Review
Medicine, General & Internal
Esmee J. Grobbee, Pieter Ha Wisse, Eline H. Schreuders, Aafke van Roon, Leonie van Dam, Ann G. Zauber, Iris Lansdorp-Vogelaar, Wichor Bramer, Sarah Berhane, Jonathan J. Deeks, Ewout W. Steyerberg, Monique E. van Leerdam, Manon Cw Spaander, Ernst J. Kuipers
Summary: FIT is superior to gFOBT in detecting advanced colorectal neoplasia and colorectal cancer in average-risk individuals. The specificity of both tests was similar, while the sensitivity of FIT was significantly higher than gFOBT at pre-specified specificities.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Oncology
Sara G. Ribe, Edoardo Botteri, Magnus Loberg, Kristin R. Randel, Mette Kalager, Jens Aksel Nilsen, Elisabeth H. Gulichsen, Oyvind Holme
Summary: This study investigated the impact of time interval between faecal immunochemical testing (FIT) cycles on the detection rate of colorectal cancer (CRC) and advanced neoplasia (AN). The results showed that although the detection rates of CRC and AN increased with increasing time interval between FITs, individuals who had undetectable faecal haemoglobin (f-Hb) at the first screening round had a substantially lower risk of CRC at the next screening round compared to individuals with detectable f-Hb.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Gemma Ibanez-Sanz, Nuria Mila, Carmen Vidal, Judith Rocamora, Victor Moreno, Rebeca Sanz-Pamplona, Montse Garcia
Summary: This study found a significant increase in mortality rate in patients with interval CRC compared to screen-detected CRC, with a 74% increase in mortality rate. These differences were still present even when restricting for advanced-cancers participants. Stratified analysis for type of faecal occult blood test showed a lower mortality rate only among FIT screen-detected CRCs.
Review
Gastroenterology & Hepatology
Noel Pin-Vieito, Manuel Puga, Daniel Fernandez-de-Castro, Joaquin Cubiella
Summary: FIT is widely used as a biomarker for colorectal cancer diagnosis and plays a crucial role in screening and surveillance. This review summarizes the diagnostic efficacy of FIT in symptomatic patients and post-adenoma resection, as well as discusses the potential impact of FIT strategies on healthcare resources and CRC prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Editorial Material
Medicine, General & Internal
John M. M. Carethers
Summary: A 56-year-old man with no significant medical history declined screening colonoscopy in the past but now wants a less invasive test due to his father's death from colorectal cancer. What is the next course of action?
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Gastroenterology & Hepatology
Reinier G. S. Meester, Hilliene J. van de Schootbrugge-vandermeer, Emilie C. H. Breekveldt, Lucie de Jonge, Esther Toes-Zoutendijk, Arthur Kooyker, Daan Nieboer, Christian R. Ramakers, Manon C. W. Spaander, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, Iris D. Nagtegaal, Evelien Dekker, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The prognostic potential of repeated faecal haemoglobin (F-Hb) concentration measurements in faecal immunochemical test (FIT)-based screening for colorectal cancer (CRC) was examined. The study found that F-Hb concentrations in rounds 1 and 2 were the strongest predictors. In external validation, the model retained similar discrimination accuracy. This suggests that individuals can be accurately identified as low or high risk based on age, sex, and prior F-Hb concentrations, and risk stratification should be considered based on this information.
Review
Public, Environmental & Occupational Health
Zilin Luo, Xuesi Dong, Chenran Wang, Wei Cao, Yadi Zheng, Zheng Wu, Yongjie Xu, Liang Zhao, Fei Wang, Jibin Li, Jiansong Ren, Jufang Shi, Wanqing Chen, Ni Li
Summary: This study systematically reviewed observational studies on the association between socioeconomic status (SES) and adherence to colorectal cancer (CRC) screening. The findings showed that individuals with high SES had higher adherence to screening compared to those with low SES. Neighborhood SES or small-area SES was more effective in assessing the association between SES and adherence than individual SES.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Medicine, General & Internal
Paulina Wieszczy, Michal F. Kaminski, Magnus Loberg, Marek Bugajski, Michael Bretthauer, Mette Kalager
Summary: Estimates of overdiagnosis of colorectal cancer through screening methods such as sigmoidoscopy and FOBT varied significantly depending on model assumptions. Microsimulation models showed a wide range of overdiagnosis percentages for both screening methods, indicating caution should be exercised when using these models to inform guidelines.
