Functional imaging: what evidence is there for its utility in clinical trials of targeted therapies?

Early prediction of response to sorafenib treatment in patients with hepatocellular carcinoma (HCC) with 18F- fluorodeoxyglucose-positron emission tomography (18F-FDG-PET)

(2017) E. Siemerink et al.   JOURNAL OF CLINICAL ONCOLOGY

Diffusion-Weighted Magnetic Resonance Imaging as a Cancer Biomarker: Consensus and Recommendations

(2015) Anwar R. Padhani et al.   NEOPLASIA

A Feasibility Study of Parametric Response Map Analysis of Diffusion-Weighted Magnetic Resonance Imaging Scans of Head and Neck Cancer Patients for Providing Early Detection of Therapeutic Efficacy

(2014) Craig J. Galbán et al.   Translational Oncology

Early Evaluation of Cancer Response by a New Functional Biomarker: Apparent Diffusion Coefficient

(2011) Ying-Shi Sun et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Pharmacodynamic Study Using FLT PET/CT in Patients with Renal Cell Cancer and Other Solid Malignancies Treated with Sunitinib Malate

(2011) G. Liu et al.   CLINICAL CANCER RESEARCH

Advances in MRI Assessment of Gliomas and Response to Anti-VEGF Therapy

(2011) Whitney B. Pope et al.   Current Neurology and Neuroscience Reports

Assessing response in bone metastases in prostate cancer with diffusion weighted MRI

(2011) C. Messiou et al.   EUROPEAN RADIOLOGY

Perfusion Estimated With Rapid Dynamic Contrast-Enhanced Magnetic Resonance Imaging Correlates Inversely With Vascular Endothelial Growth Factor Expression and Pimonidazole Staining in Head-and-Neck Cancer: A Pilot Study

(2011) Stephanie B. Donaldson et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Monitoring Response to Antiangiogenic Treatment and Predicting Outcomes in Advanced Hepatocellular Carcinoma Using Image Biomarkers, CT Perfusion, Tumor Density, and Tumor Size (RECIST)

(2011) Tao Jiang et al.   INVESTIGATIVE RADIOLOGY

Differentiating treatment-induced necrosis from recurrent/progressive brain tumor using nonmodel-based semiquantitative indices derived from dynamic contrast-enhanced T1-weighted MR perfusion

(2011) J. Narang et al.   NEURO-ONCOLOGY

A phase I study to determine the safety, pharmacokinetics and pharmacodynamics of a dual VEGFR and FGFR inhibitor, brivanib, in patients with advanced or metastatic solid tumors

(2010) D. J. Jonker et al.   ANNALS OF ONCOLOGY

Pilot study of DCE-MRI to predict progression-free survival with sorafenib therapy in renal cell carcinoma

(2010) Keith T. Flaherty et al.   CANCER BIOLOGY & THERAPY

Metastatic Renal Cell Carcinoma Treated with Sunitinib: Early Evaluation of Treatment Response Using Dynamic Contrast-Enhanced Ultrasonography

(2010) N. Lassau et al.   CLINICAL CANCER RESEARCH

Perfusion MRI in the early clinical development of antivascular drugs: decorations or decision making tools?

(2010) Martin Zweifel et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Quantitative Parametric Perfusion Images Using 15O-Labeled Water and a Clinical PET/CT Scanner: Test-Retest Variability in Lung Cancer

(2010) A. A. M. van der Veldt et al.   JOURNAL OF NUCLEAR MEDICINE

Bone Metastases from Prostate Cancer: Assessing Treatment Response by Using Diffusion-weighted Imaging and Functional Diffusion Maps—Initial Observations

(2010) Carolin Reischauer et al.   RADIOLOGY

Metastatic Renal Carcinoma: Evaluation of Antiangiogenic Therapy with Dynamic Contrast-enhanced CT

(2010) Laure S. Fournier et al.   RADIOLOGY

Advanced Hepatocellular Carcinoma: Early Evaluation of Response to Bevacizumab Therapy at Dynamic Contrast-enhanced US with Quantification—Preliminary Results

(2010) Nathalie Lassau et al.   RADIOLOGY

Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy

(2009) M Beloueche-Babari et al.   BRITISH JOURNAL OF CANCER

A “Vascular Normalization Index” as Potential Mechanistic Biomarker to Predict Survival after a Single Dose of Cediranib in Recurrent Glioblastoma Patients

(2009) A. Gregory Sorensen et al.   CANCER RESEARCH

Phase I Study of the Angiogenesis Inhibitor BIBF 1120 in Patients with Advanced Solid Tumors

(2009) K. Mross et al.   CLINICAL CANCER RESEARCH

mTOR Inhibitor RAD001 (Everolimus) Has Antiangiogenic/Vascular Properties Distinct from a VEGFR Tyrosine Kinase Inhibitor

