Article Oncology

A Novel Subgroup of UCHL1-Related Cancers Is Associated with Genomic Instability and Sensitivity to DNA-Damaging Treatment

Sebastian Burkart, Christopher Weusthof, Karam Khorani, Sonja Steen, Fabian Stoegbauer, Kristian Unger, Julia Hess, Horst Zitzelsberger, Claus Belka, Ina Kurth, Jochen Hess

Summary: In this study, a new subgroup of UCHL1-related cancers was identified across multiple solid tumor entities and characterized by increased genomic instability and vulnerability to DNA-damaging treatment, with a favorable prognosis after radiotherapy. A novel classification model was established for accurate identification of UCHL1-related cancers, providing a basis for further research.

CANCERS (2023)

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Article Health Care Sciences & Services

Tackling Thyroid Cancer in Europe-The Challenges and Opportunities

Denis Horgan, Dagmar Fuehrer-Sakel, Paula Soares, Clara Alvarez, Laura Fugazzola, Romana T. Netea-Maier, Barbara Jarzab, Marta Kozaric, Beate Bartes, James Schuster-Bruce, Luigino Dal Maso, Martin Schlumberger, Furio Pacini

Summary: Thyroid cancer, the most common malignancy of the endocrine system, is usually curable, but there are still challenges regarding knowledge improvement, early identification, and reducing overdiagnosis. The European Alliance for Personalised Medicine hosted an expert panel discussion, which proposed recommendations on improving infrastructure, funding, and promoting collaboration to enhance patient care.

HEALTHCARE (2022)

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Article Oncology

Increased replication stress and R-loop accumulation in EGFRvIII-expressing glioblastoma present new therapeutic opportunities

Nina Struve, Konstantin Hoffer, Anna-Sophie Weik, Britta Riepen, Leonie Krug, Meryem H. Cetin, Jasmin Burmester, Leonie Ott, Jana Liebing, Fruzsina Gatzemeier, Justus Muller-Goebel, Mirja Gerbach, Lara Bussmann, Ann Christin Parplys, Kristian Unger, Wael Y. Mansour, Ulrich Schuller, Thorsten Rieckmann, Cordula Petersen, Kai Rothkamm, Susan C. Short, Malte Kriegs

Summary: This study reveals that the expression of EGFRvIII in a type of brain glioblastoma leads to increased replication stress, as well as genomic instability. These findings may provide new insights for the treatment of glioblastoma.

NEURO-ONCOLOGY ADVANCES (2022)

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Article Endocrinology & Metabolism

The role of thyroid sonographic malignancy risk features when the fine needle aspiration biopsy result is indeterminate

Agnieszka Kotecka-Blicharz, Marcela Krzempek, Alexander Jorge Cortez, Malgorzata Oczko-Wojciechowska, Agnieszka Czarniecka, Ewa Nozynska, Ewa Chmielik, Barbara Jarzab, Jolanta Krajewska

Summary: This study retrospectively reviewed thyroid ultrasound scans from 175 adult patients with thyroid nodules and indeterminate cytopathology results to assess the relationship between sonographic malignancy risk features and thyroid cancer risk. The results showed that the accumulation of sonographic risk features only significantly increased malignancy risk in certain categories of thyroid nodules.

ENDOKRYNOLOGIA POLSKA (2022)

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