Review
Oncology
Laura F. Gruner, Efrat L. Amitay, Thomas Heisser, Feng Guo, Tobias Niedermaier, Anton Gies, Michael Hoffmeister, Hermann Brenner
Summary: This systematic review examined the effectiveness of various invitation strategies in colorectal cancer screening programs, revealing that advance notification, mailing of fecal occult blood tests, and reminders have the potential to significantly increase participation rates. Multifaceted invitation strategies were found to be the most effective in increasing usage rates of fecal occult blood tests for colorectal cancer screening.
Review
Gastroenterology & Hepatology
Marina Hanna, Neelendu Dey, William M. Grady
Summary: Colorectal cancer is a common cancer globally and is a leading cause of cancer-related deaths. Current screening methods for colorectal cancer have limitations and many people are not compliant with screening recommendations. Novel screening tests based on advances in molecular biology, genetics, and epigenetics, as well as sequencing technologies and computational analytic methods, have been developed to improve early detection of colorectal cancer.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Lasse Kaalby, Ulrik Deding, Issam Al-Najami, Gabriele Berg-Beckhoff, Thomas Bjorsum-Meyer, Tinne Laurberg, Aasma Shaukat, Robert J. C. Steele, Anastasios Koulaouzidis, Morten Rasmussen, Morten Kobaek-Larsen, Gunnar Baatrup
Summary: New research suggests that faecal haemoglobin concentration (f-Hb) can indicate the presence of serious diseases not related to colorectal cancer (CRC). This study found an association between increasing f-Hb and the risk of mortality, as well as an increased risk of dying from respiratory disease, cardiovascular disease, and other cancers. f-Hb may be a potential biomarker for non-CRC diseases.
Article
Multidisciplinary Sciences
Miriam P. van der Meulen, Esther Toes-Zoutendijk, Manon C. W. Spaander, Evelien Dekker, Johannes M. G. Bonfrer, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, M. F. van Velthuysen, Maarten G. J. Thomeer, Harriet van Veldhuizen, Harry J. de Koning, Iris Lansdorp-Vogelaar, Monique E. van Leerdam
Summary: The participation rate in FIT screening is lower for individuals with a lower socioeconomic status (SES), but they have a higher detection rate for advanced neoplasia. Screening has the potential to reduce health inequalities in CRC mortality.
Article
Medicine, General & Internal
Salim Maher, Sarah Rolls, Gokulan Pavendranathan, Sean Westbury, Anna C. Akon, Amany Zekry
Summary: This study evaluated the efficacy of a nurse-led virtual clinic model in reducing waiting times for colonoscopy and improving patient experience. The results showed that compared to the standard outpatient clinic model, the virtual clinic model reduced waiting time for colonoscopy by approximately 71 days and did not increase adverse events.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Oncology
Lasse Kaalby, Issam Al-Najami, Ulrik Deding, Gabriele Berg-Beckhoff, Robert J. C. Steele, Morten Kobaek-Larsen, Aasma Shaukat, Morten Rasmussen, Gunnar Baatrup
Summary: This study found that screening participants with detectable fecal hemoglobin had higher mortality rates and different causes of death compared to those without. Fecal hemoglobin may serve as a marker for diseases not directly related to colorectal cancer and may be targeted for preventive measures in the future.