(2009) H. A. Lane et al.   CLINICAL CANCER RESEARCH

Decreased Blood Flow with Increased Metabolic Activity: A Novel Sign of Pancreatic Tumor Aggressiveness

(2009) G. Komar et al.   CLINICAL CANCER RESEARCH

Clinical relevance of contrast-enhanced ultrasound in monitoring anti-angiogenic therapy of cancer: Current status and perspectives

(2009) Michele Lamuraglia et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Molecular imaging of hypoxia with radiolabelled agents

(2009) Gilles Mees et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Reproducibility and changes in the apparent diffusion coefficients of solid tumours treated with combretastatin A4 phosphate and bevacizumab in a two-centre phase I clinical trial

(2009) Dow-Mu Koh et al.   EUROPEAN RADIOLOGY

Early Quantitative Evaluation of a Tumor Vasculature Disruptive Agent AVE8062 Using Dynamic Contrast-Enhanced Ultrasonography

(2009) Sonia Lavisse et al.   INVESTIGATIVE RADIOLOGY

Efficacy, Safety, and Potential Biomarkers of Sunitinib Monotherapy in Advanced Hepatocellular Carcinoma: A Phase II Study

(2009) Andrew X. Zhu et al.   JOURNAL OF CLINICAL ONCOLOGY

[18F]Fluorodeoxyglucose Positron Emission Tomography Correlates With Akt Pathway Activity but Is Not Predictive of Clinical Outcome During mTOR Inhibitor Therapy

(2009) Wen Wee Ma et al.   JOURNAL OF CLINICAL ONCOLOGY

Repeatability of 18F-FDG PET in a Multicenter Phase I Study of Patients with Advanced Gastrointestinal Malignancies

(2009) L. M. Velasquez et al.   JOURNAL OF NUCLEAR MEDICINE

From RECIST to PERCIST: Evolving Considerations for PET Response Criteria in Solid Tumors

(2009) R. L. Wahl et al.   JOURNAL OF NUCLEAR MEDICINE

The parametric response map is an imaging biomarker for early cancer treatment outcome

(2009) Craig J Galbán et al.   NATURE MEDICINE

Molecular PET and PET/CT imaging of tumour cell proliferation using F-18 fluoro-L-thymidine: a comprehensive evaluation

(2009) Tara Barwick et al.   NUCLEAR MEDICINE COMMUNICATIONS

Predicting Pathologic Response to Neoadjuvant Chemotherapy in Breast Cancer by Using MR Imaging and Quantitative1H MR Spectroscopy

(2009) Hyeon-Man Baek et al.   RADIOLOGY

PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer

(2008) Farrokh Dehdashti et al.   BREAST CANCER RESEARCH AND TREATMENT

Effects of the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235 on the Tumor Vasculature: Implications for Clinical Imaging

(2008) C. R. Schnell et al.   CANCER RESEARCH

18F-Fluoro-2-Deoxy-Glucose Uptake Predicts Clinical Outcome in Patients with Gefitinib-Treated Non-Small Cell Lung Cancer

(2008) I. I. Na et al.   CLINICAL CANCER RESEARCH

[18F]Fluorothymidine Positron Emission Tomography before and 7 Days after Gefitinib Treatment Predicts Response in Patients with Advanced Adenocarcinoma of the Lung

(2008) H.-J. Sohn et al.   CLINICAL CANCER RESEARCH

Imaging of HER-2 Overexpression in Tumors for Guiding Therapy

(2008) V. Tolmachev   CURRENT PHARMACEUTICAL DESIGN

Reproducibility of quantitative 18F-3′-deoxy-3′-fluorothymidine measurements using positron emission tomography

(2008) Adrianus J. de Langen et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Dynamic Contrast-Enhanced Magnetic Resonance Imaging Pharmacodynamic Biomarker Study of Sorafenib in Metastatic Renal Carcinoma

(2008) Olwen M. Hahn et al.   JOURNAL OF CLINICAL ONCOLOGY

Tumor Metabolism and Blood Flow Changes by Positron Emission Tomography: Relation to Survival in Patients Treated With Neoadjuvant Chemotherapy for Locally Advanced Breast Cancer

(2008) Lisa K. Dunnwald et al.   JOURNAL OF CLINICAL ONCOLOGY

Reproducibility of Tumor Perfusion Measurements Using 15O-Labeled Water and PET

(2008) A. J. de Langen et al.   JOURNAL OF NUCLEAR MEDICINE

Reproducibility of Standardized Uptake Value Measurements Determined by 18F-FDG PET in Malignant Tumors

(2008) C. Nahmias et al.   JOURNAL OF NUCLEAR MEDICINE

Usefulness of FDG-PET for early prediction of the response to gefitinib in non-small cell lung cancer

(2007) Noriaki Sunaga et al.   LUNG CANCER