Article
Public, Environmental & Occupational Health
Johanna Wangmar, Yvonne Wengstrom, Anna Jervaeus, Kaisa Fritzell
Summary: The acceptability of colorectal cancer screening procedures is crucial for the success of screening programs. This study explored how individuals experience CRC screening, finding that experiences vary from having no worries to experiencing bothersome emotions, logistical concerns, inconsistent information, and unmet expectations. Improving patient experiences may involve using one-sample FITs, optimizing bowel preparation for colonoscopies, and delivering clear information and emotional support at the right time.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Rheumatology
Matthias Klimek, Gisela Buchele, Martin Rehm, Jan Beyersmann, Klaus-Peter Gunther, Hermann Brenner, Til Sturmer, Rolf E. Brenner, Dietrich Rothenbacher
Summary: This study aimed to investigate the relationship between OA-specific assessment values and long-term mortality in patients with advanced OA undergoing arthroplasty. The Ulm Osteoarthritis Study found that arthroplasty reduced pain and improved function, but there was no association between joint-specific WOMAC assessments and long-term mortality. However, generic function assessments were associated with increased risk of mortality.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Medicine, General & Internal
Sha Sha, Thi Mai Ngoc Nguyen, Sabine Kuznia, Tobias Niedermaier, Anna Zhu, Hermann Brenner, Ben Schoettker
Summary: A study on the UK Biobank cohort found that the use of vitamin D supplements is associated with lower all-cause mortality and reduced mortality from cancer, cardiovascular disease, and respiratory disease.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Pathology
Elizabeth Alwers, Jakob N. Kather, Matthias Kloor, Alexander Brobeil, Katrin E. Tagscherer, Wilfried Roth, Amelie Echle, Efrat L. Amitay, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister
Summary: This study examined and validated the association between an immune cell score similar to the Immunoscore and CRC patient survival as well as established molecular tumor markers. The immune cell score was found to be significantly associated with better patient survival, indicating its potential as a strong prognostic marker.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Letter
Gastroenterology & Hepatology
Thomas Heisser, Michael Hoffmeister, Hermann Brenner
Article
Oncology
Rafael Cardoso, Michael Hoffmeister, Hermann Brenner
Summary: This study analyzed the key characteristics of breast cancer screening programs and mammography use in European countries. The findings showed significant variations in screening programs and mammography use across different countries, calling for improved utilization of mammography screening across Europe, especially in countries with lower development levels.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Tobias Niedermaier, Thomas Gredner, Michael Hoffmeister, Ute Mons, Hermann Brenner
Summary: Consumption of processed meat is carcinogenic, particularly in relation to colorectal cancer risk, according to the IARC. Reducing intake of processed and red meat in Germany can significantly reduce the incidence of colorectal cancer.
Article
Nutrition & Dietetics
Tafirenyika Gwenzi, Petra Schrotz-King, Ben Schoettker, Michael Hoffmeister, Hermann Brenner
Summary: According to recent evidence, the prognostic value of Vitamin D (VitD) status for colorectal cancer (CRC) patients might be confined to patients with the GG genotype of Cdx2, a functional polymorphism of the VitD receptor gene. In this study, the researchers aimed to validate these findings in a cohort of CRC patients by measuring serum VitD concentration and performing Cdx2 genotyping. The results showed that VitD deficiency is associated with poorer survival, particularly in patients with the GG genotype of Cdx2.
Article
Cardiac & Cardiovascular Systems
Paul M. Haller, Alina Gossling, Christina Magnussen, Hermann Brenner, Ben Schoettker, Licia Iacoviello, Simona Costanzo, Frank Kee, Wolfgang Koenig, Allan Linneberg, Chaterina Sujana, Barbara Thorand, Veikko Salomaa, Teemu J. Niiranen, Stefan Soederberg, Henry Voelzke, Marcus Doerr, Susana Sans, Teresa Padro, Stephan B. Felix, Matthias Nauck, Astrid Petersmann, Luigi Palmieri, Chiara Donfrancesco, Roberto De Ponti, Giovanni Veronesi, Marco M. Ferrario, Kari Kuulasmaa, Tanja Zeller, Francisco M. Ojeda, Stefan Blankenberg, Dirk Westermann
Summary: This study demonstrates the role of cardiac biomarkers in predicting cardiovascular events and death in both general population and individuals with known diabetes. The findings suggest that these biomarkers can help identify individuals at highest risk for cardiovascular events and improve early identification of high-risk individuals. Therefore, they should be considered for routine risk assessment and can enhance the initiation of preventive therapies.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Oncology
Niki Dimou, Andre E. Kim, Orlagh Flanagan, Neil Murphy, Virginia Diez-Obrero, Anna Shcherbina, Elom K. Aglago, Emmanouil Bouras, Peter T. Campbell, Graham Casey, Steven Gallinger, Stephen B. Gruber, Mark A. Jenkins, Yi Lin, Victor Moreno, Edward Ruiz-Narvaez, Mariana C. Stern, Yu Tian, Kostas K. Tsilidis, Volker Arndt, Elizabeth L. Barry, James W. Baurley, Sonja I. Berndt, Stephane Bezieau, Stephanie A. Bien, D. Timothy Bishop, Hermann Brenner, Arif Budiarto, Robert Carreras-Torres, Tjeng Wawan Cenggoro, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Xuechen Chen, David V. Conti, Christopher H. Dampier, Matthew Devall, David A. Drew, Jane C. Figueiredo, Graham G. Giles, Andrea Gsur, Tabitha A. Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R. Huyghe, Kristina Jordahl, Eric Kawaguchi, Temitope O. Keku, Susanna C. Larsson, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Bharuno Mahesworo, John Morrison, Polly A. Newcomb, Christina C. Newton, Mireia Obon-Santacana, Jennifer Ose, Rish K. Pai, Julie R. Palmer, Nikos Papadimitriou, Bens Pardamean, Anita R. Peoples, Paul D. P. Pharoah, Elizabeth A. Platz, John D. Potter, Gad Rennert, Peter C. Scacheri, Robert E. Schoen, Yu-Ru Su, Catherine M. Tangen, Stephen N. Thibodeau, Duncan C. Thomas, Cornelia M. Ulrich, Caroline Y. Um, Franzel J. B. van Duijnhoven, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Emily White, Alicja Wolk, Michael O. Woods, Conghui Qu, Anshul Kundaje, Li Hsu, W. James Gauderman, Marc J. Gunter, Ulrike Peters
Summary: Diabetes is a risk factor for colorectal cancer, but the mechanisms and genetic variants affecting this relationship are still unclear. Through genome-wide gene-environment interaction analysis, it was found that variations in insulin signaling gene (SLC30A8) and immune function gene (LRCH1) may modify the association between diabetes and colorectal cancer risk.
BRITISH JOURNAL OF CANCER
(2023)
Review
Nutrition & Dietetics
Tafirenyika Gwenzi, Anna Zhu, Petra Schrotz-King, Ben Schoettker, Michael Hoffmeister, Hermann Brenner
Summary: This systematic review and meta-analysis evaluated the effects of vitamin D3 supplementation on serum inflammatory biomarkers among patients with cancer or pre-cancerous lesions. The study found that vitamin D3 supplementation significantly reduced TNF-a levels and may have a suppressive effect on tumor-promoting inflammatory response in patients with cancer or pre-cancerous lesions.
CLINICAL NUTRITION
(2023)
Article
Oncology
Thu Thi Pham, Katharina Nimptsch, Nikos Papadimitriou, Krasimira Aleksandrova, Mazda Jenab, Marc J. Gunter, Loic Le Marchand, Li Li, Brigid M. Lynch, Sergi Castellvi-Bel, Amanda I. Phipps, Stephanie L. Schmit, Hermann Brenner, Shuji Ogino, Edward Giovannucci, Tobias Pischon
Summary: This study used Mendelian randomization to investigate the association between genetically determined circulating resistin concentrations and the risk of colorectal cancer (CRC). The results showed no evidence of a relationship between genetically determined circulating resistin concentrations and the risk of CRC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Hengjing Li, Xuechen Chen, Michael Hoffmeister, Hermann Brenner
Summary: The incidence of colorectal cancer (CRC) in younger adults is increasing in many countries. This study aimed to evaluate the association of smoking exposure with early-onset CRC (EOCRC) risk and compare it with late-onset CRC (LOCRC). The results showed that smoking is a strong risk factor for both EOCRC and LOCRC.
JNCI CANCER SPECTRUM
(2023)
Review
Oncology
Xianzhe Li, Lara Stassen, Petra Schrotz-King, Zitong Zhao, Rafael Cardoso, Janhavi R. Raut, Megha Bhardwaj, Hermann Brenner
Summary: This systematic review evaluated fecal carcinoembryonic antigen (FCEA) as a biomarker for the noninvasive diagnosis and diagnosis of colorectal cancer (CRC). The study found significant differences in FCEA levels between CRC and control groups, and the diagnostic performance of FCEA was superior to that of serum carcinoembryonic antigen (SCEA), suggesting its potential role as a novel and easily measurable biomarker for the diagnosis of CRC. However, more comprehensive evaluation in screening settings is needed due to limited evidence from clinical studies.
Article
Oncology
Mani Etemad, Foteini Christodoulou, Stefanie Uhlig, Jessica C. Hassel, Petra Schrotz-King, Hermann Brenner, Cornelia M. Ulrich, Karen Bieback, Harald Klueter, Peter Bugert
Summary: This study investigated the effect of platelet activation on CLEC-2 expression and sCLEC-2 plasma level. PDPN significantly increased the aggregation response induced by classical agonists. Stimulation of platelets with ADP or PDPN caused a significant decrease in CLEC-2 on platelets and sCLEC-2 in the plasma. The plasma level of sCLEC-2 was lower in most tumor patients, except for glioblastoma patients who displayed higher levels